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Items: 1 to 50 of 76


Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome Editing.

Garcia B, Lee J, Edraki A, Hidalgo-Reyes Y, Erwood S, Mir A, Trost CN, Seroussi U, Stanley SY, Cohn RD, Claycomb JM, Sontheimer EJ, Maxwell KL, Davidson AR.

Cell Rep. 2019 Nov 12;29(7):1739-1746.e5. doi: 10.1016/j.celrep.2019.10.017.


Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States.

Sun W, Yang J, Cheng Z, Amrani N, Liu C, Wang K, Ibraheim R, Edraki A, Huang X, Wang M, Wang J, Liu L, Sheng G, Yang Y, Lou J, Sontheimer EJ, Wang Y.

Mol Cell. 2019 Dec 19;76(6):938-952.e5. doi: 10.1016/j.molcel.2019.09.025. Epub 2019 Oct 24.


Tissue-restricted genome editing in vivo specified by microRNA-repressible anti-CRISPR proteins.

Lee J, Mou H, Ibraheim R, Liang SQ, Liu P, Xue W, Sontheimer EJ.

RNA. 2019 Nov;25(11):1421-1431. doi: 10.1261/rna.071704.119. Epub 2019 Aug 22.


Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2.

Thavalingam A, Cheng Z, Garcia B, Huang X, Shah M, Sun W, Wang M, Harrington L, Hwang S, Hidalgo-Reyes Y, Sontheimer EJ, Doudna J, Davidson AR, Moraes TF, Wang Y, Maxwell KL.

Nat Commun. 2019 Jun 26;10(1):2806. doi: 10.1038/s41467-019-10577-3.


X-Tracting a New CRISPR-Cas Genome-Editing Platform from Metagenomic Data Sets.

Sontheimer EJ.

CRISPR J. 2019 Jun;2:148-150. doi: 10.1089/crispr.2019.29061.ejs. No abstract available.


A Unified Resource for Tracking Anti-CRISPR Names.

Bondy-Denomy J, Davidson AR, Doudna JA, Fineran PC, Maxwell KL, Moineau S, Peng X, Sontheimer EJ, Wiedenheft B.

CRISPR J. 2018 Oct;1:304-305. doi: 10.1089/crispr.2018.0043. No abstract available.


Adapting dCas9-APEX2 for subnuclear proteomic profiling.

Gao XD, Rodríguez TC, Sontheimer EJ.

Methods Enzymol. 2019;616:365-383. doi: 10.1016/bs.mie.2018.10.030. Epub 2018 Dec 10.


A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing.

Edraki A, Mir A, Ibraheim R, Gainetdinov I, Yoon Y, Song CQ, Cao Y, Gallant J, Xue W, Rivera-Pérez JA, Sontheimer EJ.

Mol Cell. 2019 Feb 21;73(4):714-726.e4. doi: 10.1016/j.molcel.2018.12.003. Epub 2018 Dec 20.


Publisher Correction: Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing.

Bolukbasi MF, Liu P, Luk K, Kwok SF, Gupta A, Amrani N, Sontheimer EJ, Zhu LJ, Wolfe SA.

Nat Commun. 2018 Dec 10;9(1):5294. doi: 10.1038/s41467-018-07776-9.


NmeCas9 is an intrinsically high-fidelity genome-editing platform.

Amrani N, Gao XD, Liu P, Edraki A, Mir A, Ibraheim R, Gupta A, Sasaki KE, Wu T, Donohoue PD, Settle AH, Lied AM, McGovern K, Fuller CK, Cameron P, Fazzio TG, Zhu LJ, Wolfe SA, Sontheimer EJ.

Genome Biol. 2018 Dec 5;19(1):214. doi: 10.1186/s13059-018-1591-1.


Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins.

Lee J, Mir A, Edraki A, Garcia B, Amrani N, Lou HE, Gainetdinov I, Pawluk A, Ibraheim R, Gao XD, Liu P, Davidson AR, Maxwell KL, Sontheimer EJ.

mBio. 2018 Dec 4;9(6). pii: e02321-18. doi: 10.1128/mBio.02321-18.


Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing.

Bolukbasi MF, Liu P, Luk K, Kwok SF, Gupta A, Amrani N, Sontheimer EJ, Zhu LJ, Wolfe SA.

Nat Commun. 2018 Nov 19;9(1):4856. doi: 10.1038/s41467-018-07310-x. Erratum in: Nat Commun. 2018 Dec 10;9(1):5294.


All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo.

Ibraheim R, Song CQ, Mir A, Amrani N, Xue W, Sontheimer EJ.

Genome Biol. 2018 Sep 19;19(1):137. doi: 10.1186/s13059-018-1515-0.


Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing.

Mir A, Alterman JF, Hassler MR, Debacker AJ, Hudgens E, Echeverria D, Brodsky MH, Khvorova A, Watts JK, Sontheimer EJ.

