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Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks.

Cristini A, Ricci G, Britton S, Salimbeni S, Huang SN, Marinello J, Calsou P, Pommier Y, Favre G, Capranico G, Gromak N, Sordet O.

Cell Rep. 2019 Sep 17;28(12):3167-3181.e6. doi: 10.1016/j.celrep.2019.08.041.


A Targeted Protein Degradation Cell-Based Screening for Nanobodies Selective toward the Cellular RHOB GTP-Bound Conformation.

Bery N, Keller L, Soulié M, Gence R, Iscache AL, Cherier J, Cabantous S, Sordet O, Lajoie-Mazenc I, Pedelacq JD, Favre G, Olichon A.

Cell Chem Biol. 2019 Sep 11. pii: S2451-9456(19)30274-0. doi: 10.1016/j.chembiol.2019.08.009. [Epub ahead of print]


The RND1 Small GTPase: Main Functions and Emerging Role in Oncogenesis.

Mouly L, Gilhodes J, Lemarié A, Cohen-Jonathan Moyal E, Toulas C, Favre G, Sordet O, Monferran S.

Int J Mol Sci. 2019 Jul 24;20(15). pii: E3612. doi: 10.3390/ijms20153612. Review.


DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells.

De Magis A, Manzo SG, Russo M, Marinello J, Morigi R, Sordet O, Capranico G.

Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):816-825. doi: 10.1073/pnas.1810409116. Epub 2018 Dec 27.


PARP-1-dependent RND1 transcription induced by topoisomerase I cleavage complexes confers cellular resistance to camptothecin.

Mouly L, Mamouni K, Gence R, Cristini A, Cherier J, Castinel A, Legrand M, Favre G, Sordet O, Monferran S.

Cell Death Dis. 2018 Sep 12;9(9):931. doi: 10.1038/s41419-018-0981-3.


Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters.

Marinello J, Bertoncini S, Aloisi I, Cristini A, Malagoli Tagliazucchi G, Forcato M, Sordet O, Capranico G.

PLoS One. 2016 Jan 19;11(1):e0147053. doi: 10.1371/journal.pone.0147053. eCollection 2016.


DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.

Cristini A, Park JH, Capranico G, Legube G, Favre G, Sordet O.

Nucleic Acids Res. 2016 Feb 18;44(3):1161-78. doi: 10.1093/nar/gkv1196. Epub 2015 Nov 17.


The c-Jun/RHOB/AKT pathway confers resistance of BRAF-mutant melanoma cells to MAPK inhibitors.

Delmas A, Cherier J, Pohorecka M, Medale-Giamarchi C, Meyer N, Casanova A, Sordet O, Lamant L, Savina A, Pradines A, Favre G.

Oncotarget. 2015 Jun 20;6(17):15250-64.


RhoB promotes γH2AX dephosphorylation and DNA double-strand break repair.

Mamouni K, Cristini A, Guirouilh-Barbat J, Monferran S, Lemarié A, Faye JC, Lopez BS, Favre G, Sordet O.

Mol Cell Biol. 2014 Aug;34(16):3144-55. doi: 10.1128/MCB.01525-13. Epub 2014 Jun 9.


RhoB promotes cancer initiation by protecting keratinocytes from UVB-induced apoptosis but limits tumor aggressiveness.

Meyer N, Peyret-Lacombe A, Canguilhem B, Médale-Giamarchi C, Mamouni K, Cristini A, Monferran S, Lamant L, Filleron T, Pradines A, Sordet O, Favre G.

J Invest Dermatol. 2014 Jan;134(1):203-212. doi: 10.1038/jid.2013.278. Epub 2013 Jun 21.


[Immunization and preventive care for young people in Switzerland].

Meynard A, Markham-Genequand L, Torriani C, Haller DM, du Sordet OC, Narring F.

Rev Med Suisse. 2012 Jun 13;8(345):1261-5. Review. French.


Characterization of novel antisense HIF-1α transcripts in human cancers.

Bertozzi D, Iurlaro R, Sordet O, Marinello J, Zaffaroni N, Capranico G.

Cell Cycle. 2011 Sep 15;10(18):3189-97. Epub 2011 Sep 15.


γ-H2AX detection in peripheral blood lymphocytes, splenocytes, bone marrow, xenografts, and skin.

Redon CE, Nakamura AJ, Sordet O, Dickey JS, Gouliaeva K, Tabb B, Lawrence S, Kinders RJ, Bonner WM, Sedelnikova OA.

Methods Mol Biol. 2011;682:249-70. doi: 10.1007/978-1-60327-409-8_18.


Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage.

Conti C, Leo E, Eichler GS, Sordet O, Martin MM, Fan A, Aladjem MI, Pommier Y.

Cancer Res. 2010 Jun 1;70(11):4470-80. doi: 10.1158/0008-5472.CAN-09-3028. Epub 2010 May 11.


