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Multiview Cluster Analysis Identifies Variable Corticosteroid Response Phenotypes in Severe Asthma.

Wu W, Bang S, Bleecker ER, Castro M, Denlinger L, Erzurum SC, Fahy JV, Fitzpatrick AM, Gaston BM, Hastie AT, Israel E, Jarjour NN, Levy BD, Mauger DT, Meyers DA, Moore WC, Peters M, Phillips BR, Phipatanakul W, Sorkness RL, Wenzel SE.

Am J Respir Crit Care Med. 2019 Jan 25. doi: 10.1164/rccm.201808-1543OC. [Epub ahead of print]


Disparate diagnostic accuracy of lung function tests as predictors of poor asthma control in children.

Smith CJ, Spaeder MC, Sorkness RL, Teague WG.

J Asthma. 2019 Jan 21:1-8. doi: 10.1080/02770903.2019.1566471. [Epub ahead of print]


Racial disparities in asthma-related health care use in the National Heart, Lung, and Blood Institute's Severe Asthma Research Program.

Fitzpatrick AM, Gillespie SE, Mauger DT, Phillips BR, Bleecker ER, Israel E, Meyers DA, Moore WC, Sorkness RL, Wenzel SE, Bacharier LB, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston BM, Jarjour NN, Larkin A, Levy BD, Ly NP, Ortega VE, Peters SP, Phipatanakul W, Ramratnam S, Teague WG.

J Allergy Clin Immunol. 2019 Jan 8. pii: S0091-6749(18)31732-9. doi: 10.1016/j.jaci.2018.11.022. [Epub ahead of print]


Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma.

DeBoer MD, Phillips BR, Mauger DT, Zein J, Erzurum SC, Fitzpatrick AM, Gaston BM, Myers R, Ross KR, Chmiel J, Lee MJ, Fahy JV, Peters M, Ly NP, Wenzel SE, Fajt ML, Holguin F, Moore WC, Peters SP, Meyers D, Bleecker ER, Castro M, Coverstone AM, Bacharier LB, Jarjour NN, Sorkness RL, Ramratnam S, Irani AM, Israel E, Levy B, Phipatanakul W, Gaffin JM, Gerald Teague W.

BMC Pulm Med. 2018 Apr 10;18(1):58. doi: 10.1186/s12890-018-0612-x.


Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy.

Kattan M, Bacharier LB, O'Connor GT, Cohen R, Sorkness RL, Morgan W, Gergen PJ, Jaffee KF, Visness CM, Wood RA, Bloomberg GR, Doyle S, Burton R, Gern JE.

J Allergy Clin Immunol Pract. 2018 Sep - Oct;6(5):1596-1603.e6. doi: 10.1016/j.jaip.2017.12.028. Epub 2018 Feb 13.


Lumen area change (Delta Lumen) between inspiratory and expiratory multidetector computed tomography as a measure of severe outcomes in asthmatic patients.

Shim SS, Schiebler ML, Evans MD, Jarjour N, Sorkness RL, Denlinger LC, Rodriguez A, Wenzel S, Hoffman EA, Lin CL, Gierada DS, Castro M, Fain SB; National Heart, Lung, and Blood Institute's Severe Asthma Research Program.

J Allergy Clin Immunol. 2018 Dec;142(6):1773-1780.e9. doi: 10.1016/j.jaci.2017.12.1004. Epub 2018 Feb 10.


Regional Heterogeneity of Lobar Ventilation in Asthma Using Hyperpolarized Helium-3 MRI.

Zha W, Kruger SJ, Cadman RV, Mummy DG, Evans MD, Nagle SK, Denlinger LC, Jarjour NN, Sorkness RL, Fain SB.

Acad Radiol. 2018 Feb;25(2):169-178. doi: 10.1016/j.acra.2017.09.014. Epub 2017 Nov 23.


Obstruction phenotype as a predictor of asthma severity and instability in children.

