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Items: 1 to 50 of 76

1.

Synthesis of (+)-Lineariifolianone and Related Cyclopropenone-Containing Sesquiterpenoids.

Reber KP, Gilbert IW, Strassfeld DA, Sorensen EJ.

J Org Chem. 2019 May 3;84(9):5524-5534. doi: 10.1021/acs.joc.9b00478. Epub 2019 Apr 16.

PMID:
30938526
2.

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.

Balaguer FA, Mühlethaler T, Estévez-Gallego J, Calvo E, Giménez-Abián JF, Risinger AL, Sorensen EJ, Vanderwal CD, Altmann KH, Mooberry SL, Steinmetz MO, Oliva MÁ, Prota AE, Díaz JF.

Int J Mol Sci. 2019 Mar 20;20(6). pii: E1392. doi: 10.3390/ijms20061392.

3.

Ir(iii)-catalyzed ortho C-H alkylations of (hetero)aromatic aldehydes using alkyl boron reagents.

Chen XY, Sorensen EJ.

Chem Sci. 2018 Oct 3;9(48):8951-8956. doi: 10.1039/c8sc03606c. eCollection 2018 Dec 28.

4.

Recent applications of C-H functionalization in complex natural product synthesis.

Abrams DJ, Provencher PA, Sorensen EJ.

Chem Soc Rev. 2018 Dec 7;47(23):8925-8967. doi: 10.1039/c8cs00716k. Epub 2018 Nov 14.

PMID:
30426998
5.

Installation of Multiple Aryl Ether Crosslinks onto Non-Native Substrate Peptides by the Vancomycin OxyB.

Forneris CC, Ozturk S, Sorensen EJ, Seyedsayamdost MR.

Tetrahedron. 2018 Jun 28;74(26):3231-3237. doi: 10.1016/j.tet.2018.04.028. Epub 2018 Apr 13.

6.

Modulating OxyB-Catalyzed Cross-Coupling Reactions in Vancomycin Biosynthesis by Incorporation of Diverse d-Tyr Analogues.

Ozturk S, Forneris CC, Nguy AKL, Sorensen EJ, Seyedsayamdost MR.

J Org Chem. 2018 Jul 6;83(13):7309-7317. doi: 10.1021/acs.joc.8b00916. Epub 2018 Jun 19.

PMID:
29806454
7.

Pd-Catalyzed, ortho C-H Methylation and Fluorination of Benzaldehydes Using Orthanilic Acids as Transient Directing Groups.

Chen XY, Sorensen EJ.

J Am Chem Soc. 2018 Feb 28;140(8):2789-2792. doi: 10.1021/jacs.8b00048. Epub 2018 Feb 9.

PMID:
29412651
8.

Pd-Catalyzed Ortho C-H Hydroxylation of Benzaldehydes Using a Transient Directing Group.

Chen XY, Ozturk S, Sorensen EJ.

Org Lett. 2017 Dec 1;19(23):6280-6283. doi: 10.1021/acs.orglett.7b02906. Epub 2017 Nov 11.

PMID:
29129077
9.

Efficient substrate screening and inhibitor testing of human CYP4Z1 using permeabilized recombinant fission yeast.

Yan Q, Machalz D, Zöllner A, Sorensen EJ, Wolber G, Bureik M.

Biochem Pharmacol. 2017 Dec 15;146:174-187. doi: 10.1016/j.bcp.2017.09.011. Epub 2017 Sep 23.

PMID:
28951277
10.

A Stereocontrolled Annulation of the Taccalonolide Epoxy Lactone onto the Molecular Framework of trans-Androsterone.

Danielsson J, Sun DX, Chen XY, Risinger AL, Mooberry SL, Sorensen EJ.

Org Lett. 2017 Sep 15;19(18):4892-4895. doi: 10.1021/acs.orglett.7b02349. Epub 2017 Aug 29.

PMID:
28849658
11.

In Vitro Reconstitution of OxyA Enzymatic Activity Clarifies Late Steps in Vancomycin Biosynthesis.

Forneris CC, Ozturk S, Gibson MI, Sorensen EJ, Seyedsayamdost MR.

ACS Chem Biol. 2017 Sep 15;12(9):2248-2253. doi: 10.1021/acschembio.7b00456. Epub 2017 Aug 2.

12.

Toward a mild dehydroformylation using base-metal catalysis.

Abrams DJ, West JG, Sorensen EJ.

Chem Sci. 2017 Mar 1;8(3):1954-1959. doi: 10.1039/c6sc04607j. Epub 2016 Nov 9.

13.

Synthesis of Fluorenones from Benzaldehydes and Aryl Iodides: Dual C-H Functionalizations Using a Transient Directing Group.

Chen XY, Ozturk S, Sorensen EJ.

Org Lett. 2017 Mar 3;19(5):1140-1143. doi: 10.1021/acs.orglett.7b00161. Epub 2017 Feb 22.

