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Characteristics of Real-World Metastatic Non-Small Cell Lung Cancer Patients Treated with Nivolumab and Pembrolizumab During the Year Following Approval.

Khozin S, Abernethy AP, Nussbaum NC, Zhi J, Curtis MD, Tucker M, Lee SE, Light DE, Gossai A, Sorg RA, Torres AZ, Patel P, Blumenthal GM, Pazdur R.

Oncologist. 2018 Mar;23(3):328-336. doi: 10.1634/theoncologist.2017-0353. Epub 2018 Jan 9.


Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence.

Moreno-Gámez S, Sorg RA, Domenech A, Kjos M, Weissing FJ, van Doorn GS, Veening JW.

Nat Commun. 2017 Oct 11;8(1):854. doi: 10.1038/s41467-017-00903-y.


5-Aminolevulinic acid-based photodynamic therapy of chordoma: In vitro experiments on a human tumor cell line.

Cornelius JF, Eismann L, Ebbert L, Senger B, Petridis AK, Kamp MA, Sorg RV, Steiger HJ.

Photodiagnosis Photodyn Ther. 2017 Dec;20:111-115. doi: 10.1016/j.pdpdt.2017.09.011. Epub 2017 Sep 22.


Real-world first-line treatment and overall survival in non-small cell lung cancer without known EGFR mutations or ALK rearrangements in US community oncology setting.

Abernethy AP, Arunachalam A, Burke T, McKay C, Cao X, Sorg R, Carbone DP.

PLoS One. 2017 Jun 23;12(6):e0178420. doi: 10.1371/journal.pone.0178420. eCollection 2017.


High-throughput CRISPRi phenotyping identifies new essential genes in Streptococcus pneumoniae.

Liu X, Gallay C, Kjos M, Domenech A, Slager J, van Kessel SP, Knoops K, Sorg RA, Zhang JR, Veening JW.

Mol Syst Biol. 2017 May 10;13(5):931. doi: 10.15252/msb.20167449.


Collective Resistance in Microbial Communities by Intracellular Antibiotic Deactivation.

Sorg RA, Lin L, van Doorn GS, Sorg M, Olson J, Nizet V, Veening JW.

PLoS Biol. 2016 Dec 27;14(12):e2000631. doi: 10.1371/journal.pbio.2000631. eCollection 2016 Dec.


Human glioblastoma stem-like cells accumulate protoporphyrin IX when subjected to exogenous 5-aminolaevulinic acid, rendering them sensitive to photodynamic treatment.

Schimanski A, Ebbert L, Sabel MC, Finocchiaro G, Lamszus K, Ewelt C, Etminan N, Fischer JC, Sorg RV.

J Photochem Photobiol B. 2016 Oct;163:203-10. doi: 10.1016/j.jphotobiol.2016.08.043. Epub 2016 Aug 27.


Risk of Ocular Complications in Patients with Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis.

Dick AD, Tundia N, Sorg R, Zhao C, Chao J, Joshi A, Skup M.

Ophthalmology. 2016 Mar;123(3):655-62. doi: 10.1016/j.ophtha.2015.10.028. Epub 2015 Dec 19. Erratum in: Ophthalmology. 2016 Nov;123(11):2439.


Projected Economic Impact of Increased Use of Biologic Treatments For Rheumatoid Arthritis In Argentina, Colombia, And Mexico Over 10 Years.

Rojas Serrano J, de Abreu MM, Tundia N, Skup M, Sorg R, Macaulay D, Bao Y, Chaves L, Chao J.

Value Health. 2015 Nov;18(7):A806. doi: 10.1016/j.jval.2015.09.079. Epub 2015 Oct 20. No abstract available.


Microscale insights into pneumococcal antibiotic mutant selection windows.

Sorg RA, Veening JW.

Nat Commun. 2015 Oct 30;6:8773. doi: 10.1038/ncomms9773.


