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The rostromedial tegmental nucleus: a key modulator of pain and opioid analgesia.

Taylor NE, Long H, Pei J, Kukutla P, Phero A, Hadaegh F, Abdelnabi A, Solt K, Brenner GJ.

Pain. 2019 Nov;160(11):2524-2534. doi: 10.1097/j.pain.0000000000001647.


Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery.

Hemmings HC Jr, Riegelhaupt PM, Kelz MB, Solt K, Eckenhoff RG, Orser BA, Goldstein PA.

Trends Pharmacol Sci. 2019 Jul;40(7):464-481. doi: 10.1016/ Epub 2019 May 27. Review.


The Role of Glutamatergic and Dopaminergic Neurons in the Periaqueductal Gray/Dorsal Raphe: Separating Analgesia and Anxiety.

Taylor NE, Pei J, Zhang J, Vlasov KY, Davis T, Taylor E, Weng FJ, Van Dort CJ, Solt K, Brown EN.

eNeuro. 2019 Feb 19;6(1). pii: ENEURO.0018-18.2019. doi: 10.1523/ENEURO.0018-18.2019. eCollection 2019 Jan-Feb.


Escape From Oblivion: Neural Mechanisms of Emergence From General Anesthesia.

Kelz MB, García PS, Mashour GA, Solt K.

Anesth Analg. 2019 Apr;128(4):726-736. doi: 10.1213/ANE.0000000000004006. Review.


Developing a personalized closed-loop controller of medically-induced coma in a rodent model.

Yang Y, Lee JT, Guidera JA, Vlasov KY, Pei J, Brown EN, Solt K, Shanechi MM.

J Neural Eng. 2019 Jun;16(3):036022. doi: 10.1088/1741-2552/ab0ea4. Epub 2019 Mar 11.


Electroencephalogram dynamics during general anesthesia predict the later incidence and duration of burst-suppression during cardiopulmonary bypass.

Plummer GS, Ibala R, Hahm E, An J, Gitlin J, Deng H, Shelton KT, Solt K, Qu JZ, Akeju O.

Clin Neurophysiol. 2019 Jan;130(1):55-60. doi: 10.1016/j.clinph.2018.11.003. Epub 2018 Nov 16.


Using Anesthesia to Reveal the Elements of Consciousness.

Solt K.

Trends Cogn Sci. 2018 Nov;22(11):961-962. doi: 10.1016/j.tics.2018.07.016. Epub 2018 Aug 10.


Optogenetics and Chemogenetics.

Vlasov K, Van Dort CJ, Solt K.

Methods Enzymol. 2018;603:181-196. doi: 10.1016/bs.mie.2018.01.022. Epub 2018 Mar 19.


Optogenetic activation of 5-HT neurons in the dorsal raphe suppresses seizure-induced respiratory arrest and produces anticonvulsant effect in the DBA/1 mouse SUDEP model.

Zhang H, Zhao H, Zeng C, Van Dort C, Faingold CL, Taylor NE, Solt K, Feng HJ.

Neurobiol Dis. 2018 Feb;110:47-58. doi: 10.1016/j.nbd.2017.11.003. Epub 2017 Nov 13.


Design, implementation, and evaluation of a physiological closed-loop control device for medically-induced coma.

Jingzhi An, Purdon PL, Solt K, Sims NM, Brown EN, Westover MB.

Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:4313-4316. doi: 10.1109/EMBC.2017.8037810.


Sevoflurane Induces Coherent Slow-Delta Oscillations in Rats.

Guidera JA, Taylor NE, Lee JT, Vlasov KY, Pei J, Stephen EP, Mayo JP, Brown EN, Solt K.

Front Neural Circuits. 2017 Jul 4;11:36. doi: 10.3389/fncir.2017.00036. eCollection 2017.


Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha.

Nagasaka Y, Wepler M, Thoonen R, Sips PY, Allen K, Graw JA, Yao V, Burns SM, Muenster S, Brouckaert P, Miller K, Solt K, Buys ES, Ichinose F, Zapol WM.

BMC Anesthesiol. 2017 Jun 14;17(1):76. doi: 10.1186/s12871-017-0368-5.


Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia.

Taylor NE, Van Dort CJ, Kenny JD, Pei J, Guidera JA, Vlasov KY, Lee JT, Boyden ES, Brown EN, Solt K.

Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12826-12831. doi: 10.1073/pnas.1614340113. Epub 2016 Oct 24.


Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats.

Kenny JD, Chemali JJ, Cotten JF, Van Dort CJ, Kim SE, Ba D, Taylor NE, Brown EN, Solt K.

Anesth Analg. 2016 Nov;123(5):1210-1219.


Electrical stimulation of the parabrachial nucleus induces reanimation from isoflurane general anesthesia.

