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Items: 1 to 50 of 616

1.

eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer.

Müller D, Shin S, Goullet de Rugy T, Samain R, Baer R, Strehaiano M, Masvidal-Sanz L, Guillermet-Guibert J, Jean C, Tsukumo Y, Sonenberg N, Marion F, Guilbaud N, Hoffmann JS, Larsson O, Bousquet C, Pyronnet S, Martineau Y.

JCI Insight. 2019 Nov 1;4(21). pii: 121951. doi: 10.1172/jci.insight.121951.

2.

Wakefulness/sleep architecture and electroencephalographic activity in mice lacking the translational repressor 4E-BP1 or 4E-BP2.

Areal CC, Cao R, Sonenberg N, Mongrain V.

Sleep. 2019 Sep 25. pii: zsz210. doi: 10.1093/sleep/zsz210. [Epub ahead of print]

PMID:
31553042
3.

The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.

Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R.

Neuron. 2019 Aug 26. pii: S0896-6273(19)30691-9. doi: 10.1016/j.neuron.2019.08.007. [Epub ahead of print]

PMID:
31522764
4.

V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss.

Mohammad AH, Assadian S, Couture F, Lefebvre KJ, El-Assaad W, Barrès V, Ouellet V, Boulay PL, Yang J, Latour M, Furic L, Muller W, Sonenberg N, Mes-Masson AM, Saad F, Day R, Teodoro JG.

Oncotarget. 2019 Aug 13;10(48):4923-4936. doi: 10.18632/oncotarget.27075. eCollection 2019 Aug 13.

5.

Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation.

Kim TH, Tsang B, Vernon RM, Sonenberg N, Kay LE, Forman-Kay JD.

Science. 2019 Aug 23;365(6455):825-829. doi: 10.1126/science.aax4240.

PMID:
31439799
6.

Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2.

Wiebe S, Nagpal A, Truong VT, Park J, Skalecka A, He AJ, Gamache K, Khoutorsky A, Gantois I, Sonenberg N.

Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):18060-18067. doi: 10.1073/pnas.1908126116. Epub 2019 Aug 19.

PMID:
31427534
7.

The Organizing Principles of Eukaryotic Ribosome Recruitment.

Pelletier J, Sonenberg N.

Annu Rev Biochem. 2019 Jun 20;88:307-335. doi: 10.1146/annurev-biochem-013118-111042.

PMID:
31220979
8.

4E-BP1 and 4E-BP2 double knockout mice are protected from aging-associated sarcopenia.

Le Bacquer O, Combe K, Patrac V, Ingram B, Combaret L, Dardevet D, Montaurier C, Salles J, Giraudet C, Guillet C, Sonenberg N, Boirie Y, Walrand S.

J Cachexia Sarcopenia Muscle. 2019 Jun;10(3):696-709. doi: 10.1002/jcsm.12412. Epub 2019 Mar 29.

9.

Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis.

Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7973-7981. doi: 10.1073/pnas.1816023116. Epub 2019 Mar 29.

10.

A threonyl-tRNA synthetase-mediated translation initiation machinery.

Jeong SJ, Park S, Nguyen LT, Hwang J, Lee EY, Giong HK, Lee JS, Yoon I, Lee JH, Kim JH, Kim HK, Kim D, Yang WS, Kim SY, Lee CY, Yu K, Sonenberg N, Kim MH, Kim S.

Nat Commun. 2019 Mar 22;10(1):1357. doi: 10.1038/s41467-019-09086-0.

11.

4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer.

Wang Z, Feng X, Molinolo AA, Martin D, Vitale-Cross L, Nohata N, Ando M, Wahba A, Amornphimoltham P, Wu X, Gilardi M, Allevato M, Wu V, Steffen DJ, Tofilon P, Sonenberg N, Califano J, Chen Q, Lippman SM, Gutkind JS.

Cancer Res. 2019 Apr 1;79(7):1438-1450. doi: 10.1158/0008-5472.CAN-18-1220. Epub 2019 Mar 20.

PMID:
30894372
12.

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation.

Tsang B, Arsenault J, Vernon RM, Lin H, Sonenberg N, Wang LY, Bah A, Forman-Kay JD.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4218-4227. doi: 10.1073/pnas.1814385116. Epub 2019 Feb 14.

13.

Translational Control in Stem Cells.

Tahmasebi S, Amiri M, Sonenberg N.

Front Genet. 2019 Jan 15;9:709. doi: 10.3389/fgene.2018.00709. eCollection 2018. Review.

14.

Dynamic interaction of poly(A)-binding protein with the ribosome.

Machida K, Shigeta T, Yamamoto Y, Ito T, Svitkin Y, Sonenberg N, Imataka H.

