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Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer.

Zhang Y, Wu X, Kai Y, Lee CH, Cheng F, Li Y, Zhuang Y, Ghaemmaghami J, Chuang KH, Liu Z, Meng Y, Keswani M, Gough NR, Wu X, Zhu W, Tzatsos A, Peng W, Seto E, Sotomayor EM, Zheng X.

JCI Insight. 2019 Dec 19;4(24). pii: 129344. doi: 10.1172/jci.insight.129344.


HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms.

Yue L, Sharma V, Horvat NP, Akuffo AA, Beatty MS, Murdun C, Colin C, Billington JMR, Goodheart WE, Sahakian E, Zhang L, Powers JJ, Amin NE, Lambert-Showers QT, Darville LN, Pinilla-Ibarz J, Reuther GW, Wright KL, Conti C, Lee JY, Zheng X, Ng PY, Martin MW, Marshall CG, Koomen JM, Levine RL, Verma A, Grimes HL, Sotomayor EM, Shao Z, Epling-Burnette PK.

Blood. 2020 Jan 16;135(3):191-207. doi: 10.1182/blood.2019895326.


High Red Cell Distribution Width is an Adverse Predictive and Prognostic Factor in Patients With Diffuse Large B-Cell Lymphoma Treated With Chemoimmunotherapy.

Beltran BE, Paredes S, Castro D, Cotrina E, Sotomayor EM, Castillo JJ.

Clin Lymphoma Myeloma Leuk. 2019 Sep;19(9):e551-e557. doi: 10.1016/j.clml.2019.06.005. Epub 2019 Jun 15.


Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors.

Li W, Gupta SK, Han W, Kundson RA, Nelson S, Knutson D, Greipp PT, Elsawa SF, Sotomayor EM, Gupta M.

J Hematol Oncol. 2019 Jul 9;12(1):73. doi: 10.1186/s13045-019-0761-2.


BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models.

Zhao X, Ren Y, Lawlor M, Shah BD, Park PMC, Lwin T, Wang X, Liu K, Wang M, Gao J, Li T, Xu M, Silva AS, Lee K, Zhang T, Koomen JM, Jiang H, Sudalagunta PR, Meads MB, Cheng F, Bi C, Fu K, Fan H, Dalton WS, Moscinski LC, Shain KH, Sotomayor EM, Wang GG, Gray NS, Cleveland JL, Qi J, Tao J.

Cancer Cell. 2019 May 13;35(5):752-766.e9. doi: 10.1016/j.ccell.2019.04.005.


Recent advances and future directions in mantle cell lymphoma research: report of the 2018 mantle cell lymphoma consortium workshop.

Kahl BS, Dreyling M, Gordon LI, Martin P, Quintanilla-Martinez L, Sotomayor EM.

Leuk Lymphoma. 2019 Aug;60(8):1853-1865. doi: 10.1080/10428194.2019.1571205. Epub 2019 Jan 30.


Loss of HDAC11 ameliorates clinical symptoms in a multiple sclerosis mouse model.

Sun L, Telles E, Karl M, Cheng F, Luetteke N, Sotomayor EM, Miller RH, Seto E.

Life Sci Alliance. 2018 Sep 24;1(5):e201800039. doi: 10.26508/lsa.201800039. eCollection 2018 Oct.


Silencing of HDAC6 as a therapeutic target in chronic lymphocytic leukemia.

Maharaj K, Powers JJ, Achille A, Deng S, Fonseca R, Pabon-Saldana M, Quayle SN, Jones SS, Villagra A, Sotomayor EM, Sahakian E, Pinilla-Ibarz J.

Blood Adv. 2018 Nov 13;2(21):3012-3024. doi: 10.1182/bloodadvances.2018020065.


[Expressions and prognostic significance of PTEN and PD-1 protein in patients with classical Hodgkin's lymphoma].

Xia B, Wu DW, Wang TT, Guo SQ, Wang Y, Yang HL, Xu W, Tian C, Zhang LY, Sun BC, Sotomayor EM, Zhang YZ.

Zhonghua Xue Ye Xue Za Zhi. 2018 Oct 14;39(10):839-844. doi: 10.3760/cma.j.issn.0253-2727.2018.10.010. Chinese.


