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Modulation in the microRNA repertoire is responsible for the stage-specific effects of Akt suppression on murine neuroendocrine prostate cancer.

Alwhaibi A, Gao F, Artham S, Hsia BM, Mondal A, Kolhe R, Somanath PR.

Heliyon. 2018 Sep 17;4(9):e00796. doi: 10.1016/j.heliyon.2018.e00796. eCollection 2018 Sep.


Isoform-specific effects of transforming growth factor β on endothelial-to-mesenchymal transition.

Sabbineni H, Verma A, Somanath PR.

J Cell Physiol. 2018 Nov;233(11):8418-8428. doi: 10.1002/jcp.26801. Epub 2018 Jun 1.


Endothelial Akt1 loss promotes prostate cancer metastasis via β-catenin-regulated tight-junction protein turnover.

Gao F, Alwhaibi A, Artham S, Verma A, Somanath PR.

Br J Cancer. 2018 May;118(11):1464-1475. doi: 10.1038/s41416-018-0110-1. Epub 2018 May 14.


Lack of adequate pneumococcal vaccination response in chronic lymphocytic leukaemia patients receiving ibrutinib.

Andrick B, Alwhaibi A, DeRemer DL, Quershi S, Khan R, Bryan LJ, Somanath PR, Pantin J.

Br J Haematol. 2018 Sep;182(5):712-714. doi: 10.1111/bjh.14855. Epub 2017 Jul 24. No abstract available.


Suppression of Akt1-β-catenin pathway in advanced prostate cancer promotes TGFβ1-mediated epithelial to mesenchymal transition and metastasis.

Gao F, Alwhaibi A, Sabbineni H, Verma A, Eldahshan W, Somanath PR.

Cancer Lett. 2017 Aug 28;402:177-189. doi: 10.1016/j.canlet.2017.05.028. Epub 2017 Jun 7.


Modulation of long-term endothelial-barrier integrity is conditional to the cross-talk between Akt and Src signaling.

Gao F, Sabbineni H, Artham S, Somanath PR.

J Cell Physiol. 2017 Oct;232(10):2599-2609. doi: 10.1002/jcp.25791. Epub 2017 Feb 9.


cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium.

Wang R, Islam BN, Bridges A, Sharman SK, Hu M, Hou Y, Somanath PR, Venable L, Singh N, Kim S, Sridhar S, Hofmann F, Browning DD.

Am J Pathol. 2017 Feb;187(2):377-389. doi: 10.1016/j.ajpath.2016.10.016. Epub 2016 Dec 18.


Novel roles of Src in cancer cell epithelial-to-mesenchymal transition, vascular permeability, microinvasion and metastasis.

Patel A, Sabbineni H, Clarke A, Somanath PR.

Life Sci. 2016 Jul 15;157:52-61. doi: 10.1016/j.lfs.2016.05.036. Epub 2016 May 28. Review.


Akt1 promotes stimuli-induced endothelial-barrier protection through FoxO-mediated tight-junction protein turnover.

Gao F, Artham S, Sabbineni H, Al-Azayzih A, Peng XD, Hay N, Adams RH, Byzova TV, Somanath PR.

Cell Mol Life Sci. 2016 Oct;73(20):3917-33. doi: 10.1007/s00018-016-2232-z. Epub 2016 Apr 25.


Liposome-mediated delivery of the p21 activated kinase-1 (PAK-1) inhibitor IPA-3 limits prostate tumor growth in vivo.

Al-Azayzih A, Missaoui WN, Cummings BS, Somanath PR.

Nanomedicine. 2016 Jul;12(5):1231-1239. doi: 10.1016/j.nano.2016.01.003. Epub 2016 Mar 3.


Dasatinib inhibits TGFβ-induced myofibroblast differentiation through Src-SRF Pathway.

Abdalla M, Thompson L, Gurley E, Burke S, Ujjin J, Newsome R, Somanath PR.

Eur J Pharmacol. 2015 Dec 15;769:134-42. doi: 10.1016/j.ejphar.2015.11.008. Epub 2015 Nov 6.


Genetic deletion and pharmacological inhibition of Akt1 isoform attenuates bladder cancer cell proliferation, motility and invasion.

Sabbineni H, Alwhaibi A, Goc A, Gao F, Pruitt A, Somanath PR.

Eur J Pharmacol. 2015 Oct 5;764:208-214. doi: 10.1016/j.ejphar.2015.06.059. Epub 2015 Jul 3.


The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFβ-induced pulmonary fibrosis.

Abdalla M, Sabbineni H, Prakash R, Ergul A, Fagan SC, Somanath PR.

Br J Pharmacol. 2015 Aug;172(16):4173-88. doi: 10.1111/bph.13203. Epub 2015 Jul 6.


TNFα induces inflammatory stress response in microvascular endothelial cells via Akt- and P38 MAP kinase-mediated thrombospondin-1 expression.

Fairaq A, Goc A, Artham S, Sabbineni H, Somanath PR.

