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Short axial length and hyperopic refractive error are risk factors of central serous chorioretinopathy.

Terao N, Koizumi H, Kojima K, Kusada N, Nagata K, Yamagishi T, Yoneda K, Yoshii K, Kinoshita S, Sotozono C.

Br J Ophthalmol. 2019 Nov 28. pii: bjophthalmol-2019-315236. doi: 10.1136/bjophthalmol-2019-315236. [Epub ahead of print]


Identification of HLA-A*02:06:01 as the primary disease susceptibility HLA allele in cold medicine-related Stevens-Johnson syndrome with severe ocular complications by high-resolution NGS-based HLA typing.

Nakatani K, Ueta M, Khor SS, Hitomi Y, Okudaira Y, Masuya A, Wada Y, Sotozono C, Kinoshita S, Inoko H, Tokunaga K.

Sci Rep. 2019 Nov 7;9(1):16240. doi: 10.1038/s41598-019-52619-2.


Congenital nasolacrimal duct obstruction continues trend for spontaneous resolution beyond first year of life.

Nakayama T, Watanabe A, Rajak S, Yamanaka Y, Sotozono C.

Br J Ophthalmol. 2019 Nov 1. pii: bjophthalmol-2019-314980. doi: 10.1136/bjophthalmol-2019-314980. [Epub ahead of print]


Association of HLA class I and II gene polymorphisms with acetaminophen-related Stevens-Johnson syndrome with severe ocular complications in Japanese individuals.

Ueta M, Nakamura R, Saito Y, Tokunaga K, Sotozono C, Yabe T, Aihara M, Matsunaga K, Kinoshita S.

Hum Genome Var. 2019 Oct 28;6:50. doi: 10.1038/s41439-019-0082-6. eCollection 2019.


Primary intraocular natural killer-cell lymphoma successfully treated using a multidisciplinary strategy.

Takimoto-Shimomura T, Shimura Y, Nagata K, Inaba T, Chinen Y, Tsukamoto T, Kobayashi T, Horiike S, Sotozono C, Kuroda J.

Ann Hematol. 2019 Nov;98(11):2617-2619. doi: 10.1007/s00277-019-03807-7. Epub 2019 Oct 21. No abstract available.


pH balance and lactic acid increase in the vitreous body of diabetes mellitus patients.

Mieno H, Marunaka Y, Inaba T, Kojima K, Yoneda K, Nagata K, Sotozono C.

Exp Eye Res. 2019 Nov;188:107789. doi: 10.1016/j.exer.2019.107789. Epub 2019 Sep 3.


Multicenter survey of sutureless 27-gauge vitrectomy for primary rhegmatogenous retinal detachment: a consecutive series of 410 cases.

Shinkai Y, Oshima Y, Yoneda K, Kogo J, Imai H, Watanabe A, Matsui Y, Suzuki K, Sotozono C; 27G Vitrectomy Study Group.

Graefes Arch Clin Exp Ophthalmol. 2019 Dec;257(12):2591-2600. doi: 10.1007/s00417-019-04448-2. Epub 2019 Sep 2.


Direct Reprogramming Into Corneal Epithelial Cells Using a Transcriptional Network Comprising PAX6, OVOL2, and KLF4.

Kitazawa K, Hikichi T, Nakamura T, Nakamura M, Sotozono C, Masui S, Kinoshita S.

Cornea. 2019 Nov;38 Suppl 1:S34-S41. doi: 10.1097/ICO.0000000000002074. Review.


Core Transcription Factors Promote Induction of PAX3-Positive Skeletal Muscle Stem Cells.

Sato T, Higashioka K, Sakurai H, Yamamoto T, Goshima N, Ueno M, Sotozono C.

Stem Cell Reports. 2019 Aug 13;13(2):352-365. doi: 10.1016/j.stemcr.2019.06.006. Epub 2019 Jul 25.


Human Skeletal Muscle Cells Derived from the Orbicularis Oculi Have Regenerative Capacity for Duchenne Muscular Dystrophy.

