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Items: 1 to 50 of 93

1.

Incidence and Management of Olaratumab Infusion-Related Reactions.

Van Tine BA, Govindarajan R, Attia S, Somaiah N, Barker SS, Shahir A, Barrett E, Lee P, Wacheck V, Ramage SC, Tap WD.

J Oncol Pract. 2019 Jul 3:JOP1800761. doi: 10.1200/JOP.18.00761. [Epub ahead of print]

PMID:
31268811
2.

First-in-Class, First-in-Human Study Evaluating LV305, a Dendritic-Cell Tropic Lentiviral Vector, in Sarcoma and Other Solid Tumors Expressing NY-ESO-1.

Somaiah N, Block MS, Kim JW, Shapiro GI, Do KT, Hwu P, Eder JP, Jones RL, Lu H, Ter Meulen JH, Bohac C, Chen M, Hsu FJ, Gnjatic S, Pollack SM.

Clin Cancer Res. 2019 Jun 21. doi: 10.1158/1078-0432.CCR-19-1025. [Epub ahead of print]

PMID:
31227504
3.

The degree of sclerosis is associated with prognosis in well-differentiated liposarcoma of the retroperitoneum.

Chrisinger JSA, Al-Zaid T, Keung EZ, Leung C, Lin HY, Roland CL, Torres KE, Benjamin RS, Ingram DR, Khan S, Somaiah N, Amini B, Feig BW, Lazar AJ, Wang WL.

J Surg Oncol. 2019 Sep;120(3):382-388. doi: 10.1002/jso.25585. Epub 2019 Jun 17.

PMID:
31206726
4.

MAGE-A3 is a Clinically Relevant Target in Undifferentiated Pleomorphic Sarcoma/Myxofibrosarcoma.

Conley AP, Wang WL, Livingston JA, Ravi V, Tsai JW, Ali A, Ingram DR, Lowery CD, Roland CL, Somaiah N, Hwu P, Yee C, Subbiah V, Futreal A, Lazar AJ, Patel S, Roszik J.

Cancers (Basel). 2019 May 15;11(5). pii: E677. doi: 10.3390/cancers11050677.

5.

In Regard to Spratt.

Wilkins AC, Gusterson B, Dearnaley DP, Hall E, Somaiah N.

Int J Radiat Oncol Biol Phys. 2018 Dec 1;102(5):1596-1597. doi: 10.1016/j.ijrobp.2018.08.007. No abstract available.

PMID:
31014790
6.

Alpha Particle Radium 223 Dichloride in High-risk Osteosarcoma: A Phase I Dose Escalation Trial.

Subbiah V, Anderson PM, Kairemo K, Hess K, Huh WW, Ravi V, Daw NC, Somaiah N, Ludwig JA, Benjamin RS, Chawla S, Hong DS, Meric-Bernstam F, Ravizzini G, Kleinerman E, Macapinlac H, Rohren E.

Clin Cancer Res. 2019 Jul 1;25(13):3802-3810. doi: 10.1158/1078-0432.CCR-18-3964. Epub 2019 Feb 7.

PMID:
30733229
7.

Phase II study of neoadjuvant checkpoint blockade in patients with surgically resectable undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.

Keung EZ, Lazar AJ, Torres KE, Wang WL, Cormier JN, Ashleigh Guadagnolo B, Bishop AJ, Lin H, Hunt KK, Bird J, Lewis VO, Patel SR, Wargo JA, Somaiah N, Roland CL.

BMC Cancer. 2018 Sep 24;18(1):913. doi: 10.1186/s12885-018-4829-0.

8.

Positive Tumor Response to Combined Checkpoint Inhibitors in a Patient With Refractory Alveolar Soft Part Sarcoma: A Case Report.

Conley AP, Trinh VA, Zobniw CM, Posey K, Martinez JD, Arrieta OG, Wang WL, Lazar AJ, Somaiah N, Roszik J, Patel SR.

J Glob Oncol. 2018 Sep;4:1-6. doi: 10.1200/JGO.2017.009993. Epub 2017 Jul 6. No abstract available.

9.

Prevalence of MDM2 amplification and coalterations in 523 advanced cancer patients in the MD Anderson phase 1 clinic.

