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Items: 36


From the Clinic to the Bench and Back Again in One Dog Year: How a Cross-Species Pipeline to Identify New Treatments for Sarcoma Illuminates the Path Forward in Precision Medicine.

Rao SR, Somarelli JA, Altunel E, Selmic LE, Byrum M, Sheth MU, Cheng S, Ware KE, Kim SY, Prinz JA, Devos N, Corcoran DL, Moseley A, Soderblom E, Hsu SD, Eward WC.

Front Oncol. 2020 Feb 11;10:117. doi: 10.3389/fonc.2020.00117. eCollection 2020.


Baby genomics: tracing the evolutionary changes that gave rise to placentation.

Hao Y, Lee HJ, Baraboo M, Burch K, Maurer T, Somarelli JA, Conant GC.

Genome Biol Evol. 2020 Feb 13. pii: evaa026. doi: 10.1093/gbe/evaa026. [Epub ahead of print]


Discordant and heterogeneous clinically relevant genomic alterations in circulating tumor cells vs plasma DNA from men with metastatic castration resistant prostate cancer.

Gupta S, Hovelson DH, Kemeny G, Halabi S, Foo WC, Anand M, Somarelli JA, Tomlins SA, Antonarakis ES, Luo J, Dittamore RV, George DJ, Rothwell C, Nanus DM, Armstrong AJ, Gregory SG.

Genes Chromosomes Cancer. 2020 Apr;59(4):225-239. doi: 10.1002/gcc.22824. Epub 2019 Nov 28.


Improving Cancer Drug Discovery by Studying Cancer across the Tree of Life.

Somarelli JA, Boddy AM, Gardner HL, DeWitt SB, Tuohy J, Megquier K, Sheth MU, Hsu SD, Thorne JL, London CA, Eward WC.

Mol Biol Evol. 2020 Jan 1;37(1):11-17. doi: 10.1093/molbev/msz254.


Molecular Biology and Evolution of Cancer: From Discovery to Action.

Somarelli JA, Gardner H, Cannataro VL, Gunady EF, Boddy AM, Johnson NA, Fisk JN, Gaffney SG, Chuang JH, Li S, Ciccarelli FD, Panchenko AR, Megquier K, Kumar S, Dornburg A, DeGregori J, Townsend JP.

Mol Biol Evol. 2020 Feb 1;37(2):320-326. doi: 10.1093/molbev/msz242.


Immune dysregulation and osteosarcoma: Staphylococcus aureus downregulates TGF-β and heightens the inflammatory signature in human and canine macrophages suppressed by osteosarcoma.

Tuohy JL, Somarelli JA, Borst LB, Eward WC, Lascelles BDX, Fogle JE.

Vet Comp Oncol. 2020 Mar;18(1):64-75. doi: 10.1111/vco.12529. Epub 2019 Oct 15.


Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer.

Armstrong AJ, Gupta S, Healy P, Kemeny G, Leith B, Zalutsky MR, Spritzer C, Davies C, Rothwell C, Ware K, Somarelli JA, Wood K, Ribar T, Giannakakou P, Zhang J, Gerber D, Anand M, Foo WC, Halabi S, Gregory SG, George DJ.

PLoS One. 2019 May 28;14(5):e0216934. doi: 10.1371/journal.pone.0216934. eCollection 2019.


Prospective Multicenter Validation of Androgen Receptor Splice Variant 7 and Hormone Therapy Resistance in High-Risk Castration-Resistant Prostate Cancer: The PROPHECY Study.

Armstrong AJ, Halabi S, Luo J, Nanus DM, Giannakakou P, Szmulewitz RZ, Danila DC, Healy P, Anand M, Rothwell CJ, Rasmussen J, Thornburg B, Berry WR, Wilder RS, Lu C, Chen Y, Silberstein JL, Kemeny G, Galletti G, Somarelli JA, Gupta S, Gregory SG, Scher HI, Dittamore R, Tagawa ST, Antonarakis ES, George DJ.

J Clin Oncol. 2019 May 1;37(13):1120-1129. doi: 10.1200/JCO.18.01731. Epub 2019 Mar 13.


E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms.

Jolly MK, Ware KE, Xu S, Gilja S, Shetler S, Yang Y, Wang X, Austin RG, Runyambo D, Hish AJ, Bartholf DeWitt S, George JT, Kreulen RT, Boss MK, Lazarides AL, Kerr DL, Gerber DG, Sivaraj D, Armstrong AJ, Dewhirst MW, Eward WC, Levine H, Somarelli JA.