Yamanaka Y, Takenaka N, Sakurai H, Ueno M, Kinoshita S, Sotozono C, Sato T.

Int J Mol Sci. 2019 Jul 14;20(14). pii: E3456. doi: 10.3390/ijms20143456.


A physical biomarker of the quality of cultured corneal endothelial cells and of the long-term prognosis of corneal restoration in patients.

Yamamoto A, Tanaka H, Toda M, Sotozono C, Hamuro J, Kinoshita S, Ueno M, Tanaka M.

Nat Biomed Eng. 2019 Dec;3(12):953-960. doi: 10.1038/s41551-019-0429-9. Epub 2019 Jul 22.


Clinical outcomes and time to recurrence of phototherapeutic keratectomy in Japan.

Hieda O, Kawasaki S, Yamamura K, Nakatsukasa M, Kinoshita S, Sotozono C.

Medicine (Baltimore). 2019 Jul;98(27):e16216. doi: 10.1097/MD.0000000000016216.


Gene expression analysis of conjunctival epithelium of patients with Stevens-Johnson syndrome in the chronic stage.

Ueta M, Sotozono C, Nishigaki H, Ohsako S, Yokoi N, Mizushima K, Naito Y, Kinoshita S.

BMJ Open Ophthalmol. 2019 Jun 16;4(1):e000254. doi: 10.1136/bmjophth-2018-000254. eCollection 2019.


Multiple Linear Regression Analysis of the Impact of Corneal Epithelial Thickness on Refractive Error Post Corneal Refractive Surgery.

Cho Y, Hieda O, Wakimasu K, Yamamura K, Yamasaki T, Nakamura Y, Sotozono C, Kinoshita S.

Am J Ophthalmol. 2019 Nov;207:326-332. doi: 10.1016/j.ajo.2019.05.016. Epub 2019 May 22.


Recovering vision in corneal epithelial stem cell deficient eyes.

Bains KK, Fukuoka H, Hammond GM, Sotozono C, Quantock AJ.

Cont Lens Anterior Eye. 2019 Aug;42(4):350-358. doi: 10.1016/j.clae.2019.04.006. Epub 2019 Apr 29. Review.


Expression of prostaglandin E2 receptor 3 in the eyelid epidermis of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis.

Mieno H, Ueta M, Yamada K, Yamanaka Y, Nakayama T, Watanabe A, Kinoshita S, Sotozono C.

Br J Ophthalmol. 2019 Apr 18. pii: bjophthalmol-2018-313587. doi: 10.1136/bjophthalmol-2018-313587. [Epub ahead of print]


Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder Resembling B-cell Pseudo-lymphoma on the Lip and Conjunctivae.

Miyagawa F, Aoki Y, Hayashino A, Sotozono C, Asada H.

Acta Derm Venereol. 2019 Jun 1;99(7):683-684. doi: 10.2340/00015555-3172. No abstract available.


Relationship Between Ocular Surface Epithelial Damage, Tear Abnormalities, and Blink in Patients With Dry Eye.

Kato H, Yokoi N, Watanabe A, Komuro A, Sonomura Y, Sotozono C, Kinoshita S.

Cornea. 2019 Mar;38(3):318-324. doi: 10.1097/ICO.0000000000001841.


Association of Upregulated Angiogenic Cytokines With Choroidal Abnormalities in Chronic Central Serous Chorioretinopathy.

Terao N, Koizumi H, Kojima K, Yamagishi T, Nagata K, Kitazawa K, Yamamoto Y, Yoshii K, Hiraga A, Toda M, Kinoshita S, Sotozono C, Hamuro J.

Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5924-5931. doi: 10.1167/iovs.18-25517.


Severe Dry Eye With Combined Mechanisms is Involved in the Ocular Sequelae of SJS/TEN at the Chronic Stage.

Sotozono C, Ueta M, Yokoi N.

Invest Ophthalmol Vis Sci. 2018 Nov 1;59(14):DES80-DES86. doi: 10.1167/iovs.18-24019. Review.


Involvement of anterior and posterior corneal surface area imbalance in the pathological change of keratoconus.