Dembla V, Somaiah N, Barata P, Hess K, Fu S, Janku F, Karp DD, Naing A, Piha-Paul SA, Subbiah V, Tsimberidou AM, Shaw K, Meric-Bernstam F, Hong DS.

Oncotarget. 2018 Sep 4;9(69):33232-33243. doi: 10.18632/oncotarget.26075. eCollection 2018 Sep 4.

10.

Dicentric Dose Estimates for Patients Undergoing Radiotherapy in the RTGene Study to Assess Blood Dosimetric Models and the New Bayesian Method for Gradient Exposure.

Moquet J, Higueras M, Donovan E, Boyle S, Barnard S, Bricknell C, Sun M, Gothard L, O'Brien G, Cruz-Garcia L, Badie C, Ainsbury E, Somaiah N.

Radiat Res. 2018 Sep 20. doi: 10.1667/RR15116.1. [Epub ahead of print]

PMID:
30234457
11.

Science in Focus: Biological Optimisation of Radiotherapy Fraction Size in an Era of Immune Oncology.

Wilkins A, Melcher A, Somaiah N.

Clin Oncol (R Coll Radiol). 2018 Oct;30(10):605-608. doi: 10.1016/j.clon.2018.07.001. Epub 2018 Jul 21. No abstract available.

PMID:
30041845
12.

Olaratumab in the management of advanced soft tissue sarcoma.

Zobniw CM, Trinh VA, Posey K, Somaiah N.

J Oncol Pharm Pract. 2019 Mar;25(2):442-448. doi: 10.1177/1078155218788135. Epub 2018 Jul 22. Review.

PMID:
30032714
13.

Influence of Confounding Factors on Radiation Dose Estimation Using In Vivo Validated Transcriptional Biomarkers.

Cruz-Garcia L, O'Brien G, Donovan E, Gothard L, Boyle S, Laval A, Testard I, Ponge L, Woźniak G, Miszczyk L, Candéias SM, Ainsbury E, Widlak P, Somaiah N, Badie C.

Health Phys. 2018 Jul;115(1):90-101. doi: 10.1097/HP.0000000000000844.

14.

Targeted next generation sequencing of well-differentiated/dedifferentiated liposarcoma reveals novel gene amplifications and mutations.

Somaiah N, Beird HC, Barbo A, Song J, Mills Shaw KR, Wang WL, Eterovic K, Chen K, Lazar A, Conley AP, Ravi V, Hwu P, Futreal A, Simon G, Meric-Bernstam F, Hong D.

Oncotarget. 2018 Apr 13;9(28):19891-19899. doi: 10.18632/oncotarget.24924. eCollection 2018 Apr 13.

15.

Cell-surface vimentin-positive macrophage-like circulating tumor cells as a novel biomarker of metastatic gastrointestinal stromal tumors.

Li H, Meng QH, Noh H, Somaiah N, Torres KE, Xia X, Batth IS, Joseph CP, Liu M, Wang R, Li S.

Oncoimmunology. 2018 Jan 8;7(5):e1420450. doi: 10.1080/2162402X.2017.1420450. eCollection 2018.

16.

FFPE breast tumour blocks provide reliable sources of both germline and malignant DNA for investigation of genetic determinants of individual tumour responses to treatment.

Wilkins A, Chauhan R, Rust A, Pearson A, Daley F, Manodoro F, Fenwick K, Bliss J, Yarnold J, Somaiah N.

Breast Cancer Res Treat. 2018 Aug;170(3):573-581. doi: 10.1007/s10549-018-4798-7. Epub 2018 Apr 26.

17.

Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin.

Beird HC, Wu CC, Ingram DR, Wang WL, Alimohamed A, Gumbs C, Little L, Song X, Feig BW, Roland CL, Zhang J, Benjamin RS, Hwu P, Lazar AJ, Futreal PA, Somaiah N.

Cold Spring Harb Mol Case Stud. 2018 Apr 2;4(2). pii: a002386. doi: 10.1101/mcs.a002386. Print 2018 Apr.

18.