Muindi F, Kenny JD, Taylor NE, Solt K, Wilson MA, Brown EN, Van Dort CJ.

Behav Brain Res. 2016 Jun 1;306:20-5. doi: 10.1016/j.bbr.2016.03.021. Epub 2016 Mar 10.


Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain.

Chemali JJ, Kenny JD, Olutola O, Taylor NE, Kimchi EY, Purdon PL, Brown EN, Solt K.

Br J Anaesth. 2015 Jul;115 Suppl 1:i58-i65. doi: 10.1093/bja/aev112.


The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.

Purdon PL, Pavone KJ, Akeju O, Smith AC, Sampson AL, Lee J, Zhou DW, Solt K, Brown EN.

Br J Anaesth. 2015 Jul;115 Suppl 1:i46-i57. doi: 10.1093/bja/aev213.


Dextroamphetamine (but Not Atomoxetine) Induces Reanimation from General Anesthesia: Implications for the Roles of Dopamine and Norepinephrine in Active Emergence.

Kenny JD, Taylor NE, Brown EN, Solt K.

PLoS One. 2015 Jul 6;10(7):e0131914. doi: 10.1371/journal.pone.0131914. eCollection 2015.


Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA/1 mice.

Zeng C, Long X, Cotten JF, Forman SA, Solt K, Faingold CL, Feng HJ.

Epilepsy Behav. 2015 Apr;45:1-7. doi: 10.1016/j.yebeh.2015.02.013. Epub 2015 Mar 13.


Propofol and sevoflurane induce distinct burst suppression patterns in rats.

Kenny JD, Westover MB, Ching S, Brown EN, Solt K.

Front Syst Neurosci. 2014 Dec 18;8:237. doi: 10.3389/fnsys.2014.00237. eCollection 2014.


Electrical stimulation of the ventral tegmental area induces reanimation from general anesthesia.

Solt K, Van Dort CJ, Chemali JJ, Taylor NE, Kenny JD, Brown EN.

Anesthesiology. 2014 Aug;121(2):311-9. doi: 10.1097/ALN.0000000000000117.


A brain-machine interface for control of medically-induced coma.

Shanechi MM, Chemali JJ, Liberman M, Solt K, Brown EN.

PLoS Comput Biol. 2013 Oct;9(10):e1003284. doi: 10.1371/journal.pcbi.1003284. Epub 2013 Oct 31.


A brain-machine interface for control of burst suppression in medical coma.

Shanechi MM, Chemali JJ, Liberman M, Solt K, Brown EN.

Conf Proc IEEE Eng Med Biol Soc. 2013;2013:1575-8. doi: 10.1109/EMBC.2013.6609815.


Burst suppression probability algorithms: state-space methods for tracking EEG burst suppression.

Chemali J, Ching S, Purdon PL, Solt K, Brown EN.

J Neural Eng. 2013 Oct;10(5):056017. doi: 10.1088/1741-2560/10/5/056017. Epub 2013 Sep 10.


Real-time closed-loop control in a rodent model of medically induced coma using burst suppression.

Ching S, Liberman MY, Chemali JJ, Westover MB, Kenny JD, Solt K, Purdon PL, Brown EN.

Anesthesiology. 2013 Oct;119(4):848-60. doi: 10.1097/ALN.0b013e31829d4ab4.


Case records of the Massachusetts General Hospital. Case 40-2012. A 43-year-old woman with cardiorespiratory arrest after a cesarean section.

Ecker JL, Solt K, Fitzsimons MG, MacGillivray TE.

N Engl J Med. 2012 Dec 27;367(26):2528-36. doi: 10.1056/NEJMcpc1201413. No abstract available.


Activation of D1 dopamine receptors induces emergence from isoflurane general anesthesia.

Taylor NE, Chemali JJ, Brown EN, Solt K.

Anesthesiology. 2013 Jan;118(1):30-9. doi: 10.1097/ALN.0b013e318278c896.


Assessing the effects of pharmacological agents on respiratory dynamics using time-series modeling.

Wong KF, Gong JJ, Cotten JF, Solt K, Brown EN.

IEEE Trans Biomed Eng. 2013 Apr;60(4):1118-25. doi: 10.1109/TBME.2012.2225834. Epub 2012 Oct 25.


General anesthesia: activating a sleep switch?

Solt K.

Curr Biol. 2012 Nov 6;22(21):R918-9. doi: 10.1016/j.cub.2012.09.033.


Management of opioid analgesic overdose.

Brown EN, Solt K.

N Engl J Med. 2012 Oct 4;367(14):1370-1; author reply 1372-3. doi: 10.1056/NEJMc1209707. No abstract available.


Active emergence from propofol general anesthesia is induced by methylphenidate.

Chemali JJ, Van Dort CJ, Brown EN, Solt K.