Kitazawa K, Itoi M, Yokota I, Wakimasu K, Cho Y, Nakamura Y, Hieda O, Kinoshita S, Sotozono C.

Sci Rep. 2018 Oct 9;8(1):14993. doi: 10.1038/s41598-018-33490-z.


"Progress in Corneal Research and Practice in Japan and Abroad": The 23rd Annual Meeting of the Kyoto Cornea Club, November 24 and 25, 2017.

Nishida K, Sotozono C, Yamagami S, Shiraishi A, Saika S, Fukushima A, Hori Y.

Cornea. 2018 Nov;37 Suppl 1:S37-S38. doi: 10.1097/ICO.0000000000001723. No abstract available.


Topical non-steroidal anti-inflammatory drugs for the treatment of cystoid macular edema post Descemet's stripping automated endothelial keratoplasty.

Kitazawa K, Kayukawa K, Wakimasu K, Inatomi T, Hieda O, Mori K, Sotozono C, Kinoshita S.

Jpn J Ophthalmol. 2018 Nov;62(6):615-620. doi: 10.1007/s10384-018-0621-6. Epub 2018 Sep 25.


The trend of resistance to antibiotics for ocular infection of Staphylococcus aureus, coagulase-negative staphylococci, and Corynebacterium compared with 10-years previous: A retrospective observational study.

Deguchi H, Kitazawa K, Kayukawa K, Kondoh E, Fukumoto A, Yamasaki T, Kinoshita S, Sotozono C.

PLoS One. 2018 Sep 7;13(9):e0203705. doi: 10.1371/journal.pone.0203705. eCollection 2018.


The Efficacy of Sodium-Glucose Cotransporter 2 (SGLT2) inhibitors for the treatment of chronic diabetic macular oedema in vitrectomised eyes: a retrospective study.

Mieno H, Yoneda K, Yamazaki M, Sakai R, Sotozono C, Fukui M.

BMJ Open Ophthalmol. 2018 Jul 23;3(1):e000130. doi: 10.1136/bmjophth-2017-000130. eCollection 2018.


Moderately Long-Term Safety and Efficacy of Repeat Penetrating Keratoplasty.

Kitazawa K, Wakimasu K, Kayukawa K, Yokota I, Inatomi T, Hieda O, Sotozono C, Kinoshita S.

Cornea. 2018 Oct;37(10):1255-1259. doi: 10.1097/ICO.0000000000001694.


Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration.

Terao N, Koizumi H, Kojima K, Yamagishi T, Yamamoto Y, Yoshii K, Kitazawa K, Hiraga A, Toda M, Kinoshita S, Sotozono C, Hamuro J.

Sci Rep. 2018 Jul 12;8(1):10520. doi: 10.1038/s41598-018-28484-w.


Endothelial cell loss and graft survival after penetrating keratoplasty for laser iridotomy-induced bullous keratopathy.

Okumura N, Kusakabe A, Koizumi N, Wakimasu K, Kayukawa K, Kondo M, Mori K, Sotozono C, Kinoshita S.

Jpn J Ophthalmol. 2018 Jul;62(4):438-442. doi: 10.1007/s10384-018-0598-1. Epub 2018 May 15.


Effect of Posterior Corneal Vesicles on Corneal Endothelial Cell Density and Anisometropic Amblyopia.

Noguchi A, Okumura N, Sotozono C, Kinoshita S.

Cornea. 2018 Jul;37(7):813-817. doi: 10.1097/ICO.0000000000001612.


A new surgical approach for punctal occlusion using fibrous tissue from under the lacrimal caruncle.

Yokoi N, Komuro A, Sotozono C, Kinoshita S.

Clin Ophthalmol. 2018 Mar 6;12:463-472. doi: 10.2147/OPTH.S155209. eCollection 2018.


Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy.

Kinoshita S, Koizumi N, Ueno M, Okumura N, Imai K, Tanaka H, Yamamoto Y, Nakamura T, Inatomi T, Bush J, Toda M, Hagiya M, Yokota I, Teramukai S, Sotozono C, Hamuro J.

