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Items: 1 to 50 of 93

1.

Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression.

Mohamed BA, Hartmann N, Tirilomis P, Sekeres K, Li W, Neef S, Richter C, Zeisberg EM, Kattner L, Didié M, Guan K, Schmitto JD, Lehnart SE, Luther S, Voigt N, Seidler T, Sossalla S, Hasenfuss G, Toischer K.

Sci Transl Med. 2018 Sep 12;10(458). pii: eaan0724. doi: 10.1126/scitranslmed.aan0724.

PMID:
30209242
2.

Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure.

Fischer TH, Eiringhaus J, Dybkova N, Saadatmand A, Pabel S, Weber S, Wang Y, Köhn M, Tirilomis T, Ljubojevic S, Renner A, Gummert J, Maier LS, Hasenfuß G, El-Armouche A, Sossalla S.

Eur J Heart Fail. 2018 Sep 7. doi: 10.1002/ejhf.1297. [Epub ahead of print]

PMID:
30191648
3.

Empagliflozin reduces Ca/calmodulin-dependent kinase II activity in isolated ventricular cardiomyocytes.

Mustroph J, Wagemann O, Lücht CM, Trum M, Hammer KP, Sag CM, Lebek S, Tarnowski D, Reinders J, Perbellini F, Terracciano C, Schmid C, Schopka S, Hilker M, Zausig Y, Pabel S, Sossalla ST, Schweda F, Maier LS, Wagner S.

ESC Heart Fail. 2018 Aug;5(4):642-648. doi: 10.1002/ehf2.12336.

4.

The detrimental potential of arrhythmia-induced cardiomyopathy.

Eiringhaus J, Hamer OW, Hollemann D, Brochhausen C, Vollmann D, Maier LS, Sossalla S.

ESC Heart Fail. 2018 Aug 6. doi: 10.1002/ehf2.12343. [Epub ahead of print]

PMID:
30079993
5.

Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy.

Bergau L, Willems R, Sprenkeler DJ, Fischer TH, Flevari P, Hasenfuß G, Katsaras D, Kirova A, Lehnart SE, Lüthje L, Röver C, Seegers J, Sossalla S, Dunnink A, Sritharan R, Tuinenburg AE, Vandenberk B, Vos MA, Wijers SC, Friede T, Zabel M.

Int J Cardiol. 2018 Jun 28. pii: S0167-5273(18)32262-9. doi: 10.1016/j.ijcard.2018.06.103. [Epub ahead of print]

6.

Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart.

Dybkova N, Ahmad S, Pabel S, Tirilomis P, Hartmann N, Fischer TH, Bengel P, Tirilomis T, Ljubojevic S, Renner A, Gummert J, Ellenberger D, Wagner S, Frey N, Maier LS, Streckfuss-Boemeke K, Hasenfuss G, Sossalla S.

Cardiovasc Res. 2018 Jun 20. doi: 10.1093/cvr/cvy152. [Epub ahead of print]

PMID:
29931291
7.

Arrhythmia-Induced Cardiomyopathy.

Sossalla S, Vollmann D.

Dtsch Arztebl Int. 2018 May 11;115(19):335-341. doi: 10.3238/arztebl.2018.0335.

8.

SCN10A-Dependent Late INa Current: Never Too Late for Cardiac Conduction?

Maier LS, Sossalla S, Schulze-Bahr E.

Circ Genom Precis Med. 2018 May;11(5):e002167. doi: 10.1161/CIRCGEN.118.002167. No abstract available.

PMID:
29752401
9.

SR Ca2+-leak and disordered excitation-contraction coupling as the basis for arrhythmogenic and negative inotropic effects of acute ethanol exposure.

Mustroph J, Wagemann O, Lebek S, Tarnowski D, Ackermann J, Drzymalski M, Pabel S, Schmid C, Wagner S, Sossalla S, Maier LS, Neef S.

J Mol Cell Cardiol. 2018 Mar;116:81-90. doi: 10.1016/j.yjmcc.2018.02.002. Epub 2018 Feb 3.

10.

Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans.

Koentges C, Pepin ME, Müsse C, Pfeil K, Alvarez SVV, Hoppe N, Hoffmann MM, Odening KE, Sossalla S, Zirlik A, Hein L, Bode C, Wende AR, Bugger H.

