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Immunotherapy in Oral Cancer.

Mohan SP, Bhaskaran MK, George AL, Thirutheri A, Somasundaran M, Pavithran A.

J Pharm Bioallied Sci. 2019 May;11(Suppl 2):S107-S111. doi: 10.4103/JPBS.JPBS_31_19. Review.


Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody.

Prachanronarong KL, Canale AS, Liu P, Somasundaran M, Hou S, Poh YP, Han T, Zhu Q, Renzette N, Zeldovich KB, Kowalik TF, Kurt-Yilmaz N, Jensen JD, Bolon DNA, Marasco WA, Finberg RW, Schiffer CA, Wang JP.

J Virol. 2019 Jan 4;93(2). pii: e01639-18. doi: 10.1128/JVI.01639-18. Print 2019 Jan 15.


Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions.

Silvas TV, Hou S, Myint W, Nalivaika E, Somasundaran M, Kelch BA, Matsuo H, Kurt Yilmaz N, Schiffer CA.

Sci Rep. 2018 May 14;8(1):7511. doi: 10.1038/s41598-018-25881-z.


Ultradeep single-molecule real-time sequencing of HIV envelope reveals complete compartmentalization of highly macrophage-tropic R5 proviral variants in brain and CXCR4-using variants in immune and peripheral tissues.

Brese RL, Gonzalez-Perez MP, Koch M, O'Connell O, Luzuriaga K, Somasundaran M, Clapham PR, Dollar JJ, Nolan DJ, Rose R, Lamers SL.

J Neurovirol. 2018 Aug;24(4):439-453. doi: 10.1007/s13365-018-0633-5. Epub 2018 Apr 23.


HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded.

Quitadamo B, Peters PJ, Repik A, O'Connell O, Mou Z, Koch M, Somasundaran M, Brody R, Luzuriaga K, Wallace A, Wang S, Lu S, McCauley S, Luban J, Duenas-Decamp M, Gonzalez-Perez MP, Clapham PR.

J Virol. 2018 Jan 2;92(2). pii: e00841-17. doi: 10.1128/JVI.00841-17. Print 2018 Jan 15.


Early Epstein-Barr Virus Genomic Diversity and Convergence toward the B95.8 Genome in Primary Infection.

Weiss ER, Lamers SL, Henderson JL, Melnikov A, Somasundaran M, Garber M, Selin L, Nusbaum C, Luzuriaga K.

J Virol. 2018 Jan 2;92(2). pii: e01466-17. doi: 10.1128/JVI.01466-17. Print 2018 Jan 15.


Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity.

Kouno T, Silvas TV, Hilbert BJ, Shandilya SMD, Bohn MF, Kelch BA, Royer WE, Somasundaran M, Kurt Yilmaz N, Matsuo H, Schiffer CA.

Nat Commun. 2017 Apr 28;8:15024. doi: 10.1038/ncomms15024.


Oro-facial digital syndrome (type II) with lingual lipomas.

Abdulla R, Somasundaran M.

Indian J Med Res. 2016 Oct;144(4):636-637. doi: 10.4103/0971-5916.200889. No abstract available.


High Epstein-Barr Virus Load and Genomic Diversity Are Associated with Generation of gp350-Specific Neutralizing Antibodies following Acute Infectious Mononucleosis.

Weiss ER, Alter G, Ogembo JG, Henderson JL, Tabak B, BakiƟ Y, Somasundaran M, Garber M, Selin L, Luzuriaga K.

J Virol. 2016 Dec 16;91(1). pii: e01562-16. doi: 10.1128/JVI.01562-16. Print 2017 Jan 1.


Early Combination Antiretroviral Therapy Limits Exposure to HIV-1 Replication and Cell-Associated HIV-1 DNA Levels in Infants.

McManus M, Mick E, Hudson R, Mofenson LM, Sullivan JL, Somasundaran M, Luzuriaga K; PACTG 356 Investigators.

PLoS One. 2016 Apr 22;11(4):e0154391. doi: 10.1371/journal.pone.0154391. eCollection 2016.


