Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 27

1.

Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm.

Raimondi F, Inoue A, Kadji FMN, Shuai N, Gonzalez JC, Singh G, de la Vega AA, Sotillo R, Fischer B, Aoki J, Gutkind JS, Russell RB.

Oncogene. 2019 Sep;38(38):6491-6506. doi: 10.1038/s41388-019-0895-2. Epub 2019 Jul 23.

2.

Club cells form lung adenocarcinomas and maintain the alveoli of adult mice.

Spella M, Lilis I, Pepe MA, Chen Y, Armaka M, Lamort AS, Zazara DE, Roumelioti F, Vreka M, Kanellakis NI, Wagner DE, Giannou AD, Armenis V, Arendt KA, Klotz LV, Toumpanakis D, Karavana V, Zakynthinos SG, Giopanou I, Marazioti A, Aidinis V, Sotillo R, Stathopoulos GT.

Elife. 2019 May 29;8. pii: e45571. doi: 10.7554/eLife.45571.

3.

Identification of a highly lethal V3+ TP53+ subset in ALK+ lung adenocarcinoma.

Christopoulos P, Kirchner M, Bozorgmehr F, Endris V, Elsayed M, Budczies J, Ristau J, Penzel R, Herth FJ, Heussel CP, Eichhorn M, Muley T, Meister M, Fischer JR, Rieken S, Lasitschka F, Bischoff H, Sotillo R, Schirmacher P, Thomas M, Stenzinger A.

Int J Cancer. 2019 Jan 1;144(1):190-199. doi: 10.1002/ijc.31893. Epub 2018 Oct 30.

PMID:
30255938
4.

Plk1 overexpression induces chromosomal instability and suppresses tumor development.

de Cárcer G, Venkateswaran SV, Salgueiro L, El Bakkali A, Somogyi K, Rowald K, Montañés P, Sanclemente M, Escobar B, de Martino A, McGranahan N, Malumbres M, Sotillo R.

Nat Commun. 2018 Aug 1;9(1):3012. doi: 10.1038/s41467-018-05429-5.

5.

Metabolic shifts in residual breast cancer drive tumor recurrence.

Havas KM, Milchevskaya V, Radic K, Alladin A, Kafkia E, Garcia M, Stolte J, Klaus B, Rotmensz N, Gibson TJ, Burwinkel B, Schneeweiss A, Pruneri G, Patil KR, Sotillo R, Jechlinger M.

J Clin Invest. 2017 Jun 1;127(6):2091-2105. doi: 10.1172/JCI89914. Epub 2017 May 15.

6.

Cellular Prion Protein PrPC and Ecto-5'-Nucleotidase Are Markers of the Cellular Stress Response to Aneuploidy.

Domingues PH, Nanduri LSY, Seget K, Venkateswaran SV, Agorku D, Viganó C, von Schubert C, Nigg EA, Swanton C, Sotillo R, Bosio A, Storchová Z, Hardt O.

Cancer Res. 2017 Jun 1;77(11):2914-2926. doi: 10.1158/0008-5472.CAN-16-3052. Epub 2017 Apr 4.

7.

Pan-cancer analysis distinguishes transcriptional changes of aneuploidy from proliferation.

Buccitelli C, Salgueiro L, Rowald K, Sotillo R, Mardin BR, Korbel JO.

Genome Res. 2017 Apr;27(4):501-511. doi: 10.1101/gr.212225.116. Epub 2017 Mar 20.

8.

Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.

Weischenfeldt J, Dubash T, Drainas AP, Mardin BR, Chen Y, Stütz AM, Waszak SM, Bosco G, Halvorsen AR, Raeder B, Efthymiopoulos T, Erkek S, Siegl C, Brenner H, Brustugun OT, Dieter SM, Northcott PA, Petersen I, Pfister SM, Schneider M, Solberg SK, Thunissen E, Weichert W, Zichner T, Thomas R, Peifer M, Helland A, Ball CR, Jechlinger M, Sotillo R, Glimm H, Korbel JO.

Nat Genet. 2017 Jan;49(1):65-74. doi: 10.1038/ng.3722. Epub 2016 Nov 21.

9.

Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth.

Rowald K, Mantovan M, Passos J, Buccitelli C, Mardin BR, Korbel JO, Jechlinger M, Sotillo R.

