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Trimerization of dopamine transporter triggered by AIM-100 binding: Molecular mechanism and effect of mutations.

Cheng MH, Ponzoni L, Sorkina T, Lee JY, Zhang S, Sorkin A, Bahar I.

Neuropharmacology. 2019 Jun 20:107676. doi: 10.1016/j.neuropharm.2019.107676. [Epub ahead of print]


Generation of endogenous pH-sensitive EGF receptor and its application in high-throughput screening for proteins involved in clathrin-mediated endocytosis.

Larsen MB, Perez Verdaguer M, Schmidt BF, Bruchez MP, Watkins SC, Sorkin A.

Elife. 2019 May 8;8. pii: e46135. doi: 10.7554/eLife.46135.


Localization dynamics of endogenous fluorescently labeled RAF1 in EGF-stimulated cells.

Surve SV, Myers PJ, Clayton SA, Watkins SC, Lazzara MJ, Sorkin A.

Mol Biol Cell. 2019 Feb 15;30(4):506-523. doi: 10.1091/mbc.E18-08-0512. Epub 2018 Dec 26.


Association Between 6-Week Postdischarge Risk Classification and 12-Month Outcomes After Orthopedic Trauma.

Castillo RC, Huang Y, Scharfstein D, Frey K, Bosse MJ, Pollak AN, Vallier HA, Archer KR, Hymes RA, Newcomb AB, MacKenzie EJ, Wegener S; Major Extremity Trauma Research Consortium (METRC), Hsu JR, Karunakar MA, Seymour RB, Sims SH, Flores E, Churchill C, Hak DJ, Henderson CE, Mir HR, Chan DS, Shah AR, Steverson B, Westberg J, Gary JL, Achor TS, Choo A, Munz JW, Porrey M, Hendrickson S, Breslin MA, McKinley TO, Gaski GE, Kempton LB, Sorkin AT, Virkus WW, Hill LC, Jones CB, Sietsema DL, O'Toole RV, Ordonio K, Howe AL, Zerhusen TJ Jr, Obremskey W, Boyce RH, Jahangir AA, Molina CS, Sethi MK, Vanston SW, Carroll EA, Drye DY, Holden MB, Collins SC, Wysocki E.

JAMA Surg. 2019 Feb 1;154(2):e184824. doi: 10.1001/jamasurg.2018.4824. Epub 2019 Feb 20.


Response to Letter to the Editor: Costs and Radiographic Outcomes of Rotational Ankle Fractures Treated by Orthopaedic Surgeons With or Without Trauma Fellowship Training.

Virkus WW, Wetzel RJ, McKinley TO, Sorkin AT, Cheeseman JS, Hill LC, Kempton LB.

J Am Acad Orthop Surg. 2019 Feb 1;27(3):e143-e145. doi: 10.5435/JAAOS-D-18-00509. No abstract available.


Intramedullary Nailing of Periarticular Fractures.

Virkus WW, Kempton LB, Sorkin AT, Gaski GE.

J Am Acad Orthop Surg. 2018 Sep 15;26(18):629-639. doi: 10.5435/JAAOS-D-16-00849. Review.


Costs and Radiographic Outcomes of Rotational Ankle Fractures Treated by Orthopaedic Surgeons With or Without Trauma Fellowship Training.

Virkus WW, Wetzel RJ, McKinley TO, Sorkin AT, Cheesman JS, Hill LC, Kempton LB.

J Am Acad Orthop Surg. 2018 Jun 15;26(12):e261-e268. doi: 10.5435/JAAOS-D-16-00687.


Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter.

Sorkina T, Ma S, Larsen MB, Watkins SC, Sorkin A.

Elife. 2018 Apr 9;7. pii: e32293. doi: 10.7554/eLife.32293.


Prevalence of Iron Deficiency and Iron Deficiency Anemia in Strenuously Training Male Army Recruits.

Epstein D, Borohovitz A, Merdler I, Furman M, Atalli E, Sorkin A, Stainfeld Y, Isenberg Y, Mashiach T, Shapira S, Weisshof R, Dann EJ.

