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Items: 1 to 50 of 172

1.

The Treatment of Impaired Wound Healing in Diabetes: Looking among Old Drugs.

Spampinato SF, Caruso GI, De Pasquale R, Sortino MA, Merlo S.

Pharmaceuticals (Basel). 2020 Apr 1;13(4). pii: E60. doi: 10.3390/ph13040060. Review.

2.

New thiazolyl-pyrazoline derivatives bearing nitrogen mustard as potential antimicrobial and antiprotozoal agents.

Cuartas V, Robledo SM, Vélez ID, Crespo MDP, Sortino M, Zacchino S, Nogueras M, Cobo J, Upegui Y, Pineda T, Yepes L, Insuasty B.

Arch Pharm (Weinheim). 2020 Mar 18:e1900351. doi: 10.1002/ardp.201900351. [Epub ahead of print]

PMID:
32187709
3.

SIRT1 Mediates Melatonin's Effects on Microglial Activation in Hypoxia: In Vitro and In Vivo Evidence.

Merlo S, Luaces JP, Spampinato SF, Toro-Urrego N, Caruso GI, D'Amico F, Capani F, Sortino MA.

Biomolecules. 2020 Feb 27;10(3). pii: E364. doi: 10.3390/biom10030364.

4.

The ambiguous role of microglia in Aβ toxicity: Chances for therapeutic intervention.

Merlo S, Spampinato SF, Caruso GI, Sortino MA.

Curr Neuropharmacol. 2020 Jan 30. doi: 10.2174/1570159X18666200131105418. [Epub ahead of print]

PMID:
32003695
5.

Astrocyte-Derived Paracrine Signals: Relevance for Neurogenic Niche Regulation and Blood-Brain Barrier Integrity.

Spampinato SF, Bortolotto V, Canonico PL, Sortino MA, Grilli M.

Front Pharmacol. 2019 Nov 21;10:1346. doi: 10.3389/fphar.2019.01346. eCollection 2019. Review.

6.

β-amyloid and Oxidative Stress: Perspectives in Drug Development.

Caruso G, Spampinato SF, Cardaci V, Caraci F, Sortino MA, Merlo S.

Curr Pharm Des. 2019;25(45):4771-4781. doi: 10.2174/1381612825666191209115431.

PMID:
31814548
7.

Photodynamic activity of Tagetes minuta extracts against superficial fungal infections.

Giacone L, Cordisco E, Garrido MC, Petenatti E, Sortino M.

Med Mycol. 2019 Nov 14. pii: myz114. doi: 10.1093/mmy/myz114. [Epub ahead of print]

PMID:
31724710
8.

Rescue of Noradrenergic System as a Novel Pharmacological Strategy in the Treatment of Chronic Pain: Focus on Microglia Activation.

Caraci F, Merlo S, Drago F, Caruso G, Parenti C, Sortino MA.

Front Pharmacol. 2019 Sep 12;10:1024. doi: 10.3389/fphar.2019.01024. eCollection 2019. Review.

9.

The epistatic interaction between the dopamine D3 receptor and dysbindin-1 modulates higher-order cognitive functions in mice and humans.

Leggio GM, Torrisi SA, Mastrogiacomo R, Mauro D, Chisari M, Devroye C, Scheggia D, Nigro M, Geraci F, Pintori N, Giurdanella G, Costa L, Bucolo C, Ferretti V, Sortino MA, Ciranna L, De Luca MA, Mereu M, Managò F, Salomone S, Drago F, Papaleo F.

Mol Psychiatry. 2019 Sep 6. doi: 10.1038/s41380-019-0511-4. [Epub ahead of print]

PMID:
31492942
10.

Astrocytes Modify Migration of PBMCs Induced by β-Amyloid in a Blood-Brain Barrier in vitro Model.

Spampinato SF, Merlo S, Fagone E, Fruciano M, Barbagallo C, Kanda T, Sano Y, Purrello M, Vancheri C, Ragusa M, Sortino MA.

Front Cell Neurosci. 2019 Jul 23;13:337. doi: 10.3389/fncel.2019.00337. eCollection 2019.

11.

Mechanistic studies of Candida albicans photodynamic inactivation with Porophyllum obscurum hexanic extract and its isolated thiophenic compounds.

Postigo A, Schiavi PC, Funes M, Sortino M.

Photodiagnosis Photodyn Ther. 2019 Jun;26:420-429. doi: 10.1016/j.pdpdt.2019.05.003. Epub 2019 May 10.

PMID:
31078713
12.

