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Items: 43

1.

Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas.

Saponara E, Visentin M, Baschieri F, Seleznik G, Martinelli P, Esposito I, Buschmann J, Chen R, Parrotta R, Borgeaud N, Bombardo M, Malagola E, Caflisch A, Farhan H, Graf R, Sonda S.

J Pathol. 2018 Nov;246(3):352-365. doi: 10.1002/path.5147. Epub 2018 Oct 4.

PMID:
30058725
2.

Enhanced proliferation of pancreatic acinar cells in MRL/MpJ mice is driven by severe acinar injury but independent of inflammation.

Bombardo M, Malagola E, Chen R, Carta A, Seleznik GM, Hills AP, Graf R, Sonda S.

Sci Rep. 2018 Jun 20;8(1):9391. doi: 10.1038/s41598-018-27422-0.

3.

Inhibition of Class I Histone Deacetylases Abrogates Tumor Growth Factor β Expression and Development of Fibrosis during Chronic Pancreatitis.

Bombardo M, Chen R, Malagola E, Saponara E, Hills AP, Graf R, Sonda S.

Mol Pharmacol. 2018 Aug;94(2):793-801. doi: 10.1124/mol.117.110924. Epub 2018 Jun 7.

PMID:
29880639
4.

Class I histone deacetylase inhibition improves pancreatitis outcome by limiting leukocyte recruitment and acinar-to-ductal metaplasia.

Bombardo M, Saponara E, Malagola E, Chen R, Seleznik GM, Haumaitre C, Quilichini E, Zabel A, Reding T, Graf R, Sonda S.

Br J Pharmacol. 2017 Nov;174(21):3865-3880. doi: 10.1111/bph.13984. Epub 2017 Sep 20.

5.

Development of autoimmune pancreatitis is independent of CDKN1A/p21-mediated pancreatic inflammation.

Seleznik GM, Reding T, Peter L, Gupta A, Steiner SG, Sonda S, Verbeke CS, Dejardin E, Khatkov I, Segerer S, Heikenwalder M, Graf R.

Gut. 2018 Sep;67(9):1663-1673. doi: 10.1136/gutjnl-2016-313458. Epub 2017 Aug 3.

PMID:
28774888
6.

Ibuprofen and diclofenac treatments reduce proliferation of pancreatic acinar cells upon inflammatory injury and mitogenic stimulation.

Bombardo M, Malagola E, Chen R, Rudnicka A, Graf R, Sonda S.

Br J Pharmacol. 2018 Jan;175(2):335-347. doi: 10.1111/bph.13867. Epub 2017 Jun 16.

PMID:
28542719
7.

1-Deoxysphingolipid-induced neurotoxicity involves N-methyl-d-aspartate receptor signaling.

Güntert T, Hänggi P, Othman A, Suriyanarayanan S, Sonda S, Zuellig RA, Hornemann T, Ogunshola OO.

Neuropharmacology. 2016 Nov;110(Pt A):211-222. doi: 10.1016/j.neuropharm.2016.03.033. Epub 2016 Mar 23.

PMID:
27016021
8.

Inactivation of TGFβ receptor II signalling in pancreatic epithelial cells promotes acinar cell proliferation, acinar-to-ductal metaplasia and fibrosis during pancreatitis.

Grabliauskaite K, Saponara E, Reding T, Bombardo M, Seleznik GM, Malagola E, Zabel A, Faso C, Sonda S, Graf R.

J Pathol. 2016 Feb;238(3):434-45. doi: 10.1002/path.4666. Epub 2015 Nov 28.

PMID:
26510396
9.

Serotonin promotes acinar dedifferentiation following pancreatitis-induced regeneration in the adult pancreas.

Saponara E, Grabliauskaite K, Bombardo M, Buzzi R, Silva AB, Malagola E, Tian Y, Hehl AB, Schraner EM, Seleznik GM, Zabel A, Reding T, Sonda S, Graf R.

