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Items: 1 to 50 of 169


Noninvasive evaluation of pulmonary artery pressure during exercise: the importance of right atrial hypertension.

Obokata M, Kane GC, Sorimachi H, Reddy YNV, Olson TP, Egbe AC, Melenovsky V, Borlaug BA.

Eur Respir J. 2020 Feb 12;55(2). pii: 1901617. doi: 10.1183/13993003.01617-2019. Print 2020 Feb.


The relationship between antecedent creatinine decreases and outcomes in patients undergoing hemodialysis.

Harada T, Sorimachi H, Obokata M, Sunaga H, Ishida H, Ito K, Ogawa T, Ando Y, Kurabayashi M, Negishi K.

Hemodial Int. 2020 Jan;24(1):89-98. doi: 10.1111/hdi.12794. Epub 2019 Oct 21.


Sex differences in left ventricular afterload and diastolic function are independent from the aortic size.

Sorimachi H, Kurosawa K, Yoshida K, Obokata M, Noguchi T, Naka M, Tange S, Kurabayashi M, Negishi K.

PLoS One. 2019 Apr 4;14(4):e0214907. doi: 10.1371/journal.pone.0214907. eCollection 2019.


Relationships of high cardiac output with ventricular morphology, myocardial energetics, and energy costs in hemodialysis patients with preserved ejection fraction.

Harada T, Obokata M, Kurosawa K, Sorimachi H, Yoshida K, Ishida H, Ito K, Ogawa T, Ando Y, Kurabayashi M, Negishi K.

Int J Cardiovasc Imaging. 2019 Mar;35(3):469-479. doi: 10.1007/s10554-018-1472-4. Epub 2018 Oct 16.


[Left Atrial Strain Independently and Incrementally Predicts High Risk Thromboembolic Findings Over CHA2DS2-VASc Score and BNP].

Kurosawa K, Negishi K, Obokata M, Sorimachi H, Masuda K, Machida T, Kurabayashi M, Murakami M.

Rinsho Byori. 2017 Feb;65(2):138-146. Japanese.


[Does calpain inhibition always rescue us?].

Sorimachi H, Ono Y.

Seikagaku. 2016 Dec;88(6):704-22. Review. Japanese. No abstract available.


A Gastrointestinal Calpain Complex, G-calpain, Is a Heterodimer of CAPN8 and CAPN9 Calpain Isoforms, Which Play Catalytic and Regulatory Roles, Respectively.

Hata S, Kitamura F, Yamaguchi M, Shitara H, Murakami M, Sorimachi H.

J Biol Chem. 2016 Dec 30;291(53):27313-27322. doi: 10.1074/jbc.M116.763912. Epub 2016 Nov 23.


Calpain research for drug discovery: challenges and potential.

Ono Y, Saido TC, Sorimachi H.

Nat Rev Drug Discov. 2016 Dec;15(12):854-876. doi: 10.1038/nrd.2016.212. Epub 2016 Nov 11. Review.


Effect of Sex Differences on the Association Between Stroke Risk and Left Atrial Anatomy or Mechanics in Patients With Atrial Fibrillation.

Yoshida K, Obokata M, Kurosawa K, Sorimachi H, Kurabayashi M, Negishi K.

Circ Cardiovasc Imaging. 2016 Oct;9(10). pii: e004999.


Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.

Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A.

J Clin Invest. 2016 Sep 1;126(9):3417-32. doi: 10.1172/JCI85880. Epub 2016 Aug 15.


Amino acid sequence alignment of vertebrate CAPN3/calpain-3/p94.

Ono Y, Sorimachi H.

Data Brief. 2015 Oct 4;5:366-7. doi: 10.1016/j.dib.2015.09.021. eCollection 2015 Dec.


Predictions of Cleavability of Calpain Proteolysis by Quantitative Structure-Activity Relationship Analysis Using Newly Determined Cleavage Sites and Catalytic Efficiencies of an Oligopeptide Array.

