Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 137

1.

Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact.

Salo VT, Li S, Vihinen H, Hölttä-Vuori M, Szkalisity A, Horvath P, Belevich I, Peränen J, Thiele C, Somerharju P, Zhao H, Santinho A, Thiam AR, Jokitalo E, Ikonen E.

Dev Cell. 2019 Aug 19;50(4):478-493.e9. doi: 10.1016/j.devcel.2019.05.016. Epub 2019 Jun 6.

PMID:
31178403
2.

The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins.

El Omari K, Li S, Kotecha A, Walter TS, Bignon EA, Harlos K, Somerharju P, De Haas F, Clare DK, Molin M, Hurtado F, Li M, Grimes JM, Bamford DH, Tischler ND, Huiskonen JT, Stuart DI, Roine E.

Nat Commun. 2019 Feb 19;10(1):846. doi: 10.1038/s41467-019-08728-7.

3.

Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2.

Pekkinen M, Terhal PA, Botto LD, Henning P, Mäkitie RE, Roschger P, Jain A, Kol M, Kjellberg MA, Paschalis EP, van Gassen K, Murray M, Bayrak-Toydemir P, Magnusson MK, Jans J, Kausar M, Carey JC, Somerharju P, Lerner UH, Olkkonen VM, Klaushofer K, Holthuis JC, Mäkitie O.

JCI Insight. 2019 Apr 4;4(7). pii: 126180. doi: 10.1172/jci.insight.126180. eCollection 2019 Apr 4.

4.

ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol.

Koponen A, Arora A, Takahashi K, Kentala H, Kivelä AM, Jääskeläinen E, Peränen J, Somerharju P, Ikonen E, Viitala T, Olkkonen VM.

Biochimie. 2019 Mar;158:90-101. doi: 10.1016/j.biochi.2018.12.013. Epub 2018 Dec 24.

PMID:
30590084
5.

Mechanistic principles underlying regulation of the actin cytoskeleton by phosphoinositides.

Senju Y, Kalimeri M, Koskela EV, Somerharju P, Zhao H, Vattulainen I, Lappalainen P.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E8977-E8986. doi: 10.1073/pnas.1705032114. Epub 2017 Oct 9.

6.

Dynamics and energetics of the mammalian phosphatidylinositol transfer protein phospholipid exchange cycle.

Grabon A, Orłowski A, Tripathi A, Vuorio J, Javanainen M, Róg T, Lönnfors M, McDermott MI, Siebert G, Somerharju P, Vattulainen I, Bankaitis VA.

J Biol Chem. 2017 Sep 1;292(35):14438-14455. doi: 10.1074/jbc.M117.791467. Epub 2017 Jul 17.

7.

Simple and rapid biochemical method to synthesize labeled or unlabeled phosphatidylinositol species.

Hänninen S, Batchu KC, Hokynar K, Somerharju P.

J Lipid Res. 2017 Jun;58(6):1259-1264. doi: 10.1194/jlr.D075960. Epub 2017 Apr 18.

8.

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases.

Kol M, Panatala R, Nordmann M, Swart L, van Suijlekom L, Cabukusta B, Hilderink A, Grabietz T, Mina JGM, Somerharju P, Korneev S, Tafesse FG, Holthuis JCM.

J Lipid Res. 2017 May;58(5):962-973. doi: 10.1194/jlr.M076133. Epub 2017 Mar 23.

9.

Factors regulating the substrate specificity of cytosolic phospholipase A2-alpha in vitro.

Batchu KC, Hänninen S, Jha SK, Jeltsch M, Somerharju P.

Biochim Biophys Acta. 2016 Nov;1861(11):1597-1604. doi: 10.1016/j.bbalip.2016.06.022. Epub 2016 Jul 1.

PMID:
27377346
10.

The PNPLA-family phospholipases involved in glycerophospholipid homeostasis of HeLa cells.

Hermansson M, Hänninen S, Hokynar K, Somerharju P.

Biochim Biophys Acta. 2016 Sep;1861(9 Pt A):1058-1065. doi: 10.1016/j.bbalip.2016.06.007. Epub 2016 Jun 15.

PMID:
27317427
11.

Two-ligand priming mechanism for potentiated phosphoinositide synthesis is an evolutionarily conserved feature of Sec14-like phosphatidylinositol and phosphatidylcholine exchange proteins.

Huang J, Ghosh R, Tripathi A, Lönnfors M, Somerharju P, Bankaitis VA.