Cell Rep. 2016 Jun 21;15(12):2679-91. doi: 10.1016/j.celrep.2016.05.048. Epub 2016 Jun 9.

10.

Is aneuploidy deciding your fate?

Rowald K, Sotillo R.

Cell Cycle. 2014;13(9):1370. doi: 10.4161/cc.28753. Epub 2014 Apr 3. No abstract available.

11.

Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition.

Schvartzman JM, Duijf PH, Sotillo R, Coker C, Benezra R.

Cancer Cell. 2011 Jun 14;19(6):701-14. doi: 10.1016/j.ccr.2011.04.017.

12.

A woman with reddish nodule on the skin of the breast.

Aneiros-Fernandez J, Arias-Santiago S, Sotillo R, Menjon-Beltran S, Concha A.

Dermatol Online J. 2011 Feb 15;17(2):11.

13.

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal.

Sotillo R, Schvartzman JM, Socci ND, Benezra R.

Nature. 2010 Mar 18;464(7287):436-40. doi: 10.1038/nature08803. Epub 2010 Feb 21.

14.

Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

Schvartzman JM, Sotillo R, Benezra R.

Nat Rev Cancer. 2010 Feb;10(2):102-15. doi: 10.1038/nrc2781. Review.

15.

Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity.

Sotillo R, Schvartzman JM, Benezra R.

Cancer Cell. 2009 Dec 8;16(6):451-2. doi: 10.1016/j.ccr.2009.11.014.

16.

Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo.

Diaz-Rodríguez E, Sotillo R, Schvartzman JM, Benezra R.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16719-24. doi: 10.1073/pnas.0803504105. Epub 2008 Oct 21.

17.

Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I.

Niault T, Hached K, Sotillo R, Sorger PK, Maro B, Benezra R, Wassmann K.

PLoS One. 2007 Nov 28;2(11):e1165.

18.

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice.

Sotillo R, Hernando E, Díaz-Rodríguez E, Teruya-Feldstein J, Cordón-Cardo C, Lowe SW, Benezra R.

Cancer Cell. 2007 Jan;11(1):9-23. Epub 2006 Dec 28.

19.

Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases.

Barbacid M, Ortega S, Sotillo R, Odajima J, Martín A, Santamaría D, Dubus P, Malumbres M.

Cold Spring Harb Symp Quant Biol. 2005;70:233-40.

PMID:
16869759
20.

Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity.

Sotillo R, Renner O, Dubus P, Ruiz-Cabello J, Martín-Caballero J, Barbacid M, Carnero A, Malumbres M.

Cancer Res. 2005 May 1;65(9):3846-52.

21.

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6.

Malumbres M, Sotillo R, Santamaría D, Galán J, Cerezo A, Ortega S, Dubus P, Barbacid M.

Cell. 2004 Aug 20;118(4):493-504.

22.

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.

Ortega S, Prieto I, Odajima J, Martín A, Dubus P, Sotillo R, Barbero JL, Malumbres M, Barbacid M.

Nat Genet. 2003 Sep;35(1):25-31. Epub 2003 Aug 17.

PMID:
12923533
23.

Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number.

Martín J, Hunt SL, Dubus P, Sotillo R, Néhmé-Pélluard F, Magnuson MA, Parlow AF, Malumbres M, Ortega S, Barbacid M.

Oncogene. 2003 Aug 14;22(34):5261-9.

PMID:
12917627
24.

Driving the cell cycle to cancer.

Malumbres M, Hunt SL, Sotillo R, Martín J, Odajima J, Martín A, Dubus P, Ortega S, Barbacid M.

Adv Exp Med Biol. 2003;532:1-11. Review.

PMID:
12908544
25.

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.

Sotillo R, Dubus P, Martín J, de la Cueva E, Ortega S, Malumbres M, Barbacid M.

EMBO J. 2001 Dec 3;20(23):6637-47.

26.

Invasive melanoma in Cdk4-targeted mice.

Sotillo R, García JF, Ortega S, Martin J, Dubus P, Barbacid M, Malumbres M.

Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13312-7. Epub 2001 Oct 23.

27.

Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis.

Latres E, Malumbres M, Sotillo R, Martín J, Ortega S, Martín-Caballero J, Flores JM, Cordón-Cardo C, Barbacid M.

EMBO J. 2000 Jul 3;19(13):3496-506.

Supplemental Content

Loading ...
Support Center