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Items: 1 to 50 of 59

1.

GDP-l-fucose synthase is a CD4+ T cell-specific autoantigen in DRB3*02:02 patients with multiple sclerosis.

Planas R, Santos R, Tomas-Ojer P, Cruciani C, Lutterotti A, Faigle W, Schaeren-Wiemers N, Espejo C, Eixarch H, Pinilla C, Martin R, Sospedra M.

Sci Transl Med. 2018 Oct 10;10(462). pii: eaat4301. doi: 10.1126/scitranslmed.aat4301.

PMID:
30305453
2.

Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis.

Jelcic I, Al Nimer F, Wang J, Lentsch V, Planas R, Jelcic I, Madjovski A, Ruhrmann S, Faigle W, Frauenknecht K, Pinilla C, Santos R, Hammer C, Ortiz Y, Opitz L, Grönlund H, Rogler G, Boyman O, Reynolds R, Lutterotti A, Khademi M, Olsson T, Piehl F, Sospedra M, Martin R.

Cell. 2018 Sep 20;175(1):85-100.e23. doi: 10.1016/j.cell.2018.08.011. Epub 2018 Aug 30.

3.

Current evidence on the potential therapeutic applications of transcranial magnetic stimulation in multiple sclerosis: A systematic review of the literature.

León Ruiz M, Sospedra M, Arce Arce S, Tejeiro-Martínez J, Benito-León J.

Neurologia. 2018 Jun 10. pii: S0213-4853(18)30153-1. doi: 10.1016/j.nrl.2018.03.023. [Epub ahead of print] English, Spanish.

4.

B cells in multiple sclerosis.

Sospedra M.

Curr Opin Neurol. 2018 Jun;31(3):256-262. doi: 10.1097/WCO.000000000000563.

PMID:
29629941
5.

Detailed Characterization of T Cell Receptor Repertoires in Multiple Sclerosis Brain Lesions.

Planas R, Metz I, Martin R, Sospedra M.

Front Immunol. 2018 Mar 19;9:509. doi: 10.3389/fimmu.2018.00509. eCollection 2018.

6.

Phenotypic and functional complexity of brain-infiltrating T cells in Rasmussen encephalitis.

Al Nimer F, Jelcic I, Kempf C, Pieper T, Budka H, Sospedra M, Martin R.

Neurol Neuroimmunol Neuroinflamm. 2017 Dec 8;5(1):e419. doi: 10.1212/NXI.0000000000000419. eCollection 2018 Jan.

7.

Prevention and therapy of JC polyomavirus-mediated progressive multifocal leukoencephalopathy - a realistic possibility?

Jelcic I, Combaluzier B, Jelcic I, Sospedra M, Grimm J, Martin R.

Swiss Med Wkly. 2017 Oct 31;147:w14520. doi: 10.4414/smw.2017.14520. eCollection 2017.

8.

Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis.

Martin R, Sospedra M, Rosito M, Engelhardt B.

Eur J Immunol. 2016 Sep;46(9):2078-90. doi: 10.1002/eji.201646485. Review.

9.

OMIP-033: A comprehensive single step staining protocol for human T- and B-cell subsets.

Brodie T, Rothaeusler K, Sospedra M.

Cytometry A. 2016 Jul;89(7):629-32. doi: 10.1002/cyto.a.22889. Epub 2016 Jun 8. No abstract available.

10.

Immunology of Multiple Sclerosis.

Sospedra M, Martin R.

Semin Neurol. 2016 Apr;36(2):115-27. doi: 10.1055/s-0036-1579739. Epub 2016 Apr 26. Review.

PMID:
27116718
11.

Mechanisms of immune escape in central nervous system infection with neurotropic JC virus variant.

Jelcic I, Jelcic I, Kempf C, Largey F, Planas R, Schippling S, Budka H, Sospedra M, Martin R.

Ann Neurol. 2016 Mar;79(3):404-18. doi: 10.1002/ana.24574. Epub 2016 Feb 13.

12.

Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions.

Planas R, Metz I, Ortiz Y, Vilarrasa N, Jelčić I, Salinas-Riester G, Heesen C, Brück W, Martin R, Sospedra M.

