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Understanding the Fate of Environmental Chemicals Inside Living Organisms: NMR-Based 13C Isotopic Suppression Selects Only the Molecule of Interest within 13C-Enriched Organisms.

Lane D, Liaghati Mobarhan Y, Soong R, Ning P, Bermel W, Tabatabaei Anaraki M, Wu B, Heumann H, Gundy M, Boenisch H, Jeong TY, Kovacevic V, Simpson MJ, Simpson AJ.

Anal Chem. 2019 Dec 3;91(23):15000-15008. doi: 10.1021/acs.analchem.9b03596. Epub 2019 Nov 13.


Comprehensive biomarker analyses identifies HER2, EGFR, MET RNA expression and thymidylate synthase 5'UTR SNP as predictors of benefit from S-1 adjuvant chemotherapy in Japanese patients with stage II/III gastric cancer.

Yoshikawa T, Aoyama T, Sakamaki K, Oshima T, Lin J, Zhang S, Sapari NS, Soong R, Tan I, Chan XB, Bottomley D, Hewitt LC, Arai T, Teh BT, Epstein D, Ogata T, Kameda Y, Miyagi Y, Tsuburaya A, Morita S, Grabsch HI, Tan P.

J Cancer. 2019 Aug 28;10(21):5130-5138. doi: 10.7150/jca.34741. eCollection 2019.


Selective Amino Acid-Only in Vivo NMR: A Powerful Tool To Follow Stress Processes.

Lane D, Soong R, Bermel W, Ning P, Dutta Majumdar R, Tabatabaei-Anaraki M, Heumann H, Gundy M, Bönisch H, Liaghati Mobarhan Y, Simpson MJ, Simpson AJ.

ACS Omega. 2019 May 22;4(5):9017-9028. doi: 10.1021/acsomega.9b00931. eCollection 2019 May 31.


Rapid Chemical Reaction Monitoring by Digital Microfluidics-NMR: Proof of Principle Towards an Automated Synthetic Discovery Platform.

Wu B, von der Ecken S, Swyer I, Li C, Jenne A, Vincent F, Schmidig D, Kuehn T, Beck A, Busse F, Stronks H, Soong R, Wheeler AR, Simpson A.

Angew Chem Int Ed Engl. 2019 Oct 21;58(43):15372-15376. doi: 10.1002/anie.201910052. Epub 2019 Sep 12.


Future challenges and new approaches: general discussion.

Afonso C, Chaux C, Davies AN, Delsuc MA, Fernandez Lima F, Gauchotte-Lindsay C, Giusti P, Goodacre R, Hawkes JA, Hertkorn N, Jansen JJ, Kew W, Kuhn S, Lubben A, McGill D, Nilsson M, Parkinson J, Rodgers RP, Rogers S, Schmitt-Kopplin P, Schoenmakers PJ, Shintu L, Soong R, Summerfield S, Surman A, Uhrín D, van der Hooft JJJ.

Faraday Discuss. 2019 Aug 15;218(0):505-523. doi: 10.1039/c9fd90046b. No abstract available.


Next Generation Sequencing Reveals Novel Mutations in Mismatch Repair Genes and Other Cancer Predisposition Genes in Asian Patients with Suspected Lynch Syndrome.

Ow SGW, Tan KT, Yang H, Yap HL, Sapari NSB, Ong PY, Soong R, Lee SC.

Clin Colorectal Cancer. 2019 Dec;18(4):e324-e334. doi: 10.1016/j.clcc.2019.05.007. Epub 2019 Jun 7.


Focusing on "the important" through targeted NMR experiments: an example of selective 13C-12C bond detection in complex mixtures.

Jenne A, Soong R, Bermel W, Sharma N, Masi A, Tabatabaei Anaraki M, Simpson A.

Faraday Discuss. 2019 Aug 15;218(0):372-394. doi: 10.1039/c8fd00213d.


Aggregation of Microtubule Binding Repeats of Tau Protein is Promoted by Cu2.

Ahmadi S, Zhu S, Sharma R, Wu B, Soong R, Dutta Majumdar R, Wilson DJ, Simpson AJ, Kraatz HB.

