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An Evaluation of T-Cell Functionality After Flow Cytometry Sorting Revealed p38 MAPK Activation.

Andrä I, Ulrich H, Dürr S, Soll D, Henkel L, Angerpointner C, Ritter J, Przibilla S, Stadler H, Effenberger M, Busch DH, Schiemann M.

Cytometry A. 2020 Jan 16. doi: 10.1002/cyto.a.23964. [Epub ahead of print]


Initiation of Protein Synthesis with Non-Canonical Amino Acids In Vivo.

Tharp JM, Ad O, Amikura K, Ward FR, Garcia EM, Cate JHD, Schepartz A, Söll D.

Angew Chem Int Ed Engl. 2019 Dec 11. doi: 10.1002/anie.201914671. [Epub ahead of print]


The Nbp35/ApbC homolog acts as a nonessential [4Fe-4S] transfer protein in methanogenic archaea.

Zhao C, Lyu Z, Long F, Akinyemi T, Manakongtreecheep K, Söll D, Whitman WB, Vinyard DJ, Liu Y.

FEBS Lett. 2019 Nov 11. doi: 10.1002/1873-3468.13673. [Epub ahead of print]


Archaeal Ribosomal Proteins Possess Nuclear Localization Signal-Type Motifs: Implications for the Origin of the Cell Nucleus.

Melnikov S, Kwok HS, Manakongtreecheep K, van den Elzen A, Thoreen CC, Söll D.

Mol Biol Evol. 2020 Jan 1;37(1):124-133. doi: 10.1093/molbev/msz207.


Translation of Diverse Aramid- and 1,3-Dicarbonyl-peptides by Wild Type Ribosomes in Vitro.

Ad O, Hoffman KS, Cairns AG, Featherston AL, Miller SJ, Söll D, Schepartz A.

ACS Cent Sci. 2019 Jul 24;5(7):1289-1294. doi: 10.1021/acscentsci.9b00460. Epub 2019 Jun 26.


A cysteinyl-tRNA synthetase variant confers resistance against selenite toxicity and decreases selenocysteine misincorporation.

Hoffman KS, Vargas-Rodriguez O, Bak DW, Mukai T, Woodward LK, Weerapana E, Söll D, Reynolds NM.

J Biol Chem. 2019 Aug 23;294(34):12855-12865. doi: 10.1074/jbc.RA119.008219. Epub 2019 Jul 11.


Clinical outcome of a patient with lysosomal acid lipase deficiency and first results after initiation of treatment with Sebelipase alfa: A case report.

Soll D, Spira D, Hollstein T, Haberbosch L, Demuth I, Steinhagen-Thiessen E, Bobbert T, Spranger J, Kassner U.

Mol Genet Metab Rep. 2019 Jun 18;20:100479. doi: 10.1016/j.ymgmr.2019.100479. eCollection 2019 Sep.


Reciprocal signaling and direct physical interactions between fibroblasts and breast cancer cells in a 3D environment.

Wessels DJ, Pradhan N, Park YN, Klepitsch MA, Lusche DF, Daniels KJ, Conway KD, Voss ER, Hegde SV, Conway TP, Soll DR.

PLoS One. 2019 Jun 24;14(6):e0218854. doi