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Items: 1 to 50 of 158

1.

Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor.

Sizun G, Pierra C, Peyronnet J, Badaroux E, Rabeson C, Benzaria-Prad S, Surleraux D, Loi AG, Musiu C, Liuzzi M, Seifer M, Standring D, Sommadossi JP, Gosselin G.

Future Med Chem. 2015;7(13):1675-700. doi: 10.4155/fmc.15.96. Epub 2015 Oct 1.

PMID:
26424162
2.

Synthesis and antiviral evaluation of 4'-C-azidomethyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides.

Griffon JF, Dumas A, Storer R, Sommadossi JP, Gosselin G.

Nucleosides Nucleotides Nucleic Acids. 2009 May;28(5):435-49. doi: 10.1080/15257770903044531.

PMID:
20183594
3.

Synthesis and antiviral evaluation of thieno[3,4-d]pyrimidine C-nucleoside analogues of 2',3'-dideoxy- and 2',3'-dideoxy-2',3'-didehydro-adenosine and -inosine.

Hamann M, Pierra C, Sommadossi JP, Musiu C, Vargiu L, Liuzzi M, Storer R, Gosselin G.

Bioorg Med Chem. 2009 Mar 15;17(6):2321-6. doi: 10.1016/j.bmc.2009.02.011. Epub 2009 Feb 14.

PMID:
19254848
4.

Synthesis of the first example of a nucleoside analogue bearing a 5'-deoxy-beta-D-allo-septanose as a seven-membered ring sugar moiety.

Sizun G, Dukhan D, Griffon JF, Griffe L, Meillon JC, Leroy F, Storer R, Sommadossi JP, Gosselin G.

Carbohydr Res. 2009 Mar 10;344(4):448-53. doi: 10.1016/j.carres.2008.12.019. Epub 2009 Jan 3.

PMID:
19147123
5.

Synthesis and antiviral evaluation of 4-fluoropyrazole-3-carboxamide nucleoside derivatives.

Leroy F, Chaves D, Dukhan D, Storer R, Sommadossi JP, Loi AG, Cadeddu A, Fanti M, Boscu N, Bassetti F, Liuzzi M, Gosselin G.

Nucleic Acids Symp Ser (Oxf). 2008;(52):617-8. doi: 10.1093/nass/nrn312.

PMID:
18776531
6.

Synthesis and antiviral evaluation of a seven-membered sugar ring nucleoside analog, 9-(5-deoxy-beta-D-allo-septanosyl)-adenine.

Sizun G, Griffon JF, Griffe L, Dukhan D, Storer R, Sommadossi JP, Loi AG, Musiu C, Poddesu B, Cadeddu A, Fanti M, Boscu N, Bassetti F, Liuzzi M, Gosselin G.

Nucleic Acids Symp Ser (Oxf). 2008;(52):611-2. doi: 10.1093/nass/nrn309.

PMID:
18776528
7.

Synthesis and study of 9-deazaguanosine derivatives as potential inhibitors of RNA virus replication.

Hamann M, Pierra C, Storer R, Sommadossi JP, Loi AG, Cadeddu A, Fanti M, Boscu N, Bassetti F, Liuzzi M, Gosselin G.

Nucleic Acids Symp Ser (Oxf). 2008;(52):603-4. doi: 10.1093/nass/nrn305.

PMID:
18776524
8.

Synthesis and antiviral evaluation of 7-fluoro-7-deaza-2-aminopurine nucleoside derivatives.

Leroy F, Chaves D, Dukhan D, Storer R, Sommadossi JP, Loi AG, Cadeddu A, Fanti M, Boscu N, Bassetti F, Liuzzi M, Gosselin G.

Nucleic Acids Symp Ser (Oxf). 2008;(52):595-6. doi: 10.1093/nass/nrn301.

PMID:
18776520
9.

Synthesis of beta-L-2'-deoxythymidine (L-dT).