Basic Res Cardiol. 2017 Dec 29;113(1):8. doi: 10.1007/s00395-017-0666-6.

PMID:
29288409
11.

The contractile adaption to preload depends on the amount of afterload.

Schotola H, Sossalla ST, Renner A, Gummert J, Danner BC, Schott P, Toischer K.

ESC Heart Fail. 2017 Nov;4(4):468-478. doi: 10.1002/ehf2.12164. Epub 2017 Apr 19.

12.

Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes.

Streckfuss-Bömeke K, Tiburcy M, Fomin A, Luo X, Li W, Fischer C, Özcelik C, Perrot A, Sossalla S, Haas J, Vidal RO, Rebs S, Khadjeh S, Meder B, Bonn S, Linke WA, Zimmermann WH, Hasenfuss G, Guan K.

J Mol Cell Cardiol. 2017 Dec;113:9-21. doi: 10.1016/j.yjmcc.2017.09.008. Epub 2017 Sep 21.

13.

Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy.

Borchert T, Hübscher D, Guessoum CI, Lam TD, Ghadri JR, Schellinger IN, Tiburcy M, Liaw NY, Li Y, Haas J, Sossalla S, Huber MA, Cyganek L, Jacobshagen C, Dressel R, Raaz U, Nikolaev VO, Guan K, Thiele H, Meder B, Wollnik B, Zimmermann WH, Lüscher TF, Hasenfuss G, Templin C, Streckfuss-Bömeke K.

J Am Coll Cardiol. 2017 Aug 22;70(8):975-991. doi: 10.1016/j.jacc.2017.06.061.

14.

The novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy by modulating calcineurin signaling.

Dierck F, Kuhn C, Rohr C, Hille S, Braune J, Sossalla S, Molt S, van der Ven PFM, Fürst DO, Frey N.

J Biol Chem. 2017 Sep 15;292(37):15180-15191. doi: 10.1074/jbc.M117.786764. Epub 2017 Jul 17.

15.

Erratum to: Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation.

Meyer-Roxlau S, Lämmle S, Opitz A, Künzel S, Joos JP, Neef S, Sekeres K, Sossalla S, Schöndube F, Alexiou K, Maier LS, Dobrev D, Guan K, Weber S, El-Armouche A.

Basic Res Cardiol. 2017 Sep;112(5):51. doi: 10.1007/s00395-017-0638-x. No abstract available.

PMID:
28688054
16.

Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation.

Meyer-Roxlau S, Lämmle S, Opitz A, Künzel S, Joos JP, Neef S, Sekeres K, Sossalla S, Schöndube F, Alexiou K, Maier LS, Dobrev D, Guan K, Weber S, El-Armouche A.

Basic Res Cardiol. 2017 Jul;112(4):43. doi: 10.1007/s00395-017-0635-0. Epub 2017 Jun 9. Erratum in: Basic Res Cardiol. 2017 Sep;112(5):51.

PMID:
28597249
17.

Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure.

Dewenter M, Neef S, Vettel C, Lämmle S, Beushausen C, Zelarayan LC, Katz S, von der Lieth A, Meyer-Roxlau S, Weber S, Wieland T, Sossalla S, Backs J, Brown JH, Maier LS, El-Armouche A.

Circ Heart Fail. 2017 May;10(5):e003840. doi: 10.1161/CIRCHEARTFAILURE.117.003840.

18.

TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels.

Borlepawar A, Rangrez AY, Bernt A, Christen L, Sossalla S, Frank D, Frey N.

J Biol Chem. 2017 Jun 16;292(24):10180-10196. doi: 10.1074/jbc.M116.752543. Epub 2017 May 2.

19.

Inhibition of Late Sodium Current as an Innovative Antiarrhythmic Strategy.

Bengel P, Ahmad S, Sossalla S.

Curr Heart Fail Rep. 2017 Jun;14(3):179-186. doi: 10.1007/s11897-017-0333-0. Review.

PMID:
28455610
20.

Ablation outperforming antiarrhythmic drugs need for more research.

Sossalla S.

