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Items: 1 to 50 of 601

1.

HGF-induced migration depends on the PI(3,4,5)P3-binding microexon-spliced variant of the Arf6 exchange factor cytohesin-1.

Ratcliffe CDH, Siddiqui N, Coelho PP, Laterreur N, Cookey TN, Sonenberg N, Park M.

J Cell Biol. 2018 Nov 7. pii: jcb.201804106. doi: 10.1083/jcb.201804106. [Epub ahead of print]

PMID:
30404949
2.

Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma.

Cerezo M, Guemiri R, Druillennec S, Girault I, Malka-Mahieu H, Shen S, Allard D, Martineau S, Welsch C, Agoussi S, Estrada C, Adam J, Libenciuc C, Routier E, Roy S, Désaubry L, Eggermont AM, Sonenberg N, Scoazec JY, Eychène A, Vagner S, Robert C.

Nat Med. 2018 Oct 29. doi: 10.1038/s41591-018-0217-1. [Epub ahead of print]

PMID:
30374200
3.

Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders.

Gantois I, Popic J, Khoutorsky A, Sonenberg N.

Annu Rev Med. 2018 Oct 26. doi: 10.1146/annurev-med-081117-041238. [Epub ahead of print]

PMID:
30365357
4.

Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis.

Zakaria C, Sean P, Hoang HD, Leroux LP, Watson M, Workenhe ST, Hearnden J, Pearl D, Truong VT, Robichaud N, Yanagiya A, Tahmasebi S, Jafarnejad SM, Jia JJ, Pelin A, Diallo JS, Le Boeuf F, Bell JC, Mossman KL, Graber TE, Jaramillo M, Sonenberg N, Alain T.

PLoS Pathog. 2018 Aug 23;14(8):e1007264. doi: 10.1371/journal.ppat.1007264. eCollection 2018 Aug.

5.

Protein Synthesis and Translational Control: A Historical Perspective.

Tahmasebi S, Sonenberg N, Hershey JWB, Mathews MB.

Cold Spring Harb Perspect Biol. 2018 Aug 6. pii: a035584. doi: 10.1101/cshperspect.a035584. [Epub ahead of print]

PMID:
30082466
6.

Translation deregulation in human disease.

Tahmasebi S, Khoutorsky A, Mathews MB, Sonenberg N.

Nat Rev Mol Cell Biol. 2018 Jul 23. doi: 10.1038/s41580-018-0034-x. [Epub ahead of print] Review.

PMID:
30038383
7.

Principles of Translational Control.

Hershey JWB, Sonenberg N, Mathews MB.

Cold Spring Harb Perspect Biol. 2018 Jun 29. pii: a032607. doi: 10.1101/cshperspect.a032607. [Epub ahead of print]

PMID:
29959195
8.

Translational Control in Cancer.

Robichaud N, Sonenberg N, Ruggero D, Schneider RJ.

Cold Spring Harb Perspect Biol. 2018 Jun 29. pii: a032896. doi: 10.1101/cshperspect.a032896. [Epub ahead of print]

PMID:
29959193
9.

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E.

Aguilar-Valles A, Haji N, De Gregorio D, Matta-Camacho E, Eslamizade MJ, Popic J, Sharma V, Cao R, Rummel C, Tanti A, Wiebe S, Nuñez N, Comai S, Nadon R, Luheshi G, Mechawar N, Turecki G, Lacaille JC, Gobbi G, Sonenberg N.

Nat Commun. 2018 Jun 25;9(1):2459. doi: 10.1038/s41467-018-04883-5.

10.

Neuronal Regulation of eIF2α Function in Health and Neurological Disorders.

Moon SL, Sonenberg N, Parker R.

Trends Mol Med. 2018 Jun;24(6):575-589. doi: 10.1016/j.molmed.2018.04.001. Epub 2018 Apr 30. Review.

PMID:
29716790
11.

Removing 4E-BP Enables Synapses to Refine without Postsynaptic Activity.

Chong Y, Saviuk N, Pie B, Basisty N, Quinn RK, Schilling B, Sonenberg N, Cooper E, Haghighi AP.

Cell Rep. 2018 Apr 3;23(1):11-22. doi: 10.1016/j.celrep.2018.03.040.

12.

mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction.

Liu D, Stowie A, de Zavalia N, Leise T, Pathak SS, Drewes LR, Davidson AJ, Amir S, Sonenberg N, Cao R.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3296-E3304. doi: 10.1073/pnas.1721578115. Epub 2018 Mar 19.

13.

Beyond molecular tumor heterogeneity: protein synthesis takes control.

Ramon Y Cajal S, Castellvi J, Hümmer S, Peg V, Pelletier J, Sonenberg N.