N Engl J Med. 2018 Mar 15;378(11):995-1003. doi: 10.1056/NEJMoa1712770.


Topical ganciclovir treatment post-Descemet's stripping automated endothelial keratoplasty for patients with bullous keratopathy induced by cytomegalovirus.

Kitazawa K, Jongkhajornpong P, Inatomi T, Koizumi N, Kayukawa K, Wakimasu K, Sotozono C, Kinoshita S.

Br J Ophthalmol. 2018 Sep;102(9):1293-1297. doi: 10.1136/bjophthalmol-2017-311145. Epub 2018 Jan 23.


Downregulation of interferon-γ-induced protein 10 in the tears of patients with Stevens-Johnson syndrome with severe ocular complications in the chronic stage.

Ueta M, Nishigaki H, Sotozono C, Kinoshita S.

BMJ Open Ophthalmol. 2017 Aug 7;1(1):e000073. doi: 10.1136/bmjophth-2017-000073. eCollection 2017.


Long-Term Outcome After Penetrating Keratoplasty in a Pedigree With the G177E Mutation in the UBIAD1 Gene for Schnyder Corneal Dystrophy.

Kitazawa K, Wakimasu K, Kayukawa K, Sugimoto M, Nakai J, Weiss JS, Ueno M, Sotozono C, Kinoshita S.

Cornea. 2018 May;37(5):554-559. doi: 10.1097/ICO.0000000000001511.


Wide-field contact specular microscopy analysis of corneal endothelium post trabeculectomy.

Okumura N, Matsumoto D, Okazaki Y, Koizumi N, Sotozono C, Kinoshita S, Mori K.

Graefes Arch Clin Exp Ophthalmol. 2018 Apr;256(4):751-757. doi: 10.1007/s00417-017-3889-1. Epub 2018 Jan 4.


Ocular-muscle surgery for filamentary keratitis that developed in double elevator palsy.

Hieda O, Yokoi N, Sotozono C.

Int Med Case Rep J. 2017 Dec 4;10:385-388. doi: 10.2147/IMCRJ.S128964. eCollection 2017.



Kitazawa K, Kayukawa K, Wakimasu K, Yokota I, Inatomi T, Hieda O, Mori K, Sotozono C, Kinoshita S.

Ophthalmology. 2017 Dec;124(12):e86-e87. doi: 10.1016/j.ophtha.2017.06.022. No abstract available.


Immunohistochemical Detection of Propionibacterium acnes in the Retinal Granulomas in Patients with Ocular Sarcoidosis.

Nagata K, Eishi Y, Uchida K, Yoneda K, Hatanaka H, Yasuhara T, Nagata M, Sotozono C, Kinoshita S.

Sci Rep. 2017 Nov 9;7(1):15226. doi: 10.1038/s41598-017-15710-0.


Unique circumferential peripheral keratitis in relapsing polychondritis: A case report.

Motozawa N, Nakamura T, Takagi S, Fujihara M, Hirami Y, Ishida K, Sotozono C, Kurimoto Y.

Medicine (Baltimore). 2017 Oct;96(41):e7951. doi: 10.1097/MD.0000000000007951.


The existence of dead cells in donor corneal endothelium preserved with storage media.

Kitazawa K, Inatomi T, Tanioka H, Kawasaki S, Nakagawa H, Hieda O, Fukuoka H, Okumura N, Koizumi N, Iliakis B, Sotozono C, Kinoshita S.

Br J Ophthalmol. 2017 Dec;101(12):1725-1730. doi: 10.1136/bjophthalmol-2017-310913. Epub 2017 Oct 5.


Severe Corneal Disorders Developed After Brimonidine Tartrate Ophthalmic Solution Use.

Maruyama Y, Ikeda Y, Yokoi N, Mori K, Kato H, Ueno M, Kinoshita S, Sotozono C.

Cornea. 2017 Dec;36(12):1567-1569. doi: 10.1097/ICO.0000000000001370.


Mucocutaneous inflammation in the Ikaros Family Zinc Finger 1-keratin 5-specific transgenic mice.