Ki67 Is an Independent Predictor of Recurrence in the Largest Randomized Trial of 3 Radiation Fractionation Schedules in Localized Prostate Cancer.

Wilkins AC, Gusterson B, Szijgyarto Z, Haviland J, Griffin C, Stuttle C, Daley F, Corbishley CM, Dearnaley DP, Hall E, Somaiah N; CHHiP Trial Investigators.

Int J Radiat Oncol Biol Phys. 2018 Jun 1;101(2):309-315. doi: 10.1016/j.ijrobp.2018.01.072. Epub 2018 Feb 3. Erratum in: Int J Radiat Oncol Biol Phys. 2019 May 1;104(1):226.

19.

Salvage Surgery for Recurrent Retroperitoneal Well-Differentiated Liposarcoma: Early Reoperation may not Provide Benefit.

Ikoma N, Roland CL, Torres KE, Chiang YJ, Wang WL, Somaiah N, Mann GN, Hunt KK, Cormier JN, Feig BW.

Ann Surg Oncol. 2018 Aug;25(8):2193-2200. doi: 10.1245/s10434-018-6417-6. Epub 2018 Mar 8.

20.

Identification of preoperative factors associated with outcomes following surgical management of intra-abdominal recurrent or metastatic GIST following neoadjuvant tyrosine kinase inhibitor therapy.

Roland CL, Bednarski BK, Watson K, Torres KE, Cormier JN, Wang WL, Lazar AJ, Somaiah N, Hunt KK, Feig BW.

J Surg Oncol. 2018 Apr;117(5):879-885. doi: 10.1002/jso.24988. Epub 2018 Feb 15.

21.

Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues.

Khan AA, Paget JT, McLaughlin M, Kyula JN, Wilkinson MJ, Pencavel T, Mansfield D, Roulstone V, Seth R, Halle M, Somaiah N, Boult JKR, Robinson SP, Pandha HS, Vile RG, Melcher AA, Harris PA, Harrington KJ.

Sci Transl Med. 2018 Jan 24;10(425). pii: eaar2041. doi: 10.1126/scitranslmed.aar2041.

22.

FDXR is a biomarker of radiation exposure in vivo.

O'Brien G, Cruz-Garcia L, Majewski M, Grepl J, Abend M, Port M, Tichý A, Sirak I, Malkova A, Donovan E, Gothard L, Boyle S, Somaiah N, Ainsbury E, Ponge L, Slosarek K, Miszczyk L, Widlak P, Green E, Patel N, Kudari M, Gleeson F, Vinnikov V, Starenkiy V, Artiukh S, Vasyliev L, Zaman A, Badie C.

Sci Rep. 2018 Jan 12;8(1):684. doi: 10.1038/s41598-017-19043-w.

23.

Analysis of the immune infiltrate in undifferentiated pleomorphic sarcoma of the extremity and trunk in response to radiotherapy: Rationale for combination neoadjuvant immune checkpoint inhibition and radiotherapy.

Keung EZ, Tsai JW, Ali AM, Cormier JN, Bishop AJ, Guadagnolo BA, Torres KE, Somaiah N, Hunt KK, Wargo JA, Lazar AJ, Wang WL, Roland CL.

Oncoimmunology. 2017 Oct 31;7(2):e1385689. doi: 10.1080/2162402X.2017.1385689. eCollection 2018.

24.

Characteristics and outcomes of patients with advanced sarcoma enrolled in early phase immunotherapy trials.

Groisberg R, Hong DS, Behrang A, Hess K, Janku F, Piha-Paul S, Naing A, Fu S, Benjamin R, Patel S, Somaiah N, Conley A, Meric-Bernstam F, Subbiah V.

J Immunother Cancer. 2017 Dec 19;5(1):100. doi: 10.1186/s40425-017-0301-y.

25.

Concomitant organ resection does not improve outcomes in primary retroperitoneal well-differentiated liposarcoma: A retrospective cohort study at a major sarcoma center.

Ikoma N, Roland CL, Torres KE, Chiang YJ, Wang WL, Somaiah N, Mann GN, Hunt KK, Cormier JN, Feig BW.

J Surg Oncol. 2018 May;117(6):1188-1194. doi: 10.1002/jso.24951. Epub 2017 Dec 11.