Sci Rep. 2018 Nov 28;8(1):17435. doi: 10.1038/s41598-018-35753-1.

15.

Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain.

Megat S, Ray PR, Moy JK, Lou TF, Barragán-Iglesias P, Li Y, Pradhan G, Wanghzou A, Ahmad A, Burton MD, North RY, Dougherty PM, Khoutorsky A, Sonenberg N, Webster KR, Dussor G, Campbell ZT, Price TJ.

J Neurosci. 2019 Jan 16;39(3):393-411. doi: 10.1523/JNEUROSCI.2661-18.2018. Epub 2018 Nov 20.

16.

HGF-induced migration depends on the PI(3,4,5)P3-binding microexon-spliced variant of the Arf6 exchange factor cytohesin-1.

Ratcliffe CDH, Siddiqui N, Coelho PP, Laterreur N, Cookey TN, Sonenberg N, Park M.

J Cell Biol. 2019 Jan 7;218(1):285-298. doi: 10.1083/jcb.201804106. Epub 2018 Nov 7.

17.

Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma.

Cerezo M, Guemiri R, Druillennec S, Girault I, Malka-Mahieu H, Shen S, Allard D, Martineau S, Welsch C, Agoussi S, Estrada C, Adam J, Libenciuc C, Routier E, Roy S, Désaubry L, Eggermont AM, Sonenberg N, Scoazec JY, Eychène A, Vagner S, Robert C.

Nat Med. 2018 Dec;24(12):1877-1886. doi: 10.1038/s41591-018-0217-1. Epub 2018 Oct 29.

PMID:
30374200
18.

Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders.

Gantois I, Popic J, Khoutorsky A, Sonenberg N.

Annu Rev Med. 2019 Jan 27;70:167-181. doi: 10.1146/annurev-med-081117-041238. Epub 2018 Oct 26.

PMID:
30365357
19.

Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis.

Zakaria C, Sean P, Hoang HD, Leroux LP, Watson M, Workenhe ST, Hearnden J, Pearl D, Truong VT, Robichaud N, Yanagiya A, Tahmasebi S, Jafarnejad SM, Jia JJ, Pelin A, Diallo JS, Le Boeuf F, Bell JC, Mossman KL, Graber TE, Jaramillo M, Sonenberg N, Alain T.

PLoS Pathog. 2018 Aug 23;14(8):e1007264. doi: 10.1371/journal.ppat.1007264. eCollection 2018 Aug.

20.

Protein Synthesis and Translational Control: A Historical Perspective.

Tahmasebi S, Sonenberg N, Hershey JWB, Mathews MB.

Cold Spring Harb Perspect Biol. 2019 Sep 3;11(9). pii: a035584. doi: 10.1101/cshperspect.a035584. Review.

PMID:
30082466
21.

Translation deregulation in human disease.

Tahmasebi S, Khoutorsky A, Mathews MB, Sonenberg N.

Nat Rev Mol Cell Biol. 2018 Dec;19(12):791-807. doi: 10.1038/s41580-018-0034-x. Review.

PMID:
30038383
22.

Principles of Translational Control.

Hershey JWB, Sonenberg N, Mathews MB.

Cold Spring Harb Perspect Biol. 2019 Sep 3;11(9). pii: a032607. doi: 10.1101/cshperspect.a032607. Review.

PMID:
29959195
23.

Translational Control in Cancer.

Robichaud N, Sonenberg N, Ruggero D, Schneider RJ.

Cold Spring Harb Perspect Biol. 2019 Jul 1;11(7). pii: a032896. doi: 10.1101/cshperspect.a032896. Review.

PMID:
29959193
24.

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E.

Aguilar-Valles A, Haji N, De Gregorio D, Matta-Camacho E, Eslamizade MJ, Popic J, Sharma V, Cao R, Rummel C, Tanti A, Wiebe S, Nuñez N, Comai S, Nadon R, Luheshi G, Mechawar N, Turecki G, Lacaille JC, Gobbi G, Sonenberg N.

Nat Commun. 2018 Jun 25;9(1):2459. doi: 10.1038/s41467-018-04883-5.

25.

Neuronal Regulation of eIF2α Function in Health and Neurological Disorders.

Moon SL, Sonenberg N, Parker R.

Trends Mol Med. 2018 Jun;24(6):575-589. doi: 10.1016/j.molmed.2018.04.001. Epub 2018 Apr 30. Review.

PMID:
29716790
26.

Removing 4E-BP Enables Synapses to Refine without Postsynaptic Activity.

Chong Y, Saviuk N, Pie B, Basisty N, Quinn RK, Schilling B, Sonenberg N, Cooper E, Haghighi AP.