Ueta M, Hamuro J, Nishigaki H, Nakamura N, Shinomiya K, Mizushima K, Hitomi Y, Tamagawa-Mineoka R, Yokoi N, Naito Y, Tokunaga K, Katoh N, Sotozono C, Kinoshita S.

Allergy. 2018 Feb;73(2):395-404. doi: 10.1111/all.13308. Epub 2017 Oct 16.


"Progress in Corneal Research and Practice in Japan and Abroad," 22nd Annual Meeting of the Kyoto Cornea Club, November 25 and 26, 2016.

Nishida K, Sotozono C, Yamagami S, Shiraishi A, Saika S, Fukushima A, Hori Y.

Cornea. 2017 Nov;36 Suppl 1:S1-S2. doi: 10.1097/ICO.0000000000001342. No abstract available.


Predictive clinical factors of cystoid macular edema in patients with Descemet's stripping automated endothelial keratoplasty.

Kitazawa K, Kayukawa K, Wakimasu K, Yokota I, Inatomi T, Hieda O, Mori K, Sotozono C, Kinoshita S.

Sci Rep. 2017 Aug 7;7(1):7412. doi: 10.1038/s41598-017-07079-x.


Impact of surgical timing of postoperative ocular motility in orbital blowout fractures.

Yamanaka Y, Watanabe A, Sotozono C, Kinoshita S.

Br J Ophthalmol. 2018 Mar;102(3):398-403. doi: 10.1136/bjophthalmol-2017-310312. Epub 2017 Jul 25.



Yoneda K, Morikawa K, Oshima Y, Kinoshita S, Sotozono C; Japan Microincision Vitrectomy Surgery Study Group.

Retina. 2017 Nov;37(11):2130-2137. doi: 10.1097/IAE.0000000000001442.


Classification of Fluorescein Breakup Patterns: A Novel Method of Differential Diagnosis for Dry Eye.

Yokoi N, Georgiev GA, Kato H, Komuro A, Sonomura Y, Sotozono C, Tsubota K, Kinoshita S.

Am J Ophthalmol. 2017 Aug;180:72-85. doi: 10.1016/j.ajo.2017.05.022. Epub 2017 Jun 1.


Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.