Cardiovasc Res. 2017 Apr 1;113(5):e4-e5. doi: 10.1093/cvr/cvx037. No abstract available.

PMID:
28384368
21.

Fatal myocardial infarction due to pseudo aneurysm of the aortic annulus after TAVR.

Sossalla S, Frank D, Frey N.

Clin Res Cardiol. 2017 Jun;106(6):468-470. doi: 10.1007/s00392-017-1088-z. Epub 2017 Mar 1. No abstract available.

PMID:
28251278
22.

Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation.

Rangrez AY, Pott J, Kluge A, Frauen R, Stiebeling K, Hoppe P, Sossalla S, Frey N, Frank D.

Biochim Biophys Acta Mol Cell Res. 2017 Apr;1864(4):634-644. doi: 10.1016/j.bbamcr.2017.01.004. Epub 2017 Jan 10.

23.

Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction.

Vettel C, Lindner M, Dewenter M, Lorenz K, Schanbacher C, Riedel M, Lämmle S, Meinecke S, Mason FE, Sossalla S, Geerts A, Hoffmann M, Wunder F, Brunner FJ, Wieland T, Mehel H, Karam S, Lechêne P, Leroy J, Vandecasteele G, Wagner M, Fischmeister R, El-Armouche A.

Circ Res. 2017 Jan 6;120(1):120-132. doi: 10.1161/CIRCRESAHA.116.310069. Epub 2016 Oct 31.

PMID:
27799254
24.

Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophy.

Bernt A, Rangrez AY, Eden M, Jungmann A, Katz S, Rohr C, Müller OJ, Katus HA, Sossalla ST, Williams T, Ritter O, Frank D, Frey N.

Sci Rep. 2016 Oct 21;6:35758. doi: 10.1038/srep35758.

25.

Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes.

Hartmann N, Pabel S, Herting J, Schatter F, Renner A, Gummert J, Schotola H, Danner BC, Maier LS, Frey N, Hasenfuss G, Fischer TH, Sossalla S.

Heart Rhythm. 2017 Mar;14(3):412-419. doi: 10.1016/j.hrthm.2016.09.014. Epub 2016 Sep 17.

PMID:
27650424
26.

Enhanced cardiac TBC1D10C expression lowers heart rate and enhances exercise capacity and survival.

Volland C, Bremer S, Hellenkamp K, Hartmann N, Dybkova N, Khadjeh S, Kutschenko A, Liebetanz D, Wagner S, Unsöld B, Didié M, Toischer K, Sossalla S, Hasenfuß G, Seidler T.

Sci Rep. 2016 Sep 26;6:33853. doi: 10.1038/srep33853.

27.

The Significance of the Late Na+ Current for Arrhythmia Induction and the Therapeutic Antiarrhythmic Potential of Ranolazine.

Mason FE, Sossalla S.

J Cardiovasc Pharmacol Ther. 2016 Apr 28. pii: 1074248416644989. [Epub ahead of print]

PMID:
27130298
28.

The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology.

Hartmann N, Mason FE, Braun I, Pabel S, Voigt N, Schotola H, Fischer TH, Dobrev D, Danner BC, Renner A, Gummert J, Belardinelli L, Frey N, Maier LS, Hasenfuss G, Sossalla S.

J Mol Cell Cardiol. 2016 May;94:95-106. doi: 10.1016/j.yjmcc.2016.03.012. Epub 2016 Apr 4.

PMID:
27056421
29.

Inhibition of CaMKII Attenuates Progressing Disruption of Ca(2+) Homeostasis Upon Left Ventricular Assist Device Implantation in Human Heart Failure.

Fischer TH, Kleinwächter A, Herting J, Eiringhaus J, Hartmann N, Renner A, Gummert J, Haverich A, Schmitto JD, Sossalla S.

Artif Organs. 2016 Aug;40(8):719-26. doi: 10.1111/aor.12677. Epub 2016 Jan 27.

PMID:
26816346
30.

Sex difference in appropriate shocks but not mortality during long-term follow-up in patients with implantable cardioverter-defibrillators.

Seegers J, Conen D, Jung K, Bergau L, Dorenkamp M, Lüthje L, Sohns C, Sossalla ST, Fischer TH, Hasenfuss G, Friede T, Zabel M.