Cell Rep. 2018 Apr 3;23(1):11-22. doi: 10.1016/j.celrep.2018.03.040.

27.

mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction.

Liu D, Stowie A, de Zavalia N, Leise T, Pathak SS, Drewes LR, Davidson AJ, Amir S, Sonenberg N, Cao R.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3296-E3304. doi: 10.1073/pnas.1721578115. Epub 2018 Mar 19.

28.

Beyond molecular tumor heterogeneity: protein synthesis takes control.

Ramon Y Cajal S, Castellvi J, Hümmer S, Peg V, Pelletier J, Sonenberg N.

Oncogene. 2018 May;37(19):2490-2501. doi: 10.1038/s41388-018-0152-0. Epub 2018 Feb 21. Review.

29.

Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils.

Robichaud N, Hsu BE, Istomine R, Alvarez F, Blagih J, Ma EH, Morales SV, Dai DL, Li G, Souleimanova M, Guo Q, Del Rincon SV, Miller WH Jr, Ramón Y Cajal S, Park M, Jones RG, Piccirillo CA, Siegel PM, Sonenberg N.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2202-E2209. doi: 10.1073/pnas.1717439115. Epub 2018 Feb 20.

30.

The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer.

Ding M, Van der Kwast TH, Vellanki RN, Foltz WD, McKee TD, Sonenberg N, Pandolfi PP, Koritzinsky M, Wouters BG.

Mol Cancer Res. 2018 Apr;16(4):682-695. doi: 10.1158/1541-7786.MCR-17-0696. Epub 2018 Feb 16.

31.

Translational control of ERK signaling through miRNA/4EHP-directed silencing.

Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N.

Elife. 2018 Feb 7;7. pii: e35034. doi: 10.7554/eLife.35034.

32.

Aminoacylation of Proteins: New Targets for the Old ARSenal.

Jafarnejad SM, Kim SH, Sonenberg N.

Cell Metab. 2018 Jan 9;27(1):1-3. doi: 10.1016/j.cmet.2017.12.012.

33.

Eukaryotic initiation factor 4F-sidestepping resistance mechanisms arising from expression heterogeneity.

Chu J, Ramon Y Cajal S, Sonenberg N, Pelletier J.

Curr Opin Genet Dev. 2018 Feb;48:89-96. doi: 10.1016/j.gde.2017.11.002. Epub 2017 Nov 21. Review.

PMID:
29169064
34.

Structural Dynamics of the GW182 Silencing Domain Including its RNA Recognition motif (RRM) Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry.

Cieplak-Rotowska MK, Tarnowski K, Rubin M, Fabian MR, Sonenberg N, Dadlez M, Niedzwiecka A.

J Am Soc Mass Spectrom. 2018 Jan;29(1):158-173. doi: 10.1007/s13361-017-1830-9. Epub 2017 Oct 27.

35.

Profile of Michael N. Hall, 2017 Albert Lasker Basic Medical Research Awardee: Target of rapamycin, cell growth, and translational control.

Sonenberg N.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11564-11567. doi: 10.1073/pnas.1716203114. Epub 2017 Oct 19. No abstract available.

36.

Fragile X syndrome.

Hagerman RJ, Berry-Kravis E, Hazlett HC, Bailey DB Jr, Moine H, Kooy RF, Tassone F, Gantois I, Sonenberg N, Mandel JL, Hagerman PJ.

Nat Rev Dis Primers. 2017 Sep 29;3:17065. doi: 10.1038/nrdp.2017.65. Review.

PMID:
28960184
37.

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.

Morita M, Prudent J, Basu K, Goyon V, Katsumura S, Hulea L, Pearl D, Siddiqui N, Strack S, McGuirk S, St-Pierre J, Larsson O, Topisirovic I, Vali H, McBride HM, Bergeron JJ, Sonenberg N.

Mol Cell. 2017 Sep 21;67(6):922-935.e5. doi: 10.1016/j.molcel.2017.08.013. Epub 2017 Sep 14.

38.

Epiregulin and EGFR interactions are involved in pain processing.

Martin LJ, Smith SB, Khoutorsky A, Magnussen CA, Samoshkin A, Sorge RE, Cho C, Yosefpour N, Sivaselvachandran S, Tohyama S, Cole T, Khuong TM, Mir E, Gibson DG, Wieskopf JS, Sotocinal SG, Austin JS, Meloto CB, Gitt JH, Gkogkas C, Sonenberg N, Greenspan JD, Fillingim RB, Ohrbach R, Slade GD, Knott C, Dubner R, Nackley AG, Ribeiro-da-Silva A, Neely GG, Maixner W, Zaykin DV, Mogil JS, Diatchenko L.