Shinkai-Ouchi F, Koyama S, Ono Y, Hata S, Ojima K, Shindo M, duVerle D, Ueno M, Kitamura F, Doi N, Takigawa I, Mamitsuka H, Sorimachi H.

Mol Cell Proteomics. 2016 Apr;15(4):1262-80. doi: 10.1074/mcp.M115.053413. Epub 2016 Jan 21.


An eccentric calpain, CAPN3/p94/calpain-3.

Ono Y, Ojima K, Shinkai-Ouchi F, Hata S, Sorimachi H.

Biochimie. 2016 Mar;122:169-87. doi: 10.1016/j.biochi.2015.09.010. Epub 2015 Sep 10. Review.


Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells.

Sasaki K, Takada K, Ohte Y, Kondo H, Sorimachi H, Tanaka K, Takahama Y, Murata S.

Nat Commun. 2015 Jun 23;6:7484. doi: 10.1038/ncomms8484.


Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice.

Sato S, Kawamata Y, Takahashi A, Imai Y, Hanyu A, Okuma A, Takasugi M, Yamakoshi K, Sorimachi H, Kanda H, Ishikawa Y, Sone S, Nishioka Y, Ohtani N, Hara E.

Nat Commun. 2015 Apr 29;6:7035. doi: 10.1038/ncomms8035.


The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation.

Ono Y, Shindo M, Doi N, Kitamura F, Gregorio CC, Sorimachi H.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5527-36. doi: 10.1073/pnas.1411959111. Epub 2014 Dec 15.


Muscle-specific calpain-3 is phosphorylated in its unique insertion region for enrichment in a myofibril fraction.

Ojima K, Ono Y, Hata S, Noguchi S, Nishino I, Sorimachi H.

Genes Cells. 2014 Nov;19(11):830-41. doi: 10.1111/gtc.12181. Epub 2014 Sep 24.


Involvement of calpain-7 in epidermal growth factor receptor degradation via the endosomal sorting pathway.

Maemoto Y, Ono Y, Kiso S, Shibata H, Takahara T, Sorimachi H, Maki M.

FEBS J. 2014 Aug;281(16):3642-55. doi: 10.1111/febs.12886. Epub 2014 Jul 8.


Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy.

Buck D, Smith JE 3rd, Chung CS, Ono Y, Sorimachi H, Labeit S, Granzier HL.

J Gen Physiol. 2014 Feb;143(2):215-30. doi: 10.1085/jgp.201311129.


Calpain-6 deficiency promotes skeletal muscle development and regeneration.

Tonami K, Hata S, Ojima K, Ono Y, Kurihara Y, Amano T, Sato T, Kawamura Y, Kurihara H, Sorimachi H.

PLoS Genet. 2013;9(8):e1003668. doi: 10.1371/journal.pgen.1003668. Epub 2013 Aug 1.


Efficient expression and purification of recombinant human μ-calpain using an Escherichia coli expression system.

Hata S, Kitamura F, Sorimachi H.

Genes Cells. 2013 Sep;18(9):753-63. doi: 10.1111/gtc.12071. Epub 2013 Jun 21.


PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1.

Ono Y, Iemura S, Novak SM, Doi N, Kitamura F, Natsume T, Gregorio CC, Sorimachi H.

J Mol Biol. 2013 Aug 23;425(16):2955-72. doi: 10.1016/j.jmb.2013.05.009. Epub 2013 May 21.


Understanding the substrate specificity of conventional calpains.

Sorimachi H, Mamitsuka H, Ono Y.

Biol Chem. 2012 Sep;393(9):853-71. doi: 10.1515/hsz-2012-0143. Review.


Intravitreal injection or topical eye-drop application of a μ-calpain C2L domain peptide protects against photoreceptor cell death in Royal College of Surgeons' rats, a model of retinitis pigmentosa.

Ozaki T, Nakazawa M, Yamashita T, Sorimachi H, Hata S, Tomita H, Isago H, Baba A, Ishiguro S.

Biochim Biophys Acta. 2012 Nov;1822(11):1783-95. doi: 10.1016/j.bbadis.2012.07.018. Epub 2012 Aug 3.