Oncogene. 2018 May;37(19):2490-2501. doi: 10.1038/s41388-018-0152-0. Epub 2018 Feb 21. Review.

14.

Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils.

Robichaud N, Hsu BE, Istomine R, Alvarez F, Blagih J, Ma EH, Morales SV, Dai DL, Li G, Souleimanova M, Guo Q, Del Rincon SV, Miller WH Jr, Ramón Y Cajal S, Park M, Jones RG, Piccirillo CA, Siegel PM, Sonenberg N.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2202-E2209. doi: 10.1073/pnas.1717439115. Epub 2018 Feb 20.

15.

The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer.

Ding M, Van der Kwast TH, Vellanki RN, Foltz WD, McKee TD, Sonenberg N, Pandolfi PP, Koritzinsky M, Wouters BG.

Mol Cancer Res. 2018 Apr;16(4):682-695. doi: 10.1158/1541-7786.MCR-17-0696. Epub 2018 Feb 16.

PMID:
29453322
16.

Translational control of ERK signaling through miRNA/4EHP-directed silencing.

Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N.

Elife. 2018 Feb 7;7. pii: e35034. doi: 10.7554/eLife.35034.

17.

Aminoacylation of Proteins: New Targets for the Old ARSenal.

Jafarnejad SM, Kim SH, Sonenberg N.

Cell Metab. 2018 Jan 9;27(1):1-3. doi: 10.1016/j.cmet.2017.12.012.

PMID:
29320701
18.

Eukaryotic initiation factor 4F-sidestepping resistance mechanisms arising from expression heterogeneity.

Chu J, Cajal SRY, Sonenberg N, Pelletier J.

Curr Opin Genet Dev. 2018 Feb;48:89-96. doi: 10.1016/j.gde.2017.11.002. Epub 2017 Nov 21. Review.

PMID:
29169064
19.

Structural Dynamics of the GW182 Silencing Domain Including its RNA Recognition motif (RRM) Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry.

Cieplak-Rotowska MK, Tarnowski K, Rubin M, Fabian MR, Sonenberg N, Dadlez M, Niedzwiecka A.

J Am Soc Mass Spectrom. 2018 Jan;29(1):158-173. doi: 10.1007/s13361-017-1830-9. Epub 2017 Oct 27.

20.

Profile of Michael N. Hall, 2017 Albert Lasker Basic Medical Research Awardee: Target of rapamycin, cell growth, and translational control.

Sonenberg N.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11564-11567. doi: 10.1073/pnas.1716203114. Epub 2017 Oct 19. No abstract available.

21.

Fragile X syndrome.

Hagerman RJ, Berry-Kravis E, Hazlett HC, Bailey DB Jr, Moine H, Kooy RF, Tassone F, Gantois I, Sonenberg N, Mandel JL, Hagerman PJ.

Nat Rev Dis Primers. 2017 Sep 29;3:17065. doi: 10.1038/nrdp.2017.65. Review.

PMID:
28960184
22.

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.

Morita M, Prudent J, Basu K, Goyon V, Katsumura S, Hulea L, Pearl D, Siddiqui N, Strack S, McGuirk S, St-Pierre J, Larsson O, Topisirovic I, Vali H, McBride HM, Bergeron JJ, Sonenberg N.

Mol Cell. 2017 Sep 21;67(6):922-935.e5. doi: 10.1016/j.molcel.2017.08.013. Epub 2017 Sep 14.

23.

Epiregulin and EGFR interactions are involved in pain processing.

Martin LJ, Smith SB, Khoutorsky A, Magnussen CA, Samoshkin A, Sorge RE, Cho C, Yosefpour N, Sivaselvachandran S, Tohyama S, Cole T, Khuong TM, Mir E, Gibson DG, Wieskopf JS, Sotocinal SG, Austin JS, Meloto CB, Gitt JH, Gkogkas C, Sonenberg N, Greenspan JD, Fillingim RB, Ohrbach R, Slade GD, Knott C, Dubner R, Nackley AG, Ribeiro-da-Silva A, Neely GG, Maixner W, Zaykin DV, Mogil JS, Diatchenko L.

J Clin Invest. 2017 Sep 1;127(9):3353-3366. doi: 10.1172/JCI87406. Epub 2017 Aug 7.

24.

Translation is actively regulated during the differentiation of CD8+ effector T cells.

Araki K, Morita M, Bederman AG, Konieczny BT, Kissick HT, Sonenberg N, Ahmed R.

Nat Immunol. 2017 Sep;18(9):1046-1057. doi: 10.1038/ni.3795. Epub 2017 Jul 17.

25.

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.