PMID:
28225629
14.

Diastereoselective syntheses of substituted cis-hydrindanones featuring sequential inter- and intramolecular Michael reactions.

Liu J, Marsini MA, Bedell TA, Reider PJ, Sorensen EJ.

Tetrahedron. 2016 Jun 30;72(26):3713-3717. doi: 10.1016/j.tet.2016.03.039. Epub 2016 Mar 15.

15.

The Uranyl Cation as a Visible-Light Photocatalyst for C(sp(3) )-H Fluorination.

West JG, Bedell TA, Sorensen EJ.

Angew Chem Int Ed Engl. 2016 Jul 25;55(31):8923-7. doi: 10.1002/anie.201603149. Epub 2016 Jun 20.

16.

Design and Synthesis of Molecular Scaffolds with Anti-infective Activity.

Liu J, Bedell TA, West JG, Sorensen EJ.

Tetrahedron. 2016 Jun 23;72(25):3579-3592. Epub 2016 Jan 28. No abstract available.

17.

Rapid Construction of a Benzo-Fused Indoxamycin Core Enabled by Site-Selective C-H Functionalizations.

Bedell TA, Hone GA, Valette D, Yu JQ, Davies HM, Sorensen EJ.

Angew Chem Int Ed Engl. 2016 Jul 11;55(29):8270-4. doi: 10.1002/anie.201602024. Epub 2016 May 20.

PMID:
27206223
18.

Acceptorless dehydrogenation of small molecules through cooperative base metal catalysis.

West JG, Huang D, Sorensen EJ.

Nat Commun. 2015 Dec 11;6:10093. doi: 10.1038/ncomms10093.

19.

An expedient synthesis of maraviroc (UK-427,857) via C-H functionalization.

Bedell TA, Hone GAB, Bois JD, Sorensen EJ.

Tetrahedron Lett. 2015 Jun 3;56(23):3620-3623. doi: 10.1016/j.tetlet.2015.01.074.

20.

Biomimetic total synthesis of gracilioethers B and C.

Norris MD, Perkins MV, Sorensen EJ.

Org Lett. 2015 Feb 6;17(3):668-71. doi: 10.1021/ol503695j. Epub 2015 Jan 26.

PMID:
25621375
21.

Tandem Diels-Alder and retro-ene reactions of 1-sulfenyl- and 1-sulfonyl-1,3-dienes as a traceless route to cyclohexenes.

Choi J, Park H, Yoo HJ, Kim S, Sorensen EJ, Lee C.

J Am Chem Soc. 2014 Jul 16;136(28):9918-21. doi: 10.1021/ja505721v. Epub 2014 Jul 1.

PMID:
24964017
22.

An enantiospecific synthesis of jiadifenolide.

Siler DA, Mighion JD, Sorensen EJ.

Angew Chem Int Ed Engl. 2014 May 19;53(21):5332-5. doi: 10.1002/anie.201402335. Epub 2014 Apr 23.

23.

Toward a synthesis of hirsutellone B by the concept of double cyclization.

Reber KP, Tilley SD, Carson CA, Sorensen EJ.

J Org Chem. 2013 Oct 4;78(19):9584-607. doi: 10.1021/jo401799f. Epub 2013 Sep 23.

24.

Ligand synthesis and passivation for silver and large gold nanoparticles for single-particle-based sensing and spectroscopy.

Montiel D, Yates EV, Sun L, Sampias MM, Malona J, Sorensen EJ, Yang H.

Methods Mol Biol. 2013;1025:237-50. doi: 10.1007/978-1-62703-462-3_18.

PMID:
23918342
25.

A chemical synthesis of 11-methoxy mitragynine pseudoindoxyl featuring the interrupted Ugi reaction.

Kim J, Schneekloth JS Jr, Sorensen EJ.

Chem Sci. 2012 Sep 1;3(9):2849-2852.

26.

Organic synthesis: A biochemical messenger made easily.

Sorensen EJ.

Nature. 2012 Sep 13;489(7415):214-5. doi: 10.1038/489214a. No abstract available.

PMID:
22972292
27.

The catalytic asymmetric Diels-Alder reactions and post-cycloaddition reductive transpositions of 1-hydrazinodienes.

Xie H, Sammis GM, Flamme EM, Kraml CM, Sorensen EJ.

Chemistry. 2011 Sep 26;17(40):11131-4. doi: 10.1002/chem.201102394. Epub 2011 Sep 5. No abstract available.

28.

Concise, stereocontrolled synthesis of the citrinadin B core architecture.

Guerrero CA, Sorensen EJ.

Org Lett. 2011 Oct 7;13(19):5164-7. doi: 10.1021/ol2020362. Epub 2011 Sep 6.

29.

Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis.

Lotesta SD, Liu J, Yates EV, Krieger I, Sacchettini JC, Freundlich JS, Sorensen EJ.