J Pathol. 2015 Dec;237(4):495-507. doi: 10.1002/path.4595. Epub 2015 Sep 10.

10.

p21(WAF1) (/Cip1) limits senescence and acinar-to-ductal metaplasia formation during pancreatitis.

Grabliauskaite K, Hehl AB, Seleznik GM, Saponara E, Schlesinger K, Zuellig RA, Dittmann A, Bain M, Reding T, Sonda S, Graf R.

J Pathol. 2015 Feb;235(3):502-14. doi: 10.1002/path.4440. Epub 2014 Nov 6.

11.

Deoxysphingolipids, novel biomarkers for type 2 diabetes, are cytotoxic for insulin-producing cells.

Zuellig RA, Hornemann T, Othman A, Hehl AB, Bode H, Güntert T, Ogunshola OO, Saponara E, Grabliauskaite K, Jang JH, Ungethuem U, Wei Y, von Eckardstein A, Graf R, Sonda S.

Diabetes. 2014 Apr;63(4):1326-39. doi: 10.2337/db13-1042. Epub 2013 Dec 30.

12.

Toxoplasma gondii salvages sphingolipids from the host Golgi through the rerouting of selected Rab vesicles to the parasitophorous vacuole.

Romano JD, Sonda S, Bergbower E, Smith ME, Coppens I.

Mol Biol Cell. 2013 Jun;24(12):1974-95. doi: 10.1091/mbc.E12-11-0827. Epub 2013 Apr 24.

13.

Introduction of caveolae structural proteins into the protozoan Toxoplasma results in the formation of heterologous caveolae but not caveolar endocytosis.

Lige B, Romano JD, Sampels V, Sonda S, Joiner KA, Coppens I.

PLoS One. 2012;7(12):e51773. doi: 10.1371/journal.pone.0051773. Epub 2012 Dec 14.

14.

Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii.

Pratt S, Wansadhipathi-Kannangara NK, Bruce CR, Mina JG, Shams-Eldin H, Casas J, Hanada K, Schwarz RT, Sonda S, Denny PW.

Mol Biochem Parasitol. 2013 Jan;187(1):43-51. doi: 10.1016/j.molbiopara.2012.11.007. Epub 2012 Dec 16.

15.

Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

Yoshida T, Akahoshi F, Sakashita H, Kitajima H, Nakamura M, Sonda S, Takeuchi M, Tanaka Y, Ueda N, Sekiguchi S, Ishige T, Shima K, Nabeno M, Abe Y, Anabuki J, Soejima A, Yoshida K, Takashina Y, Ishii S, Kiuchi S, Fukuda S, Tsutsumiuchi R, Kosaka K, Murozono T, Nakamaru Y, Utsumi H, Masutomi N, Kishida H, Miyaguchi I, Hayashi Y.

Bioorg Med Chem. 2012 Oct 1;20(19):5705-19. doi: 10.1016/j.bmc.2012.08.012. Epub 2012 Aug 17.

PMID:
22959556
16.

Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group.

Yoshida T, Akahoshi F, Sakashita H, Sonda S, Takeuchi M, Tanaka Y, Nabeno M, Kishida H, Miyaguchi I, Hayashi Y.

Bioorg Med Chem. 2012 Aug 15;20(16):5033-41. doi: 10.1016/j.bmc.2012.06.033. Epub 2012 Jul 5.

PMID:
22824762
17.

The herpes simplex virus 1 U(S)3 regulates phospholipid synthesis.

Wild P, de Oliveira AP, Sonda S, Schraner EM, Ackermann M, Tobler K.

Virology. 2012 Oct 25;432(2):353-60. doi: 10.1016/j.virol.2012.06.020. Epub 2012 Jul 11.

18.

Serotonin regulates amylase secretion and acinar cell damage during murine pancreatitis.