Mol Cell Biochem. 2015 Aug;406(1-2):227-36. doi: 10.1007/s11010-015-2440-0. Epub 2015 May 12.


p70 S6-kinase mediates the cooperation between Akt1 and Mek1 pathways in fibroblast-mediated extracellular matrix remodeling.

Goc A, Sabbineni H, Abdalla M, Somanath PR.

Biochim Biophys Acta. 2015 Jul;1853(7):1626-35. doi: 10.1016/j.bbamcr.2015.03.016. Epub 2015 Apr 2.


P21 activated kinase-1 mediates transforming growth factor β1-induced prostate cancer cell epithelial to mesenchymal transition.

Al-Azayzih A, Gao F, Somanath PR.

Biochim Biophys Acta. 2015 May;1853(5):1229-39. doi: 10.1016/j.bbamcr.2015.02.023. Epub 2015 Mar 6.


Discrete functions of GSK3α and GSK3β isoforms in prostate tumor growth and micrometastasis.

Gao F, Al-Azayzih A, Somanath PR.

Oncotarget. 2015 Mar 20;6(8):5947-62.


Differential effects of Akt1 signaling on short- versus long-term consequences of myocardial infarction and reperfusion injury.

Ma L, Kerr BA, Naga Prasad SV, Byzova TV, Somanath PR.

Lab Invest. 2014 Oct;94(10):1083-91. doi: 10.1038/labinvest.2014.95. Epub 2014 Jul 21.


Clinically relevant doses of candesartan inhibit growth of prostate tumor xenografts in vivo through modulation of tumor angiogenesis.

Alhusban A, Al-Azayzih A, Goc A, Gao F, Fagan SC, Somanath PR.

J Pharmacol Exp Ther. 2014 Sep;350(3):635-45. doi: 10.1124/jpet.114.216382. Epub 2014 Jul 2.


Candesartan induces a prolonged proangiogenic effect and augments endothelium-mediated neuroprotection after oxygen and glucose deprivation: role of vascular endothelial growth factors A and B.

Soliman S, Ishrat T, Pillai A, Somanath PR, Ergul A, El-Remessy AB, Fagan SC.

J Pharmacol Exp Ther. 2014 Jun;349(3):444-57. doi: 10.1124/jpet.113.212613. Epub 2014 Mar 28.


Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo.

Goc A, Al-Husein B, Katsanevas K, Steinbach A, Lou U, Sabbineni H, DeRemer DL, Somanath PR.

Oncotarget. 2014 Feb 15;5(3):775-87.


Akt1 mediates α-smooth muscle actin expression and myofibroblast differentiation via myocardin and serum response factor.

Abdalla M, Goc A, Segar L, Somanath PR.

J Biol Chem. 2013 Nov 15;288(46):33483-93. doi: 10.1074/jbc.M113.504290. Epub 2013 Oct 8.


Interference with akt signaling protects against myocardial infarction and death by limiting the consequences of oxidative stress.

Kerr BA, Ma L, West XZ, Ding L, Malinin NL, Weber ME, Tischenko M, Goc A, Somanath PR, Penn MS, Podrez EA, Byzova TV.

Sci Signal. 2013 Aug 6;6(287):ra67. doi: 10.1126/scisignal.2003948.


Suppression of interactions between prostate tumor cell-surface integrin and endothelial ICAM-1 by simvastatin inhibits micrometastasis.

Al-Husein B, Goc A, Somanath PR.

J Cell Physiol. 2013 Nov;228(11):2139-48. doi: 10.1002/jcp.24381.


P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion.

Goc A, Al-Azayzih A, Abdalla M, Al-Husein B, Kavuri S, Lee J, Moses K, Somanath PR.

J Biol Chem. 2013 Feb 1;288(5):3025-35. doi: 10.1074/jbc.M112.424770. Epub 2012 Dec 20.


Antiangiogenic therapy for cancer: an update.

Al-Husein B, Abdalla M, Trepte M, Deremer DL, Somanath PR.

Pharmacotherapy. 2012 Dec;32(12):1095-111. doi: 10.1002/phar.1147. Review.


TGFβ1 induces apoptosis in invasive prostate cancer and bladder cancer cells via Akt-independent, p38 MAPK and JNK/SAPK-mediated activation of caspases.

Al-Azayzih A, Gao F, Goc A, Somanath PR.

Biochem Biophys Res Commun. 2012 Oct 12;427(1):165-70. doi: 10.1016/j.bbrc.2012.09.035. Epub 2012 Sep 16.


Simultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosis.

Goc A, Kochuparambil ST, Al-Husein B, Al-Azayzih A, Mohammad S, Somanath PR.

BMC Cancer. 2012 Sep 14;12:409. doi: 10.1186/1471-2407-12-409.


Rac1 activation driven by 14-3-3ζ dimerization promotes prostate cancer cell-matrix interactions, motility and transendothelial migration.

Goc A, Abdalla M, Al-Azayzih A, Somanath PR.

PLoS One. 2012;7(7):e40594. doi: 10.1371/journal.pone.0040594. Epub 2012 Jul 13.


Akt1 mediates prostate cancer cell microinvasion and chemotaxis to metastatic stimuli via integrin β₃ affinity modulation.