Aung T, Ozaki M, Lee MC, Schlötzer-Schrehardt U, Thorleifsson G, Mizoguchi T, Igo RP Jr, Haripriya A, Williams SE, Astakhov YS, Orr AC, Burdon KP, Nakano S, Mori K, Abu-Amero K, Hauser M, Li Z, Prakadeeswari G, Bailey JNC, Cherecheanu AP, Kang JH, Nelson S, Hayashi K, Manabe SI, Kazama S, Zarnowski T, Inoue K, Irkec M, Coca-Prados M, Sugiyama K, Järvelä I, Schlottmann P, Lerner SF, Lamari H, Nilgün Y, Bikbov M, Park KH, Cha SC, Yamashiro K, Zenteno JC, Jonas JB, Kumar RS, Perera SA, Chan ASY, Kobakhidze N, George R, Vijaya L, Do T, Edward DP, de Juan Marcos L, Pakravan M, Moghimi S, Ideta R, Bach-Holm D, Kappelgaard P, Wirostko B, Thomas S, Gaston D, Bedard K, Greer WL, Yang Z, Chen X, Huang L, Sang J, Jia H, Jia L, Qiao C, Zhang H, Liu X, Zhao B, Wang YX, Xu L, Leruez S, Reynier P, Chichua G, Tabagari S, Uebe S, Zenkel M, Berner D, Mossböck G, Weisschuh N, Hoja U, Welge-Luessen UC, Mardin C, Founti P, Chatzikyriakidou A, Pappas T, Anastasopoulos E, Lambropoulos A, Ghosh A, Shetty R, Porporato N, Saravanan V, Venkatesh R, Shivkumar C, Kalpana N, Sarangapani S, Kanavi MR, Beni AN, Yazdani S, Lashay A, Naderifar H, Khatibi N, Fea A, Lavia C, Dallorto L, Rolle T, Frezzotti P, Paoli D, Salvi E, Manunta P, Mori Y, Miyata K, Higashide T, Chihara E, Ishiko S, Yoshida A, Yanagi M, Kiuchi Y, Ohashi T, Sakurai T, Sugimoto T, Chuman H, Aihara M, Inatani M, Miyake M, Gotoh N, Matsuda F, Yoshimura N, Ikeda Y, Ueno M, Sotozono C, Jeoung JW, Sagong M, Park KH, Ahn J, Cruz-Aguilar M, Ezzouhairi SM, Rafei A, Chong YF, Ng XY, Goh SR, Chen Y, Yong VHK, Khan MI, Olawoye OO, Ashaye AO, Ugbede I, Onakoya A, Kizor-Akaraiwe N, Teekhasaenee C, Suwan Y, Supakontanasan W, Okeke S, Uche NJ, Asimadu I, Ayub H, Akhtar F, Kosior-Jarecka E, Lukasik U, Lischinsky I, Castro V, Grossmann RP, Sunaric Megevand G, Roy S, Dervan E, Silke E, Rao A, Sahay P, Fornero P, Cuello O, Sivori D, Zompa T, Mills RA, Souzeau E, Mitchell P, Wang JJ, Hewitt AW, Coote M, Crowston JG, Astakhov SY, Akopov EL, Emelyanov A, Vysochinskaya V, Kazakbaeva G, Fayzrakhmanov R, Al-Obeidan SA, Owaidhah O, Aljasim LA, Chowbay B, Foo JN, Soh RQ, Sim KS, Xie Z, Cheong AWO, Mok SQ, Soo HM, Chen XY, Peh SQ, Heng KK, Husain R, Ho SL, Hillmer AM, Cheng CY, Escudero-Domínguez FA, González-Sarmiento R, Martinon-Torres F, Salas A, Pathanapitoon K, Hansapinyo L, Wanichwecharugruang B, Kitnarong N, Sakuntabhai A, Nguyn HX, Nguyn GTT, Nguyn TV, Zenz W, Binder A, Klobassa DS, Hibberd ML, Davila S, Herms S, Nöthen MM, Moebus S, Rautenbach RM, Ziskind A, Carmichael TR, Ramsay M, Álvarez L, García M, González-Iglesias H, Rodríguez-Calvo PP, Fernández-Vega Cueto L, Oguz Ç, Tamcelik N, Atalay E, Batu B, Aktas D, Kasım B, Wilson MR, Coleman AL, Liu Y, Challa P, Herndon L, Kuchtey RW, Kuchtey J, Curtin K, Chaya CJ, Crandall A, Zangwill LM, Wong TY, Nakano M, Kinoshita S, den Hollander AI, Vesti E, Fingert JH, Lee RK, Sit AJ, Shingleton BJ, Wang N, Cusi D, Qamar R, Kraft P, Pericak-Vance MA, Raychaudhuri S, Heegaard S, Kivelä T, Reis A, Kruse FE, Weinreb RN, Pasquale LR, Haines JL, Thorsteinsdottir U, Jonasson F, Allingham RR, Milea D, Ritch R, Kubota T, Tashiro K, Vithana EN, Micheal S, Topouzis F, Craig JE, Dubina M, Sundaresan P, Stefansson K, Wiggs JL, Pasutto F, Khor CC.

Nat Genet. 2017 Jul;49(7):993-1004. doi: 10.1038/ng.3875. Epub 2017 May 29.


Myogenic Differentiation from MYOGENIN-Mutated Human iPS Cells by CRISPR/Cas9.

Higashioka K, Koizumi N, Sakurai H, Sotozono C, Sato T.

Stem Cells Int. 2017;2017:9210494. doi: 10.1155/2017/9210494. Epub 2017 Apr 4.


Production of Homogeneous Cultured Human Corneal Endothelial Cells Indispensable for Innovative Cell Therapy.

Toda M, Ueno M, Hiraga A, Asada K, Montoya M, Sotozono C, Kinoshita S, Hamuro J.

Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2011-2020. doi: 10.1167/iovs.16-20703.


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