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Items: 48

1.

Metabolic interventions for the prevention and treatment of daptomycin non-susceptibility in Staphylococcus aureus.

Reed JM, Gardner SG, Mishra NN, Bayer AS, Somerville GA.

J Antimicrob Chemother. 2019 Aug 1;74(8):2274-2283. doi: 10.1093/jac/dkz194.

PMID:
31074482
2.

Coordinated regulation of transcription by CcpA and the Staphylococcus aureus two-component system HptRS.

Reed JM, Olson S, Brees DF, Griffin CE, Grove RA, Davis PJ, Kachman SD, Adamec J, Somerville GA.

PLoS One. 2018 Dec 12;13(12):e0207161. doi: 10.1371/journal.pone.0207161. eCollection 2018.

3.

Metabolic Mitigation of Staphylococcus aureus Vancomycin Intermediate-Level Susceptibility.

Gardner SG, Marshall DD, Daum RS, Powers R, Somerville GA.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01608-17. doi: 10.1128/AAC.01608-17. Print 2018 Jan.

4.

Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase.

Stevens E, Laabei M, Gardner S, Somerville GA, Massey RC.

Sci Rep. 2017 Oct 23;7(1):13744. doi: 10.1038/s41598-017-14110-8.

5.

CcpA Affects Infectivity of Staphylococcus aureus in a Hyperglycemic Environment.

Bischoff M, Wonnenberg B, Nippe N, Nyffenegger-Jann NJ, Voss M, Beisswenger C, Sunderkötter C, Molle V, Dinh QT, Lammert F, Bals R, Herrmann M, Somerville GA, Tschernig T, Gaupp R.

Front Cell Infect Microbiol. 2017 May 9;7:172. doi: 10.3389/fcimb.2017.00172. eCollection 2017.

6.

Genome Sequence of Streptomyces aureofaciens ATCC Strain 10762.

Gradnigo JS, Somerville GA, Huether MJ, Kemmy RJ, Johnson CM, Oliver MG, Moriyama EN.

Genome Announc. 2016 Jun 23;4(3). pii: e00615-16. doi: 10.1128/genomeA.00615-16.

7.

RpiRc Is a Pleiotropic Effector of Virulence Determinant Synthesis and Attenuates Pathogenicity in Staphylococcus aureus.

Gaupp R, Wirf J, Wonnenberg B, Biegel T, Eisenbeis J, Graham J, Herrmann M, Lee CY, Beisswenger C, Wolz C, Tschernig T, Bischoff M, Somerville GA.

Infect Immun. 2016 Jun 23;84(7):2031-2041. doi: 10.1128/IAI.00285-16. Print 2016 Jul.

8.

Regulating the Intersection of Metabolism and Pathogenesis in Gram-positive Bacteria.

Richardson AR, Somerville GA, Sonenshein AL.

Microbiol Spectr. 2015 Jun;3(3). doi: 10.1128/microbiolspec.MBP-0004-2014. Review.

9.

Staphylococcus aureus metabolic adaptations during the transition from a daptomycin susceptibility phenotype to a daptomycin nonsusceptibility phenotype.

Gaupp R, Lei S, Reed JM, Peisker H, Boyle-Vavra S, Bayer AS, Bischoff M, Herrmann M, Daum RS, Powers R, Somerville GA.

Antimicrob Agents Chemother. 2015 Jul;59(7):4226-38. doi: 10.1128/AAC.00160-15. Epub 2015 May 11.

10.

The catabolite control protein E (CcpE) affects virulence determinant production and pathogenesis of Staphylococcus aureus.

Hartmann T, Baronian G, Nippe N, Voss M, Schulthess B, Wolz C, Eisenbeis J, Schmidt-Hohagen K, Gaupp R, Sunderkötter C, Beisswenger C, Bals R, Somerville GA, Herrmann M, Molle V, Bischoff M.

J Biol Chem. 2014 Oct 24;289(43):29701-11. doi: 10.1074/jbc.M114.584979. Epub 2014 Sep 5.

11.

Influence of iron and aeration on Staphylococcus aureus growth, metabolism, and transcription.

Ledala N, Zhang B, Seravalli J, Powers R, Somerville GA.

J Bacteriol. 2014 Jun;196(12):2178-89. doi: 10.1128/JB.01475-14. Epub 2014 Apr 4.

12.