Europace. 2016 Aug;18(8):1194-202. doi: 10.1093/europace/euv361. Epub 2015 Nov 29.

31.

Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure.

Fischer TH, Herting J, Eiringhaus J, Pabel S, Hartmann NH, Ellenberger D, Friedrich M, Renner A, Gummert J, Maier LS, Zabel M, Hasenfuss G, Sossalla S.

Europace. 2016 Sep;18(9):1440-8. doi: 10.1093/europace/euv313. Epub 2015 Oct 22.

PMID:
26493982
32.

Longevity of implantable cardioverter-defibrillators in a single-center population.

Seegers J, Expósito PM, Lüthje L, Fischer T, Lueken M, Wenk H, Sossalla ST, Hasenfuss G, Zabel M.

J Interv Card Electrophysiol. 2015 Nov;44(2):179-86. doi: 10.1007/s10840-015-0044-y. Epub 2015 Aug 8.

PMID:
26253815
33.

HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease.

Mirtschink P, Krishnan J, Grimm F, Sarre A, Hörl M, Kayikci M, Fankhauser N, Christinat Y, Cortijo C, Feehan O, Vukolic A, Sossalla S, Stehr SN, Ule J, Zamboni N, Pedrazzini T, Krek W.

Nature. 2015 Jun 25;522(7557):444-449. doi: 10.1038/nature14508. Epub 2015 Jun 17.

34.

Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII.

Fischer TH, Herting J, Mason FE, Hartmann N, Watanabe S, Nikolaev VO, Sprenger JU, Fan P, Yao L, Popov AF, Danner BC, Schöndube F, Belardinelli L, Hasenfuss G, Maier LS, Sossalla S.

Cardiovasc Res. 2015 Jul 1;107(1):184-96. doi: 10.1093/cvr/cvv153. Epub 2015 May 18.

35.

[Inappropriate sinus tachycardia].

Sossalla S, Vollmann D.

Dtsch Med Wochenschr. 2015 Apr;140(8):603-7. doi: 10.1055/s-0041-101620. Epub 2015 Apr 16. Review. German.

PMID:
25945910
36.

Letter: proton pump inhibitor treatment and increased mortality in cirrhotic patients.

Schwörer H, Sossalla S, Schillinger W.

Aliment Pharmacol Ther. 2015 Jun;41(11):1224. doi: 10.1111/apt.13200. No abstract available.

37.

Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis.

Xu X, Tan X, Tampe B, Nyamsuren G, Liu X, Maier LS, Sossalla S, Kalluri R, Zeisberg M, Hasenfuss G, Zeisberg EM.

Cardiovasc Res. 2015 Mar 1;105(3):279-91. doi: 10.1093/cvr/cvv015. Epub 2015 Jan 23.

PMID:
25616414
38.

Submuscular implantation of insertable cardiac monitors improves the reliability of detection of atrial fibrillation.

Bergau L, Sohns C, Sossalla S, Muñoz-Exposito P, Luethje L, Zabel M.

J Interv Card Electrophysiol. 2015 Mar;42(2):143-9. doi: 10.1007/s10840-014-9970-3. Epub 2015 Jan 14.

PMID:
25582428
39.

Negative hemodynamic effects of pantoprazole at high infusion rates in mice.

Unsöld B, Teucher N, Didié M, Sossalla S, Jacobshagen C, Seidler T, Schillinger W, Hasenfuß G.

Cardiovasc Ther. 2015 Feb;33(1):20-6. doi: 10.1111/1755-5922.12102.

PMID:
25529757
40.

Ca(2+) /calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca(2+) leak in human ischaemic and dilated cardiomyopathy.

Fischer TH, Eiringhaus J, Dybkova N, Förster A, Herting J, Kleinwächter A, Ljubojevic S, Schmitto JD, Streckfuß-Bömeke K, Renner A, Gummert J, Hasenfuss G, Maier LS, Sossalla S.

Eur J Heart Fail. 2014 Dec;16(12):1292-300. doi: 10.1002/ejhf.163. Epub 2014 Sep 8.

41.

Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner.

