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Items: 19


Increased plasma membrane cholesterol in cystic fibrosis cells correlates with CFTR genotype and depends on de novo cholesterol synthesis.

Fang D, West RH, Manson ME, Ruddy J, Jiang D, Previs SF, Sonawane ND, Burgess JD, Kelley TJ.

Respir Res. 2010 May 20;11:61. doi: 10.1186/1465-9921-11-61.


Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model.

Tradtrantip L, Sonawane ND, Namkung W, Verkman AS.

J Med Chem. 2009 Oct 22;52(20):6447-55. doi: 10.1021/jm9009873.


Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis.

Sonawane ND, Verkman AS.

Bioorg Med Chem. 2008 Sep 1;16(17):8187-95. doi: 10.1016/j.bmc.2008.07.044. Epub 2008 Jul 23.


Nanomolar CFTR inhibition by pore-occluding divalent polyethylene glycol-malonic acid hydrazides.

Sonawane ND, Zhao D, Zegarra-Moran O, Galietta LJ, Verkman AS.

Chem Biol. 2008 Jul 21;15(7):718-28. doi: 10.1016/j.chembiol.2008.05.015.


Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease.

Yang B, Sonawane ND, Zhao D, Somlo S, Verkman AS.

J Am Soc Nephrol. 2008 Jul;19(7):1300-10. doi: 10.1681/ASN.2007070828. Epub 2008 Apr 2.


Alpha-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic fibrosis transmembrane conductance regulator chloride channel activity.

Sonawane ND, Zegarra-Moran O, Namkung W, Galietta LJ, Verkman AS.

J Pharmacol Exp Ther. 2008 May;325(2):529-35. doi: 10.1124/jpet.107.132357. Epub 2008 Feb 13.


Comparative transport efficiencies of urea analogues through urea transporter UT-B.

Zhao D, Sonawane ND, Levin MH, Yang B.

Biochim Biophys Acta. 2007 Jul;1768(7):1815-21. Epub 2007 Apr 18.


Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera.

Sonawane ND, Zhao D, Zegarra-Moran O, Galietta LJ, Verkman AS.

Gastroenterology. 2007 Apr;132(4):1234-44. Epub 2007 Feb 7.


Small molecules with antimicrobial activity against E. coli and P. aeruginosa identified by high-throughput screening.

De La Fuente R, Sonawane ND, Arumainayagam D, Verkman AS.

Br J Pharmacol. 2006 Nov;149(5):551-9. Epub 2006 Sep 18.


Luminally active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid loss in cholera.

Sonawane ND, Hu J, Muanprasat C, Verkman AS.

FASEB J. 2006 Jan;20(1):130-2. Epub 2005 Nov 29.


In vivo pharmacology and antidiarrheal efficacy of a thiazolidinone CFTR inhibitor in rodents.

Sonawane ND, Muanprasat C, Nagatani R Jr, Song Y, Verkman AS.

J Pharm Sci. 2005 Jan;94(1):134-43.


Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating.

Pedemonte N, Sonawane ND, Taddei A, Hu J, Zegarra-Moran O, Suen YF, Robins LI, Dicus CW, Willenbring D, Nantz MH, Kurth MJ, Galietta LJ, Verkman AS.

Mol Pharmacol. 2005 May;67(5):1797-807. Epub 2005 Feb 18.


ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation.

Hara-Chikuma M, Yang B, Sonawane ND, Sasaki S, Uchida S, Verkman AS.

J Biol Chem. 2005 Jan 14;280(2):1241-7. Epub 2004 Oct 25.


Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models.

Song Y, Sonawane ND, Salinas D, Qian L, Pedemonte N, Galietta LJ, Verkman AS.

J Biol Chem. 2004 Sep 24;279(39):40629-33. Epub 2004 Jul 26.


Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy.

Muanprasat C, Sonawane ND, Salinas D, Taddei A, Galietta LJ, Verkman AS.

J Gen Physiol. 2004 Aug;124(2):125-37.


Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes.

Sonawane ND, Szoka FC Jr, Verkman AS.

J Biol Chem. 2003 Nov 7;278(45):44826-31. Epub 2003 Aug 27.


Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, Galietta LJ, Verkman AS.

J Clin Invest. 2002 Dec;110(11):1651-8.


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