Identification of low-molecular-weight compounds inhibiting growth of corynebacteria: potential lead compounds for antibiotics.

Stark JL, Copeland JC, Eletsky A, Somerville GA, Szyperski T, Powers R.

ChemMedChem. 2014 Feb;9(2):282-5. doi: 10.1002/cmdc.201300386. Epub 2014 Jan 8.

13.

Revisiting Protocols for the NMR Analysis of Bacterial Metabolomes.

Halouska S, Zhang B, Gaupp R, Lei S, Snell E, Fenton RJ, Barletta RG, Somerville GA, Powers R.

J Integr OMICS. 2013 Dec;3(2):120-137.

14.

Growth and preparation of Staphylococcus epidermidis for NMR metabolomic analysis.

Somerville GA, Powers R.

Methods Mol Biol. 2014;1106:71-91. doi: 10.1007/978-1-62703-736-5_6.

PMID:
24222456
15.

Catabolite control protein E (CcpE) is a LysR-type transcriptional regulator of tricarboxylic acid cycle activity in Staphylococcus aureus.

Hartmann T, Zhang B, Baronian G, Schulthess B, Homerova D, Grubmüller S, Kutzner E, Gaupp R, Bertram R, Powers R, Eisenreich W, Kormanec J, Herrmann M, Molle V, Somerville GA, Bischoff M.

J Biol Chem. 2013 Dec 13;288(50):36116-28. doi: 10.1074/jbc.M113.516302. Epub 2013 Nov 5.

16.

A dysfunctional tricarboxylic acid cycle enhances fitness of Staphylococcus epidermidis during β-lactam stress.

Thomas VC, Kinkead LC, Janssen A, Schaeffer CR, Woods KM, Lindgren JK, Peaster JM, Chaudhari SS, Sadykov M, Jones J, AbdelGhani SM, Zimmerman MC, Bayles KW, Somerville GA, Fey PD.

MBio. 2013 Aug 20;4(4). pii: e00437-13. doi: 10.1128/mBio.00437-13. Erratum in: MBio. 2014;5(3):e01307-14. Chittezham Thomas, Vinai [corrected to Thomas, Vinai C].

17.

Reductive evolution and the loss of PDC/PAS domains from the genus Staphylococcus.

Shah N, Gaupp R, Moriyama H, Eskridge KM, Moriyama EN, Somerville GA.

BMC Genomics. 2013 Jul 31;14:524. doi: 10.1186/1471-2164-14-524.

18.
19.

Staphylococcal response to oxidative stress.

Gaupp R, Ledala N, Somerville GA.

Front Cell Infect Microbiol. 2012 Mar 16;2:33. doi: 10.3389/fcimb.2012.00033. eCollection 2012. Review.

20.

CcpA coordinates central metabolism and biofilm formation in Staphylococcus epidermidis.

Sadykov MR, Hartmann T, Mattes TA, Hiatt M, Jann NJ, Zhu Y, Ledala N, Landmann R, Herrmann M, Rohde H, Bischoff M, Somerville GA.

Microbiology. 2011 Dec;157(Pt 12):3458-68. doi: 10.1099/mic.0.051243-0. Epub 2011 Sep 29. Erratum in: Microbiology. 2012 Jul;158(Pt 7):1930.

21.

RpiR homologues may link Staphylococcus aureus RNAIII synthesis and pentose phosphate pathway regulation.

Zhu Y, Nandakumar R, Sadykov MR, Madayiputhiya N, Luong TT, Gaupp R, Lee CY, Somerville GA.

J Bacteriol. 2011 Nov;193(22):6187-96. doi: 10.1128/JB.05930-11. Epub 2011 Sep 16.

22.

NMR analysis of a stress response metabolic signaling network.

Zhang B, Halouska S, Schiaffo CE, Sadykov MR, Somerville GA, Powers R.

J Proteome Res. 2011 Aug 5;10(8):3743-54. doi: 10.1021/pr200360w. Epub 2011 Jul 8.

23.

TCA cycle inactivation in Staphylococcus aureus alters nitric oxide production in RAW 264.7 cells.

Massilamany C, Gangaplara A, Gardner DJ, Musser JM, Steffen D, Somerville GA, Reddy J.

Mol Cell Biochem. 2011 Sep;355(1-2):75-82. doi: 10.1007/s11010-011-0840-3. Epub 2011 Apr 26.