Acta Haematol. 2018;139(3):141-147. doi: 10.1159/000485736. Epub 2018 Feb 23.


Heterogeneities in Axonal Structure and Transporter Distribution Lower Dopamine Reuptake Efficiency.

Kaya C, Cheng MH, Block ER, Bartol TM, Sejnowski TJ, Sorkin A, Faeder JR, Bahar I.

eNeuro. 2018 Feb 5;5(1). pii: ENEURO.0298-17.2017. doi: 10.1523/ENEURO.0298-17.2017. eCollection 2018 Jan-Feb.


Surface loop-gap resonators for electron spin resonance at W-band.

Twig Y, Sorkin A, Cristea D, Feintuch A, Blank A.

Rev Sci Instrum. 2017 Dec;88(12):123901. doi: 10.1063/1.5000946.


EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo.

Pinilla-Macua I, Grassart A, Duvvuri U, Watkins SC, Sorkin A.

Elife. 2017 Dec 21;6. pii: e31993. doi: 10.7554/eLife.31993.


Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter.

Ma S, Cheng MH, Guthrie DA, Newman AH, Bahar I, Sorkin A.

Sci Rep. 2017 Jul 14;7(1):5399. doi: 10.1038/s41598-017-05637-x.


Insertion-related pain with intramedullary nailing.

Jang Y, Kempton LB, Mckinley TO, Sorkin AT.

Injury. 2017 Jun;48 Suppl 1:S18-S21. doi: 10.1016/j.injury.2017.04.029. Epub 2017 May 5. Review.


The search for the best infantry boot.

Milgrom C, Sorkin A, Gam A, Singer J, Nir I, Kogan B, Finestone AS.

Disaster Mil Med. 2016 Oct 10;2:14. doi: 10.1186/s40696-016-0024-5. eCollection 2016.


Ubiquitination mediates Kv1.3 endocytosis as a mechanism for protein kinase C-dependent modulation.

Martínez-Mármol R, Styrczewska K, Pérez-Verdaguer M, Vallejo-Gracia A, Comes N, Sorkin A, Felipe A.

Sci Rep. 2017 Feb 10;7:42395. doi: 10.1038/srep42395.


Testing of Junctional Tourniquets by Medics of the Israeli Defense Force in Control of Simulated Groin Hemorrhage.

Chen J, Benov A, Nadler R, Landau G, Sorkin A, Aden JK 3rd, Kragh JF Jr, Glassberg E.

J Spec Oper Med. 2016 Spring;16(1):36-42.


Endocytosis separates EGF receptors from endogenous fluorescently labeled HRas and diminishes receptor signaling to MAP kinases in endosomes.

Pinilla-Macua I, Watkins SC, Sorkin A.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2122-7. doi: 10.1073/pnas.1520301113. Epub 2016 Feb 8.


Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis.

Martínez-Mármol R, Comes N, Styrczewska K, Pérez-Verdaguer M, Vicente R, Pujadas L, Soriano E, Sorkin A, Felipe A.

Cell Mol Life Sci. 2016 Apr;73(7):1515-28. doi: 10.1007/s00018-015-2082-0. Epub 2015 Nov 5.


Brain Region-Specific Trafficking of the Dopamine Transporter.

Block ER, Nuttle J, Balcita-Pedicino JJ, Caltagarone J, Watkins SC, Sesack SR, Sorkin A.

J Neurosci. 2015 Sep 16;35(37):12845-58. doi: 10.1523/JNEUROSCI.1391-15.2015.


Methods to study endocytic trafficking of the EGF receptor.

Pinilla-Macua I, Sorkin A.

Methods Cell Biol. 2015;130:347-67. doi: 10.1016/bs.mcb.2015.05.008. Epub 2015 Jul 7.


Endocytosis of Ubiquitylation-Deficient EGFR Mutants via Clathrin-Coated Pits is Mediated by Ubiquitylation.

Fortian A, Dionne LK, Hong SH, Kim W, Gygi SP, Watkins SC, Sorkin A.

