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Connexin43 Forms Supramolecular Complexes through Non-Overlapping Binding Sites for Drebrin, Tubulin, and ZO-1.

Ambrosi C, Ren C, Spagnol G, Cavin G, Cone A, Grintsevich EE, Sosinsky GE, Sorgen PL.

PLoS One. 2016 Jun 9;11(6):e0157073. doi: 10.1371/journal.pone.0157073. eCollection 2016.


Pannexin2 oligomers localize in the membranes of endosomal vesicles in mammalian cells while Pannexin1 channels traffic to the plasma membrane.

Boassa D, Nguyen P, Hu J, Ellisman MH, Sosinsky GE.

Front Cell Neurosci. 2015 Feb 2;8:468. doi: 10.3389/fncel.2014.00468. eCollection 2014.


Atomic force microscopy shows connexin26 hemichannel clustering in purified membrane fragments.

Meckes B, Ambrosi C, Barnard H, Arce FT, Sosinsky GE, Lal R.

Biochemistry. 2014 Dec 2;53(47):7407-14. doi: 10.1021/bi501265p. Epub 2014 Nov 17.


Protein kinase Cδ-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation.

Cone AC, Cavin G, Ambrosi C, Hakozaki H, Wu-Zhang AX, Kunkel MT, Newton AC, Sosinsky GE.

J Biol Chem. 2014 Mar 28;289(13):8781-98. doi: 10.1074/jbc.M113.533265. Epub 2014 Feb 5.


Analysis of trafficking, stability and function of human connexin 26 gap junction channels with deafness-causing mutations in the fourth transmembrane helix.

Ambrosi C, Walker AE, Depriest AD, Cone AC, Lu C, Badger J, Skerrett IM, Sosinsky GE.

PLoS One. 2013 Aug 15;8(8):e70916. doi: 10.1371/journal.pone.0070916. eCollection 2013.


A comparative antibody analysis of pannexin1 expression in four rat brain regions reveals varying subcellular localizations.

Cone AC, Ambrosi C, Scemes E, Martone ME, Sosinsky GE.

Front Pharmacol. 2013 Feb 6;4:6. doi: 10.3389/fphar.2013.00006. eCollection 2013.


Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy.

Martell JD, Deerinck TJ, Sancak Y, Poulos TL, Mootha VK, Sosinsky GE, Ellisman MH, Ting AY.

Nat Biotechnol. 2012 Nov;30(11):1143-8. doi: 10.1038/nbt.2375. Epub 2012 Oct 21.


Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation.

Dolmatova E, Spagnol G, Boassa D, Baum JR, Keith K, Ambrosi C, Kontaridis MI, Sorgen PL, Sosinsky GE, Duffy HS.

Am J Physiol Heart Circ Physiol. 2012 Nov 15;303(10):H1208-18. doi: 10.1152/ajpheart.00251.2012. Epub 2012 Sep 14.


Picking faces out of a crowd: genetic labels for identification of proteins in correlated light and electron microscopy imaging.

Ellisman MH, Deerinck TJ, Shu X, Sosinsky GE.

Methods Cell Biol. 2012;111:139-55. doi: 10.1016/B978-0-12-416026-2.00008-X. Review.


Preferential electrical coupling regulates neocortical lineage-dependent microcircuit assembly.

Yu YC, He S, Chen S, Fu Y, Brown KN, Yao XH, Ma J, Gao KP, Sosinsky GE, Huang K, Shi SH.

Nature. 2012 May 2;486(7401):113-7. doi: 10.1038/nature10958.


Dimensionality Reduction on Multi-Dimensional Transfer Functions for Multi-Channel Volume Data Sets.

Kim HS, Schulze JP, Cone AC, Sosinsky GE, Martone ME.

Inf Vis. 2010 Sep 21;9(3):167-180.


Pannexin channels are not gap junction hemichannels.

Sosinsky GE, Boassa D, Dermietzel R, Duffy HS, Laird DW, MacVicar B, Naus CC, Penuela S, Scemes E, Spray DC, Thompson RJ, Zhao HB, Dahl G.

Channels (Austin). 2011 May-Jun;5(3):193-7. Epub 2011 May 1. Review.


Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels.

Oshima A, Tani K, Toloue MM, Hiroaki Y, Smock A, Inukai S, Cone A, Nicholson BJ, Sosinsky GE, Fujiyoshi Y.

J Mol Biol. 2011 Jan 21;405(3):724-35. doi: 10.1016/j.jmb.2010.10.032. Epub 2010 Nov 20.


Trafficking and recycling of the connexin43 gap junction protein during mitosis.