Regulation and physiological roles of the calpain system in muscular disorders.

Sorimachi H, Ono Y.

Cardiovasc Res. 2012 Oct 1;96(1):11-22. doi: 10.1093/cvr/cvs157. Epub 2012 Apr 27. Review.


Functional evolution of duplicated odorant-binding protein genes, Obp57d and Obp57e, in Drosophila.

Harada E, Nakagawa J, Asano T, Taoka M, Sorimachi H, Ito Y, Aigaki T, Matsuo T.

PLoS One. 2012;7(1):e29710. doi: 10.1371/journal.pone.0029710. Epub 2012 Jan 6.


Efficient expression and purification of recombinant human m-calpain using an Escherichia coli expression system at low temperature.

Hata S, Ueno M, Kitamura F, Sorimachi H.

J Biochem. 2012 Apr;151(4):417-22. doi: 10.1093/jb/mvs002. Epub 2012 Jan 9.


Does the severity of the LGMD2A phenotype in compound heterozygotes depend on the combination of mutations?

Sáenz A, Ono Y, Sorimachi H, Goicoechea M, Leturcq F, Blázquez L, García-Bragado F, Marina A, Poza JJ, Azpitarte M, Doi N, Urtasun M, Kaplan JC, López de Munain A.

Muscle Nerve. 2011 Nov;44(5):710-4. doi: 10.1002/mus.22194.


MURF1 deficiency suppresses unloading-induced effects on osteoblasts and osteoclasts to lead to bone loss.

Kondo H, Ezura Y, Nakamoto T, Hayata T, Notomi T, Sorimachi H, Takeda S, Noda M.

J Cell Biochem. 2011 Dec;112(12):3525-30. doi: 10.1002/jcb.23327.


Calpains: an elaborate proteolytic system.

Ono Y, Sorimachi H.

Biochim Biophys Acta. 2012 Jan;1824(1):224-36. doi: 10.1016/j.bbapap.2011.08.005. Epub 2011 Aug 16. Review.


[Physiological importance of calpains in gastric mucosal defense].

Hata S, Sorimachi H.

Nihon Rinsho. 2011 Jun;69(6):1116-22. Review. Japanese.


Calpain chronicle--an enzyme family under multidisciplinary characterization.

Sorimachi H, Hata S, Ono Y.

Proc Jpn Acad Ser B Phys Biol Sci. 2011;87(6):287-327. Review.


Impact of genetic insights into calpain biology.

Sorimachi H, Hata S, Ono Y.

J Biochem. 2011 Jul;150(1):23-37. doi: 10.1093/jb/mvr070. Epub 2011 May 24. Review.


Calpain cleavage prediction using multiple kernel learning.

DuVerle DA, Ono Y, Sorimachi H, Mamitsuka H.

PLoS One. 2011 May 3;6(5):e19035. doi: 10.1371/journal.pone.0019035.


Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1.

Tonami K, Kurihara Y, Arima S, Nishiyama K, Uchijima Y, Asano T, Sorimachi H, Kurihara H.

J Cell Sci. 2011 Apr 15;124(Pt 8):1214-23. doi: 10.1242/jcs.072561. Epub 2011 Mar 15.


Non-proteolytic functions of calpain-3 in sarcoplasmic reticulum in skeletal muscles.

Ojima K, Ono Y, Ottenheijm C, Hata S, Suzuki H, Granzier H, Sorimachi H.

J Mol Biol. 2011 Apr 1;407(3):439-49. doi: 10.1016/j.jmb.2011.01.057. Epub 2011 Feb 3.


Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense.

Hata S, Abe M, Suzuki H, Kitamura F, Toyama-Sorimachi N, Abe K, Sakimura K, Sorimachi H.

PLoS Genet. 2010 Jul 29;6(7):e1001040. doi: 10.1371/journal.pgen.1001040.


Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.

Ojima K, Kawabata Y, Nakao H, Nakao K, Doi N, Kitamura F, Ono Y, Hata S, Suzuki H, Kawahara H, Bogomolovas J, Witt C, Ottenheijm C, Labeit S, Granzier H, Toyama-Sorimachi N, Sorimachi M, Suzuki K, Maeda T, Abe K, Aiba A, Sorimachi H.

