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Items: 27


The Immunogenicity in Mice of HCV Core Delivered as DNA Is Modulated by Its Capacity to Induce Oxidative Stress and Oxidative Stress Response.

Jansons J, Sominskaya I, Petrakova N, Starodubova ES, Smirnova OA, Alekseeva E, Bruvere R, Eliseeva O, Skrastina D, Kashuba E, Mihailova M, Kochetkov SN, Ivanov AV, Isaguliants MG.

Cells. 2019 Feb 28;8(3). pii: E208. doi: 10.3390/cells8030208.


The chaperone dynein LL1 mediates cytoplasmic transport of empty and mature hepatitis B virus capsids.

Osseman Q, Gallucci L, Au S, Cazenave C, Berdance E, Blondot ML, Cassany A, Bégu D, Ragues J, Aknin C, Sominskaya I, Dishlers A, Rabe B, Anderson F, Panté N, Kann M.

J Hepatol. 2018 Mar;68(3):441-448. doi: 10.1016/j.jhep.2017.10.032. Epub 2017 Nov 4.


Comparative Immunogenicity in Rabbits of the Polypeptides Encoded by the 5' Terminus of Hepatitis C Virus RNA.

Sominskaya I, Jansons J, Dovbenko A, Petrakova N, Lieknina I, Mihailova M, Latyshev O, Eliseeva O, Stahovska I, Akopjana I, Petrovskis I, Isaguliants M.

J Immunol Res. 2015;2015:762426. doi: 10.1155/2015/762426. Epub 2015 Nov 2.


The Hepatitis B Virus Core Variants that Expose Foreign C-Terminal Insertions on the Outer Surface of Virus-Like Particles.

Dishlers A, Skrastina D, Renhofa R, Petrovskis I, Ose V, Lieknina I, Jansons J, Pumpens P, Sominskaya I.

Mol Biotechnol. 2015 Dec;57(11-12):1038-49. doi: 10.1007/s12033-015-9895-9.


HCV core protein uses multiple mechanisms to induce oxidative stress in human hepatoma Huh7 cells.

Ivanov AV, Smirnova OA, Petrushanko IY, Ivanova ON, Karpenko IL, Alekseeva E, Sominskaya I, Makarov AA, Bartosch B, Kochetkov SN, Isaguliants MG.

Viruses. 2015 May 29;7(6):2745-70. doi: 10.3390/v7062745.


A VLP library of C-terminally truncated Hepatitis B core proteins: correlation of RNA encapsidation with a Th1/Th2 switch in the immune responses of mice.

Sominskaya I, Skrastina D, Petrovskis I, Dishlers A, Berza I, Mihailova M, Jansons J, Akopjana I, Stahovska I, Dreilina D, Ose V, Pumpens P.

PLoS One. 2013 Sep 23;8(9):e75938. doi: 10.1371/journal.pone.0075938. eCollection 2013.


Chimeric derivatives of hepatitis B virus core particles carrying major epitopes of the rubella virus E1 glycoprotein.

Skrastina D, Petrovskis I, Petraityte R, Sominskaya I, Ose V, Lieknina I, Bogans J, Sasnauskas K, Pumpens P.

Clin Vaccine Immunol. 2013 Nov;20(11):1719-28. doi: 10.1128/CVI.00533-13. Epub 2013 Sep 4.


Fibronectin-binding nanoparticles for intracellular targeting addressed by B. burgdorferi BBK32 protein fragments.

Ranka R, Petrovskis I, Sominskaya I, Bogans J, Bruvere R, Akopjana I, Ose V, Timofejeva I, Brangulis K, Pumpens P, Baumanis V.

Nanomedicine. 2013 Jan;9(1):65-73. doi: 10.1016/j.nano.2012.05.003. Epub 2012 May 23.


N-terminal myristoylation-dependent masking of neutralizing epitopes in the preS1 attachment site of hepatitis B virus.

Bremer CM, Sominskaya I, Skrastina D, Pumpens P, El Wahed AA, Beutling U, Frank R, Fritz HJ, Hunsmann G, Gerlich WH, Glebe D.

J Hepatol. 2011 Jul;55(1):29-37. doi: 10.1016/j.jhep.2010.10.019. Epub 2010 Nov 28.


Construction and immunological evaluation of multivalent hepatitis B virus (HBV) core virus-like particles carrying HBV and HCV epitopes.

Sominskaya I, Skrastina D, Dislers A, Vasiljev D, Mihailova M, Ose V, Dreilina D, Pumpens P.

Clin Vaccine Immunol. 2010 Jun;17(6):1027-33. doi: 10.1128/CVI.00468-09. Epub 2010 Apr 21.


Nuclear entry of hepatitis B virus capsids involves disintegration to protein dimers followed by nuclear reassociation to capsids.

Rabe B, Delaleau M, Bischof A, Foss M, Sominskaya I, Pumpens P, Cazenave C, Castroviejo M, Kann M.

PLoS Pathog. 2009 Aug;5(8):e1000563. doi: 10.1371/journal.ppat.1000563. Epub 2009 Aug 28.


Enhancement of the expression of HCV core gene does not enhance core-specific immune response in DNA immunization: advantages of the heterologous DNA prime, protein boost immunization regimen.

Alekseeva E, Sominskaya I, Skrastina D, Egorova I, Starodubova E, Kushners E, Mihailova M, Petrakova N, Bruvere R, Kozlovskaya T, Isaguliants M, Pumpens P.