J Clin Invest. 2017 Sep 1;127(9):3353-3366. doi: 10.1172/JCI87406. Epub 2017 Aug 7.

39.

Translation is actively regulated during the differentiation of CD8+ effector T cells.

Araki K, Morita M, Bederman AG, Konieczny BT, Kissick HT, Sonenberg N, Ahmed R.

Nat Immunol. 2017 Sep;18(9):1046-1057. doi: 10.1038/ni.3795. Epub 2017 Jul 17.

40.

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.

Blandino-Rosano M, Barbaresso R, Jimenez-Palomares M, Bozadjieva N, Werneck-de-Castro JP, Hatanaka M, Mirmira RG, Sonenberg N, Liu M, Rüegg MA, Hall MN, Bernal-Mizrachi E.

Nat Commun. 2017 Jul 12;8:16014. doi: 10.1038/ncomms16014.

41.

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

Garzia A, Jafarnejad SM, Meyer C, Chapat C, Gogakos T, Morozov P, Amiri M, Shapiro M, Molina H, Tuschl T, Sonenberg N.

Nat Commun. 2017 Jul 7;8:16056. doi: 10.1038/ncomms16056.

42.

The MNK-eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain.

Moy JK, Khoutorsky A, Asiedu MN, Black BJ, Kuhn JL, Barragán-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio JJ, Mogil JS, Dussor G, Sonenberg N, Price TJ.

J Neurosci. 2017 Aug 2;37(31):7481-7499. doi: 10.1523/JNEUROSCI.0220-17.2017. Epub 2017 Jul 3.

43.

Translational control and the cancer cell response to stress.

Robichaud N, Sonenberg N.

Curr Opin Cell Biol. 2017 Apr;45:102-109. doi: 10.1016/j.ceb.2017.05.007. Epub 2017 Jun 2. Review.

PMID:
28582681
44.

Muscle metabolic alterations induced by genetic ablation of 4E-BP1 and 4E-BP2 in response to diet-induced obesity.

Le Bacquer O, Combe K, Montaurier C, Salles J, Giraudet C, Patrac V, Domingues-Faria C, Guillet C, Louche K, Boirie Y, Sonenberg N, Moro C, Walrand S.

Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201700128. Epub 2017 Jul 3.

PMID:
28544394
45.

Metformin ameliorates core deficits in a mouse model of fragile X syndrome.

Gantois I, Khoutorsky A, Popic J, Aguilar-Valles A, Freemantle E, Cao R, Sharma V, Pooters T, Nagpal A, Skalecka A, Truong VT, Wiebe S, Groves IA, Jafarnejad SM, Chapat C, McCullagh EA, Gamache K, Nader K, Lacaille JC, Gkogkas CG, Sonenberg N.

Nat Med. 2017 Jun;23(6):674-677. doi: 10.1038/nm.4335. Epub 2017 May 15.

PMID:
28504725
46.

Cap-binding protein 4EHP effects translation silencing by microRNAs.

Chapat C, Jafarnejad SM, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF, Sonenberg N.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5425-5430. doi: 10.1073/pnas.1701488114. Epub 2017 May 9.

47.

Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes.

Tuttle AH, Tansley S, Dossett K, Tohyama S, Khoutorsky A, Maldonado-Bouchard S, Stein L, Gerstein L, Crawhall-Duk H, Pearl R, Sukosd M, Leger P, Hardt OM, Yachnin D, Austin JS, Chan CM, Pooters T, Groves I, Martin LJ, Sonenberg N, Gkogkas CG, Mogil JS.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5515-5520. doi: 10.1073/pnas.1703477114. Epub 2017 May 8.

48.

N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density.

Svitkin YV, Cheng YM, Chakraborty T, Presnyak V, John M, Sonenberg N.

Nucleic Acids Res. 2017 Jun 2;45(10):6023-6036. doi: 10.1093/nar/gkx135.

49.

A continuum of mRNP complexes in embryonic microRNA-mediated silencing.

Wu E, Vashisht AA, Chapat C, Flamand MN, Cohen E, Sarov M, Tabach Y, Sonenberg N, Wohlschlegel J, Duchaine TF.

Nucleic Acids Res. 2017 Feb 28;45(4):2081-2098. doi: 10.1093/nar/gkw872.

50.

Acute Fasting Regulates Retrograde Synaptic Enhancement through a 4E-BP-Dependent Mechanism.

Kauwe G, Tsurudome K, Penney J, Mori M, Gray L, Calderon MR, Elazouzzi F, Chicoine N, Sonenberg N, Haghighi AP.

Neuron. 2016 Dec 21;92(6):1204-1212. doi: 10.1016/j.neuron.2016.10.063. Epub 2016 Dec 1.

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