Pierra C, Dukhan D, Gosselin G, Sommadossi JP.

Curr Protoc Nucleic Acid Chem. 2006 Apr;Chapter 14:Unit 14.3. doi: 10.1002/0471142700.nc1403s24.

PMID:
18428950
10.

Intracellular nucleoside triphosphate concentrations in HIV-infected patients on dual nucleoside reverse transcriptase inhibitor therapy.

Moore JD, Acosta EP, Johnson VA, Bassett R, Eron JJ, Fischl MA, Long MC, Kuritzkes DR, Sommadossi JP.

Antivir Ther. 2007;12(6):981-6.

PMID:
17926654
11.

2'-C-Methyl branched pyrimidine ribonucleoside analogues: potent inhibitors of RNA virus replication.

Benzaria S, Bardiot D, Bouisset T, Counor C, Rabeson C, Pierra C, Storer R, Loi AG, Cadeddu A, Mura M, Musiu C, Liuzzi M, Loddo R, Bergelson S, Bichko V, Bridges E, Cretton-Scott E, Mao J, Sommadossi JP, Seifer M, Standring D, Tausek M, Gosselin G, La Colla P.

Antivir Chem Chemother. 2007;18(4):225-42.

PMID:
17907380
12.

Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine.

Pierra C, Amador A, Benzaria S, Cretton-Scott E, D'Amours M, Mao J, Mathieu S, Moussa A, Bridges EG, Standring DN, Sommadossi JP, Storer R, Gosselin G.

J Med Chem. 2006 Nov 2;49(22):6614-20.

PMID:
17064080
13.

Synthesis, physicochemical and pharmacokinetic studies of potential prodrugs of beta-L-2'-deoxycytidine, a selective and specific anti-HBV agent.

Pierra C, Benzaria S, Dukhan D, Loi AG, La Colla P, Bridges E, Mao J, Standring D, Sommadossi JP, Gosselin G.

Antivir Chem Chemother. 2004 Sep;15(5):269-79.

PMID:
15535049
14.

Broad specificity of human phosphoglycerate kinase for antiviral nucleoside analogs.

Gallois-Montbrun S, Faraj A, Seclaman E, Sommadossi JP, Deville-Bonne D, Véron M.

Biochem Pharmacol. 2004 Nov 1;68(9):1749-56.

PMID:
15450940
16.

4'-C-methyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides revisited.

Griffon JF, Dukhan D, Pierra C, Benzaria S, Loi AG, La Colla P, Sommadossi JP, Gosselin G.

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):707-9.

PMID:
14565259
17.

A randomized trial to study first-line combination therapy with or without a protease inhibitor in HIV-1-infected patients.

van Leeuwen R, Katlama C, Murphy RL, Squires K, Gatell J, Horban A, Clotet B, Staszewski S, van Eeden A, Clumeck N, Moroni M, Pavia AT, Schmidt RE, Gonzalez-Lahoz J, Montaner J, Antunes F, Gulick R, Bánhegyi D, van der Valk M, Reiss P, van Weert L, van Leth F, Johnson VA, Sommadossi JP, Lange JM.

AIDS. 2003 May 2;17(7):987-99.

PMID:
12700448
18.

Synthesis and studies of 3'-C-trifluoromethyl nucleoside analogues bearing adenine or cytosine as the base.

Jeannot F, Gosselin G, Standring D, Bryant M, Sommadossi JP, Giulia Loi A, La Colla P, Mathé C.

Bioorg Med Chem. 2002 Oct;10(10):3153-61.

PMID:
12150860
19.

Pharmacology of beta-L-thymidine and beta-L-2'-deoxycytidine in HepG2 cells and primary human hepatocytes: relevance to chemotherapeutic efficacy against hepatitis B virus.

Hernandez-Santiago B, Placidi L, Cretton-Scott E, Faraj A, Bridges EG, Bryant ML, Rodriguez-Orengo J, Imbach JL, Gosselin G, Pierra C, Dukhan D, Sommadossi JP.

