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Report on the 2018 Cancer, Autoimmunity, and Immunology Conference.

Curran CS, Sommers CL, Young HA, Bourcier K, Mancini M, Sharon E.

J Immunol. 2019 May 15;202(10):2823-2828. doi: 10.4049/jimmunol.1900264. Epub 2019 Apr 15.


Perceived images and expected roles of Indonesian nurses.

Sommers CL, Tarihoran DE, Sembel S, Tzeng HM.

Nurs Open. 2018 May 17;5(4):501-506. doi: 10.1002/nop2.156. eCollection 2018 Oct.


Measurement of critical thinking, clinical reasoning, and clinical judgment in culturally diverse nursing students - A literature review.

Sommers CL.

Nurse Educ Pract. 2018 May;30:91-100. doi: 10.1016/j.nepr.2018.04.002. Epub 2018 Apr 12. Review. No abstract available.


Unexpected Cartilage Phenotype in CD4-Cre-Conditional SOS-Deficient Mice.

Guittard G, Gallardo DL, Li W, Melis N, Lui JC, Kortum RL, Shakarishvili NG, Huh S, Baron J, Weigert R, Kramer JA, Samelson LE, Sommers CL.

Front Immunol. 2017 Mar 23;8:343. doi: 10.3389/fimmu.2017.00343. eCollection 2017.


Hierarchical nanostructure and synergy of multimolecular signalling complexes.

Sherman E, Barr VA, Merrill RK, Regan CK, Sommers CL, Samelson LE.

Nat Commun. 2016 Jul 11;7:12161. doi: 10.1038/ncomms12161.


miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways.

Rouquette-Jazdanian AK, Kortum RL, Li W, Merrill RK, Nguyen PH, Samelson LE, Sommers CL.

PLoS One. 2015 Jun 29;10(6):e0131823. doi: 10.1371/journal.pone.0131823. eCollection 2015.


Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.

Rodriguez-Peña AB, Gomez-Rodriguez J, Kortum RL, Palmer DC, Yu Z, Guittard GC, Wohlfert EA, Silver PB, Misplon JA, Sommers CL, Feigenbaum L, Epstein SL, Caspi RR, Belkaid Y, Restifo NP, Samelson LE, Balagopalan L.

Gene Ther. 2015 Oct;22(10):781-92. doi: 10.1038/gt.2015.48. Epub 2015 Jun 18.


Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.

Guittard G, Kortum RL, Balagopalan L, Çuburu N, Nguyen P, Sommers CL, Samelson LE.

Eur J Immunol. 2015 Aug;45(8):2389-95. doi: 10.1002/eji.201445226. Epub 2015 Jun 5.


Considering culture in the use of problem-based learning to improve critical thinking - is it important?

Sommers CL.

Nurse Educ Today. 2014 Jul;34(7):1109-11. doi: 10.1016/j.nedt.2014.03.010. Epub 2014 Mar 27. No abstract available.


Diacylglycerol kinase ζ limits the generation of natural regulatory T cells.

Schmidt AM, Zou T, Joshi RP, Leichner TM, Pimentel MA, Sommers CL, Kambayashi T.

Sci Signal. 2013 Nov 26;6(303):ra101. doi: 10.1126/scisignal.2004411.


The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.

Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, Merrill RK, Nguyen PH, Li W, Agarwal I, Akpan IO, Sommers CL, Samelson LE.

Sci Signal. 2013 Nov 12;6(301):ra99. doi: 10.1126/scisignal.2004494.


miRNA signature of mouse helper T cell hyper-proliferation.

Sommers CL, Rouquette-Jazdanian AK, Robles AI, Kortum RL, Merrill RK, Li W, Nath N, Wohlfert E, Sixt KM, Belkaid Y, Samelson LE.

PLoS One. 2013 Jun 25;8(6):e66709. doi: 10.1371/journal.pone.0066709. Print 2013.


A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.

Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL.

J Immunol. 2013 Jan 1;190(1):147-58. doi: 10.4049/jimmunol.1201458. Epub 2012 Dec 3.


LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation.

Rouquette-Jazdanian AK, Sommers CL, Kortum RL, Morrison DK, Samelson LE.

Mol Cell. 2012 Oct 26;48(2):298-312. doi: 10.1016/j.molcel.2012.08.011. Epub 2012 Sep 13.