PLK1 stabilizes a MYC-dependent kinase network in aggressive B cell lymphomas.

Ren Y, Bi C, Zhao X, Lwin T, Wang C, Yuan J, Silva AS, Shah BD, Fang B, Li T, Koomen JM, Jiang H, Chavez JC, Pham LV, Sudalagunta PR, Wan L, Wang X, Dalton WS, Moscinski LC, Shain KH, Vose J, Cleveland JL, Sotomayor EM, Fu K, Tao J.

J Clin Invest. 2018 Dec 3;128(12):5517-5530. doi: 10.1172/JCI122533. Epub 2018 Nov 5.


EBV-positive diffuse large B-cell lymphoma, not otherwise specified: 2018 update on diagnosis, risk-stratification and management.

Castillo JJ, Beltran BE, Miranda RN, Young KH, Chavez JC, Sotomayor EM.

Am J Hematol. 2018 Jul;93(7):953-962. doi: 10.1002/ajh.25112. Review.


The neutrophil-lymphocyte ratio is prognostic in patients with early stage aggressive peripheral T cell lymphoma.

Beltran BE, Castro D, De La Cruz-Vargas JA, Cotrina E, Gallo A, Sotomayor EM, Castillo JJ.

Br J Haematol. 2019 Feb;184(4):650-653. doi: 10.1111/bjh.15141. Epub 2018 Feb 26. No abstract available.


The impact of the neutrophil:lymphocyte ratio in response and survival of patients with de novo diffuse large B-cell lymphoma.

Beltrán BE, Paredes S, Cotrina E, Sotomayor EM, Castillo JJ.

Leuk Res. 2018 Apr;67:82-85. doi: 10.1016/j.leukres.2018.02.011. Epub 2018 Feb 19.


Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function.

Huang J, Wang L, Dahiya S, Beier UH, Han R, Samanta A, Bergman J, Sotomayor EM, Seto E, Kozikowski AP, Hancock WW.

Sci Rep. 2017 Aug 17;7(1):8626. doi: 10.1038/s41598-017-09211-3.


Response and survival benefit with chemoimmunotherapy in Epstein-Barr virus-positive diffuse large B-cell lymphoma.

Beltran BE, Quiñones P, Morales D, Malaga JM, Chavez JC, Sotomayor EM, Castillo JJ.

Hematol Oncol. 2018 Feb;36(1):93-97. doi: 10.1002/hon.2449. Epub 2017 Jun 22.


Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology.

Sahakian E, Chen J, Powers JJ, Chen X, Maharaj K, Deng SL, Achille AN, Lienlaf M, Wang HW, Cheng F, Sodré AL, Distler A, Xing L, Perez-Villarroel P, Wei S, Villagra A, Seto E, Sotomayor EM, Horna P, Pinilla-Ibarz J.

J Leukoc Biol. 2017 Aug;102(2):475-486. doi: 10.1189/jlb.1A0415-176RRR. Epub 2017 May 26.


T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model.

Woods DM, Woan KV, Cheng F, Sodré AL, Wang D, Wu Y, Wang Z, Chen J, Powers J, Pinilla-Ibarz J, Yu Y, Zhang Y, Wu X, Zheng X, Weber J, Hancock WW, Seto E, Villagra A, Yu XZ, Sotomayor EM.

Blood. 2017 Jul 13;130(2):146-155. doi: 10.1182/blood-2016-08-731505. Epub 2017 May 26.


Mantle Cell Lymphoma: Contemporary Diagnostic and Treatment Perspectives in the Age of Personalized Medicine.

Sandoval-Sus JD, Sotomayor EM, Shah BD.

Hematol Oncol Stem Cell Ther. 2017 Sep;10(3):99-115. doi: 10.1016/j.hemonc.2017.02.003. Epub 2017 Apr 6. Review.


Recent advances and future directions in mantle cell lymphoma research: report of the 2016 mantle cell lymphoma consortium workshop.

Kahl BS, Dreyling M, Gordon LI, Quintanilla-Martinez L, Sotomayor EM.

Leuk Lymphoma. 2017 Jul;58(7):1561-1569. doi: 10.1080/10428194.2017.1283036. Epub 2017 Jan 31.