Mol Cancer Res. 2019 Jun;17(6):1391-1402. doi: 10.1158/1541-7786.MCR-18-0763. Epub 2019 Mar 12.


An Integrative Systems Biology and Experimental Approach Identifies Convergence of Epithelial Plasticity, Metabolism, and Autophagy to Promote Chemoresistance.

Xu S, Ware KE, Ding Y, Kim SY, Sheth MU, Rao S, Chan W, Armstrong AJ, Eward WC, Jolly MK, Somarelli JA.

J Clin Med. 2019 Feb 7;8(2). pii: E205. doi: 10.3390/jcm8020205.


Soft Tissue Sarcoma of the Extremities: What Is the Value of Treating at High-volume Centers?

Lazarides AL, Kerr DL, Nussbaum DP, Kreulen RT, Somarelli JA, Blazer DG 3rd, Brigman BE, Eward WC.

Clin Orthop Relat Res. 2019 Apr;477(4):718-727. doi: 10.1097/01.blo.0000533623.60399.1b.


Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas.

Jolly MK, Somarelli JA, Sheth M, Biddle A, Tripathi SC, Armstrong AJ, Hanash SM, Bapat SA, Rangarajan A, Levine H.

Pharmacol Ther. 2019 Feb;194:161-184. doi: 10.1016/j.pharmthera.2018.09.007. Epub 2018 Sep 28. Review.


Survival Outcomes in Cancer Patients Predicted by a Partial EMT Gene Expression Scoring Metric.

George JT, Jolly MK, Xu S, Somarelli JA, Levine H.

Cancer Res. 2017 Nov 15;77(22):6415-6428. doi: 10.1158/0008-5472.CAN-16-3521. Epub 2017 Sep 25.


Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?

Jolly MK, Tripathi SC, Somarelli JA, Hanash SM, Levine H.

Mol Oncol. 2017 Jul;11(7):739-754. doi: 10.1002/1878-0261.12084. Epub 2017 Jun 19. Review.


EMT and MET: necessary or permissive for metastasis?

Jolly MK, Ware KE, Gilja S, Somarelli JA, Levine H.

Mol Oncol. 2017 Jul;11(7):755-769. doi: 10.1002/1878-0261.12083. Epub 2017 Jun 12. Review.


Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells.

Ware KE, Gilja S, Xu S, Shetler S, Jolly MK, Wang X, Bartholf Dewitt S, Hish AJ, Jordan S, Eward W, Levine H, Armstrong AJ, Somarelli JA.

J Vis Exp. 2017 Apr 7;(122). doi: 10.3791/55520.


PhyloOncology: Understanding cancer through phylogenetic analysis.

Somarelli JA, Ware KE, Kostadinov R, Robinson JM, Amri H, Abu-Asab M, Fourie N, Diogo R, Swofford D, Townsend JP.

Biochim Biophys Acta Rev Cancer. 2017 Apr;1867(2):101-108. doi: 10.1016/j.bbcan.2016.10.006. Epub 2016 Oct 31. Review.


Whole Genomic Copy Number Alterations in Circulating Tumor Cells from Men with Abiraterone or Enzalutamide-Resistant Metastatic Castration-Resistant Prostate Cancer.

Gupta S, Li J, Kemeny G, Bitting RL, Beaver J, Somarelli JA, Ware KE, Gregory S, Armstrong AJ.

Clin Cancer Res. 2017 Mar 1;23(5):1346-1357. doi: 10.1158/1078-0432.CCR-16-1211. Epub 2016 Sep 6.


Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer.

Ware KE, Somarelli JA, Schaeffer D, Li J, Zhang T, Park S, Patierno SR, Freedman J, Foo WC, Garcia-Blanco MA, Armstrong AJ.

Oncotarget. 2016 Aug 2;7(31):50507-50521. doi: 10.18632/oncotarget.10476.


Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2.

Somarelli JA, Shetler S, Jolly MK, Wang X, Bartholf Dewitt S, Hish AJ, Gilja S, Eward WC, Ware KE, Levine H, Armstrong AJ, Garcia-Blanco MA.

Mol Cell Biol. 2016 Sep 12;36(19):2503-13. doi: 10.1128/MCB.00373-16. Print 2016 Oct 1.


Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.

Somarelli JA, Schaeffer D, Marengo MS, Bepler T, Rouse D, Ware KE, Hish AJ, Zhao Y, Buckley AF, Epstein JI, Armstrong AJ, Virshup DM, Garcia-Blanco MA.

