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RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger.

Artamonov MV, Sonkusare SK, Good ME, Momotani K, Eto M, Isakson BE, Le TH, Cope EL, Derewenda ZS, Derewenda U, Somlyo AV.

Sci Signal. 2018 Oct 30;11(554). pii: eaar3924. doi: 10.1126/scisignal.aar3924.


Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure.

DeLalio LJ, Keller AS, Chen J, Boyce AKJ, Artamonov MV, Askew-Page HR, Keller TCS 4th, Johnstone SR, Weaver RB, Good ME, Murphy SA, Best AK, Mintz EL, Penuela S, Greenwood IA, Machado RF, Somlyo AV, Swayne LA, Minshall RD, Isakson BE.

Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2065-2078. doi: 10.1161/ATVBAHA.118.311290.


Bacterial Expression, Purification and In Vitro Phosphorylation of Full-Length Ribosomal S6 Kinase 2 (RSK2).

Utepbergenov D, Hennig PM, Derewenda U, Artamonov MV, Somlyo AV, Derewenda ZS.

PLoS One. 2016 Oct 12;11(10):e0164343. doi: 10.1371/journal.pone.0164343. eCollection 2016.



Amin E, Jaiswal M, Derewenda U, Reis K, Nouri K, Koessmeier KT, Aspenström P, Somlyo AV, Dvorsky R, Ahmadian MR.

J Biol Chem. 2016 Sep 23;291(39):20353-71. doi: 10.1074/jbc.M116.736967. Epub 2016 Aug 1.


Role of Telokin in Regulating Murine Gastric Fundus Smooth Muscle Tension.

An C, Bhetwal BP, Sanders KM, Somlyo AV, Perrino BA.

PLoS One. 2015 Aug 10;10(8):e0134876. doi: 10.1371/journal.pone.0134876. eCollection 2015.


Signaling pathways that control rho kinase activity maintain the embryonic epicardial progenitor state.

Artamonov MV, Jin L, Franke AS, Momotani K, Ho R, Dong XR, Majesky MW, Somlyo AV.

J Biol Chem. 2015 Apr 17;290(16):10353-67. doi: 10.1074/jbc.M114.613190. Epub 2015 Mar 2.


A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells.

Billaud M, Chiu YH, Lohman AW, Parpaite T, Butcher JT, Mutchler SM, DeLalio LJ, Artamonov MV, Sandilos JK, Best AK, Somlyo AV, Thompson RJ, Le TH, Ravichandran KS, Bayliss DA, Isakson BE.

Sci Signal. 2015 Feb 17;8(364):ra17. doi: 10.1126/scisignal.2005824.


Smooth muscle myosin filament controversy, once again?

Somlyo AV.

J Physiol. 2015 Jan 15;593(2):473-5. doi: 10.1113/jphysiol.2014.285866. No abstract available.


Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction.

Straub AC, Butcher JT, Billaud M, Mutchler SM, Artamonov MV, Nguyen AT, Johnson T, Best AK, Miller MP, Palmer LA, Columbus L, Somlyo AV, Le TH, Isakson BE.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2594-600. doi: 10.1161/ATVBAHA.114.303974. Epub 2014 Oct 2.


Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure.

Lakshmikanthan S, Zieba BJ, Ge ZD, Momotani K, Zheng X, Lund H, Artamonov MV, Maas JE, Szabo A, Zhang DX, Auchampach JA, Mattson DL, Somlyo AV, Chrzanowska-Wodnicka M.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1486-94. doi: 10.1161/ATVBAHA.114.303678. Epub 2014 May 1.


Regulatory circuits in cell motility.

Somlyo A.

J Muscle Res Cell Motil. 2014 Aug;35(3-4):235. doi: 10.1007/s10974-013-9372-7. No abstract available.


Obituary of Richard A. Murphy.

Somlyo A.

J Muscle Res Cell Motil. 2013 Dec;34(5-6):437-9. doi: 10.1007/s10974-013-9369-2. Epub 2013 Nov 5. No abstract available.


Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.

Artamonov MV, Momotani K, Stevenson A, Trentham DR, Derewenda U, Derewenda ZS, Read PW, Gutkind JS, Somlyo AV.

J Biol Chem. 2013 Nov 22;288(47):34030-40. doi: 10.1074/jbc.M113.514596. Epub 2013 Oct 8.


Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor.

Carlson DA, Franke AS, Weitzel DH, Speer BL, Hughes PF, Hagerty L, Fortner CN, Veal JM, Barta TE, Zieba BJ, Somlyo AV, Sutherland C, Deng JT, Walsh MP, MacDonald JA, Haystead TA.

ACS Chem Biol. 2013 Dec 20;8(12):2715-23. doi: 10.1021/cb400407c. Epub 2013 Oct 17.


Rho-kinase: regulation, (dys)function, and inhibition.

Amin E, Dubey BN, Zhang SC, Gremer L, Dvorsky R, Moll JM, Taha MS, Nagel-Steger L, Piekorz RP, Somlyo AV, Ahmadian MR.