ACS Omega. 2019 Mar 31;4(3):5356-5366. doi: 10.1021/acsomega.8b03595. Epub 2019 Mar 15.


1D "Spikelet" Projections from Heteronuclear 2D NMR Data-Permitting 1D Chemometrics While Preserving 2D Dispersion.

Tabatabaei Anaraki M, Bermel W, Dutta Majumdar R, Soong R, Simpson M, Monnette M, Simpson AJ.

Metabolites. 2019 Jan 16;9(1). pii: E16. doi: 10.3390/metabo9010016.


Digital microfluidics and nuclear magnetic resonance spectroscopy for in situ diffusion measurements and reaction monitoring.

Swyer I, von der Ecken S, Wu B, Jenne A, Soong R, Vincent F, Schmidig D, Frei T, Busse F, Stronks HJ, Simpson AJ, Wheeler AR.

Lab Chip. 2019 Feb 12;19(4):641-653. doi: 10.1039/c8lc01214h.


Somatic mutations and immune checkpoint biomarkers.

Parris BA, Shaw E, Pang B, Soong R, Fong K, Soo RA.

Respirology. 2019 Mar;24(3):215-226. doi: 10.1111/resp.13463. Epub 2019 Jan 12. Review.


Assessing the potential of quantitative 2D HSQC NMR in 13C enriched living organisms.

Lane D, Skinner TE, Gershenzon NI, Bermel W, Soong R, Dutta Majumdar R, Liaghati Mobarhan Y, Schmidt S, Heumann H, Monette M, Simpson MJ, Simpson AJ.

J Biomol NMR. 2019 Feb;73(1-2):31-42. doi: 10.1007/s10858-018-0221-2. Epub 2019 Jan 2.


A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment.

Liu YT, Tseng TC, Soong RS, Peng CY, Cheng YH, Huang SF, Chuang TH, Kao JH, Huang LR.

J Immunother Cancer. 2018 Dec 7;6(1):144. doi: 10.1186/s40425-018-0462-3.


Improvements in lipid suppression for 1 H NMR-based metabolomics: Applications to solution-state and HR-MAS NMR in natural and in vivo samples.

Hassan Q, Dutta Majumdar R, Wu B, Lane D, Tabatabaei-Anraki M, Soong R, Simpson MJ, Simpson AJ.

Magn Reson Chem. 2018 Dec 5. doi: 10.1002/mrc.4814. [Epub ahead of print]


Covalent Rpn13-Binding Inhibitors for the Treatment of Ovarian Cancer.

Anchoori RK, Jiang R, Peng S, Soong RS, Algethami A, Rudek MA, Anders N, Hung CF, Chen X, Lu X, Kayode O, Dyba M, Walters KJ, Roden RBS.

ACS Omega. 2018 Sep 30;3(9):11917-11929. doi: 10.1021/acsomega.8b01479. Epub 2018 Sep 27.


13C quantification in heterogeneous multiphase natural samples by CMP-NMR using stepped decoupling.

Ning P, Soong R, Bermel W, Lane D, Simpson MJ, Simpson AJ.

Anal Bioanal Chem. 2018 Nov;410(27):7055-7065. doi: 10.1007/s00216-018-1306-1. Epub 2018 Aug 13.


miREM: an expectation-maximization approach for prioritizing miRNAs associated with gene-set.

Abdul Hadi LH, Xuan Lin QX, Minh TT, Loh M, Ng HK, Salim A, Soong R, Benoukraf T.

BMC Bioinformatics. 2018 Aug 10;19(1):299. doi: 10.1186/s12859-018-2292-1.


Genotype-guided versus traditional clinical dosing of warfarin in patients of Asian ancestry: a randomized controlled trial.

Syn NL, Wong AL, Lee SC, Teoh HL, Yip JWL, Seet RC, Yeo WT, Kristanto W, Bee PC, Poon LM, Marban P, Wu TS, Winther MD, Brunham LR, Soong R, Tai BC, Goh BC.

BMC Med. 2018 Jul 10;16(1):104. doi: 10.1186/s12916-018-1093-8.