Lymphomatoid Granulomatosis: A Single Institution Experience and Review of the Literature.

Chavez JC, Sandoval-Sus J, Horna P, Dalia S, Bello C, Chevernick P, Sotomayor EM, Sokol L, Shah B.

Clin Lymphoma Myeloma Leuk. 2016 Aug;16 Suppl:S170-4. doi: 10.1016/j.clml.2016.02.024.


Results of a phase II study of lenalidomide and rituximab for refractory/relapsed chronic lymphocytic leukemia.

Chavez JC, Piris-Villaespesa M, Dalia S, Powers J, Turba E, Nodzon L, Komrokji R, Sokol L, Locke FL, Lancet J, Sotomayor EM, Kharfan-Dabaja MA, Pinilla-Ibarz J.

Leuk Res. 2016 Aug;47:78-83. doi: 10.1016/j.leukres.2016.05.012. Epub 2016 May 17.


EBV-positive diffuse large B-cell lymphoma of the elderly: 2016 update on diagnosis, risk-stratification, and management.

Castillo JJ, Beltran BE, Miranda RN, Young KH, Chavez JC, Sotomayor EM.

Am J Hematol. 2016 May;91(5):529-37. doi: 10.1002/ajh.24370. Review.


HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade.

Woods DM, Sodré AL, Villagra A, Sarnaik A, Sotomayor EM, Weber J.

Cancer Immunol Res. 2015 Dec;3(12):1375-85. doi: 10.1158/2326-6066.CIR-15-0077-T. Epub 2015 Aug 21.


Flow cytometric identification of immunophenotypically aberrant T-cell clusters on skin shave biopsy specimens from patients with mycosis fungoides.

Horna P, Kurant D, Sokol L, Sotomayor EM, Moscinski L, Glass LF.

Am J Clin Pathol. 2015 Jun;143(6):785-96. doi: 10.1309/AJCPWE2HBFCGDIDS.


Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation.

Woan KV, Lienlaf M, Perez-Villaroel P, Lee C, Cheng F, Knox T, Woods DM, Barrios K, Powers J, Sahakian E, Wang HW, Canales J, Marante D, Smalley KSM, Bergman J, Seto E, Kozikowski A, Pinilla-Ibarz J, Sarnaik A, Celis E, Weber J, Sotomayor EM, Villagra A.

Mol Oncol. 2015 Aug;9(7):1447-1457. doi: 10.1016/j.molonc.2015.04.002. Epub 2015 Apr 24.


Advances and issues in mantle cell lymphoma research: report of the 2014 Mantle Cell Lymphoma Consortium Workshop.

Kahl BS, Gordon LI, Dreyling M, Gascoyne RD, Sotomayor EM.

Leuk Lymphoma. 2015;56(9):2505-11. doi: 10.3109/10428194.2015.1045903. Epub 2015 May 25.


The neutrophil-to-lymphocyte ratio is an independent prognostic factor in patients with peripheral T-cell lymphoma, unspecified.

Beltran BE, Aguilar C, Quiñones P, Morales D, Chavez JC, Sotomayor EM, Castillo JJ.

Leuk Lymphoma. 2016;57(1):58-62. doi: 10.3109/10428194.2015.1045897. Epub 2015 Jun 19.


Clinical characteristics and prognostic factors of bone lymphomas: focus on the clinical significance of multifocal bone involvement by primary bone large B-cell lymphomas.

Wu H, Bui MM, Leston DG, Shao H, Sokol L, Sotomayor EM, Zhang L.

BMC Cancer. 2014 Dec 2;14:900. doi: 10.1186/1471-2407-14-900.


Diagnostic immunophenotype of acute promyelocytic leukemia before and early during therapy with all-trans retinoic acid.

Horna P, Zhang L, Sotomayor EM, Lancet JE, Moscinski LC.

Am J Clin Pathol. 2014 Oct;142(4):546-52. doi: 10.1309/AJCPPOKEHBP53ZHV.


Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function.

Sahakian E, Powers JJ, Chen J, Deng SL, Cheng F, Distler A, Woods DM, Rock-Klotz J, Sodre AL, Youn JI, Woan KV, Villagra A, Gabrilovich D, Sotomayor EM, Pinilla-Ibarz J.