Recombination elevates the effective evolutionary rate and facilitates the establishment of HIV-1 infection in infants after mother-to-child transmission.

Sanborn KB, Somasundaran M, Luzuriaga K, Leitner T.

Retrovirology. 2015 Nov 16;12:96. doi: 10.1186/s12977-015-0222-0.


A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection.

Greenough TC, Straubhaar JR, Kamga L, Weiss ER, Brody RM, McManus MM, Lambrecht LK, Somasundaran M, Luzuriaga KF.

J Immunol. 2015 Nov 1;195(9):4185-97. doi: 10.4049/jimmunol.1401513. Epub 2015 Sep 28.


The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization.

Bohn MF, Shandilya SMD, Silvas TV, Nalivaika EA, Kouno T, Kelch BA, Ryder SP, Kurt-Yilmaz N, Somasundaran M, Schiffer CA.

Structure. 2015 May 5;23(5):903-911. doi: 10.1016/j.str.2015.03.016. Epub 2015 Apr 23.


Viremic relapse after HIV-1 remission in a perinatally infected child.

Luzuriaga K, Gay H, Ziemniak C, Sanborn KB, Somasundaran M, Rainwater-Lovett K, Mellors JW, Rosenbloom D, Persaud D.

N Engl J Med. 2015 Feb 19;372(8):786-8. doi: 10.1056/NEJMc1413931. No abstract available.


Epstein-Barr virus latent membrane protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids.

Renzette N, Somasundaran M, Brewster F, Coderre J, Weiss ER, McManus M, Greenough T, Tabak B, Garber M, Kowalik TF, Luzuriaga K.

J Virol. 2014 Apr;88(7):3744-55. doi: 10.1128/JVI.03378-13. Epub 2014 Jan 15.


Crystal structure of the DNA cytosine deaminase APOBEC3F: the catalytically active and HIV-1 Vif-binding domain.

Bohn MF, Shandilya SM, Albin JS, Kouno T, Anderson BD, McDougle RM, Carpenter MA, Rathore A, Evans L, Davis AN, Zhang J, Lu Y, Somasundaran M, Matsuo H, Harris RS, Schiffer CA.

Structure. 2013 Jun 4;21(6):1042-50. doi: 10.1016/j.str.2013.04.010. Epub 2013 May 16.


Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates.

Wang S, Kishko M, Wan S, Wang Y, Brewster F, Gray GE, Violari A, Sullivan JL, Somasundaran M, Luzuriaga K, Lu S.

Hum Vaccin Immunother. 2012 Nov 1;8(11):1638-47. doi: 10.4161/hv.22414. Epub 2012 Nov 1.


Mass spectrometry tools for analysis of intermolecular interactions.

Auclair JR, Somasundaran M, Green KM, Evans JE, Schiffer CA, Ringe D, Petsko GA, Agar JN.

Methods Mol Biol. 2012;896:387-98. doi: 10.1007/978-1-4614-3704-8_26.


First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.

Li M, Shandilya SM, Carpenter MA, Rathore A, Brown WL, Perkins AL, Harki DA, Solberg J, Hook DJ, Pandey KK, Parniak MA, Johnson JR, Krogan NJ, Somasundaran M, Ali A, Schiffer CA, Harris RS.

ACS Chem Biol. 2012 Mar 16;7(3):506-17. doi: 10.1021/cb200440y. Epub 2012 Jan 17.


Genotypic and functional properties of early infant HIV-1 envelopes.

Kishko M, Somasundaran M, Brewster F, Sullivan JL, Clapham PR, Luzuriaga K.

Retrovirology. 2011 Aug 15;8:67. doi: 10.1186/1742-4690-8-67.


Programmed Death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usage.

Greenough TC, Campellone SC, Brody R, Jain S, Sanchez-Merino V, Somasundaran M, Luzuriaga K.

PLoS One. 2010 Sep 23;5(9):e12926. doi: 10.1371/journal.pone.0012926.