Ann Clin Transl Neurol. 2015 Sep;2(9):875-93. doi: 10.1002/acn3.218. Epub 2015 Jun 8.

13.

Broadly neutralizing human monoclonal JC polyomavirus VP1-specific antibodies as candidate therapeutics for progressive multifocal leukoencephalopathy.

Jelcic I, Combaluzier B, Jelcic I, Faigle W, Senn L, Reinhart BJ, Ströh L, Nitsch RM, Stehle T, Sospedra M, Grimm J, Martin R.

Sci Transl Med. 2015 Sep 23;7(306):306ra150. doi: 10.1126/scitranslmed.aac8691. Epub 2015 Sep 23.

14.

Immunology of progressive multifocal leukoencephalopathy.

Jelcic I, Jelcic I, Faigle W, Sospedra M, Martin R.

J Neurovirol. 2015 Dec;21(6):614-22. doi: 10.1007/s13365-014-0294-y. Epub 2015 Mar 5. Review.

15.

Treating progressive multifocal leukoencephalopathy with interleukin 7 and vaccination with JC virus capsid protein VP1.

Sospedra M, Schippling S, Yousef S, Jelcic I, Bofill-Mas S, Planas R, Stellmann JP, Demina V, Cinque P, Garcea R, Croughs T, Girones R, Martin R.

Clin Infect Dis. 2014 Dec 1;59(11):1588-92. doi: 10.1093/cid/ciu682. Epub 2014 Sep 11.

16.

Antibody responses following induction of antigen-specific tolerance with antigen-coupled cells.

Peschl P, Reindl M, Schanda K, Sospedra M, Martin R, Lutterotti A.

Mult Scler. 2015 Apr;21(5):651-5. doi: 10.1177/1352458514549405. Epub 2014 Sep 8.

17.

Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice.

Antsiferova O, Müller A, Rämer PC, Chijioke O, Chatterjee B, Raykova A, Planas R, Sospedra M, Shumilov A, Tsai MH, Delecluse HJ, Münz C.

PLoS Pathog. 2014 Aug 28;10(8):e1004333. doi: 10.1371/journal.ppat.1004333. eCollection 2014 Aug.

18.

Long-term safety and efficacy of natalizumab in relapsing-remitting multiple sclerosis: impact on quality of life.

Planas R, Martin R, Sospedra M.

Patient Relat Outcome Meas. 2014 Apr 4;5:25-33. doi: 10.2147/PROM.S41768. eCollection 2014. Review.

19.

Sphingosine-1 phosphate and central nervous system.

Martin R, Sospedra M.

Curr Top Microbiol Immunol. 2014;378:149-70. doi: 10.1007/978-3-319-05879-5_7. Review.

PMID:
24728597
20.

Boswellic acids reduce Th17 differentiation via blockade of IL-1β-mediated IRAK1 signaling.

Stürner KH, Verse N, Yousef S, Martin R, Sospedra M.

Eur J Immunol. 2014 Apr;44(4):1200-12. doi: 10.1002/eji.201343629. Epub 2014 Feb 16.

21.

