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Items: 1 to 50 of 168

1.

Role of the global regulator Rex in control of NAD+ -regeneration in Clostridioides (Clostridium) difficile.

Bouillaut L, Dubois T, Francis MB, Daou N, Monot M, Sorg JA, Sonenshein AL, Dupuy B.

Mol Microbiol. 2019 Jun;111(6):1671-1688. doi: 10.1111/mmi.14245. Epub 2019 Apr 2.

PMID:
30882947
2.

Impact of CodY protein on metabolism, sporulation and virulence in Clostridioides difficile ribotype 027.

Daou N, Wang Y, Levdikov VM, Nandakumar M, Livny J, Bouillaut L, Blagova E, Zhang K, Belitsky BR, Rhee K, Wilkinson AJ, Sun X, Sonenshein AL.

PLoS One. 2019 Jan 30;14(1):e0206896. doi: 10.1371/journal.pone.0206896. eCollection 2019.

3.

Oral Immunization with Nontoxigenic Clostridium difficile Strains Expressing Chimeric Fragments of TcdA and TcdB Elicits Protective Immunity against C. difficile Infection in Both Mice and Hamsters.

Wang Y, Wang S, Bouillaut L, Li C, Duan Z, Zhang K, Ju X, Tzipori S, Sonenshein AL, Sun X.

Infect Immun. 2018 Oct 25;86(11). pii: e00489-18. doi: 10.1128/IAI.00489-18. Print 2018 Nov.

4.

A Mutation in the Bacillus subtilis rsbU Gene That Limits RNA Synthesis during Sporulation.

Rothstein DM, Lazinski D, Osburne MS, Sonenshein AL.

J Bacteriol. 2017 Jun 27;199(14). pii: e00212-17. doi: 10.1128/JB.00212-17. Print 2017 Jul 15.

5.

Structure of the Branched-chain Amino Acid and GTP-sensing Global Regulator, CodY, from Bacillus subtilis.

Levdikov VM, Blagova E, Young VL, Belitsky BR, Lebedev A, Sonenshein AL, Wilkinson AJ.

J Biol Chem. 2017 Feb 17;292(7):2714-2728. doi: 10.1074/jbc.M116.754309. Epub 2016 Dec 23.

6.

Interplay of CodY and ScoC in the Regulation of Major Extracellular Protease Genes of Bacillus subtilis.

Barbieri G, Albertini AM, Ferrari E, Sonenshein AL, Belitsky BR.

J Bacteriol. 2016 Jan 4;198(6):907-20. doi: 10.1128/JB.00894-15.

7.

Intermediate Levels of Bacillus subtilis CodY Activity Are Required for Derepression of the Branched-Chain Amino Acid Permease, BraB.

Belitsky BR, Brinsmade SR, Sonenshein AL.

PLoS Genet. 2015 Oct 16;11(10):e1005600. doi: 10.1371/journal.pgen.1005600. eCollection 2015 Oct.

8.

Three cellulosomal xylanase genes in Clostridium thermocellum are regulated by both vegetative SigA (σ(A)) and alternative SigI6 (σ(I6)) factors.

Sand A, Holwerda EK, Ruppertsberger NM, Maloney M, Olson DG, Nataf Y, Borovok I, Sonenshein AL, Bayer EA, Lamed R, Lynd LR, Shoham Y.

FEBS Lett. 2015 Oct 7;589(20 Pt B):3133-40. doi: 10.1016/j.febslet.2015.08.026. Epub 2015 Aug 29.

9.

Regulating the Intersection of Metabolism and Pathogenesis in Gram-positive Bacteria.

Richardson AR, Somerville GA, Sonenshein AL.

Microbiol Spectr. 2015 Jun;3(3). doi: 10.1128/microbiolspec.MBP-0004-2014. Review.

10.

Interactive regulation by the Bacillus subtilis global regulators CodY and ScoC.

Belitsky BR, Barbieri G, Albertini AM, Ferrari E, Strauch MA, Sonenshein AL.

Mol Microbiol. 2015 Aug;97(4):698-716. doi: 10.1111/mmi.13056. Epub 2015 Jun 6.

11.

Effects of surotomycin on Clostridium difficile viability and toxin production in vitro.

Bouillaut L, McBride S, Sorg JA, Schmidt DJ, Suarez JM, Tzipori S, Mascio C, Chesnel L, Sonenshein AL.