Nat Commun. 2018 Jul 6;9(1):2641. doi: 10.1038/s41467-018-05073-z.


A Hyperthermophilic Phage Decoration Protein Suggests Common Evolutionary Origin with Herpesvirus Triplex Proteins and an Anti-CRISPR Protein.

Stone NP, Hilbert BJ, Hidalgo D, Halloran KT, Lee J, Sontheimer EJ, Kelch BA.

Structure. 2018 Jul 3;26(7):936-947.e3. doi: 10.1016/j.str.2018.04.008. Epub 2018 May 17.


C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2.

Gao XD, Tu LC, Mir A, Rodriguez T, Ding Y, Leszyk J, Dekker J, Shaffer SA, Zhu LJ, Wolfe SA, Sontheimer EJ.

Nat Methods. 2018 Jun;15(6):433-436. doi: 10.1038/s41592-018-0006-2. Epub 2018 May 7.


CRISPRs from scratch.

Edraki A, Sontheimer EJ.

Nat Microbiol. 2018 Mar;3(3):261-262. doi: 10.1038/s41564-018-0115-9. No abstract available.


Type II-C CRISPR-Cas9 Biology, Mechanism, and Application.

Mir A, Edraki A, Lee J, Sontheimer EJ.

ACS Chem Biol. 2018 Feb 16;13(2):357-365. doi: 10.1021/acschembio.7b00855. Epub 2017 Dec 20. Review.


A Broad-Spectrum Inhibitor of CRISPR-Cas9.

Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA.

Cell. 2017 Sep 7;170(6):1224-1233.e15. doi: 10.1016/j.cell.2017.07.037. Epub 2017 Aug 24.


Inhibition of CRISPR-Cas systems by mobile genetic elements.

Sontheimer EJ, Davidson AR.

Curr Opin Microbiol. 2017 Jun;37:120-127. doi: 10.1016/j.mib.2017.06.003. Epub 2017 Jun 29. Review.


CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion.

Mou H, Smith JL, Peng L, Yin H, Moore J, Zhang XO, Song CQ, Sheel A, Wu Q, Ozata DM, Li Y, Anderson DG, Emerson CP, Sontheimer EJ, Moore MJ, Weng Z, Xue W.

Genome Biol. 2017 Jun 14;18(1):108. doi: 10.1186/s13059-017-1237-8.


Naturally Occurring Off-Switches for CRISPR-Cas9.

Pawluk A, Amrani N, Zhang Y, Garcia B, Hidalgo-Reyes Y, Lee J, Edraki A, Shah M, Sontheimer EJ, Maxwell KL, Davidson AR.

Cell. 2016 Dec 15;167(7):1829-1838.e9. doi: 10.1016/j.cell.2016.11.017. Epub 2016 Dec 8.


RNA. CRISPR goes retro.

Sontheimer EJ, Marraffini LA.

Science. 2016 Feb 26;351(6276):920-1. doi: 10.1126/science.aaf2851. No abstract available.


Cas9 gets a classmate.

Sontheimer EJ, Wolfe SA.

Nat Biotechnol. 2015 Dec 9;33(12):1240-1241. doi: 10.1038/nbt.3426. No abstract available.


DNase H Activity of Neisseria meningitidis Cas9.

Zhang Y, Rajan R, Seifert HS, Mondragón A, Sontheimer EJ.

Mol Cell. 2015 Oct 15;60(2):242-55. doi: 10.1016/j.molcel.2015.09.020.


Primary processing of CRISPR RNA by the endonuclease Cas6 in Staphylococcus epidermidis.

Wakefield N, Rajan R, Sontheimer EJ.

FEBS Lett. 2015 Oct 7;589(20 Pt B):3197-204. doi: 10.1016/j.febslet.2015.09.005. Epub 2015 Sep 10.


Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses.

Wang D, Mou H, Li S, Li Y, Hough S, Tran K, Li J, Yin H, Anderson DG, Sontheimer EJ, Weng Z, Gao G, Xue W.

Hum Gene Ther. 2015 Jul;26(7):432-42. doi: 10.1089/hum.2015.087.


The Bacterial Origins of the CRISPR Genome-Editing Revolution.

Sontheimer EJ, Barrangou R.

Hum Gene Ther. 2015 Jul;26(7):413-24. doi: 10.1089/hum.2015.091. Review.


Methods in Enzymology. The use of CRISPR/Cas9, ZFNs, and TALENs in generating site-specific genome alterations. Preface.

Doudna JA, Sontheimer EJ.

Methods Enzymol. 2014;546:xix-xx. doi: 10.1016/B978-0-12-801185-0.09983-9. No abstract available.


Structural biology. Cascading into focus.

Zhang Y, Sontheimer EJ.