Boassa D, Solan JL, Papas A, Thornton P, Lampe PD, Sosinsky GE.

Traffic. 2010 Nov;11(11):1471-86. doi: 10.1111/j.1600-0854.2010.01109.x. Epub 2010 Sep 10.


Multi-Channel Transfer Function with Dimensionality Reduction.

Kim HS, Schulze JP, Cone AC, Sosinsky GE, Martone ME.

Proc SPIE Int Soc Opt Eng. 2010 Jan 18;7530:75300A.


Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other.

Ambrosi C, Gassmann O, Pranskevich JN, Boassa D, Smock A, Wang J, Dahl G, Steinem C, Sosinsky GE.

J Biol Chem. 2010 Aug 6;285(32):24420-31. doi: 10.1074/jbc.M110.115444. Epub 2010 Jun 1.


Analysis of four connexin26 mutant gap junctions and hemichannels reveals variations in hexamer stability.

Ambrosi C, Boassa D, Pranskevich J, Smock A, Oshima A, Xu J, Nicholson BJ, Sosinsky GE.

Biophys J. 2010 May 19;98(9):1809-19. doi: 10.1016/j.bpj.2010.01.019.


The cytoplasmic accumulations of the cataract-associated mutant, Connexin50P88S, are long-lived and form in the endoplasmic reticulum.

Lichtenstein A, Gaietta GM, Deerinck TJ, Crum J, Sosinsky GE, Beyer EC, Berthoud VM.

Exp Eye Res. 2009 Mar;88(3):600-9. doi: 10.1016/j.exer.2008.11.024. Epub 2008 Dec 6.


Projection structure of a N-terminal deletion mutant of connexin 26 channel with decreased central pore density.

Oshima A, Tani K, Hiroaki Y, Fujiyoshi Y, Sosinsky GE.

Cell Commun Adhes. 2008 May;15(1):85-93. doi: 10.1080/15419060802013588.


Computational modeling of three-dimensional electrodiffusion in biological systems: application to the node of Ranvier.

Lopreore CL, Bartol TM, Coggan JS, Keller DX, Sosinsky GE, Ellisman MH, Sejnowski TJ.

Biophys J. 2008 Sep 15;95(6):2624-35. doi: 10.1529/biophysj.108.132167. Epub 2008 Jun 13.


Electron tomographic analysis of cytoskeletal cross-bridges in the paranodal region of the node of Ranvier in peripheral nerves.

Perkins GA, Sosinsky GE, Ghassemzadeh S, Perez A, Jones Y, Ellisman MH.

J Struct Biol. 2008 Mar;161(3):469-80. Epub 2007 Oct 22.


Visualizing flock house virus infection in Drosophila cells with correlated fluorescence and electron microscopy.

Lanman J, Crum J, Deerinck TJ, Gaietta GM, Schneemann A, Sosinsky GE, Ellisman MH, Johnson JE.

J Struct Biol. 2008 Mar;161(3):439-46. Epub 2007 Sep 19.


The combination of chemical fixation procedures with high pressure freezing and freeze substitution preserves highly labile tissue ultrastructure for electron tomography applications.

Sosinsky GE, Crum J, Jones YZ, Lanman J, Smarr B, Terada M, Martone ME, Deerinck TJ, Johnson JE, Ellisman MH.

J Struct Biol. 2008 Mar;161(3):359-71. Epub 2007 Sep 14.


The C-terminus of connexin43 adopts different conformations in the Golgi and gap junction as detected with structure-specific antibodies.

Sosinsky GE, Solan JL, Gaietta GM, Ngan L, Lee GJ, Mackey MR, Lampe PD.

Biochem J. 2007 Dec 15;408(3):375-85.


Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibule.

Oshima A, Tani K, Hiroaki Y, Fujiyoshi Y, Sosinsky GE.

Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10034-9. Epub 2007 Jun 5.


Markers for correlated light and electron microscopy.

Sosinsky GE, Giepmans BN, Deerinck TJ, Gaietta GM, Ellisman MH.

Methods Cell Biol. 2007;79:575-91. Review. No abstract available.


Aminosulfonate modulated pH-induced conformational changes in connexin26 hemichannels.

Yu J, Bippes CA, Hand GM, Muller DJ, Sosinsky GE.

J Biol Chem. 2007 Mar 23;282(12):8895-904. Epub 2007 Jan 16.


Mutation of a conserved threonine in the third transmembrane helix of alpha- and beta-connexins creates a dominant-negative closed gap junction channel.

Beahm DL, Oshima A, Gaietta GM, Hand GM, Smock AE, Zucker SN, Toloue MM, Chandrasekhar A, Nicholson BJ, Sosinsky GE.

