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Items: 47

1.

Characterization of spontaneous recurrent epileptiform discharges in hippocampal-entorhinal cortical slices prepared from chronic epileptic animals.

Carter DS, Deshpande LS, Rafiq A, Sombati S, DeLorenzo RJ.

Seizure. 2011 Apr;20(3):218-24. doi: 10.1016/j.seizure.2010.11.022. Epub 2010 Dec 18.

2.

Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy.

Blair RE, Deshpande LS, Sombati S, Elphick MR, Martin BR, DeLorenzo RJ.

Neuropharmacology. 2009 Sep;57(3):208-18. doi: 10.1016/j.neuropharm.2009.06.007. Epub 2009 Jun 18.

3.

Alterations in neuronal calcium levels are associated with cognitive deficits after traumatic brain injury.

Deshpande LS, Sun DA, Sombati S, Baranova A, Wilson MS, Attkisson E, Hamm RJ, DeLorenzo RJ.

Neurosci Lett. 2008 Aug 15;441(1):115-9. doi: 10.1016/j.neulet.2008.05.113. Epub 2008 Jun 7.

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Carisbamate prevents the development and expression of spontaneous recurrent epileptiform discharges and is neuroprotective in cultured hippocampal neurons.

Deshpande LS, Nagarkatti N, Ziobro JM, Sombati S, DeLorenzo RJ.

Epilepsia. 2008 Oct;49(10):1795-802. doi: 10.1111/j.1528-1167.2008.01667.x. Epub 2008 May 20.

6.

Traumatic brain injury causes a long-lasting calcium (Ca2+)-plateau of elevated intracellular Ca levels and altered Ca2+ homeostatic mechanisms in hippocampal neurons surviving brain injury.

Sun DA, Deshpande LS, Sombati S, Baranova A, Wilson MS, Hamm RJ, DeLorenzo RJ.

Eur J Neurosci. 2008 Apr;27(7):1659-72. doi: 10.1111/j.1460-9568.2008.06156.x. Epub 2008 Mar 25.

7.

The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons.

Deshpande LS, Nagarkatti N, Sombati S, DeLorenzo RJ.

Epilepsy Res. 2008 May;79(2-3):158-65. doi: 10.1016/j.eplepsyres.2008.01.002. Epub 2008 Mar 18.

8.

Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: role of NMDA receptor activation and NMDA dependent calcium entry.

Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, Attkisson E, DeLorenzo RJ.

Eur J Pharmacol. 2008 Mar 31;583(1):73-83. doi: 10.1016/j.ejphar.2008.01.025. Epub 2008 Feb 5.

9.

In vitro status epilepticus but not spontaneous recurrent seizures cause cell death in cultured hippocampal neurons.

Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, DeLorenzo RJ.

Epilepsy Res. 2007 Jul;75(2-3):171-9.

10.

NMDA channel antagonist MK-801 does not protect against bilirubin neurotoxicity.

Shapiro SM, Sombati S, Geiger A, Rice AC.

Neonatology. 2007;92(4):248-57. Epub 2007 Jun 8.

PMID:
17556843
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13.

Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neurons.

Raza M, Deshpande LS, Blair RE, Carter DS, Sombati S, DeLorenzo RJ.

Neurosci Lett. 2007 May 11;418(1):77-81. Epub 2007 Mar 12.

14.

Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus.

Deshpande LS, Blair RE, Nagarkatti N, Sombati S, Martin BR, DeLorenzo RJ.

Exp Neurol. 2007 Apr;204(2):705-13. Epub 2007 Jan 9.

15.

Endocannabinoids block status epilepticus in cultured hippocampal neurons.

Deshpande LS, Blair RE, Ziobro JM, Sombati S, Martin BR, DeLorenzo RJ.

Eur J Pharmacol. 2007 Mar 8;558(1-3):52-9. Epub 2006 Nov 22.

16.

Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy.

Deshpande LS, Sombati S, Blair RE, Carter DS, Martin BR, DeLorenzo RJ.

Neurosci Lett. 2007 Jan 3;411(1):11-6. Epub 2006 Nov 15.

17.

Altered calcium/calmodulin kinase II activity changes calcium homeostasis that underlies epileptiform activity in hippocampal neurons in culture.

Carter DS, Haider SN, Blair RE, Deshpande LS, Sombati S, DeLorenzo RJ.

J Pharmacol Exp Ther. 2006 Dec;319(3):1021-31. Epub 2006 Sep 13.

PMID:
16971505
18.

Activation of the cannabinoid type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy and status epilepticus.