Oncogene. 2016 Aug 18;35(33):4302-11. doi: 10.1038/onc.2015.497. Epub 2016 Jan 11.


Carcinosarcomas: tumors in transition?

Somarelli JA, Boss MK, Epstein JI, Armstrong AJ, Garcia-Blanco MA.

Histol Histopathol. 2015 Jun;30(6):673-87. doi: 10.14670/HH-30.673. Epub 2015 Jan 12. Review.


Cellular migration and invasion uncoupled: increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition.

Schaeffer D, Somarelli JA, Hanna G, Palmer GM, Garcia-Blanco MA.

Mol Cell Biol. 2014 Sep 15;34(18):3486-99. doi: 10.1128/MCB.00694-14. Epub 2014 Jul 7.


U1 small nuclear RNA variants differentially form ribonucleoprotein particles in vitro.

Somarelli JA, Mesa A, Rodriguez CE, Sharma S, Herrera RJ.

Gene. 2014 Apr 25;540(1):11-15. doi: 10.1016/j.gene.2014.02.054. Epub 2014 Feb 26.


The role of epithelial plasticity in prostate cancer dissemination and treatment resistance.

Bitting RL, Schaeffer D, Somarelli JA, Garcia-Blanco MA, Armstrong AJ.

Cancer Metastasis Rev. 2014 Sep;33(2-3):441-68. doi: 10.1007/s10555-013-9483-z. Review.


Differential immunoglobulin class-mediated responses to components of the U1 small nuclear ribonucleoprotein particle in systemic lupus erythematosus and mixed connective tissue disease.

Mesa A, Somarelli JA, Wu W, Martinez L, Blom MB, Greidinger EL, Herrera RJ.

Lupus. 2013 Nov;22(13):1371-81. doi: 10.1177/0961203313508444.


Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo.

Somarelli JA, Schaeffer D, Bosma R, Bonano VI, Sohn JW, Kemeny G, Ettyreddy A, Garcia-Blanco MA.

RNA. 2013 Jan;19(1):116-27. doi: 10.1261/rna.035097.112. Epub 2012 Nov 26.


Epitope mapping of the U1 small nuclear ribonucleoprotein particle in patients with systemic lupus erythematosus and mixed connective tissue disease.

Somarelli JA, Mesa A, Rodriguez R, Avellan R, Martinez L, Zang YJ, Greidinger EL, Herrera RJ.

Lupus. 2011 Mar;20(3):274-89. doi: 10.1177/0961203310387180.


Genome-based identification of spliceosomal proteins in the silk moth Bombyx mori.

Somarelli JA, Mesa A, Fuller ME, Torres JO, Rodriguez CE, Ferrer CM, Herrera RJ.

Arch Insect Biochem Physiol. 2010 Dec;75(4):231-63. doi: 10.1002/arch.20390.


Alternative splicing in multiple sclerosis and other autoimmune diseases.

Evsyukova I, Somarelli JA, Gregory SG, Garcia-Blanco MA.

RNA Biol. 2010 Jul-Aug;7(4):462-73. Epub 2010 Jul 1. Review.


To what extent did Neanderthals and modern humans interact?

Herrera KJ, Somarelli JA, Lowery RK, Herrera RJ.

Biol Rev Camb Philos Soc. 2009 May;84(2):245-57. Review.


Spliceosomal immunophilins.

Mesa A, Somarelli JA, Herrera RJ.

FEBS Lett. 2008 Jul 9;582(16):2345-51. doi: 10.1016/j.febslet.2008.06.006. Epub 2008 Jun 9. Review.


Structure-based classification of 45 FK506-binding proteins.

Somarelli JA, Lee SY, Skolnick J, Herrera RJ.

Proteins. 2008 Jul;72(1):197-208. doi: 10.1002/prot.21908.


Characterization of immunophilins in the silkmoth Bombyx mori.

Somarelli JA, Coll JL, Velandia A, Martinez L, Herrera RJ.

Arch Insect Biochem Physiol. 2007 Aug;65(4):195-209.


Evolution of the 12 kDa FK506-binding protein gene.

Somarelli JA, Herrera RJ.

Biol Cell. 2007 Jun;99(6):311-21.


Wildlife identified as major source of Escherichia coli in agriculturally dominated watersheds by BOX A1R-derived genetic fingerprints.

Somarelli JA, Makarewicz JC, Sia R, Simon R.

J Environ Manage. 2007 Jan;82(1):60-5. Epub 2006 Mar 23.


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