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Items: 1 to 50 of 76

1.

Biochemical and Functional Characterization of the Trace Amine-Associated Receptor 1 (TAAR1) Agonist RO5263397.

Espinoza S, Leo D, Sotnikova TD, Shahid M, Kääriäinen TM, Gainetdinov RR.

Front Pharmacol. 2018 Jun 21;9:645. doi: 10.3389/fphar.2018.00645. eCollection 2018.

2.

Pronounced Hyperactivity, Cognitive Dysfunctions, and BDNF Dysregulation in Dopamine Transporter Knock-out Rats.

Leo D, Sukhanov I, Zoratto F, Illiano P, Caffino L, Sanna F, Messa G, Emanuele M, Esposito A, Dorofeikova M, Budygin EA, Mus L, Efimova EV, Niello M, Espinoza S, Sotnikova TD, Hoener MC, Laviola G, Fumagalli F, Adriani W, Gainetdinov RR.

J Neurosci. 2018 Feb 21;38(8):1959-1972. doi: 10.1523/JNEUROSCI.1931-17.2018. Epub 2018 Jan 18.

3.

Recombinant Adeno-Associated Virus-mediated rescue of function in a mouse model of Dopamine Transporter Deficiency Syndrome.

Illiano P, Bass CE, Fichera L, Mus L, Budygin EA, Sotnikova TD, Leo D, Espinoza S, Gainetdinov RR.

Sci Rep. 2017 Apr 18;7:46280. doi: 10.1038/srep46280.

4.

Dopamine transporter mutant animals: a translational perspective.

Efimova EV, Gainetdinov RR, Budygin EA, Sotnikova TD.

J Neurogenet. 2016 Mar;30(1):5-15. doi: 10.3109/01677063.2016.1144751. Review.

5.

Increased context-dependent conditioning to amphetamine in mice lacking TAAR1.

Sukhanov I, Caffino L, Efimova EV, Espinoza S, Sotnikova TD, Cervo L, Fumagalli F, Gainetdinov RR.

Pharmacol Res. 2016 Jan;103:206-14. doi: 10.1016/j.phrs.2015.11.002. Epub 2015 Dec 2.

PMID:
26640076
6.

TAAR1 Modulates Cortical Glutamate NMDA Receptor Function.

Espinoza S, Lignani G, Caffino L, Maggi S, Sukhanov I, Leo D, Mus L, Emanuele M, Ronzitti G, Harmeier A, Medrihan L, Sotnikova TD, Chieregatti E, Hoener MC, Benfenati F, Tucci V, Fumagalli F, Gainetdinov RR.

Neuropsychopharmacology. 2015 Aug;40(9):2217-27. doi: 10.1038/npp.2015.65. Epub 2015 Mar 9.

7.

Postsynaptic D2 dopamine receptor supersensitivity in the striatum of mice lacking TAAR1.

Espinoza S, Ghisi V, Emanuele M, Leo D, Sukhanov I, Sotnikova TD, Chieregatti E, Gainetdinov RR.

Neuropharmacology. 2015 Jun;93:308-13. doi: 10.1016/j.neuropharm.2015.02.010. Epub 2015 Feb 24.

PMID:
25721394
8.

Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.

Masoud ST, Vecchio LM, Bergeron Y, Hossain MM, Nguyen LT, Bermejo MK, Kile B, Sotnikova TD, Siesser WB, Gainetdinov RR, Wightman RM, Caron MG, Richardson JR, Miller GW, Ramsey AJ, Cyr M, Salahpour A.

Neurobiol Dis. 2015 Feb;74:66-75. doi: 10.1016/j.nbd.2014.10.016. Epub 2014 Oct 30.

9.

Exogenous α-synuclein decreases raft partitioning of Cav2.2 channels inducing dopamine release.

Ronzitti G, Bucci G, Emanuele M, Leo D, Sotnikova TD, Mus LV, Soubrane CH, Dallas ML, Thalhammer A, Cingolani LA, Mochida S, Gainetdinov RR, Stephens GJ, Chieregatti E.

J Neurosci. 2014 Aug 6;34(32):10603-15. doi: 10.1523/JNEUROSCI.0608-14.2014.

10.

TAAR1-dependent effects of apomorphine in mice.

Sukhanov I, Espinoza S, Yakovlev DS, Hoener MC, Sotnikova TD, Gainetdinov RR.

Int J Neuropsychopharmacol. 2014 Oct;17(10):1683-93. doi: 10.1017/S1461145714000509. Epub 2014 Jun 13.

PMID:
24925023
11.

In vivo amphetamine action is contingent on αCaMKII.