PMID:
29228466
26.

Outcomes of patients with sarcoma enrolled in clinical trials of pazopanib combined with histone deacetylase, mTOR, Her2, or MEK inhibitors.

Dembla V, Groisberg R, Hess K, Fu S, Wheler J, Hong DS, Janku F, Zinner R, Piha-Paul SA, Ravi V, Benjamin RS, Patel S, Somaiah N, Herzog CE, Karp DD, Roszik J, Meric-Bernstam F, Subbiah V.

Sci Rep. 2017 Nov 21;7(1):15963. doi: 10.1038/s41598-017-13114-8.

27.

Long-Term Survival According to Histology and Radiologic Response to Preoperative Chemotherapy in 126 Patients Undergoing Resection of Non-GIST Sarcoma Liver Metastases.

Goumard C, Marcal LP, Wang WL, Somaiah N, Okuno M, Roland CL, Tzeng CD, Chun YS, Feig BW, Vauthey JN, Conrad C.

Ann Surg Oncol. 2018 Jan;25(1):107-116. doi: 10.1245/s10434-017-6144-4. Epub 2017 Nov 7.

PMID:
29116489
28.

Early Evidence of Cardiotoxicity and Tumor Response in Patients with Sarcomas after High Cumulative Dose Doxorubicin Given as a Continuous Infusion.

Quintana RA, Banchs J, Gupta R, Lin HY, Raj SD, Conley A, Ravi V, Araujo D, Benjamin RS, Patel S, Vadhan-Raj S, Somaiah N.

Sarcoma. 2017;2017:7495914. doi: 10.1155/2017/7495914. Epub 2017 Sep 26.

29.

Role of chemotherapy in dedifferentiated liposarcoma of the retroperitoneum: defining the benefit and challenges of the standard.

Livingston JA, Bugano D, Barbo A, Lin H, Madewell JE, Wang WL, Lazar AJ, Tseng WW, Roland CL, Feig BW, Pollock R, Conley AP, Benjamin RS, Patel S, Somaiah N.

Sci Rep. 2017 Sep 19;7(1):11836. doi: 10.1038/s41598-017-12132-w.

30.

First-in-Human Treatment With a Dendritic Cell-targeting Lentiviral Vector-expressing NY-ESO-1, LV305, Induces Deep, Durable Response in Refractory Metastatic Synovial Sarcoma Patient.

Pollack SM, Lu H, Gnjatic S, Somaiah N, O'Malley RB, Jones RL, Hsu FJ, Ter Meulen J.

J Immunother. 2017 Oct;40(8):302-306. doi: 10.1097/CJI.0000000000000183.

31.

Treatment patterns, efficacy and toxicity of regorafenib in gastrointestinal stromal tumour patients.

Schvartsman G, Wagner MJ, Amini B, Zobniw CM, Trinh VA, Barbo AG, Lin HY, Wang WL, Conley AP, Ravi V, Araujo DM, Zarzour MA, Benjamin RS, Patel S, Somaiah N.

Sci Rep. 2017 Aug 25;7(1):9519. doi: 10.1038/s41598-017-09132-1.

32.

Development and responses of brain metastases during treatment with trastuzumab emtansine (T-DM1) for HER2 positive advanced breast cancer: A single institution experience.

Okines A, Irfan T, Khabra K, Smith I, O'Brien M, Parton M, Noble J, Stanway S, Somaiah N, Ring A, Johnston S, Turner N.

Breast J. 2018 May;24(3):253-259. doi: 10.1111/tbj.12906. Epub 2017 Aug 22.

PMID:
28833867
33.

Results of a prospective phase 2 study of pazopanib in patients with advanced intermediate-grade or high-grade liposarcoma.

Samuels BL, Chawla SP, Somaiah N, Staddon AP, Skubitz KM, Milhem MM, Kaiser PE, Portnoy DC, Priebat DA, Walker MS, Stepanski EJ.

Cancer. 2017 Dec 1;123(23):4640-4647. doi: 10.1002/cncr.30926. Epub 2017 Aug 18.

34.

Progressive and Reversible Conduction Disease With Checkpoint Inhibitors.