Antimicrob Agents Chemother. 2002 Jun;46(6):1728-33.

20.

Stable concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid during 2 years of therapy.

van Praag RM, van Weert EC, van Heeswijk RP, Zhou XJ, Sommadossi JP, Jurriaans S, Lange JM, Hoetelmans RM, Prins JM.

Antimicrob Agents Chemother. 2002 Mar;46(3):896-9.

21.

Symptomatic lactic acidosis in hospitalized antiretroviral-treated patients with human immunodeficiency virus infection: a report of 12 cases.

Coghlan ME, Sommadossi JP, Jhala NC, Many WJ, Saag MS, Johnson VA.

Clin Infect Dis. 2001 Dec 1;33(11):1914-21. Epub 2001 Oct 24.

PMID:
11692304
22.

Antiviral beta-L-nucleosides specific for hepatitis B virus infection.

Standring DN, Bridges EG, Placidi L, Faraj A, Loi AG, Pierra C, Dukhan D, Gosselin G, Imbach JL, Hernandez B, Juodawlkis A, Tennant B, Korba B, Cote P, Cretton-Scott E, Schinazi RF, Myers M, Bryant ML, Sommadossi JP.

Antivir Chem Chemother. 2001;12 Suppl 1:119-29.

PMID:
11594678
23.

Prototype trial design for rapid dose selection of antiretroviral drugs: an example using emtricitabine (Coviracil).

Rousseau FS, Kahn JO, Thompson M, Mildvan D, Shepp D, Sommadossi JP, Delehanty J, Simpson JN, Wang LH, Quinn JB, Wakeford C, van der Horst C.

J Antimicrob Chemother. 2001 Oct;48(4):507-13.

PMID:
11581229
24.

Anti-HBV specific beta-L-2'-deoxynucleosides.

Bryant ML, Bridges EG, Placidi L, Faraj A, Loi AG, Pierra C, Dukhan D, Gosselin G, Imbach JL, Hernandez B, Juodawlkis A, Tennant B, Korba B, Cote P, Cretton-Scott E, Schinazi RF, Sommadossi JP.

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):597-607. Review.

PMID:
11563077
25.

Antiviral activity and intracellular metabolism of bis(tButylSATE) phosphotriester of beta-L-2',3'dideoxyadenosine, a potent inhibitor of HIV and HBV replication.

Placidi L, Faraj A, Loi AG, Pierra C, Egron D, Cretton-Scott E, Gosseli G, Périgaud C, Martin LT, Schinazi RF, Imbach JL, el Kouni MH, Bryant ML, Sommadossi JP.

Antivir Chem Chemother. 2001 Mar;12(2):99-108.

PMID:
11527047
26.

Intravenous infusion of cereport increases uptake and efficacy of acyclovir in herpes simplex virus-infected rat brains.

Bidanset DJ, Placidi L, Rybak R, Palmer J, Sommadossi JP, Kern ER.

Antimicrob Agents Chemother. 2001 Aug;45(8):2316-23.

27.

Stereospecific synthesis and biological evaluations of beta-L-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine.

Griffon JF, Mathé C, Faraj A, Aubertin AM, De Clercq E, Balzarini J, Sommadossi JP, Gosselin G.

Eur J Med Chem. 2001 May;36(5):447-60.

PMID:
11451533
28.

5-(Trifluoromethyl)-beta-l-2'-deoxyuridine, the L-enantiomer of trifluorothymidine: stereospecific synthesis and antiherpetic evaluations.

Salvetti R, Marchand A, Pregnolato M, Verri A, Spadari S, Focher F, Briant M, Sommadossi JP, Mathé C, Gosselin G.

Bioorg Med Chem. 2001 Jul;9(7):1731-8.

PMID:
11425574
29.

NDP kinase reactivity towards 3TC nucleotides.