Antimicrob Agents Chemother. 2015 Jul;59(7):4199-205. doi: 10.1128/AAC.00275-15. Epub 2015 May 4.

12.

CodY regulates expression of the Bacillus subtilis extracellular proteases Vpr and Mpr.

Barbieri G, Voigt B, Albrecht D, Hecker M, Albertini AM, Sonenshein AL, Ferrari E, Belitsky BR.

J Bacteriol. 2015 Apr;197(8):1423-32. doi: 10.1128/JB.02588-14. Epub 2015 Feb 9.

13.

Integration of metabolism and virulence in Clostridium difficile.

Bouillaut L, Dubois T, Sonenshein AL, Dupuy B.

Res Microbiol. 2015 May;166(4):375-83. doi: 10.1016/j.resmic.2014.10.002. Epub 2014 Oct 15. Review.

14.

The metabolic regulator CodY links Listeria monocytogenes metabolism to virulence by directly activating the virulence regulatory gene prfA.

Lobel L, Sigal N, Borovok I, Belitsky BR, Sonenshein AL, Herskovits AA.

Mol Microbiol. 2015 Feb;95(4):624-44. doi: 10.1111/mmi.12890. Epub 2014 Dec 30.

15.

Multiple regulatory mechanisms control the expression of the Geobacillus stearothermophilus gene for extracellular xylanase.

Shulami S, Shenker O, Langut Y, Lavid N, Gat O, Zaide G, Zehavi A, Sonenshein AL, Shoham Y.

J Biol Chem. 2014 Sep 12;289(37):25957-75. doi: 10.1074/jbc.M114.592873. Epub 2014 Jul 28.

16.

Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY.

Brinsmade SR, Alexander EL, Livny J, Stettner AI, Segrè D, Rhee KY, Sonenshein AL.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8227-32. doi: 10.1073/pnas.1321308111. Epub 2014 May 19.

17.

Carvacrol and trans-cinnamaldehyde reduce Clostridium difficile toxin production and cytotoxicity in vitro.

Mooyottu S, Kollanoor-Johny A, Flock G, Bouillaut L, Upadhyay A, Sonenshein AL, Venkitanarayanan K.

Int J Mol Sci. 2014 Mar 12;15(3):4415-30. doi: 10.3390/ijms15034415.

18.

CodY-mediated regulation of the Staphylococcus aureus Agr system integrates nutritional and population density signals.

Roux A, Todd DA, Velázquez JV, Cech NB, Sonenshein AL.

J Bacteriol. 2014 Mar;196(6):1184-96. doi: 10.1128/JB.00128-13. Epub 2014 Jan 3.

19.

Comment on the Howy Jacobs' Editorial "Yes we can, but do we?".

Sonenshein AL.

EMBO Rep. 2013 Dec;14(12):1027. doi: 10.1038/embor.2013.176. Epub 2013 Nov 8. No abstract available.

20.

GTP dysregulation in Bacillus subtilis cells lacking (p)ppGpp results in phenotypic amino acid auxotrophy and failure to adapt to nutrient downshift and regulate biosynthesis genes.

Kriel A, Brinsmade SR, Tse JL, Tehranchi AK, Bittner AN, Sonenshein AL, Wang JD.

J Bacteriol. 2014 Jan;196(1):189-201. doi: 10.1128/JB.00918-13. Epub 2013 Oct 25.

21.

Genome-wide identification of Bacillus subtilis CodY-binding sites at single-nucleotide resolution.

Belitsky BR, Sonenshein AL.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):7026-31. doi: 10.1073/pnas.1300428110. Epub 2013 Apr 8.

22.

Two roles for aconitase in the regulation of tricarboxylic acid branch gene expression in Bacillus subtilis.

Pechter KB, Meyer FM, Serio AW, Stülke J, Sonenshein AL.

J Bacteriol. 2013 Apr;195(7):1525-37. doi: 10.1128/JB.01690-12. Epub 2013 Jan 25.

23.

Identification of CodY targets in Bacillus anthracis by genome-wide in vitro binding analysis.

Château A, van Schaik W, Joseph P, Handke LD, McBride SM, Smeets FM, Sonenshein AL, Fouet A.

J Bacteriol. 2013 Mar;195(6):1204-13. doi: 10.1128/JB.02041-12. Epub 2013 Jan 4.

24.

Proline-dependent regulation of Clostridium difficile Stickland metabolism.

Bouillaut L, Self WT, Sonenshein AL.