Reddy N, Moudgil R, Lopez-Mattei JC, Karimzad K, Mouhayar EN, Somaiah N, Conley AP, Patel S, Giza DE, Iliescu C.

Can J Cardiol. 2017 Oct;33(10):1335.e13-1335.e15. doi: 10.1016/j.cjca.2017.05.026. Epub 2017 Jun 8.

PMID:
28822650
35.

Activity of Pazopanib and Trabectedin in Advanced Alveolar Soft Part Sarcoma.

Stacchiotti S, Mir O, Le Cesne A, Vincenzi B, Fedenko A, Maki RG, Somaiah N, Patel S, Brahmi M, Blay JY, Boye K, Sundby Hall K, Gelderblom H, Hindi N, Martin-Broto J, Kosela H, Rutkowski P, Italiano A, Duffaud F, Kobayashi E, Casali PG, Provenzano S, Kawai A.

Oncologist. 2018 Jan;23(1):62-70. doi: 10.1634/theoncologist.2017-0161. Epub 2017 Jul 28.

36.

Vincristine, Ifosfamide, and Doxorubicin for Initial Treatment of Ewing Sarcoma in Adults.

Wagner MJ, Gopalakrishnan V, Ravi V, Livingston JA, Conley AP, Araujo D, Somaiah N, Zarzour MA, Ratan R, Wang WL, Patel SR, Lazar A, Ludwig JA, Benjamin RS.

Oncologist. 2017 Oct;22(10):1271-1277. doi: 10.1634/theoncologist.2016-0464. Epub 2017 Jul 14.

37.

Preoperative breast radiation therapy: Indications and perspectives.

Lightowlers SV, Boersma LJ, Fourquet A, Kirova YM, Offersen BV, Poortmans P, Scholten AN, Somaiah N, Coles CE.

Eur J Cancer. 2017 Sep;82:184-192. doi: 10.1016/j.ejca.2017.06.014. Epub 2017 Jul 7. Review.

PMID:
28692950
38.

Randomized controlled trial of dietary fiber for the prevention of radiation-induced gastrointestinal toxicity during pelvic radiotherapy.

Wedlake L, Shaw C, McNair H, Lalji A, Mohammed K, Klopper T, Allan L, Tait D, Hawkins M, Somaiah N, Lalondrelle S, Taylor A, VanAs N, Stewart A, Essapen S, Gage H, Whelan K, Andreyev HJN.

Am J Clin Nutr. 2017 Sep;106(3):849-857. doi: 10.3945/ajcn.116.150565. Epub 2017 Jul 5.

PMID:
28679552
39.

Molecular profiling of sarcomas: new vistas for precision medicine.

Al-Zaid T, Wang WL, Somaiah N, Lazar AJ.

Virchows Arch. 2017 Aug;471(2):243-255. doi: 10.1007/s00428-017-2174-3. Epub 2017 Jun 29. Review.

PMID:
28664413
40.

High-Throughput Screening of Myxoid Liposarcoma Cell Lines: Survivin Is Essential for Tumor Growth.

de Graaff MA, Malu S, Guardiola I, Kruisselbrink AB, de Jong Y, Corver WE, Gelderblom H, Hwu P, Nielsen TO, Lazar AJ, Somaiah N, Bovée JVMG.

Transl Oncol. 2017 Aug;10(4):546-554. doi: 10.1016/j.tranon.2017.05.007. Epub 2017 Jun 24.

41.

Detection of circulating tumor cells from cryopreserved human sarcoma peripheral blood mononuclear cells.

Li H, Meng QH, Noh H, Batth IS, Somaiah N, Torres KE, Xia X, Wang R, Li S.

Cancer Lett. 2017 Sep 10;403:216-223. doi: 10.1016/j.canlet.2017.05.032. Epub 2017 Jun 23.

42.

CDK4/6 Inhibitors Sensitize Rb-positive Sarcoma Cells to Wee1 Kinase Inhibition through Reversible Cell-Cycle Arrest.

Francis AM, Alexander A, Liu Y, Vijayaraghavan S, Low KH, Yang D, Bui T, Somaiah N, Ravi V, Keyomarsi K, Hunt KK.