Chem Sci. 2011 Apr 14;2(7):1258-1261.

30.

A concise synthesis of the molecular framework of pleuromutilin.

Liu J, Lotesta SD, Sorensen EJ.

Chem Commun (Camb). 2011 Feb 7;47(5):1500-2. doi: 10.1039/c0cc04077k. Epub 2010 Nov 16.

31.

A concise and convergent synthesis of PA-824.

Marsini MA, Reider PJ, Sorensen EJ.

J Org Chem. 2010 Nov 5;75(21):7479-82. doi: 10.1021/jo1015807.

PMID:
20929201
32.

The abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis.

Freundlich JS, Lalgondar M, Wei JR, Swanson S, Sorensen EJ, Rubin EJ, Sacchettini JC.

Tuberculosis (Edinb). 2010 Sep;90(5):298-300. doi: 10.1016/j.tube.2010.08.002. Epub 2010 Aug 23.

33.
34.

Seebach's conjunctive reagent enables double cyclizations.

Chandler BD, Roland JT, Li Y, Sorensen EJ.

Org Lett. 2010 Jun 18;12(12):2746-9. doi: 10.1021/ol100845z.

35.

A hypervalent iodine-induced double annulation enables a concise synthesis of the pentacyclic core structure of the cortistatins.

Frie JL, Jeffrey CS, Sorensen EJ.

Org Lett. 2009 Dec 3;11(23):5394-7. doi: 10.1021/ol902168g.

36.

Bond formations by intermolecular and intramolecular trappings of acylketenes and their applications in natural product synthesis.

Reber KP, Tilley SD, Sorensen EJ.

Chem Soc Rev. 2009 Nov;38(11):3022-34. doi: 10.1039/b912599j. Epub 2009 Sep 2. Review.

37.
38.

An interrupted Ugi reaction enables the preparation of substituted indoxyls and aminoindoles.

Schneekloth JS Jr, Kim J, Sorensen EJ.

Tetrahedron. 2009 Apr 18;65(16):3096-3101.

39.

A rapid, asymmetric synthesis of the decahydrofluorene core of the hirsutellones.

Tilley SD, Reber KP, Sorensen EJ.

Org Lett. 2009 Feb 5;11(3):701-3. doi: 10.1021/ol802768p.

41.

Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides.

Evans MJ, Morris GM, Wu J, Olson AJ, Sorensen EJ, Cravatt BF.

Mol Biosyst. 2007 Jul;3(7):495-506. Epub 2007 May 10.

PMID:
17579775
42.

Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.

Buey RM, Calvo E, Barasoain I, Pineda O, Edler MC, Matesanz R, Cerezo G, Vanderwal CD, Day BW, Sorensen EJ, López JA, Andreu JM, Hamel E, Díaz JF.

Nat Chem Biol. 2007 Feb;3(2):117-25. Epub 2007 Jan 7.

43.

Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly.

Hamel E, Day BW, Miller JH, Jung MK, Northcote PT, Ghosh AK, Curran DP, Cushman M, Nicolaou KC, Paterson I, Sorensen EJ.

Mol Pharmacol. 2006 Nov;70(5):1555-64. Epub 2006 Aug 3.

PMID:
16887932
44.

Transition states of the retro-ene reactions of allylic diazenes.

Jabbari A, Sorensen EJ, Houk KN.

Org Lett. 2006 Jul 6;8(14):3105-7.

PMID:
16805563
45.
46.

Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling.

Evans MJ, Saghatelian A, Sorensen EJ, Cravatt BF.

Nat Biotechnol. 2005 Oct;23(10):1303-7. Epub 2005 Oct 2.

PMID:
16200062
47.

A Diels-Alder macrocyclization enables an efficient asymmetric synthesis of the antibacterial natural product abyssomicin C.

Zapf CW, Harrison BA, Drahl C, Sorensen EJ.

Angew Chem Int Ed Engl. 2005 Oct 14;44(40):6533-7. No abstract available.

PMID:
16163781
48.

Protein-reactive natural products.

Drahl C, Cravatt BF, Sorensen EJ.

Angew Chem Int Ed Engl. 2005 Sep 12;44(36):5788-809. Review.

PMID:
16149114
49.

Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site.

Edler MC, Buey RM, Gussio R, Marcus AI, Vanderwal CD, Sorensen EJ, Díaz JF, Giannakakou P, Hamel E.

Biochemistry. 2005 Aug 30;44(34):11525-38. Erratum in: Biochemistry. 2006 May 9;45(18):5932.

PMID:
16114889
50.

Design, synthesis, and reactivity of 1-hydrazinodienes for use in organic synthesis.

Sammis GM, Flamme EM, Xie H, Ho DM, Sorensen EJ.

J Am Chem Soc. 2005 Jun 22;127(24):8612-3.

PMID:
15954764

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