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Items: 18


High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model.

Davidson HW, Cepeda JR, Sekhar NS, Han J, Gao L, Sosinowski T, Zhang L.

J Vis Exp. 2019 Aug 16;(150). doi: 10.3791/59985.


How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.

Wang Y, Sosinowski T, Novikov A, Crawford F, White J, Jin N, Liu Z, Zou J, Neau D, Davidson HW, Nakayama M, Kwok WW, Gapin L, Marrack P, Kappler JW, Dai S.

Sci Immunol. 2019 Apr 5;4(34). pii: eaav7517. doi: 10.1126/sciimmunol.aav7517.


Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes.

Zhang L, Sosinowski T, Cox AR, Cepeda JR, Sekhar NS, Hartig SM, Miao D, Yu L, Pietropaolo M, Davidson HW.

J Autoimmun. 2019 Jan;96:50-58. doi: 10.1016/j.jaut.2018.08.004. Epub 2018 Aug 16.


C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.

Wang Y, Sosinowski T, Novikov A, Crawford F, Neau DB, Yang J, Kwok WW, Marrack P, Kappler JW, Dai S.

Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):162-167. doi: 10.1073/pnas.1716527115. Epub 2017 Dec 18.


An alternatively spliced IL-15 isoform modulates abrasion-induced keratinocyte activation.

Lee TL, Chang ML, Lin YJ, Tsai MH, Chang YH, Chuang CM, Chien Y, Sosinowski T, Wang CH, Chen YY, Lee CK, Chen JS, Wang LF, Kung JT, Ku CC.

J Invest Dermatol. 2015 May;135(5):1329-1337. doi: 10.1038/jid.2015.17. Epub 2015 Jan 23.


Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes.

Yang J, Chow IT, Sosinowski T, Torres-Chinn N, Greenbaum CJ, James EA, Kappler JW, Davidson HW, Kwok WW.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14840-5. doi: 10.1073/pnas.1416864111. Epub 2014 Sep 29.


The discovery of a reciprocal relationship between tyrosine-kinase signaling and cullin neddylation.

Friend SF, Peterson LK, Treacy E, Stefanski AL, Sosinowski T, Pennock ND, Berger AJ, Winn VD, Dragone LL.

PLoS One. 2013 Oct 4;8(10):e75200. doi: 10.1371/journal.pone.0075200. eCollection 2013.


CD8α+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function.

Sosinowski T, White JT, Cross EW, Haluszczak C, Marrack P, Gapin L, Kedl RM.

J Immunol. 2013 Mar 1;190(5):1936-47. doi: 10.4049/jimmunol.1203149. Epub 2013 Jan 25.


Type 1 diabetes: primary antigen/peptide/register/trimolecular complex.

Sosinowski T, Eisenbarth GS.

Immunol Res. 2013 Mar;55(1-3):270-6. doi: 10.1007/s12026-012-8367-6. Review.


Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice.

Nakayama M, Castoe T, Sosinowski T, He X, Johnson K, Haskins K, Vignali DA, Gapin L, Pollock D, Eisenbarth GS.

Diabetes. 2012 Apr;61(4):857-65. doi: 10.2337/db11-1113. Epub 2012 Feb 7.


Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.

Dragone LL, Myers MD, White C, Gadwal S, Sosinowski T, Gu H, Weiss A.

Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18202-7. Epub 2006 Nov 16.


SRC-like adaptor protein regulates B cell development and function.

Dragone LL, Myers MD, White C, Sosinowski T, Weiss A.

J Immunol. 2006 Jan 1;176(1):335-45.


Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex.

Myers MD, Sosinowski T, Dragone LL, White C, Band H, Gu H, Weiss A.

Nat Immunol. 2006 Jan;7(1):57-66. Epub 2005 Dec 4.


Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein.

Kratchmarova I, Sosinowski T, Weiss A, Witter K, Vincenz C, Pandey A.

Gene. 2001 Jan 10;262(1-2):267-73.


Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling.

Sosinowski T, Pandey A, Dixit VM, Weiss A.

J Exp Med. 2000 Feb 7;191(3):463-74.


Expression of a yeast metallothionein gene family is activated by a single metalloregulatory transcription factor.

Zhou P, Szczypka MS, Sosinowski T, Thiele DJ.

Mol Cell Biol. 1992 Sep;12(9):3766-75.

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