Sorkness RL, Zoratti EM, Kattan M, Gergen PJ, Evans MD, Visness CM, Gill M, Khurana Hershey GK, Kercsmar CM, Liu AH, O'Connor GT, Pongracic JA, Pillai D, Sorkness CA, Togias A, Wood RA, Busse WW.

J Allergy Clin Immunol. 2018 Oct;142(4):1090-1099.e4. doi: 10.1016/j.jaci.2017.09.047. Epub 2017 Nov 14.


Ventilation defect percent in helium-3 magnetic resonance imaging as a biomarker of severe outcomes in asthma.

Mummy DG, Kruger SJ, Zha W, Sorkness RL, Jarjour NN, Schiebler ML, Denlinger LC, Evans MD, Fain SB.

J Allergy Clin Immunol. 2018 Mar;141(3):1140-1141.e4. doi: 10.1016/j.jaci.2017.10.016. Epub 2017 Nov 10. No abstract available.


Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age.

Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN.

J Allergy Clin Immunol Pract. 2018 Mar - Apr;6(2):545-554.e4. doi: 10.1016/j.jaip.2017.05.032. Epub 2017 Aug 31.


Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma.

Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E; Severe Asthma Research Program.

Am J Respir Crit Care Med. 2017 Jun 1;195(11):1439-1448. doi: 10.1164/rccm.201607-1453OC.


Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations.

Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN; National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators.

Am J Respir Crit Care Med. 2017 Feb 1;195(3):302-313. doi: 10.1164/rccm.201602-0419OC.


Using MRI to Reveal (and Resolve) the Complexity of Obstructive Lung Disease.

Fain SB, Sorkness RL.

Acad Radiol. 2016 Apr;23(4):393-5. doi: 10.1016/j.acra.2016.01.007. Epub 2016 Mar 2. No abstract available.


Redistribution of inhaled hyperpolarized 3He gas during breath-hold differs by asthma severity.

Hahn AD, Cadman RV, Sorkness RL, Jarjour NN, Nagle SK, Fain SB.

J Appl Physiol (1985). 2016 Mar 1;120(5):526-36. doi: 10.1152/japplphysiol.00197.2015. Epub 2015 Dec 3.


Airway factor XIII associates with type 2 inflammation and airway obstruction in asthmatic patients.

Esnault S, Kelly EA, Sorkness RL, Evans MD, Busse WW, Jarjour NN.

J Allergy Clin Immunol. 2016 Mar;137(3):767-73.e6. doi: 10.1016/j.jaci.2015.05.053. Epub 2015 Oct 30.


Obstructive Sleep Apnea Risk, Asthma Burden, and Lower Airway Inflammation in Adults in the Severe Asthma Research Program (SARP) II.

Teodorescu M, Broytman O, Curran-Everett D, Sorkness RL, Crisafi G, Bleecker ER, Erzurum S, Gaston BM, Wenzel SE, Jarjour NN; National Institutes of Health, National Heart, Lung and Blood Institute Severe Asthma Research Program (SARP) Investigators.

J Allergy Clin Immunol Pract. 2015 Jul-Aug;3(4):566-75.e1. doi: 10.1016/j.jaip.2015.04.002. Epub 2015 May 21.


Sex-related differences in pulmonary physiologic outcome measures in a high-risk birth cohort.

Thomas AO, Jackson DJ, Evans MD, Rajamanickam V, Gangnon RE, Fain SB, Sorkness RL, Okupa AY, Thomas A, Gern JE, Lemanske RF Jr.

J Allergy Clin Immunol. 2015 Aug;136(2):282-7. doi: 10.1016/j.jaci.2014.12.1927. Epub 2015 Feb 9.


Comparison of temporal transcriptomic profiles from immature lungs of two rat strains reveals a viral response signature associated with chronic lung dysfunction.