Deconstructing Ras signaling in the thymus.

Kortum RL, Sommers CL, Pinski JM, Alexander CP, Merrill RK, Li W, Love PE, Samelson LE.

Mol Cell Biol. 2012 Jul;32(14):2748-59. doi: 10.1128/MCB.00317-12. Epub 2012 May 14.


Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor.

Sherman E, Barr V, Manley S, Patterson G, Balagopalan L, Akpan I, Regan CK, Merrill RK, Sommers CL, Lippincott-Schwartz J, Samelson LE.

Immunity. 2011 Nov 23;35(5):705-20. doi: 10.1016/j.immuni.2011.10.004. Epub 2011 Nov 4.


Targeted Sos1 deletion reveals its critical role in early T-cell development.

Kortum RL, Sommers CL, Alexander CP, Pinski JM, Li W, Grinberg A, Lee J, Love PE, Samelson LE.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12407-12. doi: 10.1073/pnas.1104295108. Epub 2011 Jul 11.


The LAT story: a tale of cooperativity, coordination, and choreography.

Balagopalan L, Coussens NP, Sherman E, Samelson LE, Sommers CL.

Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a005512. doi: 10.1101/cshperspect.a005512. Epub 2010 Jul 7. Review.


Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.

Miyaji M, Kortum RL, Surana R, Li W, Woolard KD, Simpson RM, Samelson LE, Sommers CL.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14502-7. doi: 10.1073/pnas.0903894106. Epub 2009 Aug 10.


Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps.

Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE.

Mol Biol Cell. 2008 Jul;19(7):2802-17. doi: 10.1091/mbc.E08-02-0146. Epub 2008 Apr 30.


Bam32: a novel mediator of Erk activation in T cells.

Sommers CL, Gurson JM, Surana R, Barda-Saad M, Lee J, Kishor A, Li W, Gasser AJ, Barr VA, Miyaji M, Love PE, Samelson LE.

Int Immunol. 2008 Jul;20(7):811-8. doi: 10.1093/intimm/dxn039. Epub 2008 Apr 29.


c-Cbl-mediated regulation of LAT-nucleated signaling complexes.

Balagopalan L, Barr VA, Sommers CL, Barda-Saad M, Goyal A, Isakowitz MS, Samelson LE.

Mol Cell Biol. 2007 Dec;27(24):8622-36. Epub 2007 Oct 15.


Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains.

Braiman A, Barda-Saad M, Sommers CL, Samelson LE.

EMBO J. 2006 Feb 22;25(4):774-84. Epub 2006 Feb 9.


Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.

Sommers CL, Lee J, Steiner KL, Gurson JM, Depersis CL, El-Khoury D, Fuller CL, Shores EW, Love PE, Samelson LE.

J Exp Med. 2005 Apr 4;201(7):1125-34. Epub 2005 Mar 28.


Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice.

Chiang YJ, Sommers CL, Jordan MS, Gu H, Samelson LE, Koretzky GA, Hodes RJ.

J Exp Med. 2004 Jul 5;200(1):25-34.


Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes.

Woodside KJ, Shen H, Muntzel C, Daller JA, Sommers CL, Love PE.

Gene Expr Patterns. 2004 May;4(3):315-20.


LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways.

Sommers CL, Samelson LE, Love PE.

Bioessays. 2004 Jan;26(1):61-7. Review.


The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation.

Saitoh S, Odom S, Gomez G, Sommers CL, Young HA, Rivera J, Samelson LE.

J Exp Med. 2003 Sep 1;198(5):831-43.


A LAT mutation that inhibits T cell development yet induces lymphoproliferation.

Sommers CL, Park CS, Lee J, Feng C, Fuller CL, Grinberg A, Hildebrand JA, Lacaná E, Menon RK, Shores EW, Samelson LE, Love PE.

Science. 2002 Jun 14;296(5575):2040-3.


Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.

Sommers CL, Menon RK, Grinberg A, Zhang W, Samelson LE, Love PE.

J Exp Med. 2001 Jul 16;194(2):135-42.


Fine tuning of TCR signaling by CD5.

Azzam HS, DeJarnette JB, Huang K, Emmons R, Park CS, Sommers CL, El-Khoury D, Shores EW, Love PE.