Steinkellner T, Mus L, Eisenrauch B, Constantinescu A, Leo D, Konrad L, Rickhag M, Sørensen G, Efimova EV, Kong E, Willeit M, Sotnikova TD, Kudlacek O, Gether U, Freissmuth M, Pollak DD, Gainetdinov RR, Sitte HH.

Neuropsychopharmacology. 2014 Oct;39(11):2681-93. doi: 10.1038/npp.2014.124. Epub 2014 May 29.

12.

Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission.

Daigle TL, Ferris MJ, Gainetdinov RR, Sotnikova TD, Urs NM, Jones SR, Caron MG.

Neuropsychopharmacology. 2014 Sep;39(10):2450-62. doi: 10.1038/npp.2014.97. Epub 2014 Apr 29.

13.

Sustained N-methyl-d-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling.

Ferris MJ, Milenkovic M, Liu S, Mielnik CA, Beerepoot P, John CE, España RA, Sotnikova TD, Gainetdinov RR, Borgland SL, Jones SR, Ramsey AJ.

Eur J Neurosci. 2014 Jul;40(1):2255-63. doi: 10.1111/ejn.12594. Epub 2014 Apr 23.

14.

The dopamine transporter expression level differentially affects responses to cocaine and amphetamine.

Cagniard B, Sotnikova TD, Gainetdinov RR, Zhuang X.

J Neurogenet. 2014 Mar-Jun;28(1-2):112-21. doi: 10.3109/01677063.2014.908191.

PMID:
24673634
15.

Dopamine D2 receptor relies upon PPM/PP2C protein phosphatases to dephosphorylate huntingtin protein.

Marion S, Urs NM, Peterson SM, Sotnikova TD, Beaulieu JM, Gainetdinov RR, Caron MG.

J Biol Chem. 2014 Apr 25;289(17):11715-24. doi: 10.1074/jbc.M113.544312. Epub 2014 Mar 11.

16.

Taar1-mediated modulation of presynaptic dopaminergic neurotransmission: role of D2 dopamine autoreceptors.

Leo D, Mus L, Espinoza S, Hoener MC, Sotnikova TD, Gainetdinov RR.

Neuropharmacology. 2014 Jun;81:283-91. doi: 10.1016/j.neuropharm.2014.02.007. Epub 2014 Feb 22.

PMID:
24565640
17.

D1 dopamine receptor coupling to PLCβ regulates forward locomotion in mice.

Medvedev IO, Ramsey AJ, Masoud ST, Bermejo MK, Urs N, Sotnikova TD, Beaulieu JM, Gainetdinov RR, Salahpour A.

J Neurosci. 2013 Nov 13;33(46):18125-33. doi: 10.1523/JNEUROSCI.2382-13.2013.

18.

Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice.

Siesser WB, Sachs BD, Ramsey AJ, Sotnikova TD, Beaulieu JM, Zhang X, Caron MG, Gainetdinov RR.

ACS Chem Neurosci. 2013 Jan 16;4(1):84-8. doi: 10.1021/cn300127h. Epub 2012 Oct 1.

19.

The electroretinogram as a biomarker of central dopamine and serotonin: potential relevance to psychiatric disorders.

Lavoie J, Illiano P, Sotnikova TD, Gainetdinov RR, Beaulieu JM, Hébert M.

Biol Psychiatry. 2014 Mar 15;75(6):479-86. doi: 10.1016/j.biopsych.2012.11.024. Epub 2013 Jan 7.

PMID:
23305992
20.

Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics.

Revel FG, Moreau JL, Gainetdinov RR, Ferragud A, Velázquez-Sánchez C, Sotnikova TD, Morairty SR, Harmeier A, Groebke Zbinden K, Norcross RD, Bradaia A, Kilduff TS, Biemans B, Pouzet B, Caron MG, Canales JJ, Wallace TL, Wettstein JG, Hoener MC.

Biol Psychiatry. 2012 Dec 1;72(11):934-42. doi: 10.1016/j.biopsych.2012.05.014. Epub 2012 Jun 16.

PMID:
22705041
21.

Role of catechol-O-methyltransferase (COMT)-dependent processes in Parkinson's disease and L-DOPA treatment.

Espinoza S, Manago F, Leo D, Sotnikova TD, Gainetdinov RR.

CNS Neurol Disord Drug Targets. 2012 May;11(3):251-63. Review.

PMID:
22483291
22.

The role of GRK6 in animal models of Parkinson's disease and L-DOPA treatment.

Managò F, Espinoza S, Salahpour A, Sotnikova TD, Caron MG, Premont RT, Gainetdinov RR.

Sci Rep. 2012;2:301. doi: 10.1038/srep00301. Epub 2012 Mar 5.

23.

Beyond cAMP: The Regulation of Akt and GSK3 by Dopamine Receptors.