On the effect of intramolecular H-bonding in the configurational assessment of polyhydroxylated compounds with computational methods. The hyacinthacines case.

Zanardi MM, Sortino MA, Sarotti AM.

Carbohydr Res. 2019 Feb 15;474:72-79. doi: 10.1016/j.carres.2019.01.011. Epub 2019 Jan 28.

PMID:
30798018
13.

Approaches to the mechanism of antifungal activity of Zuccagnia punctata-Larrea nitida bi-herbal combination.

Butassi E, Svetaz LA, Sortino MA, Quiroga AD, Carvalho VSD, Cortés JCG, Ribas JC, Zacchino SA.

Phytomedicine. 2019 Feb 15;54:291-301. doi: 10.1016/j.phymed.2018.06.045. Epub 2018 Jul 6.

PMID:
30668380
14.

Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1.

Caruso G, Fresta CG, Musso N, Giambirtone M, Grasso M, Spampinato SF, Merlo S, Drago F, Lazzarino G, Sortino MA, Lunte SM, Caraci F.

Cells. 2019 Jan 17;8(1). pii: E64. doi: 10.3390/cells8010064.

15.

Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer's disease mouse model.

Rocchio F, Tapella L, Manfredi M, Chisari M, Ronco F, Ruffinatti FA, Conte E, Canonico PL, Sortino MA, Grilli M, Marengo E, Genazzani AA, Lim D.

Cell Death Dis. 2019 Jan 10;10(1):24. doi: 10.1038/s41419-018-1264-8.

16.

Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?

Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F.

Front Mol Neurosci. 2018 Nov 13;11:414. doi: 10.3389/fnmol.2018.00414. eCollection 2018. Review.

17.

Composite Microparticles Based on Natural Mucoadhesive Polymers with Promising Structural Properties to Protect and Improve the Antifungal Activity of Miconazole Nitrate.

Tejada G, Lamas MC, Sortino M, Alvarez VA, Leonardi D.

AAPS PharmSciTech. 2018 Nov;19(8):3712-3722. doi: 10.1208/s12249-018-1175-0. Epub 2018 Sep 20.

PMID:
30238304
18.

General Quantum-Based NMR Method for the Assignment of Absolute Configuration by Single or Double Derivatization: Scope and Limitations.

Zanardi MM, Biglione FA, Sortino MA, Sarotti AM.

J Org Chem. 2018 Oct 5;83(19):11839-11849. doi: 10.1021/acs.joc.8b01749. Epub 2018 Sep 13.

PMID:
30180574
19.

Early compensatory responses against neuronal injury: A new therapeutic window of opportunity for Alzheimer's Disease?

Merlo S, Spampinato SF, Sortino MA.

CNS Neurosci Ther. 2019 Jan;25(1):5-13. doi: 10.1111/cns.13050. Epub 2018 Aug 12. Review.

20.

The contribution of microglia to early synaptic compensatory responses that precede β-amyloid-induced neuronal death.

Merlo S, Spampinato SF, Beneventano M, Sortino MA.

Sci Rep. 2018 May 8;8(1):7297. doi: 10.1038/s41598-018-25453-1.

21.

Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target.

Caraci F, Spampinato SF, Morgese MG, Tascedda F, Salluzzo MG, Giambirtone MC, Caruso G, Munafò A, Torrisi SA, Leggio GM, Trabace L, Nicoletti F, Drago F, Sortino MA, Copani A.

Pharmacol Res. 2018 Apr;130:374-384. doi: 10.1016/j.phrs.2018.02.007. Epub 2018 Feb 10. Review.

PMID:
29438781
22.

Synthesis and DFT Calculations of Novel Vanillin-Chalcones and Their 3-Aryl-5-(4-(2-(dimethylamino)-ethoxy)-3-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbaldehyde Derivatives as Antifungal Agents.

Illicachi LA, Montalvo-Acosta JJ, Insuasty A, Quiroga J, Abonia R, Sortino M, Zacchino S, Insuasty B.

Molecules. 2017 Sep 5;22(9). pii: E1476. doi: 10.3390/molecules22091476.

23.

Plant phenolics and terpenoids as adjuvants of antibacterial and antifungal drugs.

Zacchino SA, Butassi E, Liberto MD, Raimondi M, Postigo A, Sortino M.

Phytomedicine. 2017 Dec 15;37:27-48. doi: 10.1016/j.phymed.2017.10.018. Epub 2017 Oct 31. Review.

PMID:
29174958
24.

Shedding of Microvesicles from Microglia Contributes to the Effects Induced by Metabotropic Glutamate Receptor 5 Activation on Neuronal Death.

