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Items: 33


Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function.

Salter AI, Ivey RG, Kennedy JJ, Voillet V, Rajan A, Alderman EJ, Voytovich UJ, Lin C, Sommermeyer D, Liu L, Whiteaker JR, Gottardo R, Paulovich AG, Riddell SR.

Sci Signal. 2018 Aug 21;11(544). pii: eaat6753. doi: 10.1126/scisignal.aat6753.


Development of T-cell immunotherapy for hematopoietic stem cell transplantation recipients at risk of leukemia relapse.

Dossa RG, Cunningham T, Sommermeyer D, Medina-Rodriguez I, Biernacki MA, Foster K, Bleakley M.

Blood. 2018 Jan 4;131(1):108-120. doi: 10.1182/blood-2017-07-791608. Epub 2017 Oct 19.


REM Sleep Imposes a Vascular Load in COPD Patients Independent of Sleep Apnea.

Grote L, Sommermeyer D, Ficker J, Randerath W, Penzel T, Fietze I, Sanner B, Hedner J, Schneider H.

COPD. 2017 Dec;14(6):565-572. doi: 10.1080/15412555.2017.1365119. Epub 2017 Sep 26.


Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.

Kammertoens T, Friese C, Arina A, Idel C, Briesemeister D, Rothe M, Ivanov A, Szymborska A, Patone G, Kunz S, Sommermeyer D, Engels B, Leisegang M, Textor A, Fehling HJ, Fruttiger M, Lohoff M, Herrmann A, Yu H, Weichselbaum R, Uckert W, Hübner N, Gerhardt H, Beule D, Schreiber H, Blankenstein T.

Nature. 2017 May 4;545(7652):98-102. doi: 10.1038/nature22311. Epub 2017 Apr 26.


Fully human CD19-specific chimeric antigen receptors for T-cell therapy.

Sommermeyer D, Hill T, Shamah SM, Salter AI, Chen Y, Mohler KM, Riddell SR.

Leukemia. 2017 Oct;31(10):2191-2199. doi: 10.1038/leu.2017.57. Epub 2017 Feb 16.


Analysis of ROR1 Protein Expression in Human Cancer and Normal Tissues.

Balakrishnan A, Goodpaster T, Randolph-Habecker J, Hoffstrom BG, Jalikis FG, Koch LK, Berger C, Kosasih PL, Rajan A, Sommermeyer D, Porter PL, Riddell SR.

Clin Cancer Res. 2017 Jun 15;23(12):3061-3071. doi: 10.1158/1078-0432.CCR-16-2083. Epub 2016 Nov 16.


Vascular stiffness determined from a nocturnal digital pulse wave signal: association with sleep, sleep-disordered breathing, and hypertension.

Svedmyr S, Zou D, Sommermeyer D, Ficker JH, Randerath W, Fietze I, Sanner B, Hedner J, Grote L.

J Hypertens. 2016 Dec;34(12):2427-2433.


Targeted antibody-mediated depletion of murine CD19 CAR T cells permanently reverses B cell aplasia.

Paszkiewicz PJ, Fräßle SP, Srivastava S, Sommermeyer D, Hudecek M, Drexler I, Sadelain M, Liu L, Jensen MC, Riddell SR, Busch DH.

J Clin Invest. 2016 Nov 1;126(11):4262-4272. doi: 10.1172/JCI84813. Epub 2016 Oct 17.


Parameters of Overnight Pulse Wave under Treatment in Obstructive Sleep Apnea.

Randerath WJ, Treml M, Priegnitz C, Hedner J, Sommermeyer D, Zou D, Ficker JH, Fietze I, Penzel T, Sanner B, Grote L.

Respiration. 2016;92(3):136-43. doi: 10.1159/000448248. Epub 2016 Aug 31.


CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients.