Tumor molecular profiling of responders and non-responders following pembrolizumab monotherapy in chemotherapy resistant advanced cervical cancer.

Ngoi NYL, Heong V, Lee XW, Huang YQ, Thian YL, Choo BA, Lim D, Lim YW, Lim SE, Ilancheran A, Soong R, Tan DSP.

Gynecol Oncol Rep. 2018 Jan 31;24:1-5. doi: 10.1016/j.gore.2018.01.009. eCollection 2018 May.


Prognostic significance of immune cells in non-small cell lung cancer: meta-analysis.

Soo RA, Chen Z, Yan Teng RS, Tan HL, Iacopetta B, Tai BC, Soong R.

Oncotarget. 2018 May 15;9(37):24801-24820. doi: 10.18632/oncotarget.24835. eCollection 2018 May 15.


Development and Application of a Low-Volume Flow System for Solution-State in Vivo NMR.

Tabatabaei Anaraki M, Dutta Majumdar R, Wagner N, Soong R, Kovacevic V, Reiner EJ, Bhavsar SP, Ortiz Almirall X, Lane D, Simpson MJ, Heumann H, Schmidt S, Simpson AJ.

Anal Chem. 2018 Jul 3;90(13):7912-7921. doi: 10.1021/acs.analchem.8b00370. Epub 2018 Jun 18.


Determinants of variability of five programmed death ligand-1 immunohistochemistry assays in non-small cell lung cancer samples.

Soo RA, Yun Lim JS, Asuncion BR, Fazreen Z, Herrera MC, Mohd Omar MF, Diem Phuong NH, Seet JE, Amanuel B, Iacopetta B, Byrne D, Hendry S, Fox S, Soong R.

Oncotarget. 2018 Jan 2;9(6):6841-6851. doi: 10.18632/oncotarget.23827. eCollection 2018 Jan 23.


Finite-size effects in transcript sequencing count distribution: its power-law correction necessarily precedes downstream normalization and comparative analysis.

Wong WC, Ng HK, Tantoso E, Soong R, Eisenhaber F.

Biol Direct. 2018 Feb 12;13(1):2. doi: 10.1186/s13062-018-0204-y.


Acquired resistance to PI3K/mTOR inhibition is associated with mitochondrial DNA mutation and glycolysis.

Koh KX, Tan GH, Hui Low SH, Mohd Omar MF, Han MJ, Iacopetta B, Soo R, Beloueche-Babari M, Bhattacharya B, Soong R.

Oncotarget. 2017 Nov 24;8(66):110133-110144. doi: 10.18632/oncotarget.22655. eCollection 2017 Dec 15.


Immune checkpoint inhibitors in epidermal growth factor receptor mutant non-small cell lung cancer: Current controversies and future directions.

Soo RA, Lim SM, Syn NL, Teng R, Soong R, Mok TSK, Cho BC.

Lung Cancer. 2018 Jan;115:12-20. doi: 10.1016/j.lungcan.2017.11.009. Epub 2017 Nov 13. Review.


Guidance Statement On BRCA1/2 Tumor Testing in Ovarian Cancer Patients.

Capoluongo E, Ellison G, López-Guerrero JA, Penault-Llorca F, Ligtenberg MJL, Banerjee S, Singer C, Friedman E, Markiefka B, Schirmacher P, Büttner R, van Asperen CJ, Ray-Coquard I, Endris V, Kamel-Reid S, Percival N, Bryce J, Röthlisberger B, Soong R, de Castro DG.

Semin Oncol. 2017 Jun;44(3):187-197. doi: 10.1053/j.seminoncol.2017.08.004. Epub 2017 Sep 15. Review.


An evaluation of the challenges to developing tumor BRCA1 and BRCA2 testing methodologies for clinical practice.

Ellison G, Ahdesmäki M, Luke S, Waring PM, Wallace A, Wright R, Röthlisberger B, Ludin K, Merkelbach-Bruse S, Heydt C, Ligtenberg MJL, Mensenkamp AR, de Castro DG, Jones T, Vivancos A, Kondrashova O, Pauwels P, Weyn C, Hahnen E, Hauke J, Soong R, Lai Z, Dougherty B, Carr TH, Johnson J, Mills J, Barrett JC.