Beneventano M, Spampinato SF, Merlo S, Chisari M, Platania P, Ragusa M, Purrello M, Nicoletti F, Sortino MA.

Front Pharmacol. 2017 Nov 9;8:812. doi: 10.3389/fphar.2017.00812. eCollection 2017.

25.

Antifungal photosensitive activity of Porophyllum obscurum (Spreng.) DC.: Correlation of the chemical composition of the hexane extract with the bioactivity.

Postigo A, Funes M, Petenatti E, Bottai H, Pacciaroni A, Sortino M.

Photodiagnosis Photodyn Ther. 2017 Dec;20:263-272. doi: 10.1016/j.pdpdt.2017.10.023. Epub 2017 Oct 27.

PMID:
29111389
26.

Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice.

Zammataro M, Merlo S, Barresi M, Parenti C, Hu H, Sortino MA, Chiechio S.

Front Pharmacol. 2017 Oct 20;8:743. doi: 10.3389/fphar.2017.00743. eCollection 2017.

27.

Polycystic Ovary Syndrome: Insights into the Therapeutic Approach with Inositols.

Sortino MA, Salomone S, Carruba MO, Drago F.

Front Pharmacol. 2017 Jun 8;8:341. doi: 10.3389/fphar.2017.00341. eCollection 2017. Review.

28.

Formulation and in-vitro efficacy of antifungal mucoadhesive polymeric matrices for the delivery of miconazole nitrate.

Tejada G, Piccirilli GN, Sortino M, Salomón CJ, Lamas MC, Leonardi D.

Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:140-150. doi: 10.1016/j.msec.2017.05.034. Epub 2017 May 8.

PMID:
28629000
29.

Estrogen and Alzheimer's disease: Still an attractive topic despite disappointment from early clinical results.

Merlo S, Spampinato SF, Sortino MA.

Eur J Pharmacol. 2017 Dec 15;817:51-58. doi: 10.1016/j.ejphar.2017.05.059. Epub 2017 May 31. Review.

PMID:
28577965
30.

Antifungal toxicity of linear geranylphenol. Influence of oxigenate substituents.

Taborga L, Sortino M, Carrasco H, Butassi E, Zacchino S, Espinoza L.

Food Chem Toxicol. 2017 Nov;109(Pt 2):827-835. doi: 10.1016/j.fct.2017.05.027. Epub 2017 May 18.

PMID:
28528250
31.

Astrocytes contribute to Aβ-induced blood-brain barrier damage through activation of endothelial MMP9.

Spampinato SF, Merlo S, Sano Y, Kanda T, Sortino MA.

J Neurochem. 2017 Aug;142(3):464-477. doi: 10.1111/jnc.14068. Epub 2017 Jun 20.

32.

Development and Evaluation of Buccal Films Based on Chitosan for the Potential Treatment of Oral Candidiasis.

Tejada G, Barrera MG, Piccirilli GN, Sortino M, Frattini A, Salomón CJ, Lamas MC, Leonardi D.

AAPS PharmSciTech. 2017 May;18(4):936-946. doi: 10.1208/s12249-017-0720-6. Epub 2017 Jan 20.

PMID:
28108973
33.

Fluoxetine Prevents Aβ1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1.

Caraci F, Tascedda F, Merlo S, Benatti C, Spampinato SF, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A.

Front Pharmacol. 2016 Oct 25;7:389. eCollection 2016.

34.

Hybrid Molecules Containing a 7-Chloro-4-aminoquinoline Nucleus and a Substituted 2-Pyrazoline with Antiproliferative and Antifungal Activity.

Montoya A, Quiroga J, Abonia R, Derita M, Sortino M, Ornelas A, Zacchino S, Insuasty B.

Molecules. 2016 Jul 27;21(8). pii: E969. doi: 10.3390/molecules21080969.

35.

Purinergic P2Y1 Receptors Control Rapid Expression of Plasma Membrane Processes in Hippocampal Astrocytes.

Chisari M, Scuderi A, Ciranna L, Volsi GL, Licata F, Sortino MA.

Mol Neurobiol. 2017 Aug;54(6):4081-4093. doi: 10.1007/s12035-016-9955-6. Epub 2016 Jun 18.

PMID:
27318677
36.

Antifungal drugs combinations: a patent review 2000-2015.

Svetaz LA, Postigo A, Butassi E, Zacchino SA, Sortino MA.

Expert Opin Ther Pat. 2016;26(4):439-53. doi: 10.1517/13543776.2016.1146693. Review.