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

International Multiple Sclerosis Genetics Consortium (IMSGC), Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, Martin C, Zipp F, D'Alfonso S, Martinelli-Boneschi F, Taylor B, Harbo HF, Kockum I, Hillert J, Olsson T, Ban M, Oksenberg JR, Hintzen R, Barcellos LF; Wellcome Trust Case Control Consortium 2 (WTCCC2); International IBD Genetics Consortium (IIBDGC), Agliardi C, Alfredsson L, Alizadeh M, Anderson C, Andrews R, Søndergaard HB, Baker A, Band G, Baranzini SE, Barizzone N, Barrett J, Bellenguez C, Bergamaschi L, Bernardinelli L, Berthele A, Biberacher V, Binder TM, Blackburn H, Bomfim IL, Brambilla P, Broadley S, Brochet B, Brundin L, Buck D, Butzkueven H, Caillier SJ, Camu W, Carpentier W, Cavalla P, Celius EG, Coman I, Comi G, Corrado L, Cosemans L, Cournu-Rebeix I, Cree BA, Cusi D, Damotte V, Defer G, Delgado SR, Deloukas P, di Sapio A, Dilthey AT, Donnelly P, Dubois B, Duddy M, Edkins S, Elovaara I, Esposito F, Evangelou N, Fiddes B, Field J, Franke A, Freeman C, Frohlich IY, Galimberti D, Gieger C, Gourraud PA, Graetz C, Graham A, Grummel V, Guaschino C, Hadjixenofontos A, Hakonarson H, Halfpenny C, Hall G, Hall P, Hamsten A, Harley J, Harrower T, Hawkins C, Hellenthal G, Hillier C, Hobart J, Hoshi M, Hunt SE, Jagodic M, Jelčić I, Jochim A, Kendall B, Kermode A, Kilpatrick T, Koivisto K, Konidari I, Korn T, Kronsbein H, Langford C, Larsson M, Lathrop M, Lebrun-Frenay C, Lechner-Scott J, Lee MH, Leone MA, Leppä V, Liberatore G, Lie BA, Lill CM, Lindén M, Link J, Luessi F, Lycke J, Macciardi F, Männistö S, Manrique CP, Martin R, Martinelli V, Mason D, Mazibrada G, McCabe C, Mero IL, Mescheriakova J, Moutsianas L, Myhr KM, Nagels G, Nicholas R, Nilsson P, Piehl F, Pirinen M, Price SE, Quach H, Reunanen M, Robberecht W, Robertson NP, Rodegher M, Rog D, Salvetti M, Schnetz-Boutaud NC, Sellebjerg F, Selter RC, Schaefer C, Shaunak S, Shen L, Shields S, Siffrin V, Slee M, Sorensen PS, Sorosina M, Sospedra M, Spurkland A, Strange A, Sundqvist E, Thijs V, Thorpe J, Ticca A, Tienari P, van Duijn C, Visser EM, Vucic S, Westerlind H, Wiley JS, Wilkins A, Wilson JF, Winkelmann J, Zajicek J, Zindler E, Haines JL, Pericak-Vance MA, Ivinson AJ, Stewart G, Hafler D, Hauser SL, Compston A, McVean G, De Jager P, Sawcer SJ, McCauley JL.

Nat Genet. 2013 Nov;45(11):1353-60. doi: 10.1038/ng.2770. Epub 2013 Sep 29.

22.

JC virus granule cell neuronopathy and GCN-IRIS under natalizumab treatment.

Schippling S, Kempf C, Büchele F, Jelcic I, Bozinov O, Bont A, Linnebank M, Sospedra M, Weller M, Budka H, Martin R.

Ann Neurol. 2013 Oct;74(4):622-6. doi: 10.1002/ana.23973. Epub 2013 Sep 16.

PMID:
23868420
23.

Antigen-specific tolerance by autologous myelin peptide-coupled cells: a phase 1 trial in multiple sclerosis.

Lutterotti A, Yousef S, Sputtek A, Stürner KH, Stellmann JP, Breiden P, Reinhardt S, Schulze C, Bester M, Heesen C, Schippling S, Miller SD, Sospedra M, Martin R.

Sci Transl Med. 2013 Jun 5;5(188):188ra75. doi: 10.1126/scitranslmed.3006168.

24.

HLA-DR15-derived self-peptides are involved in increased autologous T cell proliferation in multiple sclerosis.

Mohme M, Hotz C, Stevanovic S, Binder T, Lee JH, Okoniewski M, Eiermann T, Sospedra M, Rammensee HG, Martin R.

Brain. 2013 Jun;136(Pt 6):1783-98. doi: 10.1093/brain/awt108.

25.

Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients.

Tillack K, Naegele M, Haueis C, Schippling S, Wandinger KP, Martin R, Sospedra M.

J Neuroimmunol. 2013 Aug 15;261(1-2):108-19. doi: 10.1016/j.jneuroim.2013.05.004. Epub 2013 Jun 2.

26.

T cell epitope mapping of JC polyoma virus-encoded proteome reveals reduced T cell responses in HLA-DRB1*04:01+ donors.