Science. 2014 Sep 19;345(6203):1452-3. doi: 10.1126/science.1260026. No abstract available.


SPO24 is a transcriptionally dynamic, small ORF-encoding locus required for efficient sporulation in Saccharomyces cerevisiae.

Hurtado S, Kim Guisbert KS, Sontheimer EJ.

PLoS One. 2014 Aug 15;9(8):e105058. doi: 10.1371/journal.pone.0105058. eCollection 2014.


Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis.

Hou Z, Zhang Y, Propson NE, Howden SE, Chu LF, Sontheimer EJ, Thomson JA.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15644-9. doi: 10.1073/pnas.1313587110. Epub 2013 Aug 12.


Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis.

Zhang Y, Heidrich N, Ampattu BJ, Gunderson CW, Seifert HS, Schoen C, Vogel J, Sontheimer EJ.

Mol Cell. 2013 May 23;50(4):488-503. doi: 10.1016/j.molcel.2013.05.001.


Quit stalling or you'll be silenced.

Kim Guisbert KS, Sontheimer EJ.

Cell. 2013 Feb 28;152(5):938-9. doi: 10.1016/j.cell.2013.02.025.


Small RNAs of opposite sign… but same absolute value.

Sontheimer EJ.

Cell. 2012 Dec 7;151(6):1157-8. doi: 10.1016/j.cell.2012.11.032.


Meiosis-induced alterations in transcript architecture and noncoding RNA expression in S. cerevisiae.

Kim Guisbert KS, Zhang Y, Flatow J, Hurtado S, Staley JP, Lin S, Sontheimer EJ.

RNA. 2012 Jun;18(6):1142-53. doi: 10.1261/rna.030510.111. Epub 2012 Apr 26.


Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis.

Gerbasi VR, Preall JB, Golden DE, Powell DW, Cummins TD, Sontheimer EJ.

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3204-9. doi: 10.1073/pnas.1009781108. Epub 2011 Feb 7.


Microbiology: slicer for DNA.

Sontheimer EJ, Marraffini LA.

Nature. 2010 Nov 4;468(7320):45-6. doi: 10.1038/468045a. No abstract available.


Proteomics identification of Drosophila small interfering RNA-associated factors.

Gerbasi VR, Golden DE, Hurtado SB, Sontheimer EJ.

Mol Cell Proteomics. 2010 Sep;9(9):1866-72. doi: 10.1074/mcp.M900614-MCP200. Epub 2010 May 15.


CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea.

Marraffini LA, Sontheimer EJ.

Nat Rev Genet. 2010 Mar;11(3):181-90. doi: 10.1038/nrg2749. Review.


Self versus non-self discrimination during CRISPR RNA-directed immunity.

Marraffini LA, Sontheimer EJ.

Nature. 2010 Jan 28;463(7280):568-71. doi: 10.1038/nature08703. Epub 2010 Jan 13.


Silencing by small RNAs is linked to endosomal trafficking.

Lee YS, Pressman S, Andress AP, Kim K, White JL, Cassidy JJ, Li X, Lubell K, Lim DH, Cho IS, Nakahara K, Preall JB, Bellare P, Sontheimer EJ, Carthew RW.

Nat Cell Biol. 2009 Sep;11(9):1150-6. doi: 10.1038/ncb1930. Epub 2009 Aug 16. Erratum in: Nat Cell Biol. 2009 Dec;11(12):1495.


Invasive DNA, chopped and in the CRISPR.

Marraffini LA, Sontheimer EJ.

Structure. 2009 Jun 10;17(6):786-8. doi: 10.1016/j.str.2009.05.002.


Origins and Mechanisms of miRNAs and siRNAs.

Carthew RW, Sontheimer EJ.

Cell. 2009 Feb 20;136(4):642-55. doi: 10.1016/j.cell.2009.01.035. Review.


CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA.

Marraffini LA, Sontheimer EJ.

Science. 2008 Dec 19;322(5909):1843-5. doi: 10.1126/science.1165771.


An inside job for siRNAs.

Golden DE, Gerbasi VR, Sontheimer EJ.

Mol Cell. 2008 Aug 8;31(3):309-12. doi: 10.1016/j.molcel.2008.07.008. Review.


A role for ubiquitin in the spliceosome assembly pathway.

Bellare P, Small EC, Huang X, Wohlschlegel JA, Staley JP, Sontheimer EJ.

Nat Struct Mol Biol. 2008 May;15(5):444-51. doi: 10.1038/nsmb.1401. Epub 2008 Apr 20.


A fork in the road for microRNAs.

Bellare P, Sontheimer EJ.

Nat Struct Mol Biol. 2007 Aug;14(8):684-6. No abstract available.


Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p.

Bellare P, Kutach AK, Rines AK, Guthrie C, Sontheimer EJ.

RNA. 2006 Feb;12(2):292-302.

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