J Immunol. 2001 May 1;166(9):5464-72.


Function of CD3 epsilon-mediated signals in T cell development.

Sommers CL, Dejarnette JB, Huang K, Lee J, El-Khoury D, Shores EW, Love PE.

J Exp Med. 2000 Sep 18;192(6):913-19.


LAT is essential for Fc(epsilon)RI-mediated mast cell activation.

Saitoh S, Arudchandran R, Manetz TS, Zhang W, Sommers CL, Love PE, Rivera J, Samelson LE.

Immunity. 2000 May;12(5):525-35.


RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation.

Rajagopal K, Sommers CL, Decker DC, Mitchell EO, Korthauer U, Sperling AI, Kozak CA, Love PE, Bluestone JA.

J Exp Med. 1999 Dec 6;190(11):1657-68.


LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.

Pasquet JM, Gross B, Quek L, Asazuma N, Zhang W, Sommers CL, Schweighoffer E, Tybulewicz V, Judd B, Lee JR, Koretzky G, Love PE, Samelson LE, Watson SP.

Mol Cell Biol. 1999 Dec;19(12):8326-34.


A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection.

Sommers CL, Rabin RL, Grinberg A, Tsay HC, Farber J, Love PE.

J Exp Med. 1999 Nov 15;190(10):1427-38.


Essential role of LAT in T cell development.

Zhang W, Sommers CL, Burshtyn DN, Stebbins CC, DeJarnette JB, Trible RP, Grinberg A, Tsay HC, Jacobs HM, Kessler CM, Long EO, Love PE, Samelson LE.

Immunity. 1999 Mar;10(3):323-32.


Specific requirement for CD3epsilon in T cell development.

DeJarnette JB, Sommers CL, Huang K, Woodside KJ, Emmons R, Katz K, Shores EW, Love PE.

Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14909-14.


T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma).

Shores EW, Ono M, Kawabe T, Sommers CL, Tran T, Lui K, Udey MC, Ravetch J, Love PE.

J Exp Med. 1998 Apr 6;187(7):1093-101.


Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire.

Shores EW, Tran T, Grinberg A, Sommers CL, Shen H, Love PE.

J Exp Med. 1997 Mar 3;185(5):893-900.


Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow.

Huang K, Sommers CL, Grinberg A, Kozak CA, Love PE.

Oncogene. 1996 Oct 3;13(7):1567-73.


The role of cadherin-mediated adhesion in breast cancer.

Sommers CL.

J Mammary Gland Biol Neoplasia. 1996 Apr;1(2):219-29. Review.


Murine txk: a protein tyrosine kinase gene regulated by T cell activation.

Sommers CL, Huang K, Shores EW, Grinberg A, Charlick DA, Kozak CA, Love PE.

Oncogene. 1995 Jul 20;11(2):245-51.


Regulation of vimentin gene transcription in human breast cancer cell lines.

Sommers CL, Skerker JM, Chrysogelos SA, Bosseler M, Gelmann EP.

Cell Growth Differ. 1994 Aug;5(8):839-46.


Alterations in beta-catenin phosphorylation and plakoglobin expression in human breast cancer cells.

Sommers CL, Gelmann EP, Kemler R, Cowin P, Byers SW.

Cancer Res. 1994 Jul 1;54(13):3544-52.


Oncogene-induced basement membrane invasiveness in human mammary epithelial cells.

Thompson EW, Torri J, Sabol M, Sommers CL, Byers S, Valverius EM, Martin GR, Lippman ME, Stampfer MR, Dickson RB.

Clin Exp Metastasis. 1994 May;12(3):181-94.


Differentiation state and invasiveness of human breast cancer cell lines.

Sommers CL, Byers SW, Thompson EW, Torri JA, Gelmann EP.

Breast Cancer Res Treat. 1994;31(2-3):325-35.


Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines.

Sommers CL, Heckford SE, Skerker JM, Worland P, Torri JA, Thompson EW, Byers SW, Gelmann EP.

Cancer Res. 1992 Oct 1;52(19):5190-7.


Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines.

Thompson EW, Paik S, Brünner N, Sommers CL, Zugmaier G, Clarke R, Shima TB, Torri J, Donahue S, Lippman ME, et al.

J Cell Physiol. 1992 Mar;150(3):534-44.


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