Beaulieu JM, Del'guidice T, Sotnikova TD, Lemasson M, Gainetdinov RR.

Front Mol Neurosci. 2011 Nov 1;4:38. doi: 10.3389/fnmol.2011.00038. eCollection 2011.

24.

Direct generation of functional dopaminergic neurons from mouse and human fibroblasts.

Caiazzo M, Dell'Anno MT, Dvoretskova E, Lazarevic D, Taverna S, Leo D, Sotnikova TD, Menegon A, Roncaglia P, Colciago G, Russo G, Carninci P, Pezzoli G, Gainetdinov RR, Gustincich S, Dityatev A, Broccoli V.

Nature. 2011 Jul 3;476(7359):224-7. doi: 10.1038/nature10284.

PMID:
21725324
25.

Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor.

Espinoza S, Salahpour A, Masri B, Sotnikova TD, Messa M, Barak LS, Caron MG, Gainetdinov RR.

Mol Pharmacol. 2011 Sep;80(3):416-25. doi: 10.1124/mol.111.073304. Epub 2011 Jun 13.

26.

TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity.

Revel FG, Moreau JL, Gainetdinov RR, Bradaia A, Sotnikova TD, Mory R, Durkin S, Zbinden KG, Norcross R, Meyer CA, Metzler V, Chaboz S, Ozmen L, Trube G, Pouzet B, Bettler B, Caron MG, Wettstein JG, Hoener MC.

Proc Natl Acad Sci U S A. 2011 May 17;108(20):8485-90. doi: 10.1073/pnas.1103029108. Epub 2011 Apr 27.

27.

The dopamine metabolite 3-methoxytyramine is a neuromodulator.

Sotnikova TD, Beaulieu JM, Espinoza S, Masri B, Zhang X, Salahpour A, Barak LS, Caron MG, Gainetdinov RR.

PLoS One. 2010 Oct 18;5(10):e13452. doi: 10.1371/journal.pone.0013452. Erratum in: PLoS One. 2010;5(10) doi: 10.1371/annotation/a2019934-b1cc-4781-80cb-9e09fc7ff6dc..

28.

A functional alternative splicing mutation in human tryptophan hydroxylase-2.

Zhang X, Nicholls PJ, Laje G, Sotnikova TD, Gainetdinov RR, Albert PR, Rajkowska G, Stockmeier CA, Speer MC, Steffens DC, Austin MC, McMahon FJ, Krishnan KR, Garcia-Blanco MA, Caron MG.

Mol Psychiatry. 2011 Dec;16(12):1169-76. doi: 10.1038/mp.2010.99. Epub 2010 Sep 21.

29.

Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice.

Siesser WB, Zhang X, Jacobsen JP, Sotnikova TD, Gainetdinov RR, Caron MG.

Neurosci Lett. 2010 Aug 30;481(1):6-11. doi: 10.1016/j.neulet.2010.06.035. Epub 2010 Jun 18.

30.

Noradrenergic control of cortico-striato-thalamic and mesolimbic cross-structural synchrony.

Dzirasa K, Phillips HW, Sotnikova TD, Salahpour A, Kumar S, Gainetdinov RR, Caron MG, Nicolelis MA.

J Neurosci. 2010 May 5;30(18):6387-97. doi: 10.1523/JNEUROSCI.0764-10.2010.

31.

Hyperdopaminergic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate.

Xu TX, Sotnikova TD, Liang C, Zhang J, Jung JU, Spealman RD, Gainetdinov RR, Yao WD.

J Neurosci. 2009 Nov 11;29(45):14086-99. doi: 10.1523/JNEUROSCI.0974-09.2009.

32.

Trace amine-associated receptors as emerging therapeutic targets.

Sotnikova TD, Caron MG, Gainetdinov RR.

Mol Pharmacol. 2009 Aug;76(2):229-35. doi: 10.1124/mol.109.055970. Epub 2009 Apr 23. Review.

33.

Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease.

Vinuela A, Hallett PJ, Reske-Nielsen C, Patterson M, Sotnikova TD, Caron MG, Gainetdinov RR, Isacson O.

Brain. 2008 Dec;131(Pt 12):3361-79. doi: 10.1093/brain/awn192. Epub 2008 Nov 6.

34.

Trace amine associated receptor 1 and movement control.

Sotnikova TD, Zorina OI, Ghisi V, Caron MG, Gainetdinov RR.

Parkinsonism Relat Disord. 2008;14 Suppl 2:S99-102. doi: 10.1016/j.parkreldis.2008.04.006. Epub 2008 Jun 27. Review.

PMID:
18585080
35.

Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor.