Jelcic I, Aly L, Binder TM, Jelcic I, Bofill-Mas S, Planas R, Demina V, Eiermann TH, Weber T, Girones R, Sospedra M, Martin R.

J Virol. 2013 Mar;87(6):3393-408. doi: 10.1128/JVI.02803-12. Epub 2013 Jan 9.

27.

TCR bias and HLA cross-restriction are strategies of human brain-infiltrating JC virus-specific CD4+ T cells during viral infection.

Yousef S, Planas R, Chakroun K, Hoffmeister-Ullerich S, Binder TM, Eiermann TH, Martin R, Sospedra M.

J Immunol. 2012 Oct 1;189(7):3618-30. Epub 2012 Aug 31.

28.

Displacement chromatography as first separating step in online two-dimensional liquid chromatography coupled to mass spectrometry analysis of a complex protein sample--the proteome of neutrophils.

Trusch M, Tillack K, Kwiatkowski M, Bertsch A, Ahrends R, Kohlbacher O, Martin R, Sospedra M, Schlüter H.

J Chromatogr A. 2012 Apr 6;1232:288-94. doi: 10.1016/j.chroma.2012.02.029. Epub 2012 Feb 18.

PMID:
22391494
29.

T lymphocyte priming by neutrophil extracellular traps links innate and adaptive immune responses.

Tillack K, Breiden P, Martin R, Sospedra M.

J Immunol. 2012 Apr 1;188(7):3150-9. doi: 10.4049/jimmunol.1103414. Epub 2012 Feb 20.

30.

No proinflammatory signature in CD34+ hematopoietic progenitor cells in multiple sclerosis patients.

Lutterotti A, Jelcić I, Schulze C, Schippling S, Breiden P, Mazzanti B, Reinhardt S, DiGioia M, Repice A, Massacesi L, Sputtek A, Salinas-Riester G, Kroeger N, Sospedra M, Saccardi R, Zander A, Martin R.

Mult Scler. 2012 Aug;18(8):1188-92. doi: 10.1177/1352458511434067. Epub 2012 Jan 17.

PMID:
22252466
31.

Neutrophils in multiple sclerosis are characterized by a primed phenotype.

Naegele M, Tillack K, Reinhardt S, Schippling S, Martin R, Sospedra M.

J Neuroimmunol. 2012 Jan 18;242(1-2):60-71. doi: 10.1016/j.jneuroim.2011.11.009. Epub 2011 Dec 9.

PMID:
22169406
32.

Natalizumab treatment perturbs memory- and marginal zone-like B-cell homing in secondary lymphoid organs in multiple sclerosis.

Planas R, Jelčić I, Schippling S, Martin R, Sospedra M.

Eur J Immunol. 2012 Mar;42(3):790-8. doi: 10.1002/eji.201142108. Epub 2011 Dec 27.

33.

Central role of JC virus-specific CD4+ lymphocytes in progressive multi-focal leucoencephalopathy-immune reconstitution inflammatory syndrome.

Aly L, Yousef S, Schippling S, Jelcic I, Breiden P, Matschke J, Schulz R, Bofill-Mas S, Jones L, Demina V, Linnebank M, Ogg G, Girones R, Weber T, Sospedra M, Martin R.

Brain. 2011 Sep;134(Pt 9):2687-702. doi: 10.1093/brain/awr206.

PMID:
21908874
34.

Combining positional scanning peptide libraries, HLA-DR transfectants and bioinformatics to dissect the epitope spectrum of HLA class II cross-restricted CD4+ T cell clones.

Sospedra M, Zhao Y, Giulianotti M, Simon R, Pinilla C, Martin R.

J Immunol Methods. 2010 Feb 28;353(1-2):93-101. doi: 10.1016/j.jim.2009.12.006. Epub 2009 Dec 28.

PMID:
20036243
35.

Antigen-specific therapies in MS - Current concepts and novel approaches.

Lutterotti A, Sospedra M, Martin R.

J Neurol Sci. 2008 Nov 15;274(1-2):18-22. doi: 10.1016/j.jns.2008.05.021. Epub 2008 Jul 3. Review.