24.

Using NMR metabolomics to investigate tricarboxylic acid cycle-dependent signal transduction in Staphylococcus epidermidis.

Sadykov MR, Zhang B, Halouska S, Nelson JL, Kreimer LW, Zhu Y, Powers R, Somerville GA.

J Biol Chem. 2010 Nov 19;285(47):36616-24. doi: 10.1074/jbc.M110.152843. Epub 2010 Sep 22.

25.

Direct targets of CodY in Staphylococcus aureus.

Majerczyk CD, Dunman PM, Luong TT, Lee CY, Sadykov MR, Somerville GA, Bodi K, Sonenshein AL.

J Bacteriol. 2010 Jun;192(11):2861-77. doi: 10.1128/JB.00220-10. Epub 2010 Apr 2. Erratum in: J Bacteriol. 2010 Aug;192(16):4258.

26.

Tricarboxylic acid cycle-dependent synthesis of Staphylococcus aureus Type 5 and 8 capsular polysaccharides.

Sadykov MR, Mattes TA, Luong TT, Zhu Y, Day SR, Sifri CD, Lee CY, Somerville GA.

J Bacteriol. 2010 Mar;192(5):1459-62. doi: 10.1128/JB.01377-09. Epub 2010 Jan 8.

27.

Tricarboxylic acid cycle-dependent attenuation of Staphylococcus aureus in vivo virulence by selective inhibition of amino acid transport.

Zhu Y, Xiong YQ, Sadykov MR, Fey PD, Lei MG, Lee CY, Bayer AS, Somerville GA.

Infect Immun. 2009 Oct;77(10):4256-64. doi: 10.1128/IAI.00195-09. Epub 2009 Aug 10.

28.

At the crossroads of bacterial metabolism and virulence factor synthesis in Staphylococci.

Somerville GA, Proctor RA.

Microbiol Mol Biol Rev. 2009 Jun;73(2):233-48. doi: 10.1128/MMBR.00005-09. Review.

29.

Staphylococcus aureus ClpC ATPase is a late growth phase effector of metabolism and persistence.

Chatterjee I, Schmitt S, Batzilla CF, Engelmann S, Keller A, Ring MW, Kautenburger R, Ziebuhr W, Hecker M, Preissner KT, Bischoff M, Proctor RA, Beck HP, Lenhof HP, Somerville GA, Herrmann M.

Proteomics. 2009 Mar;9(5):1152-76. doi: 10.1002/pmic.200800586.

PMID:
19253280
30.

Tricarboxylic acid cycle-dependent regulation of Staphylococcus epidermidis polysaccharide intercellular adhesin synthesis.

Sadykov MR, Olson ME, Halouska S, Zhu Y, Fey PD, Powers R, Somerville GA.

J Bacteriol. 2008 Dec;190(23):7621-32. doi: 10.1128/JB.00806-08. Epub 2008 Sep 26.

31.

Staphylococcus aureus CodY negatively regulates virulence gene expression.

Majerczyk CD, Sadykov MR, Luong TT, Lee C, Somerville GA, Sonenshein AL.

J Bacteriol. 2008 Apr;190(7):2257-65. Epub 2007 Dec 21.

32.

Staphylococcus epidermidis saeR is an effector of anaerobic growth and a mediator of acute inflammation.

Handke LD, Rogers KL, Olson ME, Somerville GA, Jerrells TJ, Rupp ME, Dunman PM, Fey PD.

Infect Immun. 2008 Jan;76(1):141-52. Epub 2007 Oct 22.

33.

Staphylococcus aureus biofilm metabolism and the influence of arginine on polysaccharide intercellular adhesin synthesis, biofilm formation, and pathogenesis.

Zhu Y, Weiss EC, Otto M, Fey PD, Smeltzer MS, Somerville GA.

Infect Immun. 2007 Sep;75(9):4219-26. Epub 2007 Jun 18.

34.

Vancomycin-intermediate Staphylococcus aureus strains have impaired acetate catabolism: implications for polysaccharide intercellular adhesin synthesis and autolysis.

Nelson JL, Rice KC, Slater SR, Fox PM, Archer GL, Bayles KW, Fey PD, Kreiswirth BN, Somerville GA.

Antimicrob Agents Chemother. 2007 Feb;51(2):616-22. Epub 2006 Nov 27.

35.