Barak LS, Salahpour A, Zhang X, Masri B, Sotnikova TD, Ramsey AJ, Violin JD, Lefkowitz RJ, Caron MG, Gainetdinov RR.

Mol Pharmacol. 2008 Sep;74(3):585-594. doi: 10.1124/mol.108.048884. Epub 2008 Jun 4.

36.

Food reward in the absence of taste receptor signaling.

de Araujo IE, Oliveira-Maia AJ, Sotnikova TD, Gainetdinov RR, Caron MG, Nicolelis MA, Simon SA.

Neuron. 2008 Mar 27;57(6):930-41. doi: 10.1016/j.neuron.2008.01.032. Erratum in: Neuron. 2008 Apr 24;58(2):295.

37.

Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter.

Salahpour A, Ramsey AJ, Medvedev IO, Kile B, Sotnikova TD, Holmstrand E, Ghisi V, Nicholls PJ, Wong L, Murphy K, Sesack SR, Wightman RM, Gainetdinov RR, Caron MG.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4405-10. doi: 10.1073/pnas.0707646105. Epub 2008 Mar 17.

38.

Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency.

Beaulieu JM, Zhang X, Rodriguiz RM, Sotnikova TD, Cools MJ, Wetsel WC, Gainetdinov RR, Caron MG.

Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1333-8. doi: 10.1073/pnas.0711496105. Epub 2008 Jan 22.

39.

A beta-arrestin 2 signaling complex mediates lithium action on behavior.

Beaulieu JM, Marion S, Rodriguiz RM, Medvedev IO, Sotnikova TD, Ghisi V, Wetsel WC, Lefkowitz RJ, Gainetdinov RR, Caron MG.

Cell. 2008 Jan 11;132(1):125-36. doi: 10.1016/j.cell.2007.11.041.

40.

Genetic NMDA receptor deficiency disrupts acute and chronic effects of cocaine but not amphetamine.

Ramsey AJ, Laakso A, Cyr M, Sotnikova TD, Salahpour A, Medvedev IO, Dykstra LA, Gainetdinov RR, Caron MG.

Neuropsychopharmacology. 2008 Oct;33(11):2701-14. doi: 10.1038/sj.npp.1301663. Epub 2008 Jan 9.

41.

Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo.

Beaulieu JM, Tirotta E, Sotnikova TD, Masri B, Salahpour A, Gainetdinov RR, Borrelli E, Caron MG.

J Neurosci. 2007 Jan 24;27(4):881-5.

42.

Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin.

Cyr M, Sotnikova TD, Gainetdinov RR, Caron MG.

FASEB J. 2006 Dec;20(14):2541-3. Epub 2006 Oct 25.

PMID:
17065224
43.

Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction.

Costa RM, Lin SC, Sotnikova TD, Cyr M, Gainetdinov RR, Caron MG, Nicolelis MA.

Neuron. 2006 Oct 19;52(2):359-69.

44.

Dopaminergic control of sleep-wake states.

Dzirasa K, Ribeiro S, Costa R, Santos LM, Lin SC, Grosmark A, Sotnikova TD, Gainetdinov RR, Caron MG, Nicolelis MA.

J Neurosci. 2006 Oct 11;26(41):10577-89.

45.

DDD mice, a novel acute mouse model of Parkinson's disease.

Sotnikova TD, Caron MG, Gainetdinov RR.

Neurology. 2006 Oct 10;67(7 Suppl 2):S12-7.

PMID:
17030735
46.

Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice.

Beaulieu JM, Sotnikova TD, Gainetdinov RR, Caron MG.

J Biol Chem. 2006 Oct 27;281(43):32072-80. Epub 2006 Sep 5.

47.

Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition.

Prado VF, Martins-Silva C, de Castro BM, Lima RF, Barros DM, Amaral E, Ramsey AJ, Sotnikova TD, Ramirez MR, Kim HG, Rossato JI, Koenen J, Quan H, Cota VR, Moraes MF, Gomez MV, Guatimosim C, Wetsel WC, Kushmerick C, Pereira GS, Gainetdinov RR, Izquierdo I, Caron MG, Prado MA.

Neuron. 2006 Sep 7;51(5):601-12.

48.

Social context-dependent singing-regulated dopamine.

Sasaki A, Sotnikova TD, Gainetdinov RR, Jarvis ED.

J Neurosci. 2006 Aug 30;26(35):9010-4.

49.

Molecular biology, pharmacology and functional role of the plasma membrane dopamine transporter.

Sotnikova TD, Beaulieu JM, Gainetdinov RR, Caron MG.

CNS Neurol Disord Drug Targets. 2006 Feb;5(1):45-56. Review.

PMID:
16613553
50.

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.

Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG.

Cell. 2005 Jul 29;122(2):261-73.

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