Turtle CJ, Hanafi LA, Berger C, Gooley TA, Cherian S, Hudecek M, Sommermeyer D, Melville K, Pender B, Budiarto TM, Robinson E, Steevens NN, Chaney C, Soma L, Chen X, Yeung C, Wood B, Li D, Cao J, Heimfeld S, Jensen MC, Riddell SR, Maloney DG.

J Clin Invest. 2016 Jun 1;126(6):2123-38. doi: 10.1172/JCI85309. Epub 2016 Apr 25.


Role of memory T cell subsets for adoptive immunotherapy.

Busch DH, Fräßle SP, Sommermeyer D, Buchholz VR, Riddell SR.

Semin Immunol. 2016 Feb;28(1):28-34. doi: 10.1016/j.smim.2016.02.001. Epub 2016 Mar 11. Review.


Inclusion of Strep-tag II in design of antigen receptors for T-cell immunotherapy.

Liu L, Sommermeyer D, Cabanov A, Kosasih P, Hill T, Riddell SR.

Nat Biotechnol. 2016 Apr;34(4):430-4. doi: 10.1038/nbt.3461. Epub 2016 Feb 22.


Detection of cardiovascular risk from a photoplethysmographic signal using a matching pursuit algorithm.

Sommermeyer D, Zou D, Ficker JH, Randerath W, Fischer C, Penzel T, Sanner B, Hedner J, Grote L.

Med Biol Eng Comput. 2016 Jul;54(7):1111-21. doi: 10.1007/s11517-015-1410-8. Epub 2015 Nov 4.


Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo.

Sommermeyer D, Hudecek M, Kosasih PL, Gogishvili T, Maloney DG, Turtle CJ, Riddell SR.

Leukemia. 2016 Feb;30(2):492-500. doi: 10.1038/leu.2015.247. Epub 2015 Sep 15.


Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells.

Berger C, Sommermeyer D, Hudecek M, Berger M, Balakrishnan A, Paszkiewicz PJ, Kosasih PL, Rader C, Riddell SR.

Cancer Immunol Res. 2015 Feb;3(2):206-16. doi: 10.1158/2326-6066.CIR-14-0163. Epub 2014 Oct 29.


The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity.

Hudecek M, Sommermeyer D, Kosasih PL, Silva-Benedict A, Liu L, Rader C, Jensen MC, Riddell SR.

Cancer Immunol Res. 2015 Feb;3(2):125-35. doi: 10.1158/2326-6066.CIR-14-0127. Epub 2014 Sep 11.


Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells.

Pinto S, Sommermeyer D, Michel C, Wilde S, Schendel D, Uckert W, Blankenstein T, Kyewski B.

Eur J Immunol. 2014 Sep;44(9):2811-21. doi: 10.1002/eji.201444499. Epub 2014 Aug 18.


Adoptive therapy with chimeric antigen receptor-modified T cells of defined subset composition.

Riddell SR, Sommermeyer D, Berger C, Liu LS, Balakrishnan A, Salter A, Hudecek M, Maloney DG, Turtle CJ.

Cancer J. 2014 Mar-Apr;20(2):141-4. doi: 10.1097/PPO.0000000000000036. Review.


The use of overnight pulse wave analysis for recognition of cardiovascular risk factors and risk: a multicentric evaluation.

Sommermeyer D, Zou D, Eder DN, Hedner J, Ficker JH, Randerath W, Priegnitz C, Penzel T, Fietze I, Sanner B, Grote L.

J Hypertens. 2014 Feb;32(2):276-85. doi: 10.1097/HJH.0000000000000039.


Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes.

Smith SN, Sommermeyer D, Piepenbrink KH, Blevins SJ, Bernhard H, Uckert W, Baker BM, Kranz DM.

J Mol Biol. 2013 Nov 15;425(22):4496-507. doi: 10.1016/j.jmb.2013.08.007. Epub 2013 Aug 14.


Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells.

Hudecek M, Lupo-Stanghellini MT, Kosasih PL, Sommermeyer D, Jensen MC, Rader C, Riddell SR.