Sag CM, Mallwitz A, Wagner S, Hartmann N, Schotola H, Fischer TH, Ungeheuer N, Herting J, Shah AM, Maier LS, Sossalla S, Unsöld B.

J Mol Cell Cardiol. 2014 Nov;76:94-105. doi: 10.1016/j.yjmcc.2014.08.016. Epub 2014 Aug 27.

PMID:
25173923
42.

Cardiac fibroblasts support cardiac inflammation in heart failure.

Lindner D, Zietsch C, Tank J, Sossalla S, Fluschnik N, Hinrichs S, Maier L, Poller W, Blankenberg S, Schultheiss HP, Tschöpe C, Westermann D.

Basic Res Cardiol. 2014;109(5):428. doi: 10.1007/s00395-014-0428-7. Epub 2014 Aug 3.

PMID:
25086637
43.

Remote magnetic navigation for circumferential pulmonary vein ablation: single-catheter technique or additional use of a circular mapping catheter?

Vollmann D, Lüthje L, Seegers J, Sohns C, Sossalla S, Sohns J, Röver C, Hasenfuß G, Zabel M.

J Interv Card Electrophysiol. 2014 Oct;41(1):65-73. doi: 10.1007/s10840-014-9912-0. Epub 2014 Jun 4.

PMID:
24893795
44.

Effects of ranolazine on torsades de pointes tachycardias in a healthy isolated rabbit heart model.

Sossalla S, Wallisch N, Toischer K, Sohns C, Vollmann D, Seegers J, Lüthje L, Maier LS, Zabel M.

Cardiovasc Ther. 2014 Aug;32(4):170-7. doi: 10.1111/1755-5922.12078.

45.

Ventricular oversensing after ICD lead replacement: what is the mechanism?

Sossalla S, Seegers J, Lüthje L, Sohns C, Zabel M, Vollmann D.

Pacing Clin Electrophysiol. 2014 Aug;37(8):1076-9. doi: 10.1111/pace.12316. Epub 2013 Nov 29. No abstract available.

PMID:
24460891
46.

Perioperative outcomes of cardiac surgery patients with ongoing ticagrelor therapy: boon and bane of a new drug.

Schotola H, Bräuer A, Meyer K, Hinz J, Schöndube FA, Bauer M, Mohite PN, Danner BC, Sossalla S, Popov AF.

Eur J Cardiothorac Surg. 2014 Aug;46(2):198-205. doi: 10.1093/ejcts/ezt571. Epub 2014 Jan 12.

PMID:
24420365
47.

Antiarrhythmic drug therapy for maintaining sinus rhythm early after pulmonary vein ablation in patients with symptomatic atrial fibrillation.

Sohns C, von Gruben V, Sossalla S, Bergau L, Seegers J, Lüthje L, Vollmann D, Zabel M.

Cardiovasc Ther. 2014 Feb;32(1):7-12. doi: 10.1111/1755-5922.12052.

PMID:
24138075
48.

Ca2+/calmodulin-dependent protein kinase II and protein kinase A differentially regulate sarcoplasmic reticulum Ca2+ leak in human cardiac pathology.

Fischer TH, Herting J, Tirilomis T, Renner A, Neef S, Toischer K, Ellenberger D, Förster A, Schmitto JD, Gummert J, Schöndube FA, Hasenfuss G, Maier LS, Sossalla S.

Circulation. 2013 Aug 27;128(9):970-81. doi: 10.1161/CIRCULATIONAHA.113.001746. Epub 2013 Jul 19.

PMID:
23877259
49.

Passive-fixation lead failure rates and long-term patient mortality in subjects implanted with Sprint Fidelis electrodes.

Vollmann D, Woronowicz S, Kmiec L, Jung K, Zenker D, Seegers J, Sossalla S, Dorenkamp M, Sohns C, Lüthje L, Hasenfuss G, Zabel M.

Europace. 2014 Feb;16(2):258-64. doi: 10.1093/europace/eut185. Epub 2013 Jun 28.

PMID:
23813451
50.

Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.

Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A.

J Am Coll Cardiol. 2013 Oct 22;62(17):1596-606. doi: 10.1016/j.jacc.2013.05.057. Epub 2013 Jun 26.

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