Blair RE, Deshpande LS, Sombati S, Falenski KW, Martin BR, DeLorenzo RJ.

J Pharmacol Exp Ther. 2006 Jun;317(3):1072-8. Epub 2006 Feb 9.

PMID:
16469864
19.

Evidence that injury-induced changes in hippocampal neuronal calcium dynamics during epileptogenesis cause acquired epilepsy.

Raza M, Blair RE, Sombati S, Carter DS, Deshpande LS, DeLorenzo RJ.

Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17522-7. Epub 2004 Dec 6.

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Inhibition of sustained repetitive firing in cultured hippocampal neurons by an aqueous fraction isolated from Delphinium denudatum.

Raza M, Shaheen F, Choudhary MI, Sombati S, Rahman AU, DeLorenzo RJ.

J Ethnopharmacol. 2004 Feb;90(2-3):367-74.

PMID:
15013203
22.

Long-lasting alterations in neuronal calcium homeostasis in an in vitro model of stroke-induced epilepsy.

Sun DA, Sombati S, Blair RE, DeLorenzo RJ.

Cell Calcium. 2004 Feb;35(2):155-63.

PMID:
14706289
23.

Anticonvulsant effect of FS-1 subfraction isolated from roots of Delphinim denudatum on hippocampal pyramidal neurons.

Raza M, Shaheen F, Choudhary MI, Rahman AU, Sombati S, Suria A, Rafiq A, DeLorenzo RJ.

Phytother Res. 2003 Jan;17(1):38-43.

PMID:
12557245
25.

Calcium-dependent epileptogenesis in an in vitro model of stroke-induced "epilepsy".

Sun DA, Sombati S, Blair RE, DeLorenzo RJ.

Epilepsia. 2002 Nov;43(11):1296-305.

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Anticonvulsant activities of ethanolic extract and aqueous fraction isolated from Delphinium denudatum.

Raza M, Shaheen F, Choudhary MI, Sombati S, Rafiq A, Suria A, Rahman A, DeLorenzo RJ.

J Ethnopharmacol. 2001 Nov;78(1):73-8.

PMID:
11585691
29.

Anticonvulsant activities of the FS-1 subfraction isolated from roots of Delphinium denudatum.

Raza M, Shaheen F, Choudhary MI, Suria A, Rahman AU, Sombati S, DeLorenzo RJ.

Phytother Res. 2001 Aug;15(5):426-30.

PMID:
11507736
30.

Inhibition of calcium/calmodulin kinase II alpha subunit expression results in epileptiform activity in cultured hippocampal neurons.

Churn SB, Sombati S, Jakoi ER, Severt L, DeLorenzo RJ.

Proc Natl Acad Sci U S A. 2000 May 9;97(10):5604-9. Erratum in: Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15285. Sievert, L [corrected to Severt, L].

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Cellular actions of topiramate: blockade of kainate-evoked inward currents in cultured hippocampal neurons.

Gibbs JW 3rd, Sombati S, DeLorenzo RJ, Coulter DA.

Epilepsia. 2000;41 Suppl 1:S10-6.

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In vitro status epilepticus causes sustained elevation of intracellular calcium levels in hippocampal neurons.

Pal S, Sombati S, Limbrick DD Jr, DeLorenzo RJ.

Brain Res. 1999 Dec 18;851(1-2):20-31.

PMID:
10642824
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37.

Inability to restore resting intracellular calcium levels as an early indicator of delayed neuronal cell death.

Limbrick DD Jr, Churn SB, Sombati S, DeLorenzo RJ.

Brain Res. 1995 Sep 4;690(2):145-56.

PMID:
8535831
38.
39.

Recurrent spontaneous seizure activity in hippocampal neuronal networks in culture.

Sombati S, Delorenzo RJ.

J Neurophysiol. 1995 Apr;73(4):1706-11.

PMID:
7643176
40.

Excitotoxicity affects membrane potential and calmodulin kinase II activity in cultured rat cortical neurons.

Churn SB, Sombati S, Taft WC, DeLorenzo RJ.

Stroke. 1993 Feb;24(2):271-7; discussion 277-8.

PMID:
8093648
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44.

Membrane currents in identified lactotrophs of rat anterior pituitary.

Lingle CJ, Sombati S, Freeman ME.

J Neurosci. 1986 Oct;6(10):2995-3005.

45.

Glutamatergic central nervous transmission in locusts.

Sombati S, Hoyle G.

J Neurobiol. 1984 Nov;15(6):507-16.

PMID:
6097646
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