Hines EA, Szakaly RJ, Leng N, Webster AT, Verheyden JM, Lashua AJ, Kendziorski C, Rosenthal LA, Gern JE, Sorkness RL, Sun X, Lemanske RF Jr.

PLoS One. 2014 Dec 1;9(12):e112997. doi: 10.1371/journal.pone.0112997. eCollection 2014.


International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma.

Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, Bateman ED, Bel EH, Bleecker ER, Boulet LP, Brightling C, Chanez P, Dahlen SE, Djukanovic R, Frey U, Gaga M, Gibson P, Hamid Q, Jajour NN, Mauad T, Sorkness RL, Teague WG.

Eur Respir J. 2014 Feb;43(2):343-73. doi: 10.1183/09031936.00202013. Epub 2013 Dec 12. Erratum in: Eur Respir J. 2014 Apr;43(4):1216. Dosage error in article text. Erratum in: Eur Respir J. 2018 Jul 27;52(1):.


Hyperpolarized Helium-3 MRI of exercise-induced bronchoconstriction during challenge and therapy.

Kruger SJ, Niles DJ, Dardzinski B, Harman A, Jarjour NN, Ruddy M, Nagle SK, Francois CJ, Sorkness RL, Burton RM, Munoz del Rio A, Fain SB.

J Magn Reson Imaging. 2014 May;39(5):1230-7. doi: 10.1002/jmri.24272. Epub 2013 Sep 4.


Markers of vascular perturbation correlate with airway structural change in asthma.

Johansson MW, Kruger SJ, Schiebler ML, Evans MD, Sorkness RL, Denlinger LC, Busse WW, Jarjour NN, Montgomery RR, Mosher DF, Fain SB.

Am J Respir Crit Care Med. 2013 Jul 15;188(2):167-78. doi: 10.1164/rccm.201301-0185OC.


Viral bronchiolitis in young rats causes small airway lesions that correlate with reduced lung function.

Sorkness RL, Szakaly RJ, Rosenthal LA, Sullivan R, Gern JE, Lemanske RF Jr, Sun X.

Am J Respir Cell Mol Biol. 2013 Nov;49(5):808-13. doi: 10.1165/rcmb.2013-0096OC.


Pulmonary 3He magnetic resonance imaging of childhood asthma.

Cadman RV, Lemanske RF Jr, Evans MD, Jackson DJ, Gern JE, Sorkness RL, Fain SB.

J Allergy Clin Immunol. 2013 Feb;131(2):369-76.e1-5. doi: 10.1016/j.jaci.2012.10.032. Epub 2012 Dec 11.


Pin1 protein regulates Smad protein signaling and pulmonary fibrosis.

Shen ZJ, Braun RK, Hu J, Xie Q, Chu H, Love RB, Stodola LA, Rosenthal LA, Szakaly RJ, Sorkness RL, Malter JS.

J Biol Chem. 2012 Jul 6;287(28):23294-305. doi: 10.1074/jbc.M111.313684. Epub 2012 May 21.


Lower respiratory tract infection induced by a genetically modified picornavirus in its natural murine host.

Rosenthal LA, Szakaly RJ, Amineva SP, Xing Y, Hill MR, Palmenberg AC, Gern JE, Sorkness RL.

PLoS One. 2012;7(2):e32061. doi: 10.1371/journal.pone.0032061. Epub 2012 Feb 15.


Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program.

Jarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SA, Chung KF, Curran-Everett D, Dweik RA, Fain SB, Fitzpatrick AM, Gaston BM, Israel E, Hastie A, Hoffman EA, Holguin F, Levy BD, Meyers DA, Moore WC, Peters SP, Sorkness RL, Teague WG, Wenzel SE, Busse WW; NHLBI Severe Asthma Research Program (SARP).

Am J Respir Crit Care Med. 2012 Feb 15;185(4):356-62. doi: 10.1164/rccm.201107-1317PP. Epub 2011 Nov 17.


