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Items: 11

1.

Membrane Dynamics of γ-Secretase Provides a Molecular Basis for β-Amyloid Binding and Processing.

Somavarapu AK, Kepp KP.

ACS Chem Neurosci. 2017 Nov 15;8(11):2424-2436. doi: 10.1021/acschemneuro.7b00208. Epub 2017 Aug 25.

PMID:
28841371
2.

The Pathogenic A2V Mutant Exhibits Distinct Aggregation Kinetics, Metal Site Structure, and Metal Exchange of the Cu2+ -Aβ Complex.

Somavarapu AK, Shen F, Teilum K, Zhang J, Mossin S, Thulstrup PW, Bjerrum MJ, Tiwari MK, Szunyogh D, Søtofte PM, Kepp KP, Hemmingsen L.

Chemistry. 2017 Oct 4;23(55):13591-13595. doi: 10.1002/chem.201703440. Epub 2017 Sep 5.

PMID:
28815875
3.

The dynamic mechanism of presenilin-1 function: Sensitive gate dynamics and loop unplugging control protein access.

Somavarapu AK, Kepp KP.

Neurobiol Dis. 2016 May;89:147-56. doi: 10.1016/j.nbd.2016.02.008. Epub 2016 Feb 4.

PMID:
26852951
4.

Loss of stability and hydrophobicity of presenilin 1 mutations causing Alzheimer's disease.

Somavarapu AK, Kepp KP.

J Neurochem. 2016 Apr;137(1):101-11. doi: 10.1111/jnc.13535. Epub 2016 Feb 11.

5.

ONRLDB--manually curated database of experimentally validated ligands for orphan nuclear receptors: insights into new drug discovery.

Nanduri R, Bhutani I, Somavarapu AK, Mahajan S, Parkesh R, Gupta P.

Database (Oxford). 2015 Dec 4;2015. pii: bav112. doi: 10.1093/database/bav112. Print 2015.

6.

Direct Correlation of Cell Toxicity to Conformational Ensembles of Genetic Aβ Variants.

Somavarapu AK, Kepp KP.

ACS Chem Neurosci. 2015 Dec 16;6(12):1990-6. doi: 10.1021/acschemneuro.5b00238. Epub 2015 Oct 15.

PMID:
26447342
7.

The Dependence of Amyloid-β Dynamics on Protein Force Fields and Water Models.

Somavarapu AK, Kepp KP.

Chemphyschem. 2015 Oct 26;16(15):3278-89. doi: 10.1002/cphc.201500415. Epub 2015 Aug 19.

PMID:
26256268
8.

Mycobacterium tuberculosis keto-mycolic acid and macrophage nuclear receptor TR4 modulate foamy biogenesis in granulomas: a case of a heterologous and noncanonical ligand-receptor pair.

Dkhar HK, Nanduri R, Mahajan S, Dave S, Saini A, Somavarapu AK, Arora A, Parkesh R, Thakur KG, Mayilraj S, Gupta P.

J Immunol. 2014 Jul 1;193(1):295-305. doi: 10.4049/jimmunol.1400092. Epub 2014 Jun 6.

9.

Structural interrogation of phosphoproteome identified by mass spectrometry reveals allowed and disallowed regions of phosphoconformation.

Somavarapu AK, Balakrishnan S, Gautam AK, Palmer DS, Venkatraman P.

BMC Struct Biol. 2014 Mar 11;14:9. doi: 10.1186/1472-6807-14-9.

10.

Discovery of multiple interacting partners of gankyrin, a proteasomal chaperone and an oncoprotein--evidence for a common hot spot site at the interface and its functional relevance.

Nanaware PP, Ramteke MP, Somavarapu AK, Venkatraman P.

Proteins. 2014 Jul;82(7):1283-300. doi: 10.1002/prot.24494. Epub 2014 Jan 15.

PMID:
24338975
11.

Identification of a novel ATPase activity in 14-3-3 proteins--evidence from enzyme kinetics, structure guided modeling and mutagenesis studies.

Ramteke MP, Shelke P, Ramamoorthy V, Somavarapu AK, Gautam AK, Nanaware PP, Karanam S, Mukhopadhyay S, Venkatraman P.

FEBS Lett. 2014 Jan 3;588(1):71-8. doi: 10.1016/j.febslet.2013.11.008. Epub 2013 Nov 20.

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