Very low ethanol concentrations affect the viability and growth recovery in post-stationary-phase Staphylococcus aureus populations.

Chatterjee I, Somerville GA, Heilmann C, Sahl HG, Maurer HH, Herrmann M.

Appl Environ Microbiol. 2006 Apr;72(4):2627-36.

36.

Staphylococcus aureus ClpC is required for stress resistance, aconitase activity, growth recovery, and death.

Chatterjee I, Becker P, Grundmeier M, Bischoff M, Somerville GA, Peters G, Sinha B, Harraghy N, Proctor RA, Herrmann M.

J Bacteriol. 2005 Jul;187(13):4488-96.

37.

Staphylococcus epidermidis polysaccharide intercellular adhesin production significantly increases during tricarboxylic acid cycle stress.

Vuong C, Kidder JB, Jacobson ER, Otto M, Proctor RA, Somerville GA.

J Bacteriol. 2005 May;187(9):2967-73.

38.

Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain.

Banks DJ, Porcella SF, Barbian KD, Beres SB, Philips LE, Voyich JM, DeLeo FR, Martin JM, Somerville GA, Musser JM.

J Infect Dis. 2004 Aug 15;190(4):727-38. Epub 2004 Jul 20.

PMID:
15272401
39.

Growth characteristics of Bartonella henselae in a novel liquid medium: primary isolation, growth-phase-dependent phage induction, and metabolic studies.

Chenoweth MR, Somerville GA, Krause DC, O'Reilly KL, Gherardini FC.

Appl Environ Microbiol. 2004 Feb;70(2):656-63.

40.

Synthesis and deformylation of Staphylococcus aureus delta-toxin are linked to tricarboxylic acid cycle activity.

Somerville GA, Cockayne A, Dürr M, Peschel A, Otto M, Musser JM.

J Bacteriol. 2003 Nov;185(22):6686-94.

41.

Rgg coordinates virulence factor synthesis and metabolism in Streptococcus pyogenes.

Chaussee MS, Somerville GA, Reitzer L, Musser JM.

J Bacteriol. 2003 Oct;185(20):6016-24.

42.

Quorum-sensing control of biofilm factors in Staphylococcus epidermidis.

Vuong C, Gerke C, Somerville GA, Fischer ER, Otto M.

J Infect Dis. 2003 Sep 1;188(5):706-18. Epub 2003 Aug 11.

PMID:
12934187
43.

Correlation of acetate catabolism and growth yield in Staphylococcus aureus: implications for host-pathogen interactions.

Somerville GA, Saïd-Salim B, Wickman JM, Raffel SJ, Kreiswirth BN, Musser JM.

Infect Immun. 2003 Aug;71(8):4724-32.

44.

Glycerol-3-phosphate acquisition in spirochetes: distribution and biological activity of glycerophosphodiester phosphodiesterase (GlpQ) among Borrelia species.

Schwan TG, Battisti JM, Porcella SF, Raffel SJ, Schrumpf ME, Fischer ER, Carroll JA, Stewart PE, Rosa P, Somerville GA.

J Bacteriol. 2003 Feb;185(4):1346-56.

45.

An apoptosis-differentiation program in human polymorphonuclear leukocytes facilitates resolution of inflammation.

Kobayashi SD, Voyich JM, Somerville GA, Braughton KR, Malech HL, Musser JM, DeLeo FR.

J Leukoc Biol. 2003 Feb;73(2):315-22.

PMID:
12554809
46.

Staphylococcus aureus aconitase inactivation unexpectedly inhibits post-exponential-phase growth and enhances stationary-phase survival.

Somerville GA, Chaussee MS, Morgan CI, Fitzgerald JR, Dorward DW, Reitzer LJ, Musser JM.

Infect Immun. 2002 Nov;70(11):6373-82.

47.

In vitro serial passage of Staphylococcus aureus: changes in physiology, virulence factor production, and agr nucleotide sequence.

Somerville GA, Beres SB, Fitzgerald JR, DeLeo FR, Cole RL, Hoff JS, Musser JM.

J Bacteriol. 2002 Mar;184(5):1430-7.

48.

Global differential gene expression in response to growth temperature alteration in group A Streptococcus.

Smoot LM, Smoot JC, Graham MR, Somerville GA, Sturdevant DE, Migliaccio CA, Sylva GL, Musser JM.

Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10416-21. Epub 2001 Aug 21.

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