Lower airway rhinovirus burden and the seasonal risk of asthma exacerbation.

Denlinger LC, Sorkness RL, Lee WM, Evans MD, Wolff MJ, Mathur SK, Crisafi GM, Gaworski KL, Pappas TE, Vrtis RF, Kelly EA, Gern JE, Jarjour NN.

Am J Respir Crit Care Med. 2011 Nov 1;184(9):1007-14. doi: 10.1164/rccm.201103-0585OC.


Sex dependence of airflow limitation and air trapping in children with severe asthma.

Sorkness RL, Teague WG, Penugonda M, Fitzpatrick AM; National Institutes of Health, National Heart, Lung, and Blood Institute's Severe Asthma Research Program.

J Allergy Clin Immunol. 2011 Apr;127(4):1073-4. doi: 10.1016/j.jaci.2010.12.1079. No abstract available.


Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma.

Dweik RA, Sorkness RL, Wenzel S, Hammel J, Curran-Everett D, Comhair SA, Bleecker E, Busse W, Calhoun WJ, Castro M, Chung KF, Israel E, Jarjour N, Moore W, Peters S, Teague G, Gaston B, Erzurum SC; National Heart, Lung, and Blood Institute Severe Asthma Research Program.

Am J Respir Crit Care Med. 2010 May 15;181(10):1033-41. doi: 10.1164/rccm.200905-0695OC. Epub 2010 Feb 4.


CAM and respiratory disease.

Sorkness RL.

Nutr Clin Pract. 2009 Oct-Nov;24(5):609-15. doi: 10.1177/0884533609342438. Review.


Three-dimensional imaging of ventilation dynamics in asthmatics using multiecho projection acquisition with constrained reconstruction.

Holmes JH, O'Halloran RL, Brodsky EK, Bley TA, Francois CJ, Velikina JV, Sorkness RL, Busse WW, Fain SB.

Magn Reson Med. 2009 Dec;62(6):1543-56. doi: 10.1002/mrm.22150.


A rat model of picornavirus-induced airway infection and inflammation.

Rosenthal LA, Amineva SP, Szakaly RJ, Lemanske RF Jr, Gern JE, Sorkness RL.

Virol J. 2009 Aug 11;6:122. doi: 10.1186/1743-422X-6-122.


Effects of a DNA vaccine in an animal model of Alternaria alternata sensitivity.

Sánchez H, Bush RK, Sorkness RL, Tuffaha A, Rosenthal LA, Phillips L.

Rev Iberoam Micol. 2009 Jun 30;26(2):121-8. doi: 10.1016/S1130-1406(09)70023-3.


Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma control.

Denlinger LC, Shi L, Guadarrama A, Schell K, Green D, Morrin A, Hogan K, Sorkness RL, Busse WW, Gern JE.

Am J Respir Crit Care Med. 2009 Feb 15;179(4):265-70. doi: 10.1164/rccm.200802-293OC. Epub 2008 Nov 21.


The asthma index: a continuous variable to characterize exacerbations of asthma.

Sorkness RL, Gonzalez-Fernandez G, Billmeyer EE, Evans MD, Gern JE, Jarjour NN.

J Allergy Clin Immunol. 2008 Oct;122(4):838-840. doi: 10.1016/j.jaci.2008.07.041. Epub 2008 Sep 5. No abstract available.


Evaluation of structure-function relationships in asthma using multidetector CT and hyperpolarized He-3 MRI.

Fain SB, Gonzalez-Fernandez G, Peterson ET, Evans MD, Sorkness RL, Jarjour NN, Busse WW, Kuhlman JE.

Acad Radiol. 2008 Jun;15(6):753-62. doi: 10.1016/j.acra.2007.10.019.


Thymic stromal lymphopoietin expression in allergic pulmonary inflammation is Pin1-dependent.

Esnault S, Rosenthal LA, Shen ZJ, Westmark CJ, Sorkness RL, Malter JS.