PMID:
18599087
36.

Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: implications for the initiation of the autoimmune response in multiple sclerosis.

Zhang X, Tang Y, Sujkowska D, Wang J, Ramgolam V, Sospedra M, Adams J, Martin R, Pinilla C, Markovic-Plese S.

Eur J Immunol. 2008 May;38(5):1297-309. doi: 10.1002/eji.200737519.

37.

Cerebrospinal fluid-infiltrating CD4+ T cells recognize Borrelia burgdorferi lysine-enriched protein domains and central nervous system autoantigens in early lyme encephalitis.

Lünemann JD, Gelderblom H, Sospedra M, Quandt JA, Pinilla C, Marques A, Martin R.

Infect Immun. 2007 Jan;75(1):243-51. Epub 2006 Oct 23.

38.

When T cells recognize a pattern, they might cause trouble.

Sospedra M, Martin R.

Curr Opin Immunol. 2006 Dec;18(6):697-703. Epub 2006 Sep 28. Review.

PMID:
17010587
39.

Infections in MS: beneficial or harmful?

Sospedra M.

Int MS J. 2006 May;13(2):39-40. No abstract available.

PMID:
16635420
40.

Molecular mimicry in multiple sclerosis.

Sospedra M, Martin R.

Autoimmunity. 2006 Feb;39(1):3-8. Review.

PMID:
16455577
41.

Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype.

Sospedra M, Muraro PA, Stefanová I, Zhao Y, Chung K, Li Y, Giulianotti M, Simon R, Mariuzza R, Pinilla C, Martin R.

J Immunol. 2006 Feb 1;176(3):1951-61.

42.

Recognition of conserved amino acid motifs of common viruses and its role in autoimmunity.

Sospedra M, Zhao Y, zur Hausen H, Muraro PA, Hamashin C, de Villiers EM, Pinilla C, Martin R.

PLoS Pathog. 2005 Dec;1(4):e41. Epub 2005 Dec 16.

43.

Antigen-specific therapies in multiple sclerosis.

Sospedra M, Martin R.

Int Rev Immunol. 2005 Sep-Dec;24(5-6):393-413. Review.

PMID:
16318988
44.

Clonotypic analysis of cerebrospinal fluid T cells during disease exacerbation and remission in a patient with multiple sclerosis.

Muraro PA, Cassiani-Ingoni R, Chung K, Packer AN, Sospedra M, Martin R.

J Neuroimmunol. 2006 Feb;171(1-2):177-83. Epub 2005 Nov 18.

PMID:
16298432
45.

Insulin alleles and autoimmune regulator (AIRE) gene expression both influence insulin expression in the thymus.

Sabater L, Ferrer-Francesch X, Sospedra M, Caro P, Juan M, Pujol-Borrell R.

J Autoimmun. 2005 Dec;25(4):312-8. Epub 2005 Oct 24.

PMID:
16246524
46.

Immunology of multiple sclerosis.

Sospedra M, Martin R.

Annu Rev Immunol. 2005;23:683-747. Review.

PMID:
15771584
47.

Different patterns of nicotinic acetylcholine receptor subunit transcription in human thymus.

Bruno R, Sabater L, Tolosa E, Sospedra M, Ferrer-Francesch X, Coll J, Foz M, Melms A, Pujol-Borrell R.

J Neuroimmunol. 2004 Apr;149(1-2):147-59.

PMID:
15020075
48.

Use of combinatorial peptide libraries for T-cell epitope mapping.

Sospedra M, Pinilla C, Martin R.

Methods. 2003 Mar;29(3):236-47. Review.

PMID:
12725789
49.

Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus.

Bruno R, Sabater L, Sospedra M, Ferrer-Francesch X, Escudero D, Martínez-Cáceres E, Pujol-Borrell R.

Eur J Immunol. 2002 Oct;32(10):2737-47.

50.

Functional antigen-independent synapses formed between T cells and dendritic cells.

Revy P, Sospedra M, Barbour B, Trautmann A.

Nat Immunol. 2001 Oct;2(10):925-31.

PMID:
11561183

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