Sonda S, Silva AB, Grabliauskaite K, Saponara E, Weber A, Jang JH, Züllig RA, Bain M, Reding Graf T, Hehl AB, Graf R.

Gut. 2013 Jun;62(6):890-8. doi: 10.1136/gutjnl-2011-301724. Epub 2012 May 16.

PMID:
22591619
19.

Herpes simplex virus 1 induces de novo phospholipid synthesis.

Sutter E, de Oliveira AP, Tobler K, Schraner EM, Sonda S, Kaech A, Lucas MS, Ackermann M, Wild P.

Virology. 2012 Aug 1;429(2):124-35. doi: 10.1016/j.virol.2012.04.004. Epub 2012 May 5.

20.

COX-2 is not required for the development of murine chronic pancreatitis.

Silva A, Weber A, Bain M, Reding T, Heikenwalder M, Sonda S, Graf R.

Am J Physiol Gastrointest Liver Physiol. 2011 Jun;300(6):G968-75. doi: 10.1152/ajpgi.00497.2010. Epub 2011 Mar 3.

21.

The P-glycoprotein inhibitor GF120918 modulates Ca2+-dependent processes and lipid metabolism in Toxoplasma gondii.

Bottova I, Sauder U, Olivieri V, Hehl AB, Sonda S.

PLoS One. 2010 Apr 8;5(4):e10062. doi: 10.1371/journal.pone.0010062.

22.

Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia.

Stefanić S, Spycher C, Morf L, Fabriàs G, Casas J, Schraner E, Wild P, Hehl AB, Sonda S.

J Lipid Res. 2010 Sep;51(9):2527-45. doi: 10.1194/jlr.M003392. Epub 2010 Mar 24.

23.

Epigenetic mechanisms regulate stage differentiation in the minimized protozoan Giardia lamblia.

Sonda S, Morf L, Bottova I, Baetschmann H, Rehrauer H, Caflisch A, Hakimi MA, Hehl AB.

Mol Microbiol. 2010 Apr;76(1):48-67. doi: 10.1111/j.1365-2958.2010.07062.x. Epub 2010 Feb 1.

24.

Neogenesis and maturation of transient Golgi-like cisternae in a simple eukaryote.

Stefanic S, Morf L, Kulangara C, Regös A, Sonda S, Schraner E, Spycher C, Wild P, Hehl AB.

J Cell Sci. 2009 Aug 15;122(Pt 16):2846-56. doi: 10.1242/jcs.049411. Epub 2009 Jul 21.

25.

Host cell P-glycoprotein is essential for cholesterol uptake and replication of Toxoplasma gondii.

Bottova I, Hehl AB, Stefanić S, Fabriàs G, Casas J, Schraner E, Pieters J, Sonda S.

J Biol Chem. 2009 Jun 26;284(26):17438-48. doi: 10.1074/jbc.M809420200. Epub 2009 Apr 22.

26.

A sphingolipid inhibitor induces a cytokinesis arrest and blocks stage differentiation in Giardia lamblia.

Sonda S, Stefanic S, Hehl AB.

Antimicrob Agents Chemother. 2008 Feb;52(2):563-9. Epub 2007 Dec 17.

27.

1,5-Benzodioxepin derivatives as a novel class of muscarinic M3 receptor antagonists.

Sonda S, Katayama K, Fujio M, Sakashita H, Inaba K, Asano K, Akira T.

Bioorg Med Chem Lett. 2007 Feb 15;17(4):925-31. Epub 2006 Nov 22.

PMID:
17188867
28.

Lipid biology of Apicomplexa: perspectives for new drug targets, particularly for Toxoplasma gondii.

Sonda S, Hehl AB.

Trends Parasitol. 2006 Jan;22(1):41-7. Epub 2005 Nov 21. Review.

PMID:
16300997
29.

Neospora caninum protein disulfide isomerase is involved in tachyzoite-host cell interaction.

Naguleswaran A, Alaeddine F, Guionaud C, Vonlaufen N, Sonda S, Jenoe P, Mevissen M, Hemphill A.