J Allergy Clin Immunol. 2008 May;121(5):1289-90. doi: 10.1016/j.jaci.2008.02.016. Epub 2008 Apr 18. No abstract available.


Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis.

Shen ZJ, Esnault S, Rosenthal LA, Szakaly RJ, Sorkness RL, Westmark PR, Sandor M, Malter JS.

J Clin Invest. 2008 Feb;118(2):479-90. doi: 10.1172/JCI32789.


Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation.

Sorkness RL, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Erzurum SC, Gaston BM, Israel E, Jarjour NN, Moore WC, Peters SP, Teague WG, Wenzel SE; National Heart, Lung, and Blood Institute Severe Asthma Research Program.

J Appl Physiol (1985). 2008 Feb;104(2):394-403. Epub 2007 Nov 8.


A critical role for Pin1 in allergic pulmonary eosinophilia in rats.

Esnault S, Rosenthal LA, Shen ZJ, Sedgwick JB, Szakaly RJ, Sorkness RL, Malter JS.

J Allergy Clin Immunol. 2007 Nov;120(5):1082-8. Epub 2007 Aug 27.


Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRI.

Holmes JH, Korosec FR, Du J, O'Halloran RL, Sorkness RL, Grist TM, Kuhlman JE, Fain SB.

J Magn Reson Imaging. 2007 Sep;26(3):630-6.


Functional lung imaging using hyperpolarized gas MRI.

Fain SB, Korosec FR, Holmes JH, O'Halloran R, Sorkness RL, Grist TM.

J Magn Reson Imaging. 2007 May;25(5):910-23. Review.


Altered allergen-induced eosinophil trafficking and physiological dysfunction in airways with preexisting virus-induced injury.

Sorkness RL, Herricks KM, Szakaly RJ, Lemanske RF Jr, Rosenthal LA.

Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L85-91. Epub 2006 Aug 11.


Noninvasive mapping of regional response to segmental allergen challenge using magnetic resonance imaging and [F-18]fluorodeoxyglucose positron emission tomography.

Holmes JH, Sorkness RL, Meibom SK, Sundaram SK, Perlman SB, Converse AK, Pyzalski RW, Hahn AD, Korosec FR, Grist TM, Fain SB.

Magn Reson Med. 2005 Jun;53(6):1243-50.


Effects of viral respiratory infections on lung development and childhood asthma.

Gern JE, Rosenthal LA, Sorkness RL, Lemanske RF Jr.

J Allergy Clin Immunol. 2005 Apr;115(4):668-74; quiz 675. Review.


Systemic and pulmonary effects of fluticasone administered through a metered-dose inhaler in rats.

Sorkness RL, Remus JL, Rosenthal LA.

J Allergy Clin Immunol. 2004 Nov;114(5):1027-32.


Contribution of airway closure to chronic postbronchiolitis airway dysfunction in rats.

Sorkness RL, Tuffaha A.

J Appl Physiol (1985). 2004 Mar;96(3):904-10. Epub 2003 Oct 31.


Attenuated innate mechanisms of interferon-gamma production in rats susceptible to postviral airway dysfunction.

Rosenthal LA, Mikus LD, Tuffaha A, Mosser AG, Sorkness RL, Lemanske RF Jr.

Am J Respir Cell Mol Biol. 2004 May;30(5):702-9. Epub 2003 Oct 30.


Liquid chromatographic determination of hydroxyproline in tissue samples.

Hutson PR, Crawford ME, Sorkness RL.

J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 5;791(1-2):427-30.


Persistence of viral RNA in 2 rat strains differing in susceptibility to postbronchiolitis airway dysfunction.

Sorkness RL, Gern JE, Grindle KA, Mosser AG, Rosenthal LA, Mikus LD, Lemanske RF Jr.

J Allergy Clin Immunol. 2002 Oct;110(4):607-9.


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