DNA double-strand breaks and ATM activation by transcription-blocking DNA lesions.

Sordet O, Nakamura AJ, Redon CE, Pommier Y.

Cell Cycle. 2010 Jan 15;9(2):274-8. Epub 2010 Jan 2.


Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks.

Sordet O, Redon CE, Guirouilh-Barbat J, Smith S, Solier S, Douarre C, Conti C, Nakamura AJ, Das BB, Nicolas E, Kohn KW, Bonner WM, Pommier Y.

EMBO Rep. 2009 Aug;10(8):887-93. doi: 10.1038/embor.2009.97. Epub 2009 Jun 26.


Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways.

Solier S, Sordet O, Kohn KW, Pommier Y.

Mol Cell Biol. 2009 Jan;29(1):68-82. doi: 10.1128/MCB.00581-08. Epub 2008 Oct 27.


Von Hippel-Lindau-coupled and transcription-coupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectedin.

Aune GJ, Takagi K, Sordet O, Guirouilh-Barbat J, Antony S, Bohr VA, Pommier Y.

Clin Cancer Res. 2008 Oct 15;14(20):6449-55. doi: 10.1158/1078-0432.CCR-08-0730.


Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I.

Sordet O, Larochelle S, Nicolas E, Stevens EV, Zhang C, Shokat KM, Fisher RP, Pommier Y.

J Mol Biol. 2008 Sep 5;381(3):540-9. doi: 10.1016/j.jmb.2008.06.028. Epub 2008 Jun 17.


Topoisomerase I requirement for death receptor-induced apoptotic nuclear fission.

Sordet O, Goldman A, Redon C, Solier S, Rao VA, Pommier Y.

J Biol Chem. 2008 Aug 22;283(34):23200-8. doi: 10.1074/jbc.M801146200. Epub 2008 Jun 13.


Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells.

Evans JW, Chernikova SB, Kachnic LA, Banath JP, Sordet O, Delahoussaye YM, Treszezamsky A, Chon BH, Feng Z, Gu Y, Wilson WR, Pommier Y, Olive PL, Powell SN, Brown JM.

Cancer Res. 2008 Jan 1;68(1):257-65. doi: 10.1158/0008-5472.CAN-06-4497.


Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters.

Takagi K, Dexheimer TS, Redon C, Sordet O, Agama K, Lavielle G, Pierré A, Bates SE, Pommier Y.

Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3229-38.


Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes.

Miao ZH, Agama K, Sordet O, Povirk L, Kohn KW, Pommier Y.

DNA Repair (Amst). 2006 Dec 9;5(12):1489-94. Epub 2006 Aug 28.


Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.

Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y.

J Biol Chem. 2006 Oct 13;281(41):30814-23. Epub 2006 Aug 10.


Repair of topoisomerase I-mediated DNA damage.

Pommier Y, Barcelo JM, Rao VA, Sordet O, Jobson AG, Thibaut L, Miao ZH, Seiler JA, Zhang H, Marchand C, Agama K, Nitiss JL, Redon C.

Prog Nucleic Acid Res Mol Biol. 2006;81:179-229. Review. No abstract available.


Targeting chk2 kinase: molecular interaction maps and therapeutic rationale.

Pommier Y, Sordet O, Rao VA, Zhang H, Kohn KW.

Curr Pharm Des. 2005;11(22):2855-72. Review.


A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.

Liao ZY, Sordet O, Zhang HL, Kohlhagen G, Antony S, Gmeiner WH, Pommier Y.

Cancer Res. 2005 Jun 1;65(11):4844-51.


Apoptotic topoisomerase I-DNA complexes induced by staurosporine-mediated oxygen radicals.

Sordet O, Khan QA, Plo I, Pourquier P, Urasaki Y, Yoshida A, Antony S, Kohlhagen G, Solary E, Saparbaev M, Laval J, Pommier Y.

J Biol Chem. 2004 Nov 26;279(48):50499-504. Epub 2004 Sep 22.


Apoptotic topoisomerase I-DNA complexes induced by oxygen radicals and mitochondrial dysfunction.

Sordet O, Khan QA, Pommier Y.

Cell Cycle. 2004 Sep;3(9):1095-7. Epub 2004 Sep 12. Review.


Hypoxia induces caspase-9 and caspase-3 activation without neuronal death in gerbil brains.

Garnier P, Prigent-Tessier A, Van Hoecke M, Bertrand N, Demougeot C, Sordet O, Swanson RA, Marie C, Beley A.

Eur J Neurosci. 2004 Aug;20(4):937-46.


Translocation of the inhibitor of apoptosis protein c-IAP1 from the nucleus to the Golgi in hematopoietic cells undergoing differentiation: a nuclear export signal-mediated event.

Plenchette S, Cathelin S, Rébé C, Launay S, Ladoire S, Sordet O, Ponnelle T, Debili N, Phan TH, Padua RA, Dubrez-Daloz L, Solary E.

