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Items: 10


A novel prostate cancer therapeutic strategy using icaritin-activated arylhydrocarbon-receptor to co-target androgen receptor and its splice variants.

Sun F, Indran IR, Zhang ZW, Tan MH, Li Y, Lim ZL, Hua R, Yang C, Soon FF, Li J, Xu HE, Cheung E, Yong EL.

Carcinogenesis. 2015 Jul;36(7):757-68. doi: 10.1093/carcin/bgv040. Epub 2015 Apr 23.


The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds.

Sasi NK, Tiwari K, Soon FF, Bonte D, Wang T, Melcher K, Xu HE, Weinreich M.

PLoS One. 2014 Nov 20;9(11):e113300. doi: 10.1371/journal.pone.0113300. eCollection 2014.


The crystal structure of the orphan nuclear receptor NR2E3/PNR ligand binding domain reveals a dimeric auto-repressed conformation.

Tan MH, Zhou XE, Soon FF, Li X, Li J, Yong EL, Melcher K, Xu HE.

PLoS One. 2013 Sep 12;8(9):e74359. doi: 10.1371/journal.pone.0074359. eCollection 2013.


Protein conformation ensembles monitored by HDX reveal a structural rationale for abscisic acid signaling protein affinities and activities.

West GM, Pascal BD, Ng LM, Soon FF, Melcher K, Xu HE, Chalmers MJ, Griffin PR.

Structure. 2013 Feb 5;21(2):229-35. doi: 10.1016/j.str.2012.12.001. Epub 2013 Jan 3.


Abscisic acid signaling: thermal stability shift assays as tool to analyze hormone perception and signal transduction.

Soon FF, Suino-Powell KM, Li J, Yong EL, Xu HE, Melcher K.

PLoS One. 2012;7(10):e47857. doi: 10.1371/journal.pone.0047857. Epub 2012 Oct 24.


Catalytic mechanism and kinase interactions of ABA-signaling PP2C phosphatases.

Zhou XE, Soon FF, Ng LM, Kovach A, Suino-Powell KM, Li J, Yong EL, Zhu JK, Xu HE, Melcher K.

Plant Signal Behav. 2012 May;7(5):581-8. doi: 10.4161/psb.19694. Epub 2012 Apr 20.


Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases.

Ng LM, Soon FF, Zhou XE, West GM, Kovach A, Suino-Powell KM, Chalmers MJ, Li J, Yong EL, Zhu JK, Griffin PR, Melcher K, Xu HE.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21259-64. doi: 10.1073/pnas.1118651109. Epub 2011 Dec 12.


Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.

Soon FF, Ng LM, Zhou XE, West GM, Kovach A, Tan MH, Suino-Powell KM, He Y, Xu Y, Chalmers MJ, Brunzelle JS, Zhang H, Yang H, Jiang H, Li J, Yong EL, Cutler S, Zhu JK, Griffin PR, Melcher K, Xu HE.

Science. 2012 Jan 6;335(6064):85-8. doi: 10.1126/science.1215106. Epub 2011 Nov 24.


Identification and mechanism of ABA receptor antagonism.

Melcher K, Xu Y, Ng LM, Zhou XE, Soon FF, Chinnusamy V, Suino-Powell KM, Kovach A, Tham FS, Cutler SR, Li J, Yong EL, Zhu JK, Xu HE.

Nat Struct Mol Biol. 2010 Sep;17(9):1102-8. doi: 10.1038/nsmb.1887. Epub 2010 Aug 22.


A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors.

Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Li J, Peterson FC, Jensen DR, Yong EL, Volkman BF, Cutler SR, Zhu JK, Xu HE.

Nature. 2009 Dec 3;462(7273):602-8. doi: 10.1038/nature08613.

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