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Items: 1 to 50 of 71

1.

Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer.

Unterleuthner D, Neuhold P, Schwarz K, Janker L, Neuditschko B, Nivarthi H, Crncec I, Kramer N, Unger C, Hengstschläger M, Eferl R, Moriggl R, Sommergruber W, Gerner C, Dolznig H.

Angiogenesis. 2019 Oct 30. doi: 10.1007/s10456-019-09688-8. [Epub ahead of print]

PMID:
31667643
2.

SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines.

Ehrenhöfer-Wölfer K, Puchner T, Schwarz C, Rippka J, Blaha-Ostermann S, Strobl U, Hörmann A, Bader G, Kornigg S, Zahn S, Sommergruber W, Schweifer N, Zichner T, Schlattl A, Neumüller RA, Shi J, Vakoc CR, Kögl M, Petronczki M, Kraut N, Pearson MA, Wöhrle S.

Sci Rep. 2019 Aug 12;9(1):11661. doi: 10.1038/s41598-019-48152-x.

3.

Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis.

Weinstabl H, Treu M, Rinnenthal J, Zahn SK, Ettmayer P, Bader G, Dahmann G, Kessler D, Rumpel K, Mischerikow N, Savarese F, Gerstberger T, Mayer M, Zoephel A, Schnitzer R, Sommergruber W, Martinelli P, Arnhof H, Peric-Simov B, Hofbauer KS, Garavel G, Scherbantin Y, Mitzner S, Fett TN, Scholz G, Bruchhaus J, Burkard M, Kousek R, Ciftci T, Sharps B, Schrenk A, Harrer C, Haering D, Wolkerstorfer B, Zhang X, Lv X, Du A, Li D, Li Y, Quant J, Pearson M, McConnell DB.

J Med Chem. 2019 Sep 12;62(17):7976-7997. doi: 10.1021/acs.jmedchem.9b00718. Epub 2019 Aug 14.

PMID:
31365252
4.

Induction of Acquired Resistance towards EGFR Inhibitor Gefitinib in a Patient-Derived Xenograft Model of Non-Small Cell Lung Cancer and Subsequent Molecular Characterization.

Schueler J, Tschuch C, Klingner K, Bug D, Peille AL, de Koning L, Oswald E, Klett H, Sommergruber W.

Cells. 2019 Jul 18;8(7). pii: E740. doi: 10.3390/cells8070740.

5.

First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro.

Wernitznig D, Kiakos K, Del Favero G, Harrer N, Machat H, Osswald A, Jakupec MA, Wernitznig A, Sommergruber W, Keppler BK.

Metallomics. 2019 Jun 19;11(6):1044-1048. doi: 10.1039/c9mt00051h.

PMID:
30942231
6.

3D-3 Tumor Models in Drug Discovery for Analysis of Immune Cell Infiltration.

Osswald A, Hedrich V, Sommergruber W.

Methods Mol Biol. 2019;1953:151-162. doi: 10.1007/978-1-4939-9145-7_10.

PMID:
30912021
7.

PREDECT Protocols for Complex 2D/3D Cultures.

Vidic S, Estrada MF, Gjerde K, Santo VE, Osswald A, Barbier M, Chong YT, Sommergruber W, de Hoogt R, Brito C, Graeser R.

Methods Mol Biol. 2019;1888:1-20. doi: 10.1007/978-1-4939-8891-4_1.

PMID:
30519938
8.

3D-3-culture: A tool to unveil macrophage plasticity in the tumour microenvironment.

Rebelo SP, Pinto C, Martins TR, Harrer N, Estrada MF, Loza-Alvarez P, Cabeçadas J, Alves PM, Gualda EJ, Sommergruber W, Brito C.

Biomaterials. 2018 May;163:185-197. doi: 10.1016/j.biomaterials.2018.02.030. Epub 2018 Feb 13.

9.

Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours.

Närhi K, Nagaraj AS, Parri E, Turkki R, van Duijn PW, Hemmes A, Lahtela J, Uotinen V, Mäyränpää MI, Salmenkivi K, Räsänen J, Linder N, Trapman J, Rannikko A, Kallioniemi O, Af Hällström TM, Lundin J, Sommergruber W, Anders S, Verschuren EW.

J Pathol. 2018 May;245(1):101-113. doi: 10.1002/path.5059. Epub 2018 Apr 2. Erratum in: J Pathol. 2019 Jan;247(1):147.

10.

Organotypic three-dimensional cancer cell cultures mirror drug responses in vivo: lessons learned from the inhibition of EGFR signaling.