Kreimeyer A, Schneider B, Sarfati R, Faraj A, Sommadossi JP, Veron M, Deville-Bonne D.

Antiviral Res. 2001 May;50(2):147-56.

PMID:
11369435
30.

Evaluation of the mutagenic and genotoxic activities of anti-hepatitis B analogs of beta-L-adenosine by the Ames test and the Comet assay.

Placidi L, De Meo M, Gosselin G, Imbach JL, Bryant ML, Dumenil G, Sommadossi JP.

Antiviral Res. 2001 May;50(2):139-45.

PMID:
11369434
31.

Indinavir, nevirapine, stavudine, and lamivudine for human immunodeficiency virus-infected, amprenavir-experienced subjects: AIDS Clinical Trials Group protocol 373.

Gulick RM, Smeaton LM, D'Aquila RT, Eron JJ, Currier JS, Gerber JG, Acosta E, Sommadossi JP, Tung R, Snyder S, Kuritzkes DR, Murphy RL; AIDS Clinical Trials Group 373 Study Team.

J Infect Dis. 2001 Mar 1;183(5):715-21. Epub 2001 Jan 30.

PMID:
11181147
32.

Plasma population pharmacokinetics and penetration into cerebrospinal fluid of indinavir in combination with zidovudine and lamivudine in HIV-1-infected patients.

Zhou XJ, Havlir DV, Richman DD, Acosta EP, Hirsch M, Collier AC, Tebas P, Sommadossi JP; AIDS Clinical Trials Study 343 Investigators.

AIDS. 2000 Dec 22;14(18):2869-76.

PMID:
11153668
33.

Antiviral L-nucleosides specific for hepatitis B virus infection.

Bryant ML, Bridges EG, Placidi L, Faraj A, Loi AG, Pierra C, Dukhan D, Gosselin G, Imbach JL, Hernandez B, Juodawlkis A, Tennant B, Korba B, Cote P, Marion P, Cretton-Scott E, Schinazi RF, Sommadossi JP.

Antimicrob Agents Chemother. 2001 Jan;45(1):229-35.

34.

Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine.

Furman PA, Jeffrey J, Kiefer LL, Feng JY, Anderson KS, Borroto-Esoda K, Hill E, Copeland WC, Chu CK, Sommadossi JP, Liberman I, Schinazi RF, Painter GR.

Antimicrob Agents Chemother. 2001 Jan;45(1):158-65.

36.

Protease Inhibitors Therapy for AIDS Patients.

Sommadossi JP, Murphy RL.

Braz J Infect Dis. 1997 Oct;1(5):226-229.

PMID:
11105142
37.

Phase I dose escalation pharmacokinetics of O-(chloroacetylcarbamoyl) fumagillol (TNP-470) and its metabolites in AIDS patients with Kaposi's sarcoma.

Moore JD, Dezube BJ, Gill P, Zhou XJ, Acosta EP, Sommadossi JP.

Cancer Chemother Pharmacol. 2000;46(3):173-9.

PMID:
11021733
38.

Effects of beta-L-3'-azido-3'-deoxythymidine 5'-triphosphate on host and viral DNA polymerases.

Faraj A, El Alaoui AM, Gosselin G, Imbach JL, Morrow C, Sommadossi JP.

Antiviral Res. 2000 Aug;47(2):97-102.

PMID:
10996397
39.

Continued lamivudine versus delavirdine in combination with indinavir and zidovudine or stavudine in lamivudine-experienced patients: results of Adult AIDS Clinical Trials Group protocol 370.

Kuritzkes DR, Bassett RL, Johnson VA, Marschner IC, Eron JJ, Sommadossi JP, Acosta EP, Murphy RL, Fife K, Wood K, Bell D, Martinez A, Pettinelli CB.

AIDS. 2000 Jul 28;14(11):1553-61.

PMID:
10983642
40.