Mol Biol Cell. 2016 Jul 15;27(14):2317-30. doi: 10.1091/mbc.E16-04-0221. Epub 2016 May 18.

12.

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site engineering of sphingomyelin synthases.

Kol M, Panatala R, Nordmann M, Swart L, van Suijlekom L, Cabukusta B, Hilderink A, Grabietz T, Mina JG, Somerharju P, Korneev S, Tafesse FG, Holthuis JC.

J Lipid Res. 2016 Jul;57(7):1273-85. doi: 10.1194/jlr.M068692. Epub 2016 May 10. Retraction in: J Lipid Res. 2017 Apr;58(4):821.

13.

A2B5+/GFAP+ Cells of Rat Spinal Cord Share a Similar Lipid Profile with Progenitor Cells: A Comparative Lipidomic Study.

Itokazu Y, Tajima N, Kerosuo L, Somerharju P, Sariola H, Yu RK, Käkelä R.

Neurochem Res. 2016 Jul;41(7):1527-44. doi: 10.1007/s11064-016-1867-3. Epub 2016 Feb 25.

PMID:
26915109
14.

Substrate efflux propensity is the key determinant of Ca2+-independent phospholipase A-β (iPLAβ)-mediated glycerophospholipid hydrolysis.

Batchu KC, Hokynar K, Jeltsch M, Mattonet K, Somerharju P.

J Biol Chem. 2015 Apr 17;290(16):10093-103. doi: 10.1074/jbc.M115.642835. Epub 2015 Feb 23.

15.

Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice.

Bickert A, Ginkel C, Kol M, vom Dorp K, Jastrow H, Degen J, Jacobs RL, Vance DE, Winterhager E, Jiang XC, Dörmann P, Somerharju P, Holthuis JC, Willecke K.

J Lipid Res. 2015 Apr;56(4):821-35. doi: 10.1194/jlr.M055269. Epub 2015 Feb 9. Erratum in: J Lipid Res. 2017 Apr;58(4):820.

16.

Is Spontaneous Translocation of Polar Lipids Between Cellular Organelles Negligible?

Somerharju P.

Lipid Insights. 2016 Apr 27;8(Suppl 1):87-93. doi: 10.4137/LPI.S31616. eCollection 2015. Review.

17.

Sphingomyelin synthase-related protein SMSr is a suppressor of ceramide-induced mitochondrial apoptosis.

Tafesse FG, Vacaru AM, Bosma EF, Hermansson M, Jain A, Hilderink A, Somerharju P, Holthuis JC.

J Cell Sci. 2014 Jan 15;127(Pt 2):445-54. doi: 10.1242/jcs.138933. Epub 2013 Nov 20.

18.

Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins.

Tafesse FG, Sanyal S, Ashour J, Guimaraes CP, Hermansson M, Somerharju P, Ploegh HL.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6406-11. doi: 10.1073/pnas.1219909110. Epub 2013 Apr 1.

19.

Phosphatidic acid is required for the constitutive ruffling and macropinocytosis of phagocytes.

Bohdanowicz M, Schlam D, Hermansson M, Rizzuti D, Fairn GD, Ueyama T, Somerharju P, Du G, Grinstein S.

Mol Biol Cell. 2013 Jun;24(11):1700-12, S1-7. doi: 10.1091/mbc.E12-11-0789. Epub 2013 Apr 10.

20.

Dynamics of the ethanolamine glycerophospholipid remodeling network.

Zhang L, Díaz-Díaz N, Zarringhalam K, Hermansson M, Somerharju P, Chuang J.

PLoS One. 2012;7(12):e50858. doi: 10.1371/journal.pone.0050858. Epub 2012 Dec 10.

21.

Import of phosphatidylserine to and export of phosphatidylethanolamine molecular species from mitochondria.

Kainu V, Hermansson M, Hänninen S, Hokynar K, Somerharju P.

Biochim Biophys Acta. 2013 Feb;1831(2):429-37. doi: 10.1016/j.bbalip.2012.11.003. Epub 2012 Nov 16.

PMID:
23159415
22.

Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid.

Garner K, Hunt AN, Koster G, Somerharju P, Groves E, Li M, Raghu P, Holic R, Cockcroft S.

J Biol Chem. 2012 Sep 14;287(38):32263-76. doi: 10.1074/jbc.M112.375840. Epub 2012 Jul 21.

23.

Tracking sphingosine metabolism and transport in sphingolipidoses: NPC1 deficiency as a test case.

Blom T, Li Z, Bittman R, Somerharju P, Ikonen E.