Mol Immunol. 2015 Feb;63(2):579-85. doi: 10.1016/j.molimm.2014.08.002. Epub 2014 Aug 23.


A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs.

Cheng F, Lienlaf M, Wang HW, Perez-Villarroel P, Lee C, Woan K, Rock-Klotz J, Sahakian E, Woods D, Pinilla-Ibarz J, Kalin J, Tao J, Hancock W, Kozikowski A, Seto E, Villagra A, Sotomayor EM.

J Immunol. 2014 Sep 15;193(6):2850-62. doi: 10.4049/jimmunol.1302778. Epub 2014 Aug 8.


Clinical roundtable monograph: CD30 in lymphoma: its role in biology, diagnostic testing, and targeted therapy.

Sotomayor EM, Young KH, Younes A.

Clin Adv Hematol Oncol. 2014 Apr;12(4 Suppl 10):1-22.


Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells.

Cheng F, Lienlaf M, Perez-Villarroel P, Wang HW, Lee C, Woan K, Woods D, Knox T, Bergman J, Pinilla-Ibarz J, Kozikowski A, Seto E, Sotomayor EM, Villagra A.

Mol Immunol. 2014 Jul;60(1):44-53. doi: 10.1016/j.molimm.2014.02.019. Epub 2014 Apr 18.


Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers.

Kizuka Y, Kitazume S, Okahara K, Villagra A, Sotomayor EM, Taniguchi N.

J Biol Chem. 2014 Apr 18;289(16):11253-61. doi: 10.1074/jbc.M114.554311. Epub 2014 Mar 10.


Quantitative flow cytometric identification of aberrant T cell clusters in erythrodermic cutaneous T cell lymphoma. Implications for staging and prognosis.

Horna P, Deaver DM, Qin D, Moscinski LC, Sotomayor EM, Glass LF, Sokol L.

J Clin Pathol. 2014 May;67(5):431-6. doi: 10.1136/jclinpath-2013-201748. Epub 2013 Dec 6.


The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity.

Woods DM, Woan K, Cheng F, Wang H, Perez-Villarroel P, Lee C, Lienlaf M, Atadja P, Seto E, Weber J, Sotomayor EM, Villagra A.

Melanoma Res. 2013 Oct;23(5):341-8. doi: 10.1097/CMR.0b013e328364c0ed.


Follicular lymphoma with leukemic phase at diagnosis: a series of seven cases and review of the literature.

Beltran BE, Quiñones P, Morales D, Alva JC, Miranda RN, Lu G, Shah BD, Sotomayor EM, Castillo JJ.

Leuk Res. 2013 Sep;37(9):1116-9. doi: 10.1016/j.leukres.2013.05.016. Epub 2013 Jun 20. Review.


Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.

Bergman JA, Woan K, Perez-Villarroel P, Villagra A, Sotomayor EM, Kozikowski AP.

J Med Chem. 2012 Nov 26;55(22):9891-9. doi: 10.1021/jm301098e. Epub 2012 Oct 23.


Stat3 inhibition augments the immunogenicity of B-cell lymphoma cells, leading to effective antitumor immunity.

Cheng F, Wang H, Horna P, Wang Z, Shah B, Sahakian E, Woan KV, Villagra A, Pinilla-Ibarz J, Sebti S, Smith M, Tao J, Sotomayor EM.

Cancer Res. 2012 Sep 1;72(17):4440-8. doi: 10.1158/0008-5472.CAN-11-3619. Epub 2012 Jun 22.


Mantle cell lymphoma: a clinically heterogeneous disease in need of tailored approaches.

Shah BD, Martin P, Sotomayor EM.

Cancer Control. 2012 Jul;19(3):227-35. Review.


Unusual concurrence of T-cell large granular lymphocytic leukemia with Franklin disease (gamma heavy chain disease) manifested with massive splenomegaly.

Zhang L, Sotomayor EM, Papenhausen PR, Shao H, Moscinski LC, Sandin RL, Caceres G, Valenica H, Malafa M, List AF, Sokol L.

Leuk Lymphoma. 2013 Jan;54(1):205-8. doi: 10.3109/10428194.2012.697561. Epub 2012 Jul 9. No abstract available.


Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice.

Kriss CL, Pinilla-Ibarz JA, Mailloux AW, Powers JJ, Tang CH, Kang CW, Zanesi N, Epling-Burnette PK, Sotomayor EM, Croce CM, Del Valle JR, Hu CC.

Blood. 2012 Aug 2;120(5):1027-38. doi: 10.1182/blood-2011-11-394346. Epub 2012 Jun 12.


Modulation of antigen-presenting cells by HDAC inhibitors: implications in autoimmunity and cancer.

Woan KV, Sahakian E, Sotomayor EM, Seto E, Villagra A.

Immunol Cell Biol. 2012 Jan;90(1):55-65. doi: 10.1038/icb.2011.96. Epub 2011 Nov 22. Review.


EBV-positive diffuse large B-cell lymphoma of the elderly: a case series from Peru.

Beltran BE, Castillo JJ, Morales D, de Mendoza FH, Quinones P, Miranda RN, Gallo A, Lopez-Ilasaca M, Butera JN, Sotomayor EM.

Am J Hematol. 2011 Aug;86(8):663-7. doi: 10.1002/ajh.22078.


Human immunodeficiency virus (HIV)-negative plasmablastic lymphoma: a single institutional experience and literature review.

Liu JJ, Zhang L, Ayala E, Field T, Ochoa-Bayona JL, Perez L, Bello CM, Chervenick PA, Bruno S, Cultrera JL, Baz RC, Kharfan-Dabaja MA, Raychaudhuri J, Sotomayor EM, Sokol L.

Leuk Res. 2011 Dec;35(12):1571-7. doi: 10.1016/j.leukres.2011.06.023. Epub 2011 Jul 12. Review.


Outcome of diffuse large B-Cell lymphoma in the United States has improved over time but racial disparities remain: review of SEER data.

Komrokji RS, Al Ali NH, Beg MS, Safa MM, Rollison D, Kharfan-Dabaja M, Bello C, Cultrera J, Sokol L, Pinilla-Ibarz J, Sotomayor EM.

Clin Lymphoma Myeloma Leuk. 2011 Jun;11(3):257-60. doi: 10.1016/j.clml.2011.03.012. Epub 2011 Apr 20.


Vaccination with patient-specific tumor-derived antigen in first remission improves disease-free survival in follicular lymphoma.

Schuster SJ, Neelapu SS, Gause BL, Janik JE, Muggia FM, Gockerman JP, Winter JN, Flowers CR, Nikcevich DA, Sotomayor EM, McGaughey DS, Jaffe ES, Chong EA, Reynolds CW, Berry DA, Santos CF, Popa MA, McCord AM, Kwak LW.

J Clin Oncol. 2011 Jul 10;29(20):2787-94. doi: 10.1200/JCO.2010.33.3005. Epub 2011 May 31.


Epigenetic repolarization of T lymphocytes from chronic lymphocytic leukemia patients using 5-aza-2'-deoxycytidine.

Dubovsky JA, Powers JJ, Gao Y, Mariusso LF, Sotomayor EM, Pinilla-Ibarz JA.

Leuk Res. 2011 Sep;35(9):1193-9. doi: 10.1016/j.leukres.2011.02.007. Epub 2011 Mar 5.


Histone deacetylase inhibitor LAQ824 augments inflammatory responses in macrophages through transcriptional regulation of IL-10.

Wang H, Cheng F, Woan K, Sahakian E, Merino O, Rock-Klotz J, Vicente-Suarez I, Pinilla-Ibarz J, Wright KL, Seto E, Bhalla K, Villagra A, Sotomayor EM.

J Immunol. 2011 Apr 1;186(7):3986-96. doi: 10.4049/jimmunol.1001101. Epub 2011 Mar 2.


A molecular and functional analysis of large granular lymphocyte expansions in patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors.

Powers JJ, Dubovsky JA, Epling-Burnette PK, Moscinski L, Zhang L, Mustjoki S, Sotomayor EM, Pinilla-Ibarz JA.

Leuk Lymphoma. 2011 Apr;52(4):668-79. doi: 10.3109/10428194.2010.550074. Epub 2011 Jan 27.

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