Hum Mutat. 2018 Mar;39(3):394-405. doi: 10.1002/humu.23375. Epub 2017 Dec 28.


Primary Epithelioid Angiosarcoma of Finger Masquerading as Epithelioid Hemangioma: Report of a Case and Analysis of Mutational Pattern in Epithelioid Hemangiomas and Angiosarcomas by Next-generation Sequencing.

Subramaniam MM, Salleh NL, Wu B, Rozario MA, Lim H, Puhaindran ME, Soong R, Lee VK.

Appl Immunohistochem Mol Morphol. 2018 Jan;26(1):e7-e13. doi: 10.1097/PAI.0000000000000551.


Towards single egg toxicity screening using microcoil NMR.

Fugariu I, Soong R, Lane D, Fey M, Maas W, Vincent F, Beck A, Schmidig D, Treanor B, Simpson AJ.

Analyst. 2017 Dec 4;142(24):4812-4824. doi: 10.1039/c7an01339f.


Environmental Nuclear Magnetic Resonance Spectroscopy: An Overview and a Primer.

Simpson AJ, Simpson MJ, Soong R.

Anal Chem. 2018 Jan 2;90(1):628-639. doi: 10.1021/acs.analchem.7b03241. Epub 2017 Dec 15.


Epstein-Barr virus-associated primary nodal T/NK-cell lymphoma shows a distinct molecular signature and copy number changes.

Ng SB, Chung TH, Kato S, Nakamura S, Takahashi E, Ko YH, Khoury JD, Yin CC, Soong R, Jeyasekharan AD, Hoppe MM, Selvarajan V, Tan SY, Lim ST, Ong CK, Nairismägi ML, Maheshwari P, Choo SN, Fan S, Lee CK, Chuang SS, Chng WJ.

Haematologica. 2018 Feb;103(2):278-287. doi: 10.3324/haematol.2017.180430. Epub 2017 Nov 2.


Measurement of fetal fraction in cell-free DNA from maternal plasma using a panel of insertion/deletion polymorphisms.

Barrett AN, Xiong L, Tan TZ, Advani HV, Hua R, Laureano-Asibal C, Soong R, Biswas A, Nagarajan N, Choolani M.

PLoS One. 2017 Oct 30;12(10):e0186771. doi: 10.1371/journal.pone.0186771. eCollection 2017.


PD-L1 expression is mainly regulated by interferon gamma associated with JAK-STAT pathway in gastric cancer.

Mimura K, Teh JL, Okayama H, Shiraishi K, Kua LF, Koh V, Smoot DT, Ashktorab H, Oike T, Suzuki Y, Fazreen Z, Asuncion BR, Shabbir A, Yong WP, So J, Soong R, Kono K.

Cancer Sci. 2018 Jan;109(1):43-53. doi: 10.1111/cas.13424. Epub 2017 Nov 18.


Value of a molecular screening program to support clinical trial enrollment in Asian cancer patients: The Integrated Molecular Analysis of Cancer (IMAC) Study.

Heong V, Syn NL, Lee XW, Sapari NS, Koh XQ, Adam Isa ZF, Sy Lim J, Lim D, Pang B, Thian YL, Ng LK, Wong AL, Soo RA, Yong WP, Chee CE, Lee SC, Goh BC, Soong R, Tan DSP.

Int J Cancer. 2018 May 1;142(9):1890-1900. doi: 10.1002/ijc.31091. Epub 2017 Oct 17.


Pharmacogenetic Analysis of the UK MRC (Medical Research Council) MAGIC Trial: Association of Polymorphisms with Toxicity and Survival in Patients Treated with Perioperative Epirubicin, Cisplatin, and 5-fluorouracil (ECF) Chemotherapy.

Smyth E, Zhang S, Cunningham D, Wotherspoon A, Soong R, Peckitt C, Valeri N, Fassan M, Rugge M, Okines A, Allum W, Stenning S, Nankivell M, Langley R, Tan P.