J Bacteriol. 2013 Feb;195(4):844-54. doi: 10.1128/JB.01492-12. Epub 2012 Dec 7.

25.

Fidaxomicin inhibits toxin production in Clostridium difficile.

Babakhani F, Bouillaut L, Sears P, Sims C, Gomez A, Sonenshein AL.

J Antimicrob Chemother. 2013 Mar;68(3):515-22. doi: 10.1093/jac/dks450. Epub 2012 Dec 2.

PMID:
23208832
26.

Use of a mariner-based transposon mutagenesis system to isolate Clostridium perfringens mutants deficient in gliding motility.

Liu H, Bouillaut L, Sonenshein AL, Melville SB.

J Bacteriol. 2013 Feb;195(3):629-36. doi: 10.1128/JB.01288-12. Epub 2012 Nov 30.

27.

Dual role of CcpC protein in regulation of aconitase gene expression in Listeria monocytogenes and Bacillus subtilis.

Mittal M, Pechter KB, Picossi S, Kim HJ, Kerstein KO, Sonenshein AL.

Microbiology. 2013 Jan;159(Pt 1):68-76. doi: 10.1099/mic.0.063388-0. Epub 2012 Nov 8.

28.

Fidaxomicin inhibits spore production in Clostridium difficile.

Babakhani F, Bouillaut L, Gomez A, Sears P, Nguyen L, Sonenshein AL.

Clin Infect Dis. 2012 Aug;55 Suppl 2:S162-9. doi: 10.1093/cid/cis453.

29.

CodY deletion enhances in vivo virulence of community-associated methicillin-resistant Staphylococcus aureus clone USA300.

Montgomery CP, Boyle-Vavra S, Roux A, Ebine K, Sonenshein AL, Daum RS.

Infect Immun. 2012 Jul;80(7):2382-9. doi: 10.1128/IAI.06172-11. Epub 2012 Apr 23.

30.

Proline utilization by Bacillus subtilis: uptake and catabolism.

Moses S, Sinner T, Zaprasis A, Stöveken N, Hoffmann T, Belitsky BR, Sonenshein AL, Bremer E.

J Bacteriol. 2012 Feb;194(4):745-58. doi: 10.1128/JB.06380-11. Epub 2011 Dec 2.

31.

CodY-mediated regulation of guanosine uptake in Bacillus subtilis.

Belitsky BR, Sonenshein AL.

J Bacteriol. 2011 Nov;193(22):6276-87. doi: 10.1128/JB.05899-11. Epub 2011 Sep 16.

32.

Dissecting complex metabolic integration provides direct genetic evidence for CodY activation by guanine nucleotides.

Brinsmade SR, Sonenshein AL.

J Bacteriol. 2011 Oct;193(20):5637-48. doi: 10.1128/JB.05510-11. Epub 2011 Aug 19.

33.

Roadblock repression of transcription by Bacillus subtilis CodY.

Belitsky BR, Sonenshein AL.

J Mol Biol. 2011 Aug 26;411(4):729-43. doi: 10.1016/j.jmb.2011.06.012. Epub 2011 Jun 15.

34.

Sublingually administered Bacillus subtilis cells expressing tetanus toxin C fragment induce protective systemic and mucosal antibodies against tetanus toxin in mice.

Amuguni JH, Lee S, Kerstein KO, Brown DW, Belitsky BR, Herrmann JE, Keusch GT, Sonenshein AL, Tzipori S.

Vaccine. 2011 Jun 24;29(29-30):4778-84. doi: 10.1016/j.vaccine.2011.04.083. Epub 2011 May 10.

PMID:
21565244
35.

The dlt operon confers resistance to cationic antimicrobial peptides in Clostridium difficile.

McBride SM, Sonenshein AL.

Microbiology. 2011 May;157(Pt 5):1457-65. doi: 10.1099/mic.0.045997-0. Epub 2011 Feb 17.

36.

Contributions of multiple binding sites and effector-independent binding to CodY-mediated regulation in Bacillus subtilis.

Belitsky BR, Sonenshein AL.

J Bacteriol. 2011 Jan;193(2):473-84. doi: 10.1128/JB.01151-10. Epub 2010 Nov 19.

37.

Identification of a genetic locus responsible for antimicrobial peptide resistance in Clostridium difficile.

McBride SM, Sonenshein AL.

Infect Immun. 2011 Jan;79(1):167-76. doi: 10.1128/IAI.00731-10. Epub 2010 Oct 25.