Biol Chem. 2013 Nov;394(11):1399-410. doi: 10.1515/hsz-2013-0181. Review.


The p90 ribosomal S6 kinase (RSK) is a mediator of smooth muscle contractility.

Artamonov M, Momotani K, Utepbergenov D, Franke A, Khromov A, Derewenda ZS, Somlyo AV.

PLoS One. 2013;8(3):e58703. doi: 10.1371/journal.pone.0058703. Epub 2013 Mar 13.


Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolution.

Derewenda U, Artamonov M, Szukalska G, Utepbergenov D, Olekhnovich N, Parikh HI, Kellogg GE, Somlyo AV, Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2013 Feb;69(Pt 2):266-75. doi: 10.1107/S0907444912045520. Epub 2013 Jan 19.


p63RhoGEF: a new switch for G(q)-mediated activation of smooth muscle.

Momotani K, Somlyo AV.

Trends Cardiovasc Med. 2012 Jul;22(5):122-7. doi: 10.1016/j.tcm.2012.07.007. Epub 2012 Aug 16. Review.


Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle.

Khromov AS, Momotani K, Jin L, Artamonov MV, Shannon J, Eto M, Somlyo AV.

J Biol Chem. 2012 Jun 15;287(25):20975-85. doi: 10.1074/jbc.M112.341479. Epub 2012 Apr 27.


p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.

Momotani K, Artamonov MV, Utepbergenov D, Derewenda U, Derewenda ZS, Somlyo AV.

Circ Res. 2011 Oct 14;109(9):993-1002. doi: 10.1161/CIRCRESAHA.111.248898. Epub 2011 Sep 1.


Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF.

Bielnicki JA, Shkumatov AV, Derewenda U, Somlyo AV, Svergun DI, Derewenda ZS.

J Biol Chem. 2011 Oct 7;286(40):35163-75. doi: 10.1074/jbc.M111.270918. Epub 2011 Aug 4.


The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity.

Zieba BJ, Artamonov MV, Jin L, Momotani K, Ho R, Franke AS, Neppl RL, Stevenson AS, Khromov AS, Chrzanowska-Wodnicka M, Somlyo AV.

J Biol Chem. 2011 May 13;286(19):16681-92. doi: 10.1074/jbc.M110.205062. Epub 2011 Mar 25.


Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes.

Hoofnagle MH, Neppl RL, Berzin EL, Teg Pipes GC, Olson EN, Wamhoff BW, Somlyo AV, Owens GK.

Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1707-21. doi: 10.1152/ajpheart.01192.2010. Epub 2011 Feb 25.


The actin associated protein palladin is important for the early smooth muscle cell differentiation.

Jin L, Gan Q, Zieba BJ, Goicoechea SM, Owens GK, Otey CA, Somlyo AV.

PLoS One. 2010 Sep 22;5(9):e12823. doi: 10.1371/journal.pone.0012823.


Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation.

Yoshida T, Gan Q, Franke AS, Ho R, Zhang J, Chen YE, Hayashi M, Majesky MW, Somlyo AV, Owens GK.

J Biol Chem. 2010 Jul 2;285(27):21175-84. doi: 10.1074/jbc.M110.112482. Epub 2010 May 3.


Phosphorylation-dependent autoinhibition of myosin light chain phosphatase accounts for Ca2+ sensitization force of smooth muscle contraction.

Khromov A, Choudhury N, Stevenson AS, Somlyo AV, Eto M.

J Biol Chem. 2009 Aug 7;284(32):21569-79. doi: 10.1074/jbc.M109.019729. Epub 2009 Jun 15.


On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.

Zheng M, Cierpicki T, Momotani K, Artamonov MV, Derewenda U, Bushweller JH, Somlyo AV, Derewenda ZS.

BMC Struct Biol. 2009 May 21;9:36. doi: 10.1186/1472-6807-9-36.


Expression of CPI-17 in smooth muscle during embryonic development and in neointimal lesion formation.

Kim JI, Young GD, Jin L, Somlyo AV, Eto M.

Histochem Cell Biol. 2009 Aug;132(2):191-8. doi: 10.1007/s00418-009-0604-2. Epub 2009 May 13.


Mechanical properties of the extracellular matrix alter expression of smooth muscle protein LPP and its partner palladin; relationship to early atherosclerosis and vascular injury.

Jin L, Hastings NE, Blackman BR, Somlyo AV.

J Muscle Res Cell Motil. 2009;30(1-2):41-55. doi: 10.1007/s10974-009-9173-1. Epub 2009 Feb 10.


Thromboxane A2-induced bi-directional regulation of cerebral arterial tone.

Neppl RL, Lubomirov LT, Momotani K, Pfitzer G, Eto M, Somlyo AV.

J Biol Chem. 2009 Mar 6;284(10):6348-60. doi: 10.1074/jbc.M807040200. Epub 2008 Dec 17.


The actin-associated protein Palladin is required for development of normal contractile properties of smooth muscle cells derived from embryoid bodies.

Jin L, Yoshida T, Ho R, Owens GK, Somlyo AV.