Clin Cancer Res. 2017 Dec 15;23(24):7543-7549. doi: 10.1158/1078-0432.CCR-16-3142. Epub 2017 Oct 2.


Carotenoids are the likely precursor of a significant fraction of marine dissolved organic matter.

Arakawa N, Aluwihare LI, Simpson AJ, Soong R, Stephens BM, Lane-Coplen D.

Sci Adv. 2017 Sep 27;3(9):e1602976. doi: 10.1126/sciadv.1602976. eCollection 2017 Sep.


Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study.

Saw WY, Tantoso E, Begum H, Zhou L, Zou R, He C, Chan SL, Tan LW, Wong LP, Xu W, Moong DKN, Lim Y, Li B, Pillai NE, Peterson TA, Bielawny T, Meikle PJ, Mundra PA, Lim WY, Luo M, Chia KS, Ong RT, Brunham LR, Khor CC, Too HP, Soong R, Wenk MR, Little P, Teo YY.

Nat Commun. 2017 Sep 21;8(1):653. doi: 10.1038/s41467-017-00413-x.


Anti-tumor efficacy evaluation of a novel monoclonal antibody targeting neutral amino acid transporter ASCT2 using patient-derived xenograft mouse models of gastric cancer.

Kasai N, Sasakawa A, Hosomi K, Poh TW, Chua BL, Yong WP, So J, Chan SL, Soong R, Kono K, Ishii T, Yamano K.

Am J Transl Res. 2017 Jul 15;9(7):3399-3410. eCollection 2017.


Comprehensive Multiphase (CMP) NMR Monitoring of the Structural Changes and Molecular Flux Within a Growing Seed.

Fortier-McGill BE, Dutta Majumdar R, Lam L, Soong R, Liaghati-Mobarhan Y, Sutrisno A, de Visser R, Simpson MJ, Wheeler HL, Campbell M, Gorissen A, Simpson AJ.

J Agric Food Chem. 2017 Aug 16;65(32):6779-6788. doi: 10.1021/acs.jafc.7b02421. Epub 2017 Aug 7.


Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized Clinical Trial.

Yap YS, Kwok LL, Syn N, Chay WY, Chia JWK, Tham CK, Wong NS, Lo SK, Dent RA, Tan S, Mok ZY, Koh KX, Toh HC, Koo WH, Loh M, Ng RCH, Choo SP, Soong RCT.

JAMA Oncol. 2017 Nov 1;3(11):1538-1545. doi: 10.1001/jamaoncol.2017.1269.


Prognostic impact and risk factors of low body mass index in patients undergoing liver transplantation.

Lee JC, Doush WMA, Wang YC, Cheng CH, Wu TH, Chen YC, Soong RS, Wu TJ, Chou HS, Chan KM, Lee WC, Lee CF.

Clin Transplant. 2017 Sep;31(9). doi: 10.1111/ctr.13048. Epub 2017 Jul 27.


Analysis of DOM phototransformation using a looped NMR system integrated with a sunlight simulator.

Dutta Majumdar R, Bliumkin L, Lane D, Soong R, Simpson M, Simpson AJ.

Water Res. 2017 Sep 1;120:64-76. doi: 10.1016/j.watres.2017.04.067. Epub 2017 Apr 29.


In-Phase Ultra High-Resolution In Vivo NMR.

Fugariu I, Bermel W, Lane D, Soong R, Simpson AJ.

Angew Chem Int Ed Engl. 2017 May 22;56(22):6324-6328. doi: 10.1002/anie.201701097. Epub 2017 Apr 5.


Significance of immune checkpoint proteins in EGFR-mutant non-small cell lung cancer.

Soo RA, Kim HR, Asuncion BR, Fazreen Z, Omar MFM, Herrera MC, Yun Lim JS, Sia G, Soong R, Cho BC.

Lung Cancer. 2017 Mar;105:17-22. doi: 10.1016/j.lungcan.2017.01.008. Epub 2017 Jan 15.


Pre-Transplantation Immune Cell Distribution and Early Post-Transplant Fungal Infection Are the Main Risk Factors of Liver Transplantation Recipients in Lower Model of End-Stage Liver Disease.