Blandino-Rosano M, Barbaresso R, Jimenez-Palomares M, Bozadjieva N, Werneck-de-Castro JP, Hatanaka M, Mirmira RG, Sonenberg N, Liu M, Rüegg MA, Hall MN, Bernal-Mizrachi E.

Nat Commun. 2017 Jul 12;8:16014. doi: 10.1038/ncomms16014.

26.

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

Garzia A, Jafarnejad SM, Meyer C, Chapat C, Gogakos T, Morozov P, Amiri M, Shapiro M, Molina H, Tuschl T, Sonenberg N.

Nat Commun. 2017 Jul 7;8:16056. doi: 10.1038/ncomms16056.

27.

The MNK-eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain.

Moy JK, Khoutorsky A, Asiedu MN, Black BJ, Kuhn JL, Barragán-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio JJ, Mogil JS, Dussor G, Sonenberg N, Price TJ.

J Neurosci. 2017 Aug 2;37(31):7481-7499. doi: 10.1523/JNEUROSCI.0220-17.2017. Epub 2017 Jul 3.

28.

Translational control and the cancer cell response to stress.

Robichaud N, Sonenberg N.

Curr Opin Cell Biol. 2017 Apr;45:102-109. doi: 10.1016/j.ceb.2017.05.007. Epub 2017 Jun 2. Review.

PMID:
28582681
29.

Muscle metabolic alterations induced by genetic ablation of 4E-BP1 and 4E-BP2 in response to diet-induced obesity.

Le Bacquer O, Combe K, Montaurier C, Salles J, Giraudet C, Patrac V, Domingues-Faria C, Guillet C, Louche K, Boirie Y, Sonenberg N, Moro C, Walrand S.

Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201700128. Epub 2017 Jul 3.

PMID:
28544394
30.

Metformin ameliorates core deficits in a mouse model of fragile X syndrome.

Gantois I, Khoutorsky A, Popic J, Aguilar-Valles A, Freemantle E, Cao R, Sharma V, Pooters T, Nagpal A, Skalecka A, Truong VT, Wiebe S, Groves IA, Jafarnejad SM, Chapat C, McCullagh EA, Gamache K, Nader K, Lacaille JC, Gkogkas CG, Sonenberg N.

Nat Med. 2017 Jun;23(6):674-677. doi: 10.1038/nm.4335. Epub 2017 May 15.

PMID:
28504725
31.

Cap-binding protein 4EHP effects translation silencing by microRNAs.

Chapat C, Jafarnejad SM, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF, Sonenberg N.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5425-5430. doi: 10.1073/pnas.1701488114. Epub 2017 May 9.

32.

Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes.

Tuttle AH, Tansley S, Dossett K, Tohyama S, Khoutorsky A, Maldonado-Bouchard S, Stein L, Gerstein L, Crawhall-Duk H, Pearl R, Sukosd M, Leger P, Hardt OM, Yachnin D, Austin JS, Chan CM, Pooters T, Groves I, Martin LJ, Sonenberg N, Gkogkas CG, Mogil JS.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5515-5520. doi: 10.1073/pnas.1703477114. Epub 2017 May 8.

33.

N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density.

Svitkin YV, Cheng YM, Chakraborty T, Presnyak V, John M, Sonenberg N.

Nucleic Acids Res. 2017 Jun 2;45(10):6023-6036. doi: 10.1093/nar/gkx135.

34.

A continuum of mRNP complexes in embryonic microRNA-mediated silencing.

Wu E, Vashisht AA, Chapat C, Flamand MN, Cohen E, Sarov M, Tabach Y, Sonenberg N, Wohlschlegel J, Duchaine TF.

Nucleic Acids Res. 2017 Feb 28;45(4):2081-2098. doi: 10.1093/nar/gkw872.

35.

Acute Fasting Regulates Retrograde Synaptic Enhancement through a 4E-BP-Dependent Mechanism.

Kauwe G, Tsurudome K, Penney J, Mori M, Gray L, Calderon MR, Elazouzzi F, Chicoine N, Sonenberg N, Haghighi AP.

Neuron. 2016 Dec 21;92(6):1204-1212. doi: 10.1016/j.neuron.2016.10.063. Epub 2016 Dec 1.

36.

Proposing a mechanism of action for ataluren.

Siddiqui N, Sonenberg N.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12353-12355. Epub 2016 Oct 19. No abstract available.

37.

Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2.

Tahmasebi S, Jafarnejad SM, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, Bourque G, Yang XJ, Tian B, Stunnenberg HG, Yamanaka Y, Blencowe BJ, Giguère V, Sonenberg N.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12360-12367. Epub 2016 Oct 24.

38.

eIF2α phosphorylation controls thermal nociception.