38.

Clostridium thermocellum cellulosomal genes are regulated by extracytoplasmic polysaccharides via alternative sigma factors.

Nataf Y, Bahari L, Kahel-Raifer H, Borovok I, Lamed R, Bayer EA, Sonenshein AL, Shoham Y.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18646-51. doi: 10.1073/pnas.1012175107. Epub 2010 Oct 11.

39.

Regulation of CodY activity through modulation of intracellular branched-chain amino acid pools.

Brinsmade SR, Kleijn RJ, Sauer U, Sonenshein AL.

J Bacteriol. 2010 Dec;192(24):6357-68. doi: 10.1128/JB.00937-10. Epub 2010 Oct 8.

40.

Development of a Bacillus subtilis-based rotavirus vaccine.

Lee S, Belitsky BR, Brinker JP, Kerstein KO, Brown DW, Clements JD, Keusch GT, Tzipori S, Sonenshein AL, Herrmann JE.

Clin Vaccine Immunol. 2010 Nov;17(11):1647-55. doi: 10.1128/CVI.00135-10. Epub 2010 Sep 1.

41.

Integration of metabolism and virulence by Clostridium difficile CodY.

Dineen SS, McBride SM, Sonenshein AL.

J Bacteriol. 2010 Oct;192(20):5350-62. doi: 10.1128/JB.00341-10. Epub 2010 Aug 13.

42.

Efficacy, heat stability and safety of intranasally administered Bacillus subtilis spore or vegetative cell vaccines expressing tetanus toxin fragment C.

Lee S, Belitsky BR, Brown DW, Brinker JP, Kerstein KO, Herrmann JE, Keusch GT, Sonenshein AL, Tzipori S.

Vaccine. 2010 Sep 24;28(41):6658-65. doi: 10.1016/j.vaccine.2010.08.016. Epub 2010 Aug 13.

PMID:
20709005
43.

Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid.

Sorg JA, Sonenshein AL.

J Bacteriol. 2010 Oct;192(19):4983-90. doi: 10.1128/JB.00610-10. Epub 2010 Jul 30.

44.

Direct targets of CodY in Staphylococcus aureus.

Majerczyk CD, Dunman PM, Luong TT, Lee CY, Sadykov MR, Somerville GA, Bodi K, Sonenshein AL.

J Bacteriol. 2010 Jun;192(11):2861-77. doi: 10.1128/JB.00220-10. Epub 2010 Apr 2. Erratum in: J Bacteriol. 2010 Aug;192(16):4258.

45.

Metabolism of bile salts in mice influences spore germination in Clostridium difficile.

Giel JL, Sorg JA, Sonenshein AL, Zhu J.

PLoS One. 2010 Jan 15;5(1):e8740. doi: 10.1371/journal.pone.0008740.

46.

Genetic and biochemical analysis of the interaction of Bacillus subtilis CodY with branched-chain amino acids.

Villapakkam AC, Handke LD, Belitsky BR, Levdikov VM, Wilkinson AJ, Sonenshein AL.

J Bacteriol. 2009 Nov;191(22):6865-76. doi: 10.1128/JB.00818-09. Epub 2009 Sep 11.

47.

The global regulator CodY regulates toxin gene expression in Bacillus anthracis and is required for full virulence.

van Schaik W, Château A, Dillies MA, Coppée JY, Sonenshein AL, Fouet A.

Infect Immun. 2009 Oct;77(10):4437-45. doi: 10.1128/IAI.00716-09. Epub 2009 Aug 3.

48.

Structural rearrangement accompanying ligand binding in the GAF domain of CodY from Bacillus subtilis.

Levdikov VM, Blagova E, Colledge VL, Lebedev AA, Williamson DC, Sonenshein AL, Wilkinson AJ.

J Mol Biol. 2009 Jul 31;390(5):1007-18. doi: 10.1016/j.jmb.2009.05.077. Epub 2009 Jun 3.

49.

Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination.

Sorg JA, Sonenshein AL.

J Bacteriol. 2009 Feb;191(3):1115-7. doi: 10.1128/JB.01260-08. Epub 2008 Dec 5.

50.

CcpC-dependent regulation of citrate synthase gene expression in Listeria monocytogenes.

Mittal M, Picossi S, Sonenshein AL.

J Bacteriol. 2009 Feb;191(3):862-72. doi: 10.1128/JB.01384-08. Epub 2008 Nov 14.

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