Traffic. 2015 Nov;16(11):1137-54. doi: 10.1111/tra.12314. Epub 2015 Sep 9.


Insights into the Modulation of Dopamine Transporter Function by Amphetamine, Orphenadrine, and Cocaine Binding.

Cheng MH, Block E, Hu F, Cobanoglu MC, Sorkin A, Bahar I.

Front Neurol. 2015 Jun 9;6:134. doi: 10.3389/fneur.2015.00134. eCollection 2015.


WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway.

Tomas A, Vaughan SO, Burgoyne T, Sorkin A, Hartley JA, Hochhauser D, Futter CE.

Nat Commun. 2015 Jun 12;6:7324. doi: 10.1038/ncomms8324.


Dopamine transporter is enriched in filopodia and induces filopodia formation.

Caltagarone J, Ma S, Sorkin A.

Mol Cell Neurosci. 2015 Sep;68:120-30. doi: 10.1016/j.mcn.2015.04.005. Epub 2015 Apr 30.


Right to try?

Lieu CH, Sorkin A, Messersmith WA.

J Clin Oncol. 2015 May 1;33(13):1518. doi: 10.1200/JCO.2014.60.6004. Epub 2015 Mar 16. No abstract available.


Feedforward regulation of mRNA stability by prolonged extracellular signal-regulated kinase activity.

Nagashima T, Inoue N, Yumoto N, Saeki Y, Magi S, Volinsky N, Sorkin A, Kholodenko BN, Okada-Hatakeyama M.

FEBS J. 2015 Feb;282(4):613-29. doi: 10.1111/febs.13172. Epub 2015 Jan 8.


Endocytosis: Past, present, and future.

Schmid SL, Sorkin A, Zerial M.

Cold Spring Harb Perspect Biol. 2014 Oct 30;6(12):a022509. doi: 10.1101/cshperspect.a022509. No abstract available.


A bifunctional converter: fluorescein quenching scFv/fluorogen activating protein for photostability and improved signal to noise in fluorescence experiments.

Saunders MJ, Block E, Sorkin A, Waggoner AS, Bruchez MP.

Bioconjug Chem. 2014 Aug 20;25(8):1556-64. doi: 10.1021/bc500273n. Epub 2014 Aug 6.


Phase diagram of solid-phase transformation in amorphous carbon nanorods.

Sorkin A, Su H.

J Phys Chem A. 2014 Oct 2;118(39):9163-72. doi: 10.1021/jp502928g. Epub 2014 Jun 18.


Medical malpractice lawsuits and the value of skilled and diverse legal counsel.

Lapuyade KD, Sorkin AC.

Semin Cutan Med Surg. 2013 Dec;32(4):230-3.


The mechanism of transforming diamond nanowires to carbon nanostructures.

Sorkin A, Su H.

Nanotechnology. 2014 Jan 24;25(3):035601. doi: 10.1088/0957-4484/25/3/035601. Epub 2013 Dec 17.


Live-cell fluorescence imaging reveals high stoichiometry of Grb2 binding to the EGF receptor sustained during endocytosis.

Fortian A, Sorkin A.

J Cell Sci. 2014 Jan 15;127(Pt 2):432-44. doi: 10.1242/jcs.137786. Epub 2013 Nov 20.


Retinal blood flow velocity in patients with age-related macular degeneration.

Burgansky-Eliash Z, Barash H, Nelson D, Grinvald A, Sorkin A, Loewenstein A, Barak A.

Curr Eye Res. 2014 Mar;39(3):304-11. doi: 10.3109/02713683.2013.840384. Epub 2013 Oct 22.


Lysine 63-linked polyubiquitination is required for EGF receptor degradation.

Huang F, Zeng X, Kim W, Balasubramani M, Fortian A, Gygi SP, Yates NA, Sorkin A.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15722-7. doi: 10.1073/pnas.1308014110. Epub 2013 Sep 9.


Endocytosis of receptor tyrosine kinases.

Goh LK, Sorkin A.