Goc A, Liu J, Byzova TV, Somanath PR.

Br J Cancer. 2012 Aug 7;107(4):713-23. doi: 10.1038/bjc.2012.295. Epub 2012 Jul 5.


Enhanced cerebral but not peripheral angiogenesis in the Goto-Kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling.

Prakash R, Somanath PR, El-Remessy AB, Kelly-Cobbs A, Stern JE, Dore-Duffy P, Johnson M, Fagan SC, Ergul A.

Diabetes. 2012 Jun;61(6):1533-42. doi: 10.2337/db11-1528. Epub 2012 Mar 8.


Vascular protection by angiotensin receptor antagonism involves differential VEGF expression in both hemispheres after experimental stroke.

Guan W, Somanath PR, Kozak A, Goc A, El-Remessy AB, Ergul A, Johnson MH, Alhusban A, Soliman S, Fagan SC.

PLoS One. 2011;6(9):e24551. doi: 10.1371/journal.pone.0024551. Epub 2011 Sep 1.


Angiotensin receptor blockers and angiogenesis: clinical and experimental evidence.

Willis LM, El-Remessy AB, Somanath PR, Deremer DL, Fagan SC.

Clin Sci (Lond). 2011 Apr;120(8):307-19. Review.


TGFβ- and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR).

Goc A, Choudhary M, Byzova TV, Somanath PR.

J Cell Physiol. 2011 Nov;226(11):3004-13. doi: 10.1002/jcp.22648.


PI3 kinase integrates Akt and MAP kinase signaling pathways in the regulation of prostate cancer.

Goc A, Al-Husein B, Kochuparambil ST, Liu J, Heston WW, Somanath PR.

Int J Oncol. 2011 Jan;38(1):267-77.


Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and reduced prostate-specific antigen expression.

Kochuparambil ST, Al-Husein B, Goc A, Soliman S, Somanath PR.

J Pharmacol Exp Ther. 2011 Feb;336(2):496-505. doi: 10.1124/jpet.110.174870. Epub 2010 Nov 8.


Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotype.

Somanath PR, Podrez EA, Chen J, Ma Y, Marchant K, Antoch M, Byzova TV.

J Cell Physiol. 2011 Jan;226(1):132-40. doi: 10.1002/jcp.22314.


PAK1 as a therapeutic target.

Kichina JV, Goc A, Al-Husein B, Somanath PR, Kandel ES.

Expert Opin Ther Targets. 2010 Jul;14(7):703-25. doi: 10.1517/14728222.2010.492779. Review.


Diverse effects of statins on angiogenesis: new therapeutic avenues.

Elewa HF, El-Remessy AB, Somanath PR, Fagan SC.

Pharmacotherapy. 2010 Feb;30(2):169-76. doi: 10.1592/phco.30.2.169. Review.


The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt.

Somanath PR, Vijai J, Kichina JV, Byzova T, Kandel ES.

Oncogene. 2009 Jun 25;28(25):2365-9. doi: 10.1038/onc.2009.114. Epub 2009 May 4.


Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis.

Somanath PR, Malinin NL, Byzova TV.

Angiogenesis. 2009;12(2):177-85. doi: 10.1007/s10456-009-9141-9. Epub 2009 Mar 8. Review.


The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells.

Feng W, McCabe NP, Mahabeleshwar GH, Somanath PR, Phillips DR, Byzova TV.

J Cell Biol. 2008 Dec 15;183(6):1145-57. doi: 10.1083/jcb.200802179.


Integrin and growth factor receptor alliance in angiogenesis.

Somanath PR, Ciocea A, Byzova TV.

Cell Biochem Biophys. 2009;53(2):53-64. doi: 10.1007/s12013-008-9040-5. Epub 2008 Dec 2. Review.


Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing.

Somanath PR, Chen J, Byzova TV.

Angiogenesis. 2008;11(3):277-88. doi: 10.1007/s10456-008-9111-7. Epub 2008 Apr 16.


Integrin affinity modulation in angiogenesis.

Mahabeleshwar GH, Chen J, Feng W, Somanath PR, Razorenova OV, Byzova TV.

Cell Cycle. 2008 Feb 1;7(3):335-47. Epub 2007 Nov 1.


Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly.

Somanath PR, Kandel ES, Hay N, Byzova TV.

J Biol Chem. 2007 Aug 3;282(31):22964-76. Epub 2007 Jun 11.


Methods for isolation of endothelial and smooth muscle cells and in vitro proliferation assays.

Mahabeleshwar GH, Somanath PR, Byzova TV.

Methods Mol Med. 2006;129:197-208.


Akt1 in endothelial cell and angiogenesis.

Somanath PR, Razorenova OV, Chen J, Byzova TV.

Cell Cycle. 2006 Mar;5(5):512-8. Epub 2006 Mar 1. Review.


Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.

Chen J, Somanath PR, Razorenova O, Chen WS, Hay N, Bornstein P, Byzova TV.

Nat Med. 2005 Nov;11(11):1188-96. Epub 2005 Oct 16.

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