Traffic. 2012 Sep;13(9):1234-43. doi: 10.1111/j.1600-0854.2012.01379.x. Epub 2012 Jun 11.

24.

Calorimetric behavior of phosphatidylcholine/phosphatidylethanolamine bilayers is compatible with the superlattice model.

Cheng KH, Virtanen J, Somerharju P.

J Phys Chem B. 2012 Feb 16;116(6):1802-11. doi: 10.1021/jp2078488. Epub 2012 Feb 6.

25.

Galactolipid deficiency in the early pathogenesis of neuronal ceroid lipofuscinosis model Cln8mnd : implications to delayed myelination and oligodendrocyte maturation.

Kuronen M, Hermansson M, Manninen O, Zech I, Talvitie M, Laitinen T, Gröhn O, Somerharju P, Eckhardt M, Cooper JD, Lehesjoki AE, Lahtinen U, Kopra O.

Neuropathol Appl Neurobiol. 2012 Aug;38(5):471-86. doi: 10.1111/j.1365-2990.2011.01233.x.

PMID:
22044361
26.

Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity.

Fairn GD, Hermansson M, Somerharju P, Grinstein S.

Nat Cell Biol. 2011 Oct 2;13(12):1424-30. doi: 10.1038/ncb2351.

PMID:
21964439
27.

OX1 orexin/hypocretin receptor activation of phospholipase D.

Jäntti MH, Putula J, Somerharju P, Frohman MA, Kukkonen JP.

Br J Pharmacol. 2012 Feb;165(4b):1109-23. doi: 10.1111/j.1476-5381.2011.01565.x.

28.

Synthesis and biosynthetic trafficking of membrane lipids.

Blom T, Somerharju P, Ikonen E.

Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a004713. doi: 10.1101/cshperspect.a004713. Review.

29.

Mechanisms of glycerophospholipid homeostasis in mammalian cells.

Hermansson M, Hokynar K, Somerharju P.

Prog Lipid Res. 2011 Jul;50(3):240-57. doi: 10.1016/j.plipres.2011.02.004. Epub 2011 Mar 5. Review.

PMID:
21382416
30.

Activity of BK(Ca) channel is modulated by membrane cholesterol content and association with Na+/K+-ATPase in human melanoma IGR39 cells.

Tajima N, Itokazu Y, Korpi ER, Somerharju P, Käkelä R.

J Biol Chem. 2011 Feb 18;286(7):5624-38. doi: 10.1074/jbc.M110.149898. Epub 2010 Dec 6.

31.

Introduction of phospholipids to cultured cells with cyclodextrin.

Kainu V, Hermansson M, Somerharju P.

J Lipid Res. 2010 Dec;51(12):3533-41. doi: 10.1194/jlr.D009373. Epub 2010 Sep 29.

32.

Acyl-chain mismatch driven superlattice arrangements in DPPC/DLPC/cholesterol bilayers.

Cannon B, Lewis A, Somerharju P, Virtanen J, Huang J, Cheng KH.

J Phys Chem B. 2010 Aug 12;114(31):10105-13. doi: 10.1021/jp105104f. Erratum in: J Phys Chem B. 2010 Sep 23;114(37):12182.

33.

New, closely related haloarchaeal viral elements with different nucleic Acid types.

Roine E, Kukkaro P, Paulin L, Laurinavicius S, Domanska A, Somerharju P, Bamford DH.

J Virol. 2010 Apr;84(7):3682-9. doi: 10.1128/JVI.01879-09. Epub 2010 Jan 20.

34.

Arachidonic acid release mediated by OX1 orexin receptors.

Turunen PM, Ekholm ME, Somerharju P, Kukkonen JP.

Br J Pharmacol. 2010 Jan;159(1):212-21. doi: 10.1111/j.1476-5381.2009.00535.x. Epub 2009 Dec 4.

35.

Substrate efflux propensity plays a key role in the specificity of secretory A-type phospholipases.

Haimi P, Hermansson M, Batchu KC, Virtanen JA, Somerharju P.

J Biol Chem. 2010 Jan 1;285(1):751-60. doi: 10.1074/jbc.M109.061218. Epub 2009 Nov 2.

36.

Instrument-independent software tools for the analysis of MS-MS and LC-MS lipidomics data.

Haimi P, Chaithanya K, Kainu V, Hermansson M, Somerharju P.

Methods Mol Biol. 2009;580:285-94. doi: 10.1007/978-1-60761-325-1_16.

PMID:
19784606
37.

Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER.