J Biol Chem. 2006 Mar 24;281(12):7994-8009. Epub 2005 Dec 28.


Development of a model for microphysiological simulations: small nodes of ranvier from peripheral nerves of mice reconstructed by electron tomography.

Sosinsky GE, Deerinck TJ, Greco R, Buitenhuys CH, Bartol TM, Ellisman MH.

Neuroinformatics. 2005;3(2):133-62.


Structural organization of gap junction channels.

Sosinsky GE, Nicholson BJ.

Biochim Biophys Acta. 2005 Jun 10;1711(2):99-125. Epub 2005 Apr 19. Review.


Tetracysteine genetic tags complexed with biarsenical ligands as a tool for investigating gap junction structure and dynamics.

Sosinsky GE, Gaietta GM, Hand G, Deerinck TJ, Han A, Mackey M, Adams SR, Bouwer J, Tsien RY, Ellisman MH.

Cell Commun Adhes. 2003 Jul-Dec;10(4-6):181-6.


Conformational changes in surface structures of isolated connexin 26 gap junctions.

Müller DJ, Hand GM, Engel A, Sosinsky GE.

EMBO J. 2002 Jul 15;21(14):3598-607.


Multicolor and electron microscopic imaging of connexin trafficking.

Gaietta G, Deerinck TJ, Adams SR, Bouwer J, Tour O, Laird DW, Sosinsky GE, Tsien RY, Ellisman MH.

Science. 2002 Apr 19;296(5567):503-7.


Isolation and characterization of gap junctions from tissue culture cells.

Hand GM, Müller DJ, Nicholson BJ, Engel A, Sosinsky GE.

J Mol Biol. 2002 Jan 25;315(4):587-600.


Purification of gap junctions.

Sosinsky GE, Perkins GA.

Methods Mol Biol. 2001;154:57-75. No abstract available.


Specific labeling of connexin43 in NRK cells using tyramide-based signal amplification and fluorescence photooxidation.

Hand GM, Martone ME, Stelljes A, Ellisman MH, Sosinsky GE.

Microsc Res Tech. 2001 Feb 1;52(3):331-43.


Electron crystallographic methods for investigating gap junction structure.

Sosinsky GE, Perkins GA.

Methods. 2000 Feb;20(2):140-55.


The Electron Microscopy Outreach Program: A Web-based resource for research and education.

Sosinsky GE, Baker TS, Hand G, Ellisman MH.

J Struct Biol. 1999 Apr-May;125(2-3):246-52. Review.


Molecular organization of gap junction membrane channels.

Sosinsky GE.

J Bioenerg Biomembr. 1996 Aug;28(4):297-309. Review.


Preparation, characterization, and structure of half gap junctional layers split with urea and EGTA.

Ghoshroy S, Goodenough DA, Sosinsky GE.

J Membr Biol. 1995 Jul;146(1):15-28.


Orientation of cholera toxin bound to model membranes.

Cabral-Lilly D, Sosinsky GE, Reed RA, McDermott MR, Shipley GG.

Biophys J. 1994 Apr;66(4):935-41.


Isolation, characterization and structure of bacterial flagellar motors containing the switch complex.

Francis NR, Sosinsky GE, Thomas D, DeRosier DJ.

J Mol Biol. 1994 Jan 28;235(4):1261-70.


Structure of the extracellular surface of the gap junction by atomic force microscopy.

Hoh JH, Sosinsky GE, Revel JP, Hansma PK.

Biophys J. 1993 Jul;65(1):149-63.


Substructure of the flagellar basal body of Salmonella typhimurium.

Sosinsky GE, Francis NR, Stallmeyer MJ, DeRosier DJ.

J Mol Biol. 1992 Jan 5;223(1):171-84.


Image analysis of gap junction structures.

Sosinsky GE.

Electron Microsc Rev. 1992;5(1):59-76. Review.


Structural studies of tropomyosin by cryoelectron microscopy and x-ray diffraction.

Cabral-Lilly D, Phillips GN Jr, Sosinsky GE, Melanson L, Chacko S, Cohen C.

Biophys J. 1991 Apr;59(4):805-14.


Correlation analysis of gap junction lattice images.

Sosinsky GE, Baker TS, Caspar DL, Goodenough DA.

Biophys J. 1990 Nov;58(5):1213-26.


Image reconstruction of the flagellar basal body of Caulobacter crescentus.

Stallmeyer MJ, Hahnenberger KM, Sosinsky GE, Shapiro L, DeRosier DJ.

J Mol Biol. 1989 Feb 5;205(3):511-8.


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