Sort by
Items per page

Send to

Choose Destination

Search results

Items: 21


Local Peroxynitrite Impairs Endothelial TRPV4 Channels and Elevates Blood Pressure in Obesity.

Ottolini M, Hong K, Cope EL, Daneva Z, DeLalio LJ, Sokolowski JD, Marziano C, Nguyen NY, Altschmied J, Haendeler J, Johnstone SR, Kalani MY, Park MS, Patel RP, Liedtke W, Isakson BE, Sonkusare SK.

Circulation. 2020 Feb 3. doi: 10.1161/CIRCULATIONAHA.119.043385. [Epub ahead of print]


Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction.

Krüger N, Biwer LA, Good ME, Ruddiman CA, Wolpe AG, DeLalio LJ, Murphy S, Macal EH Jr, Ragolia L, Serbulea V, Best AK, Leitinger N, Harris TE, Sonkusare SK, Gödecke A, Isakson BE.

Circ Res. 2020 Jan 17;126(2):232-242. doi: 10.1161/CIRCRESAHA.119.315531. Epub 2019 Dec 5.


Novel Regulators and Targets of Redox Signaling in Pulmonary Vasculature.

Daneva Z, Laubach VE, Sonkusare SK.

Curr Opin Physiol. 2019 Jun;9:87-93. doi: 10.1016/j.cophys.2019.04.026. Epub 2019 May 9.


Calcium signals that determine vascular resistance.

Ottolini M, Hong K, Sonkusare SK.

Wiley Interdiscip Rev Syst Biol Med. 2019 Sep;11(5):e1448. doi: 10.1002/wsbm.1448. Epub 2019 Mar 18. Review.


RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger.

Artamonov MV, Sonkusare SK, Good ME, Momotani K, Eto M, Isakson BE, Le TH, Cope EL, Derewenda ZS, Derewenda U, Somlyo AV.

Sci Signal. 2018 Oct 30;11(554). pii: eaar3924. doi: 10.1126/scisignal.aar3924.


TRPV4 (Transient Receptor Potential Vanilloid 4) Channel-Dependent Negative Feedback Mechanism Regulates Gq Protein-Coupled Receptor-Induced Vasoconstriction.

Hong K, Cope EL, DeLalio LJ, Marziano C, Isakson BE, Sonkusare SK.

Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):542-554. doi: 10.1161/ATVBAHA.117.310038. Epub 2018 Jan 4.


Nitric Oxide-Dependent Feedback Loop Regulates Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Cooperativity and Endothelial Function in Small Pulmonary Arteries.

Marziano C, Hong K, Cope EL, Kotlikoff MI, Isakson BE, Sonkusare SK.

J Am Heart Assoc. 2017 Dec 23;6(12). pii: e007157. doi: 10.1161/JAHA.117.007157.


Non-Endoplasmic Reticulum-Based Calr (Calreticulin) Can Coordinate Heterocellular Calcium Signaling and Vascular Function.

Biwer LA, Good ME, Hong K, Patel RK, Agrawal N, Looft-Wilson R, Sonkusare SK, Isakson BE.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):120-130. doi: 10.1161/ATVBAHA.117.309886. Epub 2017 Nov 9.


Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice.

Dalsgaard T, Sonkusare SK, Teuscher C, Poynter ME, Nelson MT.

Sci Rep. 2016 Sep 22;6:33841. doi: 10.1038/srep33841.


Gain-of-function mutation in TRPV4 identified in patients with osteonecrosis of the femoral head.

Mah W, Sonkusare SK, Wang T, Azeddine B, Pupavac M, Carrot-Zhang J, Hong K, Majewski J, Harvey EJ, Russell L, Chalk C, Rosenblatt DS, Nelson MT, Séguin C.

J Med Genet. 2016 Oct;53(10):705-9. doi: 10.1136/jmedgenet-2016-103829. Epub 2016 Jun 21.


Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators.

Sonkusare SK, Dalsgaard T, Bonev AD, Nelson MT.

J Physiol. 2016 Jun 15;594(12):3271-85. doi: 10.1113/JP271652. Epub 2016 Mar 4.


Traumatic brain injury disrupts cerebrovascular tone through endothelial inducible nitric oxide synthase expression and nitric oxide gain of function.

Villalba N, Sonkusare SK, Longden TA, Tran TL, Sackheim AM, Nelson MT, Wellman GC, Freeman K.

J Am Heart Assoc. 2014 Dec;3(6):e001474. doi: 10.1161/JAHA.114.001474.


Vascular TRP channels: performing under pressure and going with the flow.

Hill-Eubanks DC, Gonzales AL, Sonkusare SK, Nelson MT.

Physiology (Bethesda). 2014 Sep;29(5):343-60. doi: 10.1152/physiol.00009.2014. Review.


AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension.

Sonkusare SK, Dalsgaard T, Bonev AD, Hill-Eubanks DC, Kotlikoff MI, Scott JD, Santana LF, Nelson MT.

Sci Signal. 2014 Jul 8;7(333):ra66. doi: 10.1126/scisignal.2005052.


Opposing roles of smooth muscle BK channels and ryanodine receptors in the regulation of nerve-evoked constriction of mesenteric resistance arteries.

Krishnamoorthy G, Sonkusare SK, Heppner TJ, Nelson MT.

Am J Physiol Heart Circ Physiol. 2014 Apr 1;306(7):H981-8. doi: 10.1152/ajpheart.00866.2013. Epub 2014 Feb 7.


The β3 subunit contributes to vascular calcium channel upregulation and hypertension in angiotensin II-infused C57BL/6 mice.

Kharade SV, Sonkusare SK, Srivastava AK, Thakali KM, Fletcher TW, Rhee SW, Rusch NJ.

Hypertension. 2013 Jan;61(1):137-42. doi: 10.1161/HYPERTENSIONAHA.112.197863. Epub 2012 Nov 5.


Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.

Sonkusare SK, Bonev AD, Ledoux J, Liedtke W, Kotlikoff MI, Heppner TJ, Hill-Eubanks DC, Nelson MT.

Science. 2012 May 4;336(6081):597-601. doi: 10.1126/science.1216283.


Fundamental increase in pressure-dependent constriction of brain parenchymal arterioles from subarachnoid hemorrhage model rats due to membrane depolarization.

Nystoriak MA, O'Connor KP, Sonkusare SK, Brayden JE, Nelson MT, Wellman GC.

Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H803-12. doi: 10.1152/ajpheart.00760.2010. Epub 2010 Dec 10.


Intracellular Ca2+ silences L-type Ca2+ channels in mesenteric veins: mechanism of venous smooth muscle resistance to calcium channel blockers.

Thakali KM, Kharade SV, Sonkusare SK, Rhee SW, Stimers JR, Rusch NJ.

Circ Res. 2010 Mar 5;106(4):739-47. doi: 10.1161/CIRCRESAHA.109.206763. Epub 2009 Dec 31.


Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats.

Pathan AR, Viswanad B, Sonkusare SK, Ramarao P.

Life Sci. 2006 Nov 2;79(23):2209-16. Epub 2006 Jul 25.


Dementia of Alzheimer's disease and other neurodegenerative disorders--memantine, a new hope.

Sonkusare SK, Kaul CL, Ramarao P.

Pharmacol Res. 2005 Jan;51(1):1-17. Review.


Supplemental Content

Loading ...
Support Center