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Aβ-induced vulnerability propagates via the brain's default mode network.

Pascoal TA, Mathotaarachchi S, Kang MS, Mohaddes S, Shin M, Park AY, Parent MJ, Benedet AL, Chamoun M, Therriault J, Hwang H, Cuello AC, Misic B, Soucy JP, Aston JAD, Gauthier S, Rosa-Neto P.

Nat Commun. 2019 Jun 4;10(1):2353. doi: 10.1038/s41467-019-10217-w.


Brain cholinergic alterations in idiopathic REM sleep behaviour disorder: a PET imaging study with 18F-FEOBV.

Bedard MA, Aghourian M, Legault-Denis C, Postuma RB, Soucy JP, Gagnon JF, Pelletier A, Montplaisir J.

Sleep Med. 2019 Jun;58:35-41. doi: 10.1016/j.sleep.2018.12.020. Epub 2019 Jan 6.


First-in-Human Brain Imaging of [18F]TRACK, a PET tracer for Tropomyosin Receptor Kinases.

Bailey JJ, Kaiser L, Lindner S, Wüst M, Thiel A, Soucy JP, Rosa-Neto P, Scott PJH, Unterrainer M, Kaplan DR, Wängler C, Wängler B, Bartenstein P, Bernard-Gauthier V, Schirrmacher R.

ACS Chem Neurosci. 2019 Jun 19;10(6):2697-2702. doi: 10.1021/acschemneuro.9b00144. Epub 2019 Apr 29.


Joint Modeling of Resistance to Six Antimicrobials in Urinary Escherichia coli Isolates in Quebec, Canada.

Soucy JR, Schmidt AM, Frenette C, Dolcé P, Boudreault AA, Buckeridge DL, Quach C.

Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii: e02531-18. doi: 10.1128/AAC.02531-18. Print 2019 Jul.


PET imaging of freely moving interacting rats.

Miranda A, Kang MS, Blinder S, Bouhachi R, Soucy JP, Aliaga-Aliaga A, Massarweh G, Stroobants S, Staelens S, Rosa-Neto P, Verhaeghe J.

Neuroimage. 2019 May 1;191:560-567. doi: 10.1016/j.neuroimage.2019.02.064. Epub 2019 Mar 2.


Nightmare Severity Is Inversely Related to Frontal Brain Activity During Waking State Picture Viewing.

Marquis LP, Julien SH, Baril AA, Blanchette-Carrière C, Paquette T, Carr M, Soucy JP, Montplaisir J, Nielsen T.

J Clin Sleep Med. 2019 Feb 15;15(2):253-264. doi: 10.5664/jcsm.7628.


What are Clients Asking Their Therapist During Therapist-Assisted Internet-Delivered Cognitive Behaviour Therapy? A Content Analysis of Client Questions.

Soucy JN, Hadjistavropoulos HD, Pugh NE, Dear BF, Titov N.

Behav Cogn Psychother. 2019 Jul;47(4):407-420. doi: 10.1017/S1352465818000668. Epub 2019 Jan 26.


Aberrant RNA splicing is the major pathogenic effect in a knock-in mouse model of the dominantly inherited c.1430A>G human RPE65 mutation.

Li Y, Furhang R, Ray A, Duncan T, Soucy J, Mahdi R, Chaitankar V, Gieser L, Poliakov E, Qian H, Liu P, Dong L, Rogozin IB, Redmond TM.

Hum Mutat. 2019 Apr;40(4):426-443. doi: 10.1002/humu.23706. Epub 2019 Jan 25.


Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging.

Schirrmacher R, Bailey JJ, Mossine AV, Scott PJH, Kaiser L, Bartenstein P, Lindner S, Kaplan DR, Kostikov A, Fricker G, Mahringer A, Rosa-Neto P, Schirrmacher E, Wängler C, Wängler B, Thiel A, Soucy JP, Bernard-Gauthier V.

Pharmaceuticals (Basel). 2019 Jan 3;12(1). pii: E7. doi: 10.3390/ph12010007. Review.


In vivo metabotropic glutamate receptor type 5 abnormalities localize the epileptogenic zone in mesial temporal lobe epilepsy.

Lam J, DuBois JM, Rowley J, González-Otárula KA, Soucy JP, Massarweh G, Hall JA, Guiot MC, Rosa-Neto P, Kobayashi E.