Int J Parasitol. 2005 Nov;35(13):1459-72. Epub 2005 Jul 25.

PMID:
16129440
30.

Inhibitory effect of aureobasidin A on Toxoplasma gondii.

Sonda S, Sala G, Ghidoni R, Hemphill A, Pieters J.

Antimicrob Agents Chemother. 2005 May;49(5):1794-801.

31.

Synthesis and pharmacological evaluation of benzamide derivatives as selective 5-HT(4) receptor agonists.

Sonda S, Kawahara T, Katayama K, Sato N, Asano K.

Bioorg Med Chem. 2005 May 2;13(9):3295-308.

PMID:
15809165
32.

Synthesis and pharmacological properties of benzamide derivatives as selective serotonin 4 receptor agonists.

Sonda S, Katayama K, Kawahara T, Sato N, Asano K.

Bioorg Med Chem. 2004 May 15;12(10):2737-47.

PMID:
15110855
33.

Design and synthesis of orally active benzamide derivatives as potent serotonin 4 receptor agonist.

Sonda S, Kawahara T, Murozono T, Sato N, Asano K, Haga K.

Bioorg Med Chem. 2003 Sep 15;11(19):4225-34.

PMID:
12951153
34.

Pyridinylimidazole p38 mitogen-activated protein kinase inhibitors block intracellular Toxoplasma gondii replication.

Wei S, Marches F, Daniel B, Sonda S, Heidenreich K, Curiel T.

Int J Parasitol. 2002 Jul;32(8):969-77.

PMID:
12076626
35.

Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii.

Sonda S, Ting LM, Novak S, Kim K, Maher JJ, Farese RV Jr, Ernst JD.

J Biol Chem. 2001 Sep 14;276(37):34434-40. Epub 2001 Jul 16.

36.

Synthesis and pharmacological evaluation of carboxamide derivatives as selective serotoninergic 5-HT(4) receptor agonists.

Itoh K, Kanzaki K, Ikebe T, Kuroita T, Tomozane H, Sonda S, Sato N, Haga K, Kawakita T.

Eur J Med Chem. 1999 Nov 1;34(11):977-989.

PMID:
10889321
37.

Molecular characterization of a novel microneme antigen in Neospora caninum.

Sonda S, Fuchs N, Gottstein B, Hemphill A.

Mol Biochem Parasitol. 2000 Apr 30;108(1):39-51.

PMID:
10802317
38.

The antigenic composition of Neospora caninum.

Hemphill A, Fuchs N, Sonda S, Hehl A.

Int J Parasitol. 1999 Aug;29(8):1175-88. Review.

PMID:
10576569
39.

The major 36 kDa Neospora caninum tachyzoite surface protein is closely related to the major Toxoplasma gondii surface antigen.

Sonda S, Fuchs N, Connolly B, Fernandez P, Gottstein B, Hemphill A.

Mol Biochem Parasitol. 1998 Nov 30;97(1-2):97-108.

PMID:
9879890
40.
41.

Identification and characterisation of a dense granule-associated protein in Neospora caninum tachyzoites.

Hemphill A, Gajendran N, Sonda S, Fuchs N, Gottstein B, Hentrich B, Jenkins M.

Int J Parasitol. 1998 Mar;28(3):429-38.

PMID:
9559361
42.

Sequence completion, identification and definition of the fengycin operon in Bacillus subtilis 168.

Tosato V, Albertini AM, Zotti M, Sonda S, Bruschi CV.

Microbiology. 1997 Nov;143 ( Pt 11):3443-50.

PMID:
9387222
43.

Identification and partial characterization of a 36 kDa surface protein on Neospora caninum tachyzoites.

Hemphill A, Fuchs N, Sonda S, Gottstein B, Hentrich B.

Parasitology. 1997 Oct;115 ( Pt 4):371-80.

PMID:
9364563

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