PMID:
26813798
37.

Early β-Amyloid-induced Synaptic Dysfunction Is Counteracted by Estrogen in Organotypic Hippocampal Cultures.

Merlo S, Spampinato SF, Capani F, Sortino MA.

Curr Alzheimer Res. 2016;13(6):631-40.

PMID:
26805000
38.

Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity.

Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A.

J Nat Prod. 2015 Nov 25;78(11):2704-11. doi: 10.1021/acs.jnatprod.5b00621. Epub 2015 Oct 30.

PMID:
26517378
39.

High mobility group box 1 contributes to wound healing induced by inhibition of dipeptidylpeptidase 4 in cultured keratinocytes.

Sinagra T, Merlo S, Spampinato SF, Pasquale RD, Sortino MA.

Front Pharmacol. 2015 Jun 16;6:126. doi: 10.3389/fphar.2015.00126. eCollection 2015.

40.

Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes.

Spampinato SF, Merlo S, Chisari M, Nicoletti F, Sortino MA.

Front Cell Neurosci. 2015 Jan 14;8:462. doi: 10.3389/fncel.2014.00462. eCollection 2014.

41.

HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors.

Zammataro M, Sortino MA, Parenti C, Gereau RW 4th, Chiechio S.

Mol Pain. 2014 Nov 18;10:68. doi: 10.1186/1744-8069-10-68.

42.

Photodynamic inactivation of oropharyngeal Candida strains.

Postigo A, Bulacio L, Sortino M.

Phytomedicine. 2014 Sep 25;21(11):1424-31. doi: 10.1016/j.phymed.2014.04.028. Epub 2014 Jun 18.

PMID:
24950637
43.

Efficient synthesis of novel 3-aryl-5-(4-chloro-2-morpholinothiazol-5-yl)-4,5-dihydro-1H-pyrazoles and their antifungal activity alone and in combination with commercial antifungal agents.

Ramírez J, Rodríguez MV, Quiroga J, Abonia R, Sortino M, Zacchino SA, Insuasty B.

Arch Pharm (Weinheim). 2014 Aug;347(8):566-75. doi: 10.1002/ardp.201400084. Epub 2014 Jun 4.

PMID:
24895219
44.

Detection of synergistic combinations of Baccharis extracts with terbinafine against Trichophyton rubrum with high throughput screening synergy assay (HTSS) followed by 3D graphs. Behavior of some of their components.

Rodriguez MV, Sortino MA, Ivancovich JJ, Pellegrino JM, Favier LS, Raimondi MP, Gattuso MA, Zacchino SA.

Phytomedicine. 2013 Oct 15;20(13):1230-9. doi: 10.1016/j.phymed.2013.06.015. Epub 2013 Jul 30.

PMID:
23906773
45.
46.

Linagliptin: A thorough Characterization beyond Its Clinical Efficacy.

Sortino MA, Sinagra T, Canonico PL.

Front Endocrinol (Lausanne). 2013 Feb 26;4:16. doi: 10.3389/fendo.2013.00016. eCollection 2013.

47.

Oral infections caused by yeasts in patients with head and neck cancer undergoing radiotherapy. Identification of the yeasts and evaluation of their antifungal susceptibility.

Bulacio L, Paz M, Ramadán S, Ramos L, Pairoba C, Sortino M, Escovich L, López C.

J Mycol Med. 2012 Dec;22(4):348-53. doi: 10.1016/j.mycmed.2012.08.002. Epub 2012 Nov 14.

PMID:
23518170
48.

Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives.

Kouznetsov VV, Zacchino SA, Sortino M, Vargas Méndez LY, Gupta MP.

Sci Pharm. 2012 Oct-Dec;80(4):867-77. doi: 10.3797/scipharm.1209-03. Epub 2012 Oct 23.

49.

Dual effect of 17β-estradiol on NMDA-induced neuronal death: involvement of metabotropic glutamate receptor 1.

Spampinato SF, Merlo S, Molinaro G, Battaglia G, Bruno V, Nicoletti F, Sortino MA.

Endocrinology. 2012 Dec;153(12):5940-8. doi: 10.1210/en.2012-1799. Epub 2012 Oct 17.

PMID:
23077075
50.

Estrogen activates matrix metalloproteinases-2 and -9 to increase beta amyloid degradation.

Merlo S, Sortino MA.

Mol Cell Neurosci. 2012 Apr;49(4):423-9. doi: 10.1016/j.mcn.2012.02.005. Epub 2012 Feb 28.

PMID:
22402435

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