Abdelhamid NM, Chen YC, Wang YC, Cheng CH, Wu TJ, Lee CF, Wu TH, Chou HS, Chan KM, Lee WC, Soong RS.

Transplant Proc. 2017 Jan - Feb;49(1):92-97. doi: 10.1016/j.transproceed.2016.11.014.


Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.

Wahl S, Drong A, Lehne B, Loh M, Scott WR, Kunze S, Tsai PC, Ried JS, Zhang W, Yang Y, Tan S, Fiorito G, Franke L, Guarrera S, Kasela S, Kriebel J, Richmond RC, Adamo M, Afzal U, Ala-Korpela M, Albetti B, Ammerpohl O, Apperley JF, Beekman M, Bertazzi PA, Black SL, Blancher C, Bonder MJ, Brosch M, Carstensen-Kirberg M, de Craen AJ, de Lusignan S, Dehghan A, Elkalaawy M, Fischer K, Franco OH, Gaunt TR, Hampe J, Hashemi M, Isaacs A, Jenkinson A, Jha S, Kato N, Krogh V, Laffan M, Meisinger C, Meitinger T, Mok ZY, Motta V, Ng HK, Nikolakopoulou Z, Nteliopoulos G, Panico S, Pervjakova N, Prokisch H, Rathmann W, Roden M, Rota F, Rozario MA, Sandling JK, Schafmayer C, Schramm K, Siebert R, Slagboom PE, Soininen P, Stolk L, Strauch K, Tai ES, Tarantini L, Thorand B, Tigchelaar EF, Tumino R, Uitterlinden AG, van Duijn C, van Meurs JB, Vineis P, Wickremasinghe AR, Wijmenga C, Yang TP, Yuan W, Zhernakova A, Batterham RL, Smith GD, Deloukas P, Heijmans BT, Herder C, Hofman A, Lindgren CM, Milani L, van der Harst P, Peters A, Illig T, Relton CL, Waldenberger M, Järvelin MR, Bollati V, Soong R, Spector TD, Scott J, McCarthy MI, Elliott P, Bell JT, Matullo G, Gieger C, Kooner JS, Grallert H, Chambers JC.

Nature. 2017 Jan 5;541(7635):81-86. doi: 10.1038/nature20784. Epub 2016 Dec 21.


Application of CD8+ Cells Count as a Guide of Immunosuppressive Regimen Introduction for Very Sick Patients Undergoing Liver Transplantation.

Lee CF, Wang YC, Cheng CH, Wu TH, Chen YC, Soong RS, Wu TJ, Chou HS, Chan KM, Lee WC.

Transplant Proc. 2016 Dec;48(10):3356-3361. doi: 10.1016/j.transproceed.2016.09.038.


Interfacing digital microfluidics with high-field nuclear magnetic resonance spectroscopy.

Swyer I, Soong R, Dryden MD, Fey M, Maas WE, Simpson A, Wheeler AR.

Lab Chip. 2016 Nov 1;16(22):4424-4435. doi: 10.1039/c6lc01073c.


Effect of Prophylactic Antifungal Protocols on the Prognosis of Liver Transplantation: A Propensity Score Matching and Multistate Model Approach.

Chen YC, Huang TS, Wang YC, Cheng CH, Lee CF, Wu TJ, Chou HS, Chan KM, Lee WC, Soong RS.

Biomed Res Int. 2016;2016:6212503. Epub 2016 Sep 26.


Low Levels of NDRG1 in Nerve Tissue Are Predictive of Severe Paclitaxel-Induced Neuropathy.

Sundar R, Jeyasekharan AD, Pang B, Soong RC, Kumarakulasinghe NB, Ow SG, Ho J, Lim JS, Tan DS, Wilder-Smith EP, Bandla A, Tan SS, Asuncion BR, Fazreen Z, Hoppe MM, Putti TC, Poh LM, Goh BC, Lee SC.

PLoS One. 2016 Oct 7;11(10):e0164319. doi: 10.1371/journal.pone.0164319. eCollection 2016.

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