Jacobi N, Seeboeck R, Hofmann E, Schweiger H, Smolinska V, Mohr T, Boyer A, Sommergruber W, Lechner P, Pichler-Huebschmann C, Önder K, Hundsberger H, Wiesner C, Eger A.

Oncotarget. 2017 Nov 17;8(64):107423-107440. doi: 10.18632/oncotarget.22475. eCollection 2017 Dec 8.

11.

Protocols and characterization data for 2D, 3D, and slice-based tumor models from the PREDECT project.

de Hoogt R, Estrada MF, Vidic S, Davies EJ, Osswald A, Barbier M, Santo VE, Gjerde K, van Zoggel HJAA, Blom S, Dong M, Närhi K, Boghaert E, Brito C, Chong Y, Sommergruber W, van der Kuip H, van Weerden WM, Verschuren EW, Hickman J, Graeser R.

Sci Data. 2017 Nov 21;4:170170. doi: 10.1038/sdata.2017.170.

12.

Autocrine WNT2 signaling in fibroblasts promotes colorectal cancer progression.

Kramer N, Schmöllerl J, Unger C, Nivarthi H, Rudisch A, Unterleuthner D, Scherzer M, Riedl A, Artaker M, Crncec I, Lenhardt D, Schwarz T, Prieler B, Han X, Hengstschläger M, Schüler J, Eferl R, Moriggl R, Sommergruber W, Dolznig H.

Oncogene. 2017 Sep 28;36(39):5460-5472. doi: 10.1038/onc.2017.144. Epub 2017 May 29.

PMID:
28553956
13.

Stromal-derived IGF2 promotes colon cancer progression via paracrine and autocrine mechanisms.

Unger C, Kramer N, Unterleuthner D, Scherzer M, Burian A, Rudisch A, Stadler M, Schlederer M, Lenhardt D, Riedl A, Walter S, Wernitznig A, Kenner L, Hengstschläger M, Schüler J, Sommergruber W, Dolznig H.

Oncogene. 2017 Sep 21;36(38):5341-5355. doi: 10.1038/onc.2017.116. Epub 2017 May 22.

PMID:
28534511
14.

Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery.

Stock K, Estrada MF, Vidic S, Gjerde K, Rudisch A, Santo VE, Barbier M, Blom S, Arundkar SC, Selvam I, Osswald A, Stein Y, Gruenewald S, Brito C, van Weerden W, Rotter V, Boghaert E, Oren M, Sommergruber W, Chong Y, de Hoogt R, Graeser R.

Sci Rep. 2016 Jul 1;6:28951. doi: 10.1038/srep28951.

15.

Three-dimensional tumor spheroids for in vitro analysis of bacteria as gene delivery vectors in tumor therapy.

Osswald A, Sun Z, Grimm V, Ampem G, Riegel K, Westendorf AM, Sommergruber W, Otte K, Dürre P, Riedel CU.

Microb Cell Fact. 2015 Dec 12;14:199. doi: 10.1186/s12934-015-0383-5.

16.

High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts.

Rudisch A, Dewhurst MR, Horga LG, Kramer N, Harrer N, Dong M, van der Kuip H, Wernitznig A, Bernthaler A, Dolznig H, Sommergruber W.

PLoS One. 2015 Apr 28;10(4):e0124283. doi: 10.1371/journal.pone.0124283. eCollection 2015.

17.

IGFBP7, a novel tumor stroma marker, with growth-promoting effects in colon cancer through a paracrine tumor-stroma interaction.

Rupp C, Scherzer M, Rudisch A, Unger C, Haslinger C, Schweifer N, Artaker M, Nivarthi H, Moriggl R, Hengstschläger M, Kerjaschki D, Sommergruber W, Dolznig H, Garin-Chesa P.

Oncogene. 2015 Feb 12;34(7):815-25. doi: 10.1038/onc.2014.18. Epub 2014 Mar 17.

PMID:
24632618
18.

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis.

Lötsch D, Steiner E, Holzmann K, Spiegl-Kreinecker S, Pirker C, Hlavaty J, Petznek H, Hegedus B, Garay T, Mohr T, Sommergruber W, Grusch M, Berger W.

Oncotarget. 2013 Nov;4(11):1904-18.

19.

Integrative analysis of prostate cancer aggressiveness.

Feik E, Schweifer N, Baierl A, Sommergruber W, Haslinger C, Hofer P, Maj-Hes A, Madersbacher S, Gsur A.