Enhanced penetration of indinavir in cerebrospinal fluid and semen after the addition of low-dose ritonavir.

van Praag RM, Weverling GJ, Portegies P, Jurriaans S, Zhou XJ, Turner-Foisy ML, Sommadossi JP, Burger DM, Lange JM, Hoetelmans RM, Prins JM.

AIDS. 2000 Jun 16;14(9):1187-94.

PMID:
10894283
41.

In vivo antagonism with zidovudine plus stavudine combination therapy.

Havlir DV, Tierney C, Friedland GH, Pollard RB, Smeaton L, Sommadossi JP, Fox L, Kessler H, Fife KH, Richman DD.

J Infect Dis. 2000 Jul;182(1):321-5. Epub 2000 Jul 6.

PMID:
10882616
42.

In vitro activities of methylenecyclopropane analogues of nucleosides and their phosphoralaninate prodrugs against cytomegalovirus and other herpesvirus infections.

Rybak RJ, Hartline CB, Qiu YL, Zemlicka J, Harden E, Marshall G, Sommadossi JP, Kern ER.

Antimicrob Agents Chemother. 2000 Jun;44(6):1506-11.

43.

In vitro and in vivo metabolism and pharmacokinetics of bis [(t-butyl)-S-acyl-2-thioethyl]-beta-L-2',3'-dideoxy-5-fluorocytidine monophosphate.

Martin LT, Cretton-Scott E, Placidi L, Faraj A, Loi AG, Schinazi RF, McClure HM, Gosselin G, Imbach JL, Sommadossi JP.

Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):481-99.

PMID:
10772729
44.

Synthesis and antiviral evaluation of some beta-L-2', 3'-dideoxy-5-chloropyrimidine nucleosides and pronucleotides.

Pierra C, Imbach JL, De Clercq E, Balzarini J, Van Aerschot A, Herdewijn P, Faraj A, Loi AG, Sommadossi JP, Gosselin G.

Antiviral Res. 2000 Mar;45(3):169-83.

PMID:
10771081
45.

Pharmacological considerations in antiretroviral therapy.

Sommadossi JP.

Antivir Ther. 1998;3 Suppl 4:9-12. Review.

PMID:
10723503
46.

Intracellular metabolism of beta-L-2',3'-dideoxyadenosine: relevance to its limited antiviral activity.

Placidi L, Cretton-Scott E, Gosselin G, Pierra C, Schinazi RF, Imbach JL, el Kouni MH, Sommadossi JP.

Antimicrob Agents Chemother. 2000 Apr;44(4):853-8.

47.

Differential effects of antiretroviral nucleoside analogs on mitochondrial function in HepG2 cells.

Pan-Zhou XR, Cui L, Zhou XJ, Sommadossi JP, Darley-Usmar VM.

Antimicrob Agents Chemother. 2000 Mar;44(3):496-503.

48.

Inhibition of beta-globin gene expression by 3'-azido-3'-deoxythymidine in human erythroid progenitor cells.

Spiga MG, Weidner DA, Trentesaux C, LeBoeuf RD, Sommadossi JP.

Antiviral Res. 1999 Dec 31;44(3):167-77.

PMID:
10651068
49.

Drug susceptibility in HIV infection after viral rebound in patients receiving indinavir-containing regimens.

Havlir DV, Hellmann NS, Petropoulos CJ, Whitcomb JM, Collier AC, Hirsch MS, Tebas P, Sommadossi JP, Richman DD.

JAMA. 2000 Jan 12;283(2):229-34.

PMID:
10634339
50.

Safety assessment, in vitro and in vivo, and pharmacokinetics of emivirine, a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1.

Szczech GM, Furman P, Painter GR, Barry DW, Borroto-Esoda K, Grizzle TB, Blum MR, Sommadossi J, Endoh R, Niwa T, Yamamoto M, Moxham C.

Antimicrob Agents Chemother. 2000 Jan;44(1):123-30.

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