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Items: 23


A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.

Bongiovanni MN, Aprile FA, Sormanni P, Vendruscolo M.

Int J Mol Sci. 2018 May 12;19(5). pii: E1443. doi: 10.3390/ijms19051443.


Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.

Le Marchand T, de Rosa M, Salvi N, Sala BM, Andreas LB, Barbet-Massin E, Sormanni P, Barbiroli A, Porcari R, Sousa Mota C, de Sanctis D, Bolognesi M, Emsley L, Bellotti V, Blackledge M, Camilloni C, Pintacuda G, Ricagno S.

Nat Commun. 2018 Apr 25;9(1):1658. doi: 10.1038/s41467-018-04078-y.


Parapred: Antibody Paratope Prediction using Convolutional and Recurrent Neural Networks.

Liberis E, Velickovic P, Sormanni P, Vendruscolo M, Liò P.

Bioinformatics. 2018 Apr 16. doi: 10.1093/bioinformatics/bty305. [Epub ahead of print]


Corneal Dystrophy Mutations Drive Pathogenesis by Targeting TGFBIp Stability and Solubility in a Latent Amyloid-forming Domain.

Stenvang M, Schafer NP, Malmos KG, Pérez AW, Niembro O, Sormanni P, Basaiawmoit RV, Christiansen G, Andreasen M, Otzen DE.

J Mol Biol. 2018 Apr 13;430(8):1116-1140. doi: 10.1016/j.jmb.2018.03.001. Epub 2018 Mar 7.


Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.

Perni M, Challa PK, Kirkegaard JB, Limbocker R, Koopman M, Hardenberg MC, Sormanni P, Müller T, Saar KL, Roode LWY, Habchi J, Vecchi G, Fernando N, Casford S, Nollen EAA, Vendruscolo M, Dobson CM, Knowles TPJ.

J Neurosci Methods. 2018 Aug 1;306:57-67. doi: 10.1016/j.jneumeth.2018.02.005. Epub 2018 Feb 13.


MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins.

Piovesan D, Tabaro F, Paladin L, Necci M, Micetic I, Camilloni C, Davey N, Dosztányi Z, Mészáros B, Monzon AM, Parisi G, Schad E, Sormanni P, Tompa P, Vendruscolo M, Vranken WF, Tosatto SCE.

Nucleic Acids Res. 2018 Jan 4;46(D1):D471-D476. doi: 10.1093/nar/gkx1071.


Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles.

Perni M, Aprile FA, Casford S, Mannini B, Sormanni P, Dobson CM, Vendruscolo M.

Sci Rep. 2017 Nov 8;7(1):15045. doi: 10.1038/s41598-017-13755-9.


Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo.

Martínez-Sáez N, Sun S, Oldrini D, Sormanni P, Boutureira O, Carboni F, Compañón I, Deery MJ, Vendruscolo M, Corzana F, Adamo R, Bernardes GJL.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14963-14967. doi: 10.1002/anie.201708847. Epub 2017 Oct 20.


Rapid and accurate in silico solubility screening of a monoclonal antibody library.

Sormanni P, Amery L, Ekizoglou S, Vendruscolo M, Popovic B.

Sci Rep. 2017 Aug 15;7(1):8200. doi: 10.1038/s41598-017-07800-w.


Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method.

Aprile FA, Sormanni P, Perni M, Arosio P, Linse S, Knowles TPJ, Dobson CM, Vendruscolo M.

Sci Adv. 2017 Jun 21;3(6):e1700488. doi: 10.1126/sciadv.1700488. eCollection 2017 Jun.


Simultaneous quantification of protein order and disorder.

Sormanni P, Piovesan D, Heller GT, Bonomi M, Kukic P, Camilloni C, Fuxreiter M, Dosztanyi Z, Pappu RV, Babu MM, Longhi S, Tompa P, Dunker AK, Uversky VN, Tosatto SC, Vendruscolo M.

Nat Chem Biol. 2017 Mar 22;13(4):339-342. doi: 10.1038/nchembio.2331. No abstract available.


A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.

Perni M, Galvagnion C, Maltsev A, Meisl G, Müller MB, Challa PK, Kirkegaard JB, Flagmeier P, Cohen SI, Cascella R, Chen SW, Limbocker R, Sormanni P, Heller GT, Aprile FA, Cremades N, Cecchi C, Chiti F, Nollen EA, Knowles TP, Vendruscolo M, Bax A, Zasloff M, Dobson CM.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E1009-E1017. doi: 10.1073/pnas.1610586114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Mar 21;114(12 ):E2543. Limboker, Ryan [corrected to Limbocker, Ryan].


A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease.

Freer R, Sormanni P, Vecchi G, Ciryam P, Dobson CM, Vendruscolo M.

Sci Adv. 2016 Aug 10;2(8):e1600947. doi: 10.1126/sciadv.1600947. eCollection 2016 Aug.


Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.

Camilloni C, Sala BM, Sormanni P, Porcari R, Corazza A, De Rosa M, Zanini S, Barbiroli A, Esposito G, Bolognesi M, Bellotti V, Vendruscolo M, Ricagno S.

Sci Rep. 2016 May 6;6:25559. doi: 10.1038/srep25559.


Targeting disordered proteins with small molecules using entropy.

Heller GT, Sormanni P, Vendruscolo M.

Trends Biochem Sci. 2015 Sep;40(9):491-6. doi: 10.1016/j.tibs.2015.07.004. Epub 2015 Aug 11. Review.


Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins.

Sormanni P, Aprile FA, Vendruscolo M.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9902-7. doi: 10.1073/pnas.1422401112. Epub 2015 Jul 27.


A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate.

Aprile FA, Sormanni P, Vendruscolo M.

Biochemistry. 2015 Aug 18;54(32):5103-12. doi: 10.1021/acs.biochem.5b00459. Epub 2015 Aug 7.


The s2D method: simultaneous sequence-based prediction of the statistical populations of ordered and disordered regions in proteins.

Sormanni P, Camilloni C, Fariselli P, Vendruscolo M.

J Mol Biol. 2015 Feb 27;427(4):982-996. doi: 10.1016/j.jmb.2014.12.007. Epub 2014 Dec 20.


The CamSol method of rational design of protein mutants with enhanced solubility.

Sormanni P, Aprile FA, Vendruscolo M.

J Mol Biol. 2015 Jan 30;427(2):478-90. doi: 10.1016/j.jmb.2014.09.026. Epub 2014 Oct 14.


Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein.

Gianni S, Camilloni C, Giri R, Toto A, Bonetti D, Morrone A, Sormanni P, Brunori M, Vendruscolo M.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14141-6. doi: 10.1073/pnas.1405233111. Epub 2014 Sep 16.


Iterative derivation of effective potentials to sample the conformational space of proteins at atomistic scale.

Capelli R, Paissoni C, Sormanni P, Tiana G.

J Chem Phys. 2014 May 21;140(19):195101. doi: 10.1063/1.4876219.


Subdomain architecture and stability of a giant repeat protein.

Tsytlonok M, Sormanni P, Rowling PJ, Vendruscolo M, Itzhaki LS.

J Phys Chem B. 2013 Oct 24;117(42):13029-37. doi: 10.1021/jp402360x. Epub 2013 Sep 20.


Fibrillogenic propensity of the GroEL apical domain: a Janus-faced minichaperone.

Chen J, Yagi H, Sormanni P, Vendruscolo M, Makabe K, Nakamura T, Goto Y, Kuwajima K.

FEBS Lett. 2012 Apr 24;586(8):1120-7. doi: 10.1016/j.febslet.2012.03.019. Epub 2012 Mar 23.

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