J Clin Invest. 2010 Aug;120(8):2672-83. doi: 10.1172/JCI40658. Epub 2010 Jul 1.


Skeletal muscle-specific calpain is an intracellular Na+-dependent protease.

Ono Y, Ojima K, Torii F, Takaya E, Doi N, Nakagawa K, Hata S, Abe K, Sorimachi H.

J Biol Chem. 2010 Jul 23;285(30):22986-98. doi: 10.1074/jbc.M110.126946. Epub 2010 May 11.


CaMPDB: a resource for calpain and modulatory proteolysis.

duVerle D, Takigawa I, Ono Y, Sorimachi H, Mamitsuka H.

Genome Inform. 2010 Jan;22:202-13.


Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.

Yamada M, Yoshida Y, Mori D, Takitoh T, Kengaku M, Umeshima H, Takao K, Miyakawa T, Sato M, Sorimachi H, Wynshaw-Boris A, Hirotsune S.

Nat Med. 2009 Oct;15(10):1202-7. doi: 10.1038/nm.2023. Epub 2009 Sep 6.


Single-cell chemical lysis method for analyses of intracellular molecules using an array of picoliter-scale microwells.

Sasuga Y, Iwasawa T, Terada K, Oe Y, Sorimachi H, Ohara O, Harada Y.

Anal Chem. 2008 Dec 1;80(23):9141-9. doi: 10.1021/ac8016423.


Metabolism of amyloid precursor protein in COS cells transfected with a beta-secretase candidate.

Koike H, Kouchi Z, Kinouchi T, Maeda T, Sorimachi H, Saido TC, Maruyama K, Okuyama A, Suzuki K, Ishiura S.

Cytotechnology. 2000 Jul;33(1-3):213-9. doi: 10.1023/A:1008119512341.


Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle.

Hayashi C, Ono Y, Doi N, Kitamura F, Tagami M, Mineki R, Arai T, Taguchi H, Yanagida M, Hirner S, Labeit D, Labeit S, Sorimachi H.

J Biol Chem. 2008 May 23;283(21):14801-14. doi: 10.1074/jbc.M708262200. Epub 2008 Feb 29.


The importance of conserved amino acid residues in p94 protease sub-domain IIb and the IS2 region for constitutive autolysis.

Ono Y, Hayashi C, Doi N, Tagami M, Sorimachi H.

FEBS Lett. 2008 Mar 5;582(5):691-8. doi: 10.1016/j.febslet.2008.01.044. Epub 2008 Feb 5.


Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.

Koyama S, Hata S, Witt CC, Ono Y, Lerche S, Ojima K, Chiba T, Doi N, Kitamura F, Tanaka K, Abe K, Witt SH, Rybin V, Gasch A, Franz T, Labeit S, Sorimachi H.

J Mol Biol. 2008 Mar 7;376(5):1224-36. doi: 10.1016/j.jmb.2007.11.049. Epub 2007 Nov 22.


Asymmetric hydrogenation of aromatic, aliphatic, and alpha,beta-unsaturated acyl silanes catalyzed by Tol-binap/Pica ruthenium(II) complexes: practical synthesis of optically active alpha-hydroxysilanes.

Arai N, Suzuki K, Sugizaki S, Sorimachi H, Ohkuma T.

Angew Chem Int Ed Engl. 2008;47(9):1770-3. doi: 10.1002/anie.200704696. No abstract available.


Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains.

Hata S, Doi N, Kitamura F, Sorimachi H.

J Biol Chem. 2007 Sep 21;282(38):27847-56. Epub 2007 Jul 23.


Comprehensive survey of p94/calpain 3 substrates by comparative proteomics--possible regulation of protein synthesis by p94.

Ono Y, Hayashi C, Doi N, Kitamura F, Shindo M, Kudo K, Tsubata T, Yanagida M, Sorimachi H.

Biotechnol J. 2007 May;2(5):565-76.

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