Virologic and immunologic outcomes in HIV-infected Cambodian children after 18 months of highly active antiretroviral therapy (HAART).

Sophan S, Meng CY, Pean P, Harwell J, Hutton E, Trzmielina S, Somasundaran M, Luzuriaga K, Pugatch D.

Southeast Asian J Trop Med Public Health. 2010 Jan;41(1):126-37.


Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces.

Shandilya SM, Nalam MN, Nalivaika EA, Gross PJ, Valesano JC, Shindo K, Li M, Munson M, Royer WE, Harjes E, Kono T, Matsuo H, Harris RS, Somasundaran M, Schiffer CA.

Structure. 2010 Jan 13;18(1):28-38. doi: 10.1016/j.str.2009.10.016.


Low-cost HIV-1 diagnosis and quantification in dried blood spots by real time PCR.

Mehta N, Trzmielina S, Nonyane BA, Eliot MN, Lin R, Foulkes AS, McNeal K, Ammann A, Eulalievyolo V, Sullivan JL, Luzuriaga K, Somasundaran M.

PLoS One. 2009 Jun 5;4(6):e5819. doi: 10.1371/journal.pone.0005819.


Diminished human immunodeficiency virus type 1 DNA yield from dried blood spots after storage in a humid incubator at 37 degrees C compared to -20 degrees C.

Mitchell C, Jennings C, Brambilla D, Aldrovandi G, Amedee AM, Beck I, Bremer JW, Coombs R, Decker D, Fiscus S, Fitzgibbon J, Luzuriaga K, Moye J, Palumbo P, Reichelderfer P, Somasundaran M, Stevens W, Frenkel L; Dried Blood Spot Working Group of the Infant Maternal Pediatric Adolescent AIDS Clinical Trials Network.

J Clin Microbiol. 2008 Sep;46(9):2945-9. doi: 10.1128/JCM.00359-08. Epub 2008 Jul 9.


Identification and characterization of HIV-1 CD8+ T cell escape variants with impaired fitness.

Sanchez-Merino V, Farrow MA, Brewster F, Somasundaran M, Luzuriaga K.

J Infect Dis. 2008 Jan 15;197(2):300-8. doi: 10.1086/524845.


Mass spectrometry analysis of HIV-1 Vif reveals an increase in ordered structure upon oligomerization in regions necessary for viral infectivity.

Auclair JR, Green KM, Shandilya S, Evans JE, Somasundaran M, Schiffer CA.

Proteins. 2007 Nov 1;69(2):270-84.


Cytomegalovirus (CMV) IE1- and pp65-specific CD8+ T cell responses broaden over time after primary CMV infection in infants.

Gibson L, Dooley S, Trzmielina S, Somasundaran M, Fisher D, Revello MG, Luzuriaga K.

J Infect Dis. 2007 Jun 15;195(12):1789-98. Epub 2007 May 8.


Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus.

Greenough TC, Carville A, Coderre J, Somasundaran M, Sullivan JL, Luzuriaga K, Mansfield K.

Am J Pathol. 2005 Aug;167(2):455-63.


Nuclear localization of HIV type 1 Vif isolated from a long-term asymptomatic individual and potential role in virus attenuation.

Farrow MA, Somasundaran M, Zhang C, Gabuzda D, Sullivan JL, Greenough TC.

AIDS Res Hum Retroviruses. 2005 Jun;21(6):565-74. Erratum in: AIDS Res Hum Retroviruses. 2005 Aug;21(8):742.


Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice.

Greenough TC, Babcock GJ, Roberts A, Hernandez HJ, Thomas WD Jr, Coccia JA, Graziano RF, Srinivasan M, Lowy I, Finberg RW, Subbarao K, Vogel L, Somasundaran M, Luzuriaga K, Sullivan JL, Ambrosino DM.

J Infect Dis. 2005 Feb 15;191(4):507-14. Epub 2005 Jan 14.


Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2.

Li W, Greenough TC, Moore MJ, Vasilieva N, Somasundaran M, Sullivan JL, Farzan M, Choe H.

J Virol. 2004 Oct;78(20):11429-33.


Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.

Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M.

Nature. 2003 Nov 27;426(6965):450-4.


Differential kinetics and specificity of EBV-specific CD4+ and CD8+ T cells during primary infection.

Precopio ML, Sullivan JL, Willard C, Somasundaran M, Luzuriaga K.

J Immunol. 2003 Mar 1;170(5):2590-8.


Evidence for a cytopathogenicity determinant in HIV-1 Vpr.

Somasundaran M, Sharkey M, Brichacek B, Luzuriaga K, Emerman M, Sullivan JL, Stevenson M.

Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9503-8. Epub 2002 Jul 1.


Enhanced culture method for detection of replication-competent virus in peripheral blood mononuclear cells of HIV type 1-infected individuals.

Haran JP, Greenough TC, Luzuriaga K, Sullivan JL, Flanigan T, Somasundaran M.

AIDS Res Hum Retroviruses. 2002 May 20;18(8):577-83.


Long-term nonprogressive infection with human immunodeficiency virus type 1 in a hemophilia cohort.

Greenough TC, Brettler DB, Kirchhoff F, Alexander L, Desrosiers RC, O'Brien SJ, Somasundaran M, Luzuriaga K, Sullivan JL.

J Infect Dis. 1999 Dec;180(6):1790-802.


Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes (CTL), virus load, and CD4 T cell loss: evidence supporting a protective role for CTL in vivo.

Greenough TC, Brettler DB, Somasundaran M, Panicali DL, Sullivan JL.

J Infect Dis. 1997 Jul;176(1):118-25.


Detection and differentiation of Epstein-Barr virus strains by in situ polymerase chain reaction.

Tamaki H, Byron KS, Sullivan JL, Somasundaran M.

Mol Cell Probes. 1997 Jun;11(3):237-41.


In vitro characterization of HIV type 1 biological clones from asymptomatic and symptomatic pediatric patients.

Forte SE, Sullivan JL, Somasundaran M.

AIDS Res Hum Retroviruses. 1996 Nov 20;12(17):1585-93.


Major histocompatibility complex class I-restricted cytotoxic T lymphocyte responses to Epstein-Barr virus in children.

Tamaki H, Beaulieu BL, Somasundaran M, Sullivan JL.

J Infect Dis. 1995 Sep;172(3):739-46.


Non-syncytium-inducing HIV type 1 isolated from infected individuals replicates in MT-2 cells.

Forte SE, Byron KS, Sullivan JL, Somasundaran M.

AIDS Res Hum Retroviruses. 1994 Dec;10(12):1613-8.


Localization of HIV RNA in mitochondria of infected cells: potential role in cytopathogenicity.

Somasundaran M, Zapp ML, Beattie LK, Pang L, Byron KS, Bassell GJ, Sullivan JL, Singer RH.

J Cell Biol. 1994 Sep;126(6):1353-60.


Normal immune function and inability to isolate virus in culture in an individual with long-term human immunodeficiency virus type 1 infection.

Greenough TC, Somasundaran M, Brettler DB, Hesselton RM, Alimenti A, Kirchhoff F, Panicali D, Sullivan JL.

AIDS Res Hum Retroviruses. 1994 Apr;10(4):395-403.


Quantitative assessment of human immunodeficiency virus type 1 replication in human xenografts of acutely infected Hu-PBL-SCID mice.

Koup RA, Hesselton RM, Safrit JT, Somasundaran M, Sullivan JL.

AIDS Res Hum Retroviruses. 1994 Mar;10(3):279-84.


Early viremia and immune responses in vertical human immunodeficiency virus type 1 infection.

Luzuriaga K, McQuilken P, Alimenti A, Somasundaran M, Hesselton R, Sullivan JL.

J Infect Dis. 1993 May;167(5):1008-13.


Silent human immunodeficiency virus type 1 infection: a rare occurrence in a high-risk heterosexual population.

Brettler DB, Somasundaran M, Forsberg AF, Krause E, Sullivan JL.

Blood. 1992 Nov 1;80(9):2396-400.

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