Prostate. 2013 Sep;73(13):1413-26. doi: 10.1002/pros.22688. Epub 2013 Jun 27.

PMID:
23813660
20.

Expression of G protein-coupled receptor 19 in human lung cancer cells is triggered by entry into S-phase and supports G(2)-M cell-cycle progression.

Kastner S, Voss T, Keuerleber S, Glöckel C, Freissmuth M, Sommergruber W.

Mol Cancer Res. 2012 Oct;10(10):1343-58. doi: 10.1158/1541-7786.MCR-12-0139. Epub 2012 Aug 21.

21.

BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.

Hilberg F, Roth GJ, Krssak M, Kautschitsch S, Sommergruber W, Tontsch-Grunt U, Garin-Chesa P, Bader G, Zoephel A, Quant J, Heckel A, Rettig WJ.

Cancer Res. 2008 Jun 15;68(12):4774-82. doi: 10.1158/0008-5472.CAN-07-6307.

22.

hGPR87 contributes to viability of human tumor cells.

Glatt S, Halbauer D, Heindl S, Wernitznig A, Kozina D, Su KC, Puri C, Garin-Chesa P, Sommergruber W.

Int J Cancer. 2008 May 1;122(9):2008-16. doi: 10.1002/ijc.23349.

23.

c-Myc is required for transformation of FDC-P1 cells by EGFRvIII.

Rath O, Himmler A, Baum A, Sommergruber W, Beug H, Metz T.

FEBS Lett. 2007 May 29;581(13):2549-56. Epub 2007 May 8.

24.

The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity.

Aigner K, Dampier B, Descovich L, Mikula M, Sultan A, Schreiber M, Mikulits W, Brabletz T, Strand D, Obrist P, Sommergruber W, Schweifer N, Wernitznig A, Beug H, Foisner R, Eger A.

Oncogene. 2007 Oct 25;26(49):6979-88. Epub 2007 May 7.

25.

The leader region of Laminin B1 mRNA confers cap-independent translation.

Petz M, Kozina D, Huber H, Siwiec T, Seipelt J, Sommergruber W, Mikulits W.

Nucleic Acids Res. 2007;35(8):2473-82. Epub 2007 Mar 29.

26.

The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression.

Aigner K, Descovich L, Mikula M, Sultan A, Dampier B, Bonné S, van Roy F, Mikulits W, Schreiber M, Brabletz T, Sommergruber W, Schweifer N, Wernitznig A, Beug H, Foisner R, Eger A.

FEBS Lett. 2007 Apr 17;581(8):1617-24. Epub 2007 Mar 21.

27.

Leukemia-associated antigenic isoforms induce a specific immune response in children with T-ALL.

Dohnal AM, Inthal A, Felzmann T, Glatt S, Sommergruber W, Mann G, Gadner H, Panzer-Grümayer ER.

Int J Cancer. 2006 Dec 15;119(12):2870-7.

28.

Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis.

Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P.

Cancer Immun. 2006 Jul 31;6:10.

29.

Impact of constitutive IGF1/IGF2 stimulation on the transcriptional program of human breast cancer cells.

Pacher M, Seewald MJ, Mikula M, Oehler S, Mogg M, Vinatzer U, Eger A, Schweifer N, Varecka R, Sommergruber W, Mikulits W, Schreiber M.

Carcinogenesis. 2007 Jan;28(1):49-59. Epub 2006 Jun 14.

PMID:
16774935
30.

Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation.

Ferby I, Reschke M, Kudlacek O, Knyazev P, Pantè G, Amann K, Sommergruber W, Kraut N, Ullrich A, Fässler R, Klein R.

Nat Med. 2006 May;12(5):568-73. Epub 2006 Apr 30. Erratum in: Nat Med. 2006 Jul;12(7):862.

PMID:
16648858
31.

Increased expression of extracellular proteins as a hallmark of human endothelial cell in vitro senescence.

Hampel B, Fortschegger K, Ressler S, Chang MW, Unterluggauer H, Breitwieser A, Sommergruber W, Fitzky B, Lepperdinger G, Jansen-Dürr P, Voglauer R, Grillari J.

Exp Gerontol. 2006 May;41(5):474-81. Epub 2006 Apr 19.

PMID:
16626901
32.

Laser capture microdissection of epithelial cancers guided by antibodies against fibroblast activation protein and endosialin.

Rupp C, Dolznig H, Puri C, Schweifer N, Sommergruber W, Kraut N, Rettig WJ, Kerjaschki D, Garin-Chesa P.

Diagn Mol Pathol. 2006 Mar;15(1):35-42.