Ann Neurol. 2019 Feb;85(2):218-228. doi: 10.1002/ana.25404. Epub 2019 Jan 20.


Obstructive sleep apnea during REM sleep and daytime cerebral functioning: A regional cerebral blood flow study using high-resolution SPECT.

Baril AA, Gagnon K, Brayet P, Montplaisir J, Carrier J, Soucy JP, Lafond C, Blais H, d'Aragon C, Gagnon JF, Gosselin N.

J Cereb Blood Flow Metab. 2018 Nov 22:271678X18814106. doi: 10.1177/0271678X18814106. [Epub ahead of print]


A simplified radiosynthesis of [18 F]MK-6240 for tau PET imaging.

Hopewell R, Ross K, Kostikov A, Pascoal TA, Alberti T, Lacatus-Samoila M, Soucy JP, Bennacef I, Kobayashi E, Kang MS, Rosa-Neto P, Massarweh G.

J Labelled Comp Radiopharm. 2019 Feb;62(2):109-114. doi: 10.1002/jlcr.3695. Epub 2018 Dec 19.


Bifrontal Hypermetabolism on Brain FDG-PET in a Case of C9orf72-Related Behavioral Variant of Frontotemporal Dementia.

Levy JP, Bocti C, Elie D, Paquet N, Soucy JP, Ducharme S.

J Neuropsychiatry Clin Neurosci. Winter 2019;31(1):92-94. doi: 10.1176/appi.neuropsych.18050114. Epub 2018 Nov 8. No abstract available.


MYOD1 involvement in myopathy.

Lopes F, Miguet M, Mucha BE, Gauthier J, Saillour V, Nguyen CÉ, Vanasse M, Ellezam B, Michaud JL, Soucy JF, Campeau PM.

Eur J Neurol. 2018 Dec;25(12):e123-e124. doi: 10.1111/ene.13782. No abstract available.


The Tissue-Engineered Human Psoriatic Skin Substitute: A Valuable In Vitro Model to Identify Genes with Altered Expression in Lesional Psoriasis.

Rioux G, Pouliot-Bérubé C, Simard M, Benhassine M, Soucy J, Guérin SL, Pouliot R.

Int J Mol Sci. 2018 Sep 26;19(10). pii: E2923. doi: 10.3390/ijms19102923.


Impaired sensorimotor processing during complex gait precedes behavioral changes in middle-aged adults.

Mitchell T, Starrs F, Soucy JP, Thiel A, Paquette C.

J Gerontol A Biol Sci Med Sci. 2018 Sep 21. doi: 10.1093/gerona/gly210. [Epub ahead of print]


Content of client emails in internet-delivered cognitive behaviour therapy: A comparison between two trials and relationship to client outcome.

Soucy JN, Hadjistavropoulos HD, Couture CA, Owens VAM, Dear BF, Titov N.

Internet Interv. 2018 Feb 1;11:53-59. doi: 10.1016/j.invent.2018.01.006. eCollection 2018 Mar.


Mucolipidosis type IV in a child.

Chaer L, Harissi-Dagher M, Soucy JF, Ellezam B, Hamel P.

J AAPOS. 2018 Dec;22(6):469-471. doi: 10.1016/j.jaapos.2018.04.011. Epub 2018 Aug 16.


In vivo quantification of neurofibrillary tangles with [18F]MK-6240.

Pascoal TA, Shin M, Kang MS, Chamoun M, Chartrand D, Mathotaarachchi S, Bennacef I, Therriault J, Ng KP, Hopewell R, Bouhachi R, Hsiao HH, Benedet AL, Soucy JP, Massarweh G, Gauthier S, Rosa-Neto P.

Alzheimers Res Ther. 2018 Jul 31;10(1):74. doi: 10.1186/s13195-018-0402-y.


Molecular imaging in dementia: Past, present, and future.

Laforce R Jr, Soucy JP, Sellami L, Dallaire-Théroux C, Brunet F, Bergeron D, Miller BL, Ossenkoppele R.

Alzheimers Dement. 2018 Nov;14(11):1522-1552. doi: 10.1016/j.jalz.2018.06.2855. Epub 2018 Jul 18. Review.


Refining the phenotype associated with biallelic DNAJC21 mutations.