Blood. 2004 Oct 1;104(7):2035-43. Epub 2004 Jun 8.


Topoisomerase I-DNA complexes contribute to arsenic trioxide-induced apoptosis.

Sordet O, Liao Z, Liu H, Antony S, Stevens EV, Kohlhagen G, Fu H, Pommier Y.

J Biol Chem. 2004 Aug 6;279(32):33968-75. Epub 2004 Jun 3.


Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks.

Pommier Y, Sordet O, Antony S, Hayward RL, Kohn KW.

Oncogene. 2004 Apr 12;23(16):2934-49. Review.


Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications.

Rapisarda A, Uranchimeg B, Sordet O, Pommier Y, Shoemaker RH, Melillo G.

Cancer Res. 2004 Feb 15;64(4):1475-82.


Repair of and checkpoint response to topoisomerase I-mediated DNA damage.

Pommier Y, Redon C, Rao VA, Seiler JA, Sordet O, Takemura H, Antony S, Meng L, Liao Z, Kohlhagen G, Zhang H, Kohn KW.

Mutat Res. 2003 Nov 27;532(1-2):173-203. Review.


Apoptosis induced by topoisomerase inhibitors.

Sordet O, Khan QA, Kohn KW, Pommier Y.

Curr Med Chem Anticancer Agents. 2003 Jul;3(4):271-90. Review.


Increased caspase-3 activity in refractory anemias: lack of evidence for Fas pathway implication.

Boudard D, Sordet O, Piselli S, Viallet A, Guyotat D, Campos L.

Leukemia. 2002 Nov;16(11):2343-5. No abstract available.


Specific involvement of caspases in the differentiation of monocytes into macrophages.

Sordet O, Rébé C, Plenchette S, Zermati Y, Hermine O, Vainchenker W, Garrido C, Solary E, Dubrez-Daloz L.

Blood. 2002 Dec 15;100(13):4446-53. Epub 2002 Aug 8.


Intracellular redistribution of procaspases during TPA-induced differentiation of U937 human leukemic cells.

Sordet O, Rébé C, Dubrez-Daloz L, Boudard D, Solary E.

Leukemia. 2002 Aug;16(8):1569-70. No abstract available.


Modulation of apoptotic pathways triggered by cytotoxic agents.

Solary E, Plenchette S, Sordet O, Rébé C, Ducoroy P, Filomenko R, Bruey JM, Droin N, Corcos L.

Therapie. 2001 Sep-Oct;56(5):511-8. Review.


Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis.

Sordet O, Rébé C, Leroy I, Bruey JM, Garrido C, Miguet C, Lizard G, Plenchette S, Corcos L, Solary E.

Blood. 2001 Jun 15;97(12):3931-40.


Involvement of caspase-2 long isoform in Fas-mediated cell death of human leukemic cells.

Droin N, Bichat F, Rébé C, Wotawa A, Sordet O, Hammann A, Bertrand R, Solary E.

Blood. 2001 Mar 15;97(6):1835-44.


Expression and activity of caspases 1 and 3 in myelodysplastic syndromes.

Boudard D, Sordet O, Vasselon C, Revol V, Berthéas MF, Freyssenet D, Viallet A, Piselli S, Guyotat D, Campos L.

Leukemia. 2000 Dec;14(12):2045-51.


Caspase-induced proteolysis of the cyclin-dependent kinase inhibitor p27Kip1 mediates its anti-apoptotic activity.

Eymin B, Sordet O, Droin N, Munsch B, Haugg M, Van de Craen M, Vandenabeele P, Solary E.

Oncogene. 1999 Aug 26;18(34):4839-47.


Selective inhibition of apoptosis by TPA-induced differentiation of U937 leukemic cells.

Sordet O, Bettaieb A, Bruey JM, Eymin B, Droin N, Ivarsson M, Garrido C, Solary E.

Cell Death Differ. 1999 Apr;6(4):351-61.


p27Kip1 induces drug resistance by preventing apoptosis upstream of cytochrome c release and procaspase-3 activation in leukemic cells.

Eymin B, Haugg M, Droin N, Sordet O, Dimanche-Boitrel MT, Solary E.

Oncogene. 1999 Feb 18;18(7):1411-8.


[Apoptosis and chemotherapy].

Bettaieb A, Sordet O, Belon JP, Solary E.

Bull Cancer. 1999 Jan;86(1):41-6. Review. French. No abstract available.


Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production.

Lizard G, Gueldry S, Sordet O, Monier S, Athias A, Miguet C, Bessede G, Lemaire S, Solary E, Gambert P.

FASEB J. 1998 Dec;12(15):1651-63.


BCR-ABL delays apoptosis upstream of procaspase-3 activation.

Dubrez L, Eymin B, Sordet O, Droin N, Turhan AG, Solary E.

Blood. 1998 Apr 1;91(7):2415-22.


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