J Biol Chem. 2009 Jan 23;284(4):2121-30. doi: 10.1074/jbc.M806095200. Epub 2008 Nov 17.


Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.

Wooldridge AA, Fortner CN, Lontay B, Akimoto T, Neppl RL, Facemire C, Datto MB, Kwon A, McCook E, Li P, Wang S, Thresher RJ, Miller SE, Perriard JC, Gavin TP, Hickner RC, Coffman TM, Somlyo AV, Yan Z, Haystead TA.

J Biol Chem. 2008 Apr 25;283(17):11850-9. doi: 10.1074/jbc.M708628200. Epub 2008 Feb 29.


Cep57, a multidomain protein with unique microtubule and centrosomal localization domains.

Momotani K, Khromov AS, Miyake T, Stukenberg PT, Somlyo AV.

Biochem J. 2008 Jun 1;412(2):265-73. doi: 10.1042/BJ20071501.


Automated electron tomography with scanning transmission electron microscopy.

Feng J, Somlyo AP, Somlyo AV, Shao Z.

J Microsc. 2007 Dec;228(Pt 3):406-12.


Cyclic GMP regulation of myosin phosphatase: a new piece for the puzzle?

Somlyo AV.

Circ Res. 2007 Sep 28;101(7):645-7. No abstract available.


Assessment of contractility of purified smooth muscle cells derived from embryonic stem cells.

Sinha S, Wamhoff BR, Hoofnagle MH, Thomas J, Neppl RL, Deering T, Helmke BP, Bowles DK, Somlyo AV, Owens GK.

Stem Cells. 2006 Jul;24(7):1678-88. Epub 2006 Apr 6.


Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation.

Khromov AS, Wang H, Choudhury N, McDuffie M, Herring BP, Nakamoto R, Owens GK, Somlyo AP, Somlyo AV.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2440-5. Epub 2006 Feb 6.


LPP expression during in vitro smooth muscle differentiation and stent-induced vascular injury.

Gorenne I, Jin L, Yoshida T, Sanders JM, Sarembock IJ, Owens GK, Somlyo AP, Somlyo AV.

Circ Res. 2006 Feb 17;98(3):378-85. Epub 2006 Jan 5.


Crossbridge cycle in smooth muscle: kinetics assessed with flash photolysis and fluorescent probes.

Somlyo A, Khromov A, Webb M, Corrie J, Ferenczi M, Trentham D, Somlyo AP.

J Muscle Res Cell Motil. 2004;25(8):611-2. No abstract available.


Telokin mediates Ca2+-desensitization through activation of myosin phosphatase in phasic and tonic smooth muscle.

Choudhury N, Khromov AS, Somlyo AP, Somlyo AV.

J Muscle Res Cell Motil. 2004;25(8):657-65. Epub 2005 Feb 24.


Signal transduction through the RhoA/Rho-kinase pathway in smooth muscle.

Somlyo AP, Somlyo AV.

J Muscle Res Cell Motil. 2004;25(8):613-5. No abstract available.


Smooth muscle myosin: regulation and properties.

Somlyo AV, Khromov AS, Webb MR, Ferenczi MA, Trentham DR, He ZH, Sheng S, Shao Z, Somlyo AP.

Philos Trans R Soc Lond B Biol Sci. 2004 Dec 29;359(1452):1921-30. Review.


Uncoupling of GPCR and RhoA-induced Ca2+-sensitization of chicken amnion smooth muscle lacking CPI-17.

Stevenson AS, Matthew JD, Eto M, Luo S, Somlyo AP, Somlyo AV.

FEBS Lett. 2004 Dec 3;578(1-2):73-9.


The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle.

Derewenda U, Oleksy A, Stevenson AS, Korczynska J, Dauter Z, Somlyo AP, Otlewski J, Somlyo AV, Derewenda ZS.

Structure. 2004 Nov;12(11):1955-65.


Myosin light chain kinase knockout.

Somlyo AV, Wang H, Choudhury N, Khromov AS, Majesky M, Owens GK, Somlyo AP.

J Muscle Res Cell Motil. 2004;25(3):241-2. No abstract available.


ANG II type 2 receptor regulates smooth muscle growth and force generation in late fetal mouse development.

Perlegas D, Xie H, Sinha S, Somlyo AV, Owens GK.

Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H96-102. Epub 2004 Aug 26.


L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism.

Wamhoff BR, Bowles DK, McDonald OG, Sinha S, Somlyo AP, Somlyo AV, Owens GK.

Circ Res. 2004 Aug 20;95(4):406-14. Epub 2004 Jul 15.


A system for acquiring simultaneous electron energy-loss and X-ray spectrum-images.

Feng J, Somlyo AV, Somlyo AP.

J Microsc. 2004 Jul;215(Pt 1):92-9.


Myosin regulatory light chain phosphorylation and strain modulate adenosine diphosphate release from smooth muscle Myosin.

Khromov AS, Webb MR, Ferenczi MA, Trentham DR, Somlyo AP, Somlyo AV.

Biophys J. 2004 Apr;86(4):2318-28.

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