D'Amours G, Lopes F, Gauthier J, Saillour V, Nassif C, Wynn R, Alos N, Leblanc T, Capri Y, Nizard S, Lemyre E, Michaud JL, Pelletier VA, Pastore YD, Soucy JF.

Clin Genet. 2018 Aug;94(2):252-258. doi: 10.1111/cge.13370. Epub 2018 Jun 7.


Chitayat-Hall and Schaaf-Yang syndromes:a common aetiology: expanding the phenotype of MAGEL2-related disorders.

Jobling R, Stavropoulos DJ, Marshall CR, Cytrynbaum C, Axford MM, Londero V, Moalem S, Orr J, Rossignol F, Lopes FD, Gauthier J, Alos N, Rupps R, McKinnon M, Adam S, Nowaczyk MJM, Walker S, Scherer SW, Nassif C, Hamdan FF, Deal CL, Soucy JF, Weksberg R, Macleod P, Michaud JL, Chitayat D.

J Med Genet. 2018 May;55(5):316-321. doi: 10.1136/jmedgenet-2017-105222. Epub 2018 Mar 29.


Photocrosslinkable Gelatin/Tropoelastin Hydrogel Adhesives for Peripheral Nerve Repair.

Soucy JR, Shirzaei Sani E, Portillo Lara R, Diaz D, Dias F, Weiss AS, Koppes AN, Koppes RA, Annabi N.

Tissue Eng Part A. 2018 Sep;24(17-18):1393-1405. doi: 10.1089/ten.TEA.2017.0502. Epub 2018 May 9.


High-Resolution Ecological Niche Modeling of Ixodes scapularis Ticks Based on Passive Surveillance Data at the Northern Frontier of Lyme Disease Emergence in North America.

Soucy JR, Slatculescu AM, Nyiraneza C, Ogden NH, Leighton PA, Kerr JT, Kulkarni MA.

Vector Borne Zoonotic Dis. 2018 May;18(5):235-242. doi: 10.1089/vbz.2017.2234. Epub 2018 Mar 22.


Altered brain perfusion patterns in wakefulness and slow-wave sleep in sleepwalkers.

Desjardins MÈ, Baril AA, Soucy JP, Dang-Vu TT, Desautels A, Petit D, Montplaisir J, Zadra A.

Sleep. 2018 May 1;41(5). doi: 10.1093/sleep/zsy039.


Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer's disease.

Pascoal TA, Mathotaarachchi S, Shin M, Park AY, Mohades S, Benedet AL, Kang MS, Massarweh G, Soucy JP, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative.

Eur J Nucl Med Mol Imaging. 2018 Jun;45(6):1021-1030. doi: 10.1007/s00259-018-3933-3. Epub 2018 Feb 2.


The Value of Regional Cerebral Blood Flow SPECT and FDG PET in Operculoinsular Epilepsy.

Fei P, Soucy JP, Obaid S, Boucher O, Bouthillier A, Nguyen DK.

Clin Nucl Med. 2018 Mar;43(3):e67-e73. doi: 10.1097/RLU.0000000000001949.


Mildly elevated succinylacetone and normal liver function in compound heterozygotes with pathogenic and pseudodeficient FAH alleles.

Yang H, Rossignol F, Cyr D, Laframboise R, Wang SP, Soucy JF, Berthier MT, Giguère Y, Waters PJ, Mitchell GA; Québec NTBC Study Group.

Mol Genet Metab Rep. 2017 Dec 27;14:55-58. doi: 10.1016/j.ymgmr.2017.12.002. eCollection 2018 Mar.


Multimodal Imaging in Rat Model Recapitulates Alzheimer's Disease Biomarkers Abnormalities.

Parent MJ, Zimmer ER, Shin M, Kang MS, Fonov VS, Mathieu A, Aliaga A, Kostikov A, Do Carmo S, Dea D, Poirier J, Soucy JP, Gauthier S, Cuello AC, Rosa-Neto P.

J Neurosci. 2017 Dec 13;37(50):12263-12271. doi: 10.1523/JNEUROSCI.1346-17.2017. Epub 2017 Nov 2.


Phylogenetic analysis of the metazoan carotenoid oxygenase superfamily: a new ancestral gene assemblage of BCO-like (BCOL) proteins.

Poliakov E, Soucy J, Gentleman S, Rogozin IB, Redmond TM.