Genet Vaccines Ther. 2009 Jun 8;7:7. doi: 10.1186/1479-0556-7-7.


High immunogenicity of a hydrophilic component of the hepatitis B virus preS1 sequence exposed on the surface of three virus-like particle carriers.

Skrastina D, Bulavaite A, Sominskaya I, Kovalevska L, Ose V, Priede D, Pumpens P, Sasnauskas K.

Vaccine. 2008 Apr 7;26(16):1972-81. doi: 10.1016/j.vaccine.2008.02.030. Epub 2008 Feb 26.


Preparation of hepatitis C virus structural and non-structural protein fragments and studies of their immunogenicity.

Mihailova M, Fiedler M, Boos M, Petrovskis I, Sominskaya I, Roggendorf M, Viazov S, Pumpens P.

Protein Expr Purif. 2006 Nov;50(1):43-8. Epub 2006 Jun 27.


Recombinant virus-like particles as a carrier of B- and T-cell epitopes of hepatitis C virus (HCV).

Mihailova M, Boos M, Petrovskis I, Ose V, Skrastina D, Fiedler M, Sominskaya I, Ross S, Pumpens P, Roggendorf M, Viazov S.

Vaccine. 2006 May 15;24(20):4369-77. Epub 2006 Mar 15.


Signal sequences modulate the immunogenic performance of human hepatitis C virus E2 gene.

Sominskaya I, Alekseeva E, Skrastina D, Mokhonov V, Starodubova E, Jansons J, Levi M, Prilipov A, Kozlovska T, Smirnov V, Pumpens P, Isaguliants MG.

Mol Immunol. 2006 May;43(12):1941-52. Epub 2006 Jan 25.


Hepatitis B and C virus variants in long-term immunosuppressed renal transplant patients in Latvia.

Sominskaya I, Mihailova M, Jansons J, Emelyanova V, Folkmane I, Smagris E, Dumpis U, Rozentals R, Pumpens P.

Intervirology. 2005;48(2-3):192-200.


Mosaic hepatitis B virus core particles presenting the complete preS sequence of the viral envelope on their surface.

Kazaks A, Borisova G, Cvetkova S, Kovalevska L, Ose V, Sominskaya I, Pumpens P, Skrastina D, Dislers A.

J Gen Virol. 2004 Sep;85(Pt 9):2665-70.


Priming of cytotoxic T cell responses to exogenous hepatitis B virus core antigen is B cell dependent.

Lazdina U, Alheim M, Nyström J, Hultgren C, Borisova G, Sominskaya I, Pumpens P, Peterson DL, Milich DR, Sällberg M.

J Gen Virol. 2003 Jan;84(Pt 1):139-46.


An outbreak of HBV and HCV infection in a paediatric oncology ward: epidemiological investigations and prevention of further spread.

Dumpis U, Kovalova Z, Jansons J, Cupane L, Sominskaya I, Michailova M, Karayiannis P, Gardovska D, Viazov S, Ross S, Roggendorf M, Pumpens P.

J Med Virol. 2003 Mar;69(3):331-8.


Evaluation of HBs, HBc, and frCP virus-like particles for expression of human papillomavirus 16 E7 oncoprotein epitopes.

Pumpens P, Razanskas R, Pushko P, Renhof R, Gusars I, Skrastina D, Ose V, Borisova G, Sominskaya I, Petrovskis I, Jansons J, Sasnauskas K.

Intervirology. 2002;45(1):24-32.


Fine-mapping of the B-cell epitope domain at the N-terminus of the preS2 region of the hepatitis B surface antigen.

Sominskaya I, Paulij W, Jansons J, Sobotta D, Dreilina D, Sunnen C, Meisel H, Gerlich WH, Pumpens P.

J Immunol Methods. 2002 Feb 1;260(1-2):251-61.


Mapping of immunodominant B-cell epitopes and the human serum albumin-binding site in natural hepatitis B virus surface antigen of defined genosubtype.

Sobotta D, Sominskaya I, Jansons J, Meisel H, Schmitt S, Heermann KH, Kaluza G, Pumpens P, Gerlich WH.

J Gen Virol. 2000 Feb;81(Pt 2):369-78.


Fine mapping and functional characterization of two immuno-dominant regions from the preS2 sequence of hepatitis B virus.

Meisel H, Sominskaya I, Pumpens P, Pushko P, Borisova G, Deepen R, Lu X, Spiller GH, Krüger DH, Grens E, et al.

Intervirology. 1994;37(6):330-9.


Analysis of RNA phage fr coat protein assembly by insertion, deletion and substitution mutagenesis.

Pushko P, Kozlovskaya T, Sominskaya I, Brede A, Stankevica E, Ose V, Pumpens P, Grens E.

Protein Eng. 1993 Nov;6(8):883-91.


Tetrapeptide QDPR is a minimal immunodominant epitope within the preS2 domain of hepatitis B virus.

Sominskaya I, Bichko V, Pushko P, Dreimane A, Snikere D, Pumpens P.

Immunol Lett. 1992 Jul;33(2):169-72.


Determination of the minimal length of preS1 epitope recognized by a monoclonal antibody which inhibits attachment of hepatitis B virus to hepatocytes.

Sominskaya I, Pushko P, Dreilina D, Kozlovskaya T, Pumpen P.

Med Microbiol Immunol. 1992;181(4):215-26.


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