Mol Cancer Ther. 2017 Sep;16(9):1751-1764. doi: 10.1158/1535-7163.MCT-17-0040. Epub 2017 Jun 15.

43.

Clinical genomic profiling to identify actionable alterations for investigational therapies in patients with diverse sarcomas.

Groisberg R, Hong DS, Holla V, Janku F, Piha-Paul S, Ravi V, Benjamin R, Kumar Patel S, Somaiah N, Conley A, Ali SM, Schrock AB, Ross JS, Stephens PJ, Miller VA, Sen S, Herzog C, Meric-Bernstam F, Subbiah V.

Oncotarget. 2017 Jun 13;8(24):39254-39267. doi: 10.18632/oncotarget.16845.

44.

Clinical characteristics and treatment outcome in a large multicentre observational cohort of PDGFRA exon 18 mutated gastrointestinal stromal tumour patients.

Farag S, Somaiah N, Choi H, Heeres B, Wang WL, van Boven H, Nederlof P, Benjamin R, van der Graaf W, Grunhagen D, Boonstra PA, Reyners AK, Gelderblom H, Steeghs N.

Eur J Cancer. 2017 May;76:76-83. doi: 10.1016/j.ejca.2017.02.007. Epub 2017 Mar 8.

PMID:
28284172
45.

Phase I Trial of the Human Double Minute 2 Inhibitor MK-8242 in Patients With Advanced Solid Tumors.

Wagner AJ, Banerji U, Mahipal A, Somaiah N, Hirsch H, Fancourt C, Johnson-Levonas AO, Lam R, Meister AK, Russo G, Knox CD, Rose S, Hong DS.

J Clin Oncol. 2017 Apr 20;35(12):1304-1311. doi: 10.1200/JCO.2016.70.7117. Epub 2017 Feb 27.

46.

Can Abdominal Computed Tomography Imaging Help Accurately Identify a Dedifferentiated Component in a Well-Differentiated Liposarcoma?

Bhosale P, Wang J, Varma D, Jensen C, Patnana M, Wei W, Chauhan A, Feig B, Patel S, Somaiah N, Sagebiel T.

J Comput Assist Tomogr. 2016 Nov/Dec;40(6):872-879.

47.

An Unusual Case of Central Retinal Vein Occlusion and Review of the Toxicity Profile of Regorafenib in GIST Patients.

Schvartsman G, Wagner MJ, Zobniw CM, Trinh VA, Patel S, Somaiah N.

Curr Oncol Rep. 2016 Aug;18(8):49. doi: 10.1007/s11912-016-0536-7. Review.

PMID:
27319943
48.

Establishment and characterization of a new human myxoid liposarcoma cell line (DL-221) with the FUS-DDIT3 translocation.

de Graaff MA, Yu JS, Beird HC, Ingram DR, Nguyen T, Juehui Liu J, Bolshakov S, Szuhai K, Åman P, Torres KE, Lev D, Nielsen TO, Bovée JV, Lazar AJ, Somaiah N.

Lab Invest. 2016 Aug;96(8):885-94. doi: 10.1038/labinvest.2016.64. Epub 2016 Jun 6.

49.

Erratum to "Correlation between the radiation responses of fibroblasts cultured from individual patients and the risk of late reaction after breast radiotherapy" [Cancer Lett. 374/2 (2016) 324-330].

Nuta O, Somaiah N, Boyle S, Chua ML, Gothard L, Yarnold J, Rothkamm K, Herskind C.

Cancer Lett. 2016 Aug 1;378(1):68. doi: 10.1016/j.canlet.2016.05.009. Epub 2016 May 12. No abstract available.

PMID:
27197782
50.

Correlation between DNA damage responses of skin to a test dose of radiation and late adverse effects of earlier breast radiotherapy.

Somaiah N, Chua ML, Bourne S, Daley F, A' Hern R, Nuta O, Gothard L, Boyle S, Herskind C, Pearson A, Warrington J, Helyer S, Owen R, Rothkamm K, Yarnold J.

Radiother Oncol. 2016 May;119(2):244-9. doi: 10.1016/j.radonc.2016.04.012. Epub 2016 Apr 19.

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