Anesthesiology. 2012 May;116(5):998-1005. doi: 10.1097/ALN.0b013e3182518bfc.


Correcting for serial dependence in studies of respiratory dynamics.

Gong JJ, Wong KF, Cotten JF, Solt K, Brown EN.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:1721-4. doi: 10.1109/IEMBS.2011.6090493.


A state-space model of the burst suppression ratio.

Chemali JJ, Wong KF, Solt K, Brown EN.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:1431-4. doi: 10.1109/IEMBS.2011.6090354.


Methylphenidate actively induces emergence from general anesthesia.

Solt K, Cotten JF, Cimenser A, Wong KF, Chemali JJ, Brown EN.

Anesthesiology. 2011 Oct;115(4):791-803. doi: 10.1097/ALN.0b013e31822e92e5.


Inhibition of human alpha4beta2 neuronal nicotinic acetylcholine receptors by volatile aromatic anesthetics depends on drug hydrophobicity.

Solt K, Kelly EW, Cotten JF, Raines DE.

Anesth Analg. 2010 Feb 1;110(2):455-60. doi: 10.1213/ANE.0b013e3181c5f689. Epub 2009 Nov 16.


General anesthetics have additive actions on three ligand gated ion channels.

Jenkins A, Lobo IA, Gong D, Trudell JR, Solt K, Harris RA, Eger EI 2nd.

Anesth Analg. 2008 Aug;107(2):486-93. doi: 10.1213/ane.0b013e31817b70c1.


Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats.

Eger EI 2nd, Tang M, Liao M, Laster MJ, Solt K, Flood P, Jenkins A, Raines D, Hendrickx JF, Shafer SL, Yasumasa T, Sonner JM.

Anesth Analg. 2008 Aug;107(2):479-85. doi: 10.1213/01.ane.0000295805.70887.65.


Volatile aromatic anesthetics variably impact human gamma-aminobutyric acid type A receptor function.

Kelly EW, Solt K, Raines DE.

Anesth Analg. 2007 Nov;105(5):1287-92, table of contents.


Correlating the clinical actions and molecular mechanisms of general anesthetics.

Solt K, Forman SA.

Curr Opin Anaesthesiol. 2007 Aug;20(4):300-6. Review.


Hexafluorobenzene acts in the spinal cord, whereas o-difluorobenzene acts in both brain and spinal cord, to produce immobility.

Antognini JF, Raines DE, Solt K, Barter LS, Atherley RJ, Bravo E, Laster MJ, Jankowska K, Eger EI 2nd.

Anesth Analg. 2007 Apr;104(4):822-8.


Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels.

Husain SS, Nirthanan S, Ruesch D, Solt K, Cheng Q, Li GD, Arevalo E, Olsen RW, Raines DE, Forman SA, Cohen JB, Miller KW.

J Med Chem. 2006 Aug 10;49(16):4818-25.


Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration?

Dutton RC, Laster MJ, Xing Y, Sonner JM, Raines DE, Solt K, Eger EI 2nd.

Anesth Analg. 2006 May;102(5):1412-8.


Differential modulation of human N-methyl-D-aspartate receptors by structurally diverse general anesthetics.

Solt K, Eger EI 2nd, Raines DE.

Anesth Analg. 2006 May;102(5):1407-11.


Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics.

Eger EI 2nd, Liao M, Laster MJ, Won A, Popovich J, Raines DE, Solt K, Dutton RC, Cobos FV 2nd, Sonner JM.

Anesth Analg. 2006 May;102(5):1397-406.


Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein.

Solt K, Johansson JS, Raines DE.

Biochemistry. 2006 Feb 7;45(5):1435-41.


General anesthetic-induced channel gating enhancement of 5-hydroxytryptamine type 3 receptors depends on receptor subunit composition.

Solt K, Stevens RJ, Davies PA, Raines DE.

J Pharmacol Exp Ther. 2005 Nov;315(2):771-6. Epub 2005 Aug 4.


Modulation of human 5-hydroxytryptamine type 3AB receptors by volatile anesthetics and n-alcohols.

Stevens R, Rüsch D, Solt K, Raines DE, Davies PA.

J Pharmacol Exp Ther. 2005 Jul;314(1):338-45. Epub 2005 Apr 14.


Rapid cleavage of cyclic tertiary amides of Kemp's triacid: effects of ring structure.

Dougan ML, Chin JL, Solt K, Hansen DE.

Bioorg Med Chem Lett. 2004 Aug 16;14(16):4153-6.


Modulation of the voltage sensor of L-type Ca2+ channels by intracellular Ca2+.

Isaev D, Solt K, Gurtovaya O, Reeves JP, Shirokov R.

J Gen Physiol. 2004 May;123(5):555-71.

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