Sci Rep. 2017 Oct 16;7(1):13192. doi: 10.1038/s41598-017-13521-x.


Altered Regional Cerebral Blood Flow in Idiopathic Hypersomnia.

Boucetta S, Montplaisir J, Zadra A, Lachapelle F, Soucy JP, Gravel P, Dang-Vu TT.

Sleep. 2017 Oct 1;40(10). doi: 10.1093/sleep/zsx140.


A 3D-psoriatic skin model for dermatological testing: The impact of culture conditions.

Duque-Fernandez A, Gauthier L, Simard M, Jean J, Gendreau I, Morin A, Soucy J, Auger M, Pouliot R.

Biochem Biophys Rep. 2016 Sep 30;8:268-276. doi: 10.1016/j.bbrep.2016.09.012. eCollection 2016 Dec.


Quantification of brain cholinergic denervation in Alzheimer's disease using PET imaging with [18F]-FEOBV.

Aghourian M, Legault-Denis C, Soucy JP, Rosa-Neto P, Gauthier S, Kostikov A, Gravel P, Bédard MA.

Mol Psychiatry. 2017 Nov;22(11):1531-1538. doi: 10.1038/mp.2017.183. Epub 2017 Sep 12.


A Kinome-Wide Selective Radiolabeled TrkB/C Inhibitor for in Vitro and in Vivo Neuroimaging: Synthesis, Preclinical Evaluation, and First-in-Human.

Bernard-Gauthier V, Bailey JJ, Mossine AV, Lindner S, Vomacka L, Aliaga A, Shao X, Quesada CA, Sherman P, Mahringer A, Kostikov A, Grand'Maison M, Rosa-Neto P, Soucy JP, Thiel A, Kaplan DR, Fricker G, Wängler B, Bartenstein P, Schirrmacher R, Scott PJH.

J Med Chem. 2017 Aug 24;60(16):6897-6910. doi: 10.1021/acs.jmedchem.7b00396. Epub 2017 Jul 21.


Brain perfusion during rapid-eye-movement sleep successfully identifies amnestic mild cognitive impairment.

Brayet P, Petit D, Baril AA, Gosselin N, Gagnon JF, Soucy JP, Gauthier S, Kergoat MJ, Carrier J, Rouleau I, Montplaisir J.

Sleep Med. 2017 Jun;34:134-140. doi: 10.1016/j.sleep.2017.01.025. Epub 2017 Mar 30.


A case of familial transmission of the newly described DNMT3A-Overgrowth Syndrome.

Lemire G, Gauthier J, Soucy JF, Delrue MA.

Am J Med Genet A. 2017 Jul;173(7):1887-1890. doi: 10.1002/ajmg.a.38119. Epub 2017 Apr 27.


Antagonistic interactions of soil pseudomonads are structured in time.

Kraemer SA, Soucy JR, Kassen R.

FEMS Microbiol Ecol. 2017 May 1;93(5). doi: 10.1093/femsec/fix046.


Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain.

Ng KP, Pascoal TA, Mathotaarachchi S, Therriault J, Kang MS, Shin M, Guiot MC, Guo Q, Harada R, Comley RA, Massarweh G, Soucy JP, Okamura N, Gauthier S, Rosa-Neto P.

Alzheimers Res Ther. 2017 Mar 31;9(1):25. doi: 10.1186/s13195-017-0253-y.


Treatment acceptability and preferences for managing severe health anxiety: Perceptions of internet-delivered cognitive behaviour therapy among primary care patients.

Soucy JN, Hadjistavropoulos HD.

J Behav Ther Exp Psychiatry. 2017 Dec;57:14-24. doi: 10.1016/j.jbtep.2017.02.002. Epub 2017 Feb 20.


Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry.

Khalili-Mahani N, Rombouts SA, van Osch MJ, Duff EP, Carbonell F, Nickerson LD, Becerra L, Dahan A, Evans AC, Soucy JP, Wise R, Zijdenbos AP, van Gerven JM.

Hum Brain Mapp. 2017 Apr;38(4):2276-2325. doi: 10.1002/hbm.23516. Epub 2017 Feb 1. Review.


Development of "[11C]kits" for a fast, efficient and reliable production of carbon-11 labeled radiopharmaceuticals for Positron Emission Tomography.

Jolly D, Hopewell R, Kovacevic M, Li QY, Soucy JP, Kostikov A.