Vacaru AM, Tafesse FG, Ternes P, Kondylis V, Hermansson M, Brouwers JF, Somerharju P, Rabouille C, Holthuis JC.

J Cell Biol. 2009 Jun 15;185(6):1013-27. doi: 10.1083/jcb.200903152. Epub 2009 Jun 8.

38.

Cholesterol modulates the interaction of beta-amyloid peptide with lipid bilayers.

Qiu L, Lewis A, Como J, Vaughn MW, Huang J, Somerharju P, Virtanen J, Cheng KH.

Biophys J. 2009 May 20;96(10):4299-307. doi: 10.1016/j.bpj.2009.02.036.

39.

The superlattice model of lateral organization of membranes and its implications on membrane lipid homeostasis.

Somerharju P, Virtanen JA, Cheng KH, Hermansson M.

Biochim Biophys Acta. 2009 Jan;1788(1):12-23. doi: 10.1016/j.bbamem.2008.10.004. Epub 2008 Oct 25. Review.

40.

Seasonal acclimatization of brain lipidome in a eurythermal fish (Carassius carassius) is mainly determined by temperature.

Käkelä R, Mattila M, Hermansson M, Haimi P, Uphoff A, Paajanen V, Somerharju P, Vornanen M.

Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1716-28. doi: 10.1152/ajpregu.00883.2007. Epub 2008 Feb 27.

41.

Elevated globotriaosylsphingosine is a hallmark of Fabry disease.

Aerts JM, Groener JE, Kuiper S, Donker-Koopman WE, Strijland A, Ottenhoff R, van Roomen C, Mirzaian M, Wijburg FA, Linthorst GE, Vedder AC, Rombach SM, Cox-Brinkman J, Somerharju P, Boot RG, Hollak CE, Brady RO, Poorthuis BJ.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2812-7. doi: 10.1073/pnas.0712309105. Epub 2008 Feb 19.

42.

Comparison of rat epidermal keratinocyte organotypic culture (ROC) with intact human skin: lipid composition and thermal phase behavior of the stratum corneum.

Pappinen S, Hermansson M, Kuntsche J, Somerharju P, Wertz P, Urtti A, Suhonen M.

Biochim Biophys Acta. 2008 Apr;1778(4):824-34. doi: 10.1016/j.bbamem.2007.12.019. Epub 2008 Jan 4.

43.
44.

Endocytic trafficking of sphingomyelin depends on its acyl chain length.

Koivusalo M, Jansen M, Somerharju P, Ikonen E.

Mol Biol Cell. 2007 Dec;18(12):5113-23. Epub 2007 Oct 17.

45.

Acyl chain-dependent effect of lysophosphatidylcholine on human neutrophils.

Ojala PJ, Hirvonen TE, Hermansson M, Somerharju P, Parkkinen J.

J Leukoc Biol. 2007 Dec;82(6):1501-9. Epub 2007 Sep 20.

PMID:
17884992
46.

Transbilayer distribution of phospholipids in bacteriophage membranes.

Laurinavicius S, Bamford DH, Somerharju P.

Biochim Biophys Acta. 2007 Oct;1768(10):2568-77. Epub 2007 Jun 19.

47.

Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells.

Tafesse FG, Huitema K, Hermansson M, van der Poel S, van den Dikkenberg J, Uphoff A, Somerharju P, Holthuis JC.

J Biol Chem. 2007 Jun 15;282(24):17537-47. Epub 2007 Apr 22.

48.

Software tools for analysis of mass spectrometric lipidome data.

Haimi P, Uphoff A, Hermansson M, Somerharju P.

Anal Chem. 2006 Dec 15;78(24):8324-31.

PMID:
17165823
49.

Identification of alpha-1 acid glycoprotein as a lysophospholipid binding protein: a complementary role to albumin in the scavenging of lysophosphatidylcholine.

Ojala PJ, Hermansson M, Tolvanen M, Polvinen K, Hirvonen T, Impola U, Jauhiainen M, Somerharju P, Parkkinen J.

Biochemistry. 2006 Nov 28;45(47):14021-31.

PMID:
17115697
50.

Lipid headgroup superlattice modulates the activity of surface-acting cholesterol oxidase in ternary phospholipid/cholesterol bilayers.

Cheng KH, Cannon B, Metze J, Lewis A, Huang J, Vaughn MW, Zhu Q, Somerharju P, Virtanen J.

Biochemistry. 2006 Sep 12;45(36):10855-64.

PMID:
16953571

Supplemental Content

Loading ...
Support Center