Cold Spring Harb Perspect Biol. 2013 May 1;5(5):a017459. doi: 10.1101/cshperspect.a017459. Review.


Improved precision of proteomic measurements in immunoprecipitation based purifications using relative quantitation.

Rogstad SM, Sorkina T, Sorkin A, Wu CC.

Anal Chem. 2013 May 7;85(9):4301-6. doi: 10.1021/ac4002222. Epub 2013 Apr 16.


A hydrothermal anvil made of graphene nanobubbles on diamond.

Lim CH, Sorkin A, Bao Q, Li A, Zhang K, Nesladek M, Loh KP.

Nat Commun. 2013;4:1556. doi: 10.1038/ncomms2579.


Flotillins regulate membrane mobility of the dopamine transporter but are not required for its protein kinase C dependent endocytosis.

Sorkina T, Caltagarone J, Sorkin A.

Traffic. 2013 Jun;14(6):709-24. doi: 10.1111/tra.12059. Epub 2013 Mar 11.


Growing suspended graphene on C60 molecules.

Lu J, Zheng Y, Sorkin A, Loh KP.

Small. 2012 Dec 21;8(24):3728-32. doi: 10.1002/smll.201201113. Epub 2012 Aug 8. No abstract available.


Shoc2 is targeted to late endosomes and required for Erk1/2 activation in EGF-stimulated cells.

Galperin E, Abdelmoti L, Sorkin A.

PLoS One. 2012;7(5):e36469. doi: 10.1371/journal.pone.0036469. Epub 2012 May 14.


The relationship between ER-multivesicular body membrane contacts and the ESCRT machinery.

Eden ER, Burgoyne T, Edgar JR, Sorkin A, Futter CE.

Biochem Soc Trans. 2012 Apr;40(2):464-8. doi: 10.1042/BST20110774. Review.


Epitope-tagged dopamine transporter knock-in mice reveal rapid endocytic trafficking and filopodia targeting of the transporter in dopaminergic axons.

Rao A, Richards TL, Simmons D, Zahniser NR, Sorkin A.

FASEB J. 2012 May;26(5):1921-33. doi: 10.1096/fj.11-196113. Epub 2012 Jan 20.


The role of EGF receptor ubiquitination in regulating its intracellular traffic.

Eden ER, Huang F, Sorkin A, Futter CE.

Traffic. 2012 Feb;13(2):329-37. doi: 10.1111/j.1600-0854.2011.01305.x. Epub 2011 Nov 22.


Three-stage transformation pathway from nanodiamonds to fullerenes.

Sorkin A, Tay B, Su H.

J Phys Chem A. 2011 Aug 4;115(30):8327-34. doi: 10.1021/jp200449f. Epub 2011 Jul 8.


Usp18 regulates epidermal growth factor (EGF) receptor expression and cancer cell survival via microRNA-7.

Duex JE, Comeau L, Sorkin A, Purow B, Kefas B.

J Biol Chem. 2011 Jul 15;286(28):25377-86. doi: 10.1074/jbc.M111.222760. Epub 2011 May 18.


Surgical technique: static intramedullary nailing of the femur and tibia without intraoperative fluoroscopy.

White NJ, Sorkin AT, Konopka G, McKinley TO.

Clin Orthop Relat Res. 2011 Dec;469(12):3469-76. doi: 10.1007/s11999-011-1829-7. Epub 2011 Mar 3.


Protein kinase C-dependent ubiquitination and clathrin-mediated endocytosis of the cationic amino acid transporter CAT-1.

Vina-Vilaseca A, Bender-Sigel J, Sorkina T, Closs EI, Sorkin A.

J Biol Chem. 2011 Mar 11;286(10):8697-706. doi: 10.1074/jbc.M110.186858. Epub 2011 Jan 5.


Differential subcellular distribution of endosomal compartments and the dopamine transporter in dopaminergic neurons.

Rao A, Simmons D, Sorkin A.

Mol Cell Neurosci. 2011 Jan;46(1):148-58. doi: 10.1016/j.mcn.2010.08.016. Epub 2010 Sep 15.

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