Appl Radiat Isot. 2017 Mar;121:76-81. doi: 10.1016/j.apradiso.2016.11.020. Epub 2016 Dec 2.


Synergistic interaction between amyloid and tau predicts the progression to dementia.

Pascoal TA, Mathotaarachchi S, Shin M, Benedet AL, Mohades S, Wang S, Beaudry T, Kang MS, Soucy JP, Labbe A, Gauthier S, Rosa-Neto P; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2017 Jun;13(6):644-653. doi: 10.1016/j.jalz.2016.11.005. Epub 2016 Dec 23.


Educating patients about Internet-delivered cognitive behaviour therapy: Perceptions among treatment seekers and non-treatment seekers before and after viewing an educational video.

Soucy JN, Owens VAM, Hadjistavropoulos HD, Dirkse DA, Dear BF.

Internet Interv. 2016 Sep 20;6:57-63. doi: 10.1016/j.invent.2016.09.003. eCollection 2016 Nov.


Metabotropic Glutamate Receptor Type 5 (mGluR5) Cortical Abnormalities in Focal Cortical Dysplasia Identified In Vivo With [11C]ABP688 Positron-Emission Tomography (PET) Imaging.

DuBois JM, Rousset OG, Guiot MC, Hall JA, Reader AJ, Soucy JP, Rosa-Neto P, Kobayashi E.

Cereb Cortex. 2016 Oct 17;26(11):4170-4179. doi: 10.1093/cercor/bhw249.


Clinical Utility of Amyloid PET Imaging in the Differential Diagnosis of Atypical Dementias and Its Impact on Caregivers.

Bensaïdane MR, Beauregard JM, Poulin S, Buteau FA, Guimond J, Bergeron D, Verret L, Fortin MP, Houde M, Bouchard RW, Soucy JP, Laforce R.

J Alzheimers Dis. 2016 Apr 18;52(4):1251-62. doi: 10.3233/JAD-151180.


Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer's disease.

Pascoal TA, Mathotaarachchi S, Mohades S, Benedet AL, Chung CO, Shin M, Wang S, Beaudry T, Kang MS, Soucy JP, Labbe A, Gauthier S, Rosa-Neto P.

Mol Psychiatry. 2017 Feb;22(2):306-311. doi: 10.1038/mp.2016.37. Epub 2016 Mar 29.


Canadian Consensus Guidelines on Use of Amyloid Imaging in Canada: Update and Future Directions from the Specialized Task Force on Amyloid imaging in Canada.

Laforce R, Rosa-Neto P, Soucy JP, Rabinovici GD, Dubois B, Gauthier S.

Can J Neurol Sci. 2016 Jul;43(4):503-12. doi: 10.1017/cjn.2015.401. Epub 2016 Feb 26.


Dopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers.

Booij L, Welfeld K, Leyton M, Dagher A, Boileau I, Sibon I, Baker GB, Diksic M, Soucy JP, Pruessner JC, Cawley-Fiset E, Casey KF, Benkelfat C.

Transl Psychiatry. 2016 Feb 23;6:e740. doi: 10.1038/tp.2016.6.


A randomized controlled trial of guided internet-delivered cognitive behaviour therapy for older adults with generalized anxiety.

Jones SL, Hadjistavropoulos HD, Soucy JN.

J Anxiety Disord. 2016 Jan;37:1-9. doi: 10.1016/j.janxdis.2015.10.006. Epub 2015 Nov 2.


Joubert Syndrome in French Canadians and Identification of Mutations in CEP104.

Srour M, Hamdan FF, McKnight D, Davis E, Mandel H, Schwartzentruber J, Martin B, Patry L, Nassif C, Dionne-Laporte A, Ospina LH, Lemyre E, Massicotte C, Laframboise R, Maranda B, Labuda D, Décarie JC, Rypens F, Goldsher D, Fallet-Bianco C, Soucy JF, Laberge AM, Maftei C; Care4Rare Canada Consortium, Boycott K, Brais B, Boucher RM, Rouleau GA, Katsanis N, Majewski J, Elpeleg O, Kukolich MK, Shalev S, Michaud JL.

Am J Hum Genet. 2015 Nov 5;97(5):744-53. doi: 10.1016/j.ajhg.2015.09.009. Epub 2015 Oct 17.

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