PMID:
16531767
33.

Aberrant expression of caspase-14 in epithelial tumors.

Koenig U, Sommergruber W, Lippens S.

Biochem Biophys Res Commun. 2005 Sep 23;335(2):309-13.

PMID:
16061209
34.

Bone morphogenetic protein 3B silencing in non-small-cell lung cancer.

Dai Z, Popkie AP, Zhu WG, Timmers CD, Raval A, Tannehill-Gregg S, Morrison CD, Auer H, Kratzke RA, Niehans G, Amatschek S, Sommergruber W, Leone GW, Rosol T, Otterson GA, Plass C.

Oncogene. 2004 Apr 29;23(20):3521-9.

PMID:
15116090
35.

Tissue-wide expression profiling using cDNA subtraction and microarrays to identify tumor-specific genes.

Amatschek S, Koenig U, Auer H, Steinlein P, Pacher M, Gruenfelder A, Dekan G, Vogl S, Kubista E, Heider KH, Stratowa C, Schreiber M, Sommergruber W.

Cancer Res. 2004 Feb 1;64(3):844-56.

36.

Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different.

Gradi A, Svitkin YV, Sommergruber W, Imataka H, Morino S, Skern T, Sonenberg N.

J Virol. 2003 Apr;77(8):5026-9.

37.

Identification of HLA-A*0201-restricted T cell epitopes derived from the novel overexpressed tumor antigen calcium-activated chloride channel 2.

Konopitzky R, König U, Meyer RG, Sommergruber W, Wölfel T, Schweighoffer T.

J Immunol. 2002 Jul 1;169(1):540-7.

38.

Identification and characterization of 9D7, a novel human protein overexpressed in renal cell carcinoma.

Klade CS, Dohnal A, Fürst W, Sommergruber W, Heider KH, Gharwan H, Ratschek M, Adolf GR.

Int J Cancer. 2002 Jan 10;97(2):217-24. Erratum in: Int J Cancer 2002 Apr 20;98(6):956.

39.

Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer.

Scherl-Mostageer M, Sommergruber W, Abseher R, Hauptmann R, Ambros P, Schweifer N.

Oncogene. 2001 Jul 19;20(32):4402-8.

40.

Variability in gene expression patterns of Ewing tumor cell lines differing in EWS-FLI1 fusion type.

Aryee DN, Sommergruber W, Muehlbacher K, Dockhorn-Dworniczak B, Zoubek A, Kovar H.

Lab Invest. 2000 Dec;80(12):1833-44.

41.

2A proteinase of human rhinovirus cleaves cytokeratin 8 in infected HeLa cells.

Seipelt J, Liebig HD, Sommergruber W, Gerner C, Kuechler E.

J Biol Chem. 2000 Jun 30;275(26):20084-9.

42.

The structures of picornaviral proteinases.

Seipelt J, Guarné A, Bergmann E, James M, Sommergruber W, Fita I, Skern T.

Virus Res. 1999 Aug;62(2):159-68. Review.

PMID:
10507325
43.

Development of in vitro peptide substrates for human rhinovirus-14 2A protease.

Wang QM, Johnson RB, Sommergruber W, Shepherd TA.

Arch Biochem Biophys. 1998 Aug 1;356(1):12-8.

PMID:
9681985
44.

Mutational analyses support a model for the HRV2 2A proteinase.

Sommergruber W, Seipelt J, Fessl F, Skern T, Liebig HD, Casari G.

Virology. 1997 Aug 4;234(2):203-14.

46.

Cleavage specificity of human rhinovirus-2 2A protease for peptide substrates.

Wang QM, Sommergruber W, Johnson RB.

Biochem Biophys Res Commun. 1997 Jun 27;235(3):562-6.

PMID:
9207196
47.

Human rhinovirus 2A proteinase mutant and its second-site revertants.

Luderer-Gmach M, Liebig HD, Sommergruber W, Voss T, Fessl F, Skern T, Kuechler E.

Biochem J. 1996 Aug 15;318 ( Pt 1):213-8.

48.
49.

Cleavage specificity of purified recombinant hepatitis A virus 3C proteinase on natural substrates.

Schultheiss T, Sommergruber W, Kusov Y, Gauss-Müller V.

J Virol. 1995 Mar;69(3):1727-33.

50.

The 2A proteinase of human rhinovirus is a zinc containing enzyme.

Sommergruber W, Casari G, Fessl F, Seipelt J, Skern T.

Virology. 1994 Nov 1;204(2):815-8.

PMID:
7941352

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