Clin Cancer Res. 2013 Jun 15;19(12):3153-64. doi: 10.1158/1078-0432.CCR-13-0330. Epub 2013 Apr 25.


Detection of sleep disordered breathing and its central/obstructive character using nasal cannula and finger pulse oximeter.

Sommermeyer D, Zou D, Grote L, Hedner J.

J Clin Sleep Med. 2012 Oct 15;8(5):527-33. doi: 10.5664/jcsm.2148.


NY-ESO-1 antigen-reactive T cell receptors exhibit diverse therapeutic capability.

Sommermeyer D, Conrad H, Krönig H, Gelfort H, Bernhard H, Uckert W.

Int J Cancer. 2013 Mar 15;132(6):1360-7. doi: 10.1002/ijc.27792. Epub 2012 Sep 14.


Human antitumor CD8+ T cells producing Th1 polycytokines show superior antigen sensitivity and tumor recognition.

Wilde S, Sommermeyer D, Leisegang M, Frankenberger B, Mosetter B, Uckert W, Schendel DJ.

J Immunol. 2012 Jul 15;189(2):598-605. doi: 10.4049/jimmunol.1102165. Epub 2012 Jun 11.


Oximeter-based autonomic state indicator algorithm for cardiovascular risk assessment.

Grote L, Sommermeyer D, Zou D, Eder DN, Hedner J.

Chest. 2011 Feb;139(2):253-259. doi: 10.1378/chest.09-3029. Epub 2010 Jul 29.


Minimal amino acid exchange in human TCR constant regions fosters improved function of TCR gene-modified T cells.

Sommermeyer D, Uckert W.

J Immunol. 2010 Jun 1;184(11):6223-31. doi: 10.4049/jimmunol.0902055. Epub 2010 May 5.


Tumor rejection by local interferon gamma induction in established tumors is associated with blood vessel destruction and necrosis.

Briesemeister D, Sommermeyer D, Loddenkemper C, Loew R, Uckert W, Blankenstein T, Kammertoens T.

Int J Cancer. 2011 Jan 15;128(2):371-8. doi: 10.1002/ijc.25350. Epub 2010 Mar 23.


A single TCR alpha-chain with dominant peptide recognition in the allorestricted HER2/neu-specific T cell repertoire.

Liang X, Weigand LU, Schuster IG, Eppinger E, van der Griendt JC, Schub A, Leisegang M, Sommermeyer D, Anderl F, Han Y, Ellwart J, Moosmann A, Busch DH, Uckert W, Peschel C, Krackhardt AM.

J Immunol. 2010 Feb 1;184(3):1617-29. doi: 10.4049/jimmunol.0902155. Epub 2009 Dec 30.


Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional avidity.

Wilde S, Sommermeyer D, Frankenberger B, Schiemann M, Milosevic S, Spranger S, Pohla H, Uckert W, Busch DH, Schendel DJ.

Blood. 2009 Sep 3;114(10):2131-9. doi: 10.1182/blood-2009-03-209387. Epub 2009 Jul 8.


Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette.

Leisegang M, Engels B, Meyerhuber P, Kieback E, Sommermeyer D, Xue SA, Reuss S, Stauss H, Uckert W.

J Mol Med (Berl). 2008 May;86(5):573-83. doi: 10.1007/s00109-008-0317-3. Epub 2008 Mar 12. Erratum in: J Mol Med. 2008 Jul;86(7):855.


A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer.

Kieback E, Charo J, Sommermeyer D, Blankenstein T, Uckert W.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):623-8. doi: 10.1073/pnas.0710198105. Epub 2008 Jan 8.


Designer T cells by T cell receptor replacement.

Sommermeyer D, Neudorfer J, Weinhold M, Leisegang M, Engels B, Noessner E, Heemskerk MH, Charo J, Schendel DJ, Blankenstein T, Bernhard H, Uckert W.

Eur J Immunol. 2006 Nov;36(11):3052-9.

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