Khoutorsky A, Sorge RE, Prager-Khoutorsky M, Pawlowski SA, Longo G, Jafarnejad SM, Tahmasebi S, Martin LJ, Pitcher MH, Gkogkas CG, Sharif-Naeini R, Ribeiro-da-Silva A, Bourque CW, Cervero F, Mogil JS, Sonenberg N.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11949-11954. Epub 2016 Oct 3.

39.

Transcriptional induction of 4E-BP3 prolongs translation repression.

Tsukumo Y, Sonenberg N, Alain T.

Cell Cycle. 2016 Dec 16;15(24):3325-3326. doi: 10.1080/15384101.2016.1224786. Epub 2016 Aug 26. No abstract available.

40.

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs.

Signer RA, Qi L, Zhao Z, Thompson D, Sigova AA, Fan ZP, DeMartino GN, Young RA, Sonenberg N, Morrison SJ.

Genes Dev. 2016 Aug 1;30(15):1698-703. doi: 10.1101/gad.282756.116. Epub 2016 Aug 4.

41.

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer.

Chio IIC, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Öhlund D, Wright K, Filippini D, Lee EJ, Da Silva B, Schoepfer C, Wilkinson JE, Buscaglia JM, DeNicola GM, Tiriac H, Hammell M, Crawford HC, Schmidt EE, Thompson CB, Pappin DJ, Sonenberg N, Tuveson DA.

Cell. 2016 Aug 11;166(4):963-976. doi: 10.1016/j.cell.2016.06.056. Epub 2016 Jul 28.

42.

LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction.

Penney J, Tsurudome K, Liao EH, Kauwe G, Gray L, Yanagiya A, R Calderon M, Sonenberg N, Haghighi AP.

Nat Commun. 2016 Jul 19;7:12188. doi: 10.1038/ncomms12188.

43.

Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells.

Bhat M, Yanagiya A, Graber T, Razumilava N, Bronk S, Zammit D, Zhao Y, Zakaria C, Metrakos P, Pollak M, Sonenberg N, Gores G, Jaramillo M, Morita M, Alain T.

Oncotarget. 2016 Jul 18;8(31):50542-50556. doi: 10.18632/oncotarget.10671. eCollection 2017 Aug 1.

44.

Diverse cap-binding properties of Drosophila eIF4E isoforms.

Zuberek J, Kuchta K, Hernández G, Sonenberg N, Ginalski K.

Biochim Biophys Acta. 2016 Oct;1864(10):1292-303. doi: 10.1016/j.bbapap.2016.06.015. Epub 2016 Jun 29.

PMID:
27374989
45.

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3.

Tsukumo Y, Alain T, Fonseca BD, Nadon R, Sonenberg N.

Nat Commun. 2016 Jun 20;7:11776. doi: 10.1038/ncomms11776.

46.

Translational control by 5'-untranslated regions of eukaryotic mRNAs.

Hinnebusch AG, Ivanov IP, Sonenberg N.

Science. 2016 Jun 17;352(6292):1413-6. doi: 10.1126/science.aad9868. Review.

PMID:
27313038
47.

The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes.

So L, Lee J, Palafox M, Mallya S, Woxland CG, Arguello M, Truitt ML, Sonenberg N, Ruggero D, Fruman DA.

Sci Signal. 2016 May 31;9(430):ra57. doi: 10.1126/scisignal.aad8463.

48.

4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass.

Blandino-Rosano M, Scheys JO, Jimenez-Palomares M, Barbaresso R, Bender AS, Yanagiya A, Liu M, Rui L, Sonenberg N, Bernal-Mizrachi E.

Diabetes. 2016 Aug;65(8):2235-48. doi: 10.2337/db15-1443. Epub 2016 May 23.

49.

S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.

Wang F, Alain T, Szretter KJ, Stephenson K, Pol JG, Atherton MJ, Hoang HD, Fonseca BD, Zakaria C, Chen L, Rangwala Z, Hesch A, Chan ESY, Tuinman C, Suthar MS, Jiang Z, Ashkar AA, Thomas G, Kozma SC, Gale M Jr, Fitzgerald KA, Diamond MS, Mossman K, Sonenberg N, Wan Y, Lichty BD.

Nat Immunol. 2016 May;17(5):514-522. doi: 10.1038/ni.3433. Epub 2016 Apr 4.

50.

mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons.

Skalecka A, Liszewska E, Bilinski R, Gkogkas C, Khoutorsky A, Malik AR, Sonenberg N, Jaworski J.

Dev Neurobiol. 2016 Dec;76(12):1308-1327. doi: 10.1002/dneu.22392. Epub 2016 Apr 7.

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