Comparative efficacy and safety of daclatasvir/asunaprevir versus IFN-based regimens in genotype 1b hepatitis C virus infection.

Signorovitch JE, Betts KA, Song Y, Sorg RA, Li J, Behl AS, Kalsekar A.

J Comp Eff Res. 2015 Nov;4(6):593-605. doi: 10.2217/cer.15.33. Epub 2015 Jul 10. Review.


Costs and Resource Utilization Associated With Anemia and Rash in Chronic Hepatitis C Patients Treated With Direct-Acting Antiviral Agents in the United States.

Le TK, Macaulay D, Kalsekar A, Yuan Y, Sorg RA, Wei J, Wu EQ.

Clin Ther. 2015 Aug;37(8):1713-25.e3. doi: 10.1016/j.clinthera.2015.05.503. Epub 2015 Jun 22.


Treatment patterns, health care resource utilization, and costs in U.S. patients diagnosed with chronic hepatitis C infection who received telaprevir or boceprevir.

Le TK, Kalsekar A, Macaulay D, Yuan Y, Sorg RA, Behrer CR, Wei J, Wu EQ.

J Manag Care Spec Pharm. 2015 Apr;21(4):308-18.


Necrotic cell-derived high mobility group box 1 attracts antigen-presenting cells but inhibits hepatocyte growth factor-mediated tropism of mesenchymal stem cells for apoptotic cell death.

Vogel S, Börger V, Peters C, Förster M, Liebfried P, Metzger K, Meisel R, Däubener W, Trapp T, Fischer JC, Gawaz M, Sorg RV.

Cell Death Differ. 2015 Jul;22(7):1219-30. doi: 10.1038/cdd.2014.225. Epub 2015 Jan 9.


Bacillus subtilis biosensor engineered to assess meat spoilage.

Daszczuk A, Dessalegne Y, Drenth I, Hendriks E, Jo E, van Lente T, Oldebesten A, Parrish J, Poljakova W, Purwanto AA, van Raaphorst R, Boonstra M, van Heel A, Herber M, van der Meulen S, Siebring J, Sorg RA, Heinemann M, Kuipers OP, Veening JW.

ACS Synth Biol. 2014 Dec 19;3(12):999-1002. doi: 10.1021/sb5000252.


What makes the lac-pathway switch: identifying the fluctuations that trigger phenotype switching in gene regulatory systems.

Bhogale PM, Sorg RA, Veening JW, Berg J.

Nucleic Acids Res. 2014 Oct;42(18):11321-8. doi: 10.1093/nar/gku839. Epub 2014 Sep 22.


Unreserved application of epigenetic methods to define differences of DNA methylation between urinary cellular and cell-free DNA.

Ghanjati F, Beermann A, Hermanns T, Poyet C, Araúzo-Bravo MJ, Seifert HH, Schmidtpeter M, Goering W, Sorg R, Wernet P, Santourlidis S.

Cancer Biomark. 2014;14(5):295-302. doi: 10.3233/CBM-140407.


Healthcare resource use and costs of privately insured patients who switch, discontinue, or persist on anti-muscarinic therapy for overactive bladder.

Ivanova JI, Hayes-Larson E, Sorg RA, Birnbaum HG, Berner T.

J Med Econ. 2014 Oct;17(10):741-50. doi: 10.3111/13696998.2014.941066. Epub 2014 Jul 22.


Gene expression platform for synthetic biology in the human pathogen Streptococcus pneumoniae.

Sorg RA, Kuipers OP, Veening JW.

ACS Synth Biol. 2015 Mar 20;4(3):228-39. doi: 10.1021/sb500229s. Epub 2014 Jun 4.


Cytomegalovirus infection impairs immunosuppressive and antimicrobial effector functions of human multipotent mesenchymal stromal cells.

Meisel R, Heseler K, Nau J, Schmidt SK, Leineweber M, Pudelko S, Wenning J, Zimmermann A, Hengel H, Sinzger C, Degistirici Ö, Sorg RV, Däubener W.

Mediators Inflamm. 2014;2014:898630. doi: 10.1155/2014/898630. Epub 2014 Mar 23.


Activated platelets interfere with recruitment of mesenchymal stem cells to apoptotic cardiac cells via high mobility group box 1/Toll-like receptor 4-mediated down-regulation of hepatocyte growth factor receptor MET.

Vogel S, Chatterjee M, Metzger K, Borst O, Geisler T, Seizer P, Müller I, Mack A, Schumann S, Bühring HJ, Lang F, Sorg RV, Langer H, Gawaz M.

J Biol Chem. 2014 Apr 18;289(16):11068-82. doi: 10.1074/jbc.M113.530287. Epub 2014 Feb 24.


The prevalence and economic impact of prescription opioid-related side effects among patients with chronic noncancer pain.

Ivanova JI, Birnbaum HG, Yushkina Y, Sorg RA, Reed J, Merchant S.

J Opioid Manag. 2013 Jul-Aug;9(4):239-54. doi: 10.5055/jom.2013.0165.


Healthcare costs and utilization for privately insured patients treated for non-infectious uveitis in the USA.

Chu DS, Johnson SJ, Mallya UG, Davis MR, Sorg RA, Duh MS.

J Ophthalmic Inflamm Infect. 2013 Nov 6;3(1):64. doi: 10.1186/1869-5760-3-64.


Effects of care management and telehealth: a longitudinal analysis using medicare data.

Baker LC, Macaulay DS, Sorg RA, Diener MD, Johnson SJ, Birnbaum HG.

J Am Geriatr Soc. 2013 Sep;61(9):1560-7. doi: 10.1111/jgs.12407. Epub 2013 Sep 3. Erratum in: J Am Geriatr Soc. 2013 Nov;61(11):2062.


Development and validation of a claims-based prediction model for COPD severity.

Macaulay D, Sun SX, Sorg RA, Yan SY, De G, Wu EQ, Simonelli PF.

Respir Med. 2013 Oct;107(10):1568-77. doi: 10.1016/j.rmed.2013.05.012. Epub 2013 Jun 25.


Cytomegalovirus impairs the induction of indoleamine 2,3-dioxygenase mediated antimicrobial and immunoregulatory effects in human fibroblasts.

Heseler K, Schmidt SK, Spekker K, Sinzger C, Sorg RV, Quambusch M, Zimmermann A, Meisel R, Däubener W.

PLoS One. 2013 May 15;8(5):e64442. doi: 10.1371/journal.pone.0064442. Print 2013.


Migration of mesenchymal stem cells towards glioblastoma cells depends on hepatocyte-growth factor and is enhanced by aminolaevulinic acid-mediated photodynamic treatment.

Vogel S, Peters C, Etminan N, Börger V, Schimanski A, Sabel MC, Sorg RV.

Biochem Biophys Res Commun. 2013 Feb 15;431(3):428-32. doi: 10.1016/j.bbrc.2012.12.153. Epub 2013 Jan 16.


Antimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs).

Spekker K, Leineweber M, Degrandi D, Ince V, Brunder S, Schmidt SK, Stuhlsatz S, Howard JC, Schares G, Degistirici O, Meisel R, Sorg RV, Seissler J, Hemphill A, Pfeffer K, Däubener W.

Med Microbiol Immunol. 2013 Jun;202(3):197-206. doi: 10.1007/s00430-012-0281-y. Epub 2012 Dec 27.


Re.: Cost-effectiveness of denosumab vs zoledronic acid for prevention of skeletal-related events in patients with solid tumors and bone metastases in the United States.

Xie J, Diener M, Sorg R, Wu EQ, Namjoshi M.

J Med Econ. 2013;16(2):260-2. doi: 10.3111/13696998.2012.752738. Epub 2012 Dec 5. No abstract available.


Rationale for regenerative treatment in neonatology.

Haase R, Körholz D, Herting E, Sorg RV, Müller LP, Göbel U.

Klin Padiatr. 2012 Jul;224(4):230-2. Epub 2012 Jul 19. No abstract available.


Cost-effectiveness of denosumab compared with zoledronic acid in patients with breast cancer and bone metastases.

Xie J, Diener M, Sorg R, Wu EQ, Namjoshi M.

Clin Breast Cancer. 2012 Aug;12(4):247-58. doi: 10.1016/j.clbc.2012.04.001. Epub 2012 Jun 12.


Direct and indirect costs associated with Dupuytren's contracture.

Macaulay D, Ivanova J, Birnbaum H, Sorg R, Skodny P.

J Med Econ. 2012;15(4):664-71. doi: 10.3111/13696998.2012.670678. Epub 2012 Mar 21.


Platelet transfusion alters CD40L blood level and release capacity in patients suffering from thrombocytopenia.

Wenzel F, Günther W, Baertl A, Gruber W, Sorg RV, Haas R, Giers G.

Transfusion. 2012 Jun;52(6):1213-20. doi: 10.1111/j.1537-2995.2011.03438.x. Epub 2011 Nov 14.


Heat-shock protein 70-dependent dendritic cell activation by 5-aminolevulinic acid-mediated photodynamic treatment of human glioblastoma spheroids in vitro.

Etminan N, Peters C, Lakbir D, Bünemann E, Börger V, Sabel MC, Hänggi D, Steiger HJ, Stummer W, Sorg RV.

Br J Cancer. 2011 Sep 27;105(7):961-9. doi: 10.1038/bjc.2011.327. Epub 2011 Aug 23.


Minimizing hydrodynamic stress in mammalian cell culture through the lobed Taylor-Couette bioreactor.

Sorg R, Tanzeglock T, Soos M, Morbidelli M, Périlleux A, Solacroup T, Broly H.

Biotechnol J. 2011 Dec;6(12):1504-15. doi: 10.1002/biot.201000477. Epub 2011 Aug 15.


Modulation of migratory activity and invasiveness of human glioma spheroids following 5-aminolevulinic acid-based photodynamic treatment. Laboratory investigation.

Etminan N, Peters C, Ficnar J, Anlasik S, Bünemann E, Slotty PJ, Hänggi D, Steiger HJ, Sorg RV, Stummer W.

J Neurosurg. 2011 Aug;115(2):281-8. doi: 10.3171/2011.3.JNS10434. Epub 2011 Apr 22.


Dendritic cell generation and CD4+ CD25high FOXP3+ regulatory t cells in human head and neck carcinoma during radio-chemotherapy.

Schuler PJ, Börger V, Bölke E, Habermehl D, Matuschek C, Wild CA, Greve J, Bas M, Schilling B, Bergmann C, Trellakis S, Budach W, Gauler T, Brandau S, Lang S, Whiteside TL, Sorg RV, Hoffmann TK.

Eur J Med Res. 2011 Feb 24;16(2):57-62.


Human but not murine multipotent mesenchymal stromal cells exhibit broad-spectrum antimicrobial effector function mediated by indoleamine 2,3-dioxygenase.

Meisel R, Brockers S, Heseler K, Degistirici O, Bülle H, Woite C, Stuhlsatz S, Schwippert W, Jäger M, Sorg R, Henschler R, Seissler J, Dilloo D, Däubener W.

Leukemia. 2011 Apr;25(4):648-54. doi: 10.1038/leu.2010.310. Epub 2011 Jan 18.


Case report: extracranial metastasis from gliosarcoma--the influence of immune system.

Rapp M, Felsberg J, Sorg RV, Gerharz CD, Sabel M.

Br J Neurosurg. 2011 Apr;25(2):286-8. doi: 10.3109/02688697.2010.528473. Epub 2010 Dec 15.


Human cytomegalovirus: A major regulator of IFN-g induced antimicrobial and immunoregulatory effects in human mesenchymal stem cells.

Däubener W, Brockers S, Spekker K, Meisel R, Sorg R, Stuhlsatz S, Schmidt SK, Heseler K.

J Stem Cells Regen Med. 2010 Oct 23;6(2):124-5. eCollection 2010. No abstract available.


Corneal surface reconstruction using adult mesenchymal stem cells in experimental limbal stem cell deficiency in rabbits.

Reinshagen H, Auw-Haedrich C, Sorg RV, Boehringer D, Eberwein P, Schwartzkopff J, Sundmacher R, Reinhard T.

Acta Ophthalmol. 2011 Dec;89(8):741-8. doi: 10.1111/j.1755-3768.2009.01812.x. Epub 2009 Dec 21.


Hepatocyte growth factor-mediated attraction of mesenchymal stem cells for apoptotic neuronal and cardiomyocytic cells.

Vogel S, Trapp T, Börger V, Peters C, Lakbir D, Dilloo D, Sorg RV.

Cell Mol Life Sci. 2010 Jan;67(2):295-303. doi: 10.1007/s00018-009-0183-3. Epub 2009 Nov 3.


Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor.

Savastano DM, Tanofsky-Kraff M, Han JC, Ning C, Sorg RA, Roza CA, Wolkoff LE, Anandalingam K, Jefferson-George KS, Figueroa RE, Sanford EL, Brady S, Kozlosky M, Schoeller DA, Yanovski JA.

Am J Clin Nutr. 2009 Oct;90(4):912-20. doi: 10.3945/ajcn.2009.27537. Epub 2009 Aug 5.


Suppression of cellular immunity by cord blood-derived unrestricted somatic stem cells is cytokine-dependent.

Winter M, Wang XN, Däubener W, Eyking A, Rae M, Dickinson AM, Wernet P, Kögler G, Sorg RV.

J Cell Mol Med. 2009 Aug;13(8B):2465-75. doi: 10.1111/j.1582-4934.2008.00566.x. Epub 2008 Oct 31.


Hepatocyte growth factor/c-MET axis-mediated tropism of cord blood-derived unrestricted somatic stem cells for neuronal injury.

Trapp T, Kögler G, El-Khattouti A, Sorg RV, Besselmann M, Föcking M, Bührle CP, Trompeter I, Fischer JC, Wernet P.

J Biol Chem. 2008 Nov 21;283(47):32244-53. doi: 10.1074/jbc.M800862200. Epub 2008 Jul 15.


Dendritic cell vaccination in patients with malignant gliomas: current status and future directions.

de Vleeschouwer S, Rapp M, Sorg RV, Steiger HJ, Stummer W, van Gool S, Sabel M.

Neurosurgery. 2006 Nov;59(5):988-99; discussioin 999-1000. Review.


Cellular immunity of patients with malignant glioma: prerequisites for dendritic cell vaccination immunotherapy.

Rapp M, Ozcan Z, Steiger HJ, Wernet P, Sabel MC, Sorg RV.

J Neurosurg. 2006 Jul;105(1):41-50.


Regeneration of human infarcted heart muscle by intracoronary autologous bone marrow cell transplantation in chronic coronary artery disease: the IACT Study.

Strauer BE, Brehm M, Zeus T, Bartsch T, Schannwell C, Antke C, Sorg RV, Kögler G, Wernet P, Müller HW, Köstering M.

J Am Coll Cardiol. 2005 Nov 1;46(9):1651-8.


Cytokine production and hematopoiesis supporting activity of cord blood-derived unrestricted somatic stem cells.

Kögler G, Radke TF, Lefort A, Sensken S, Fischer J, Sorg RV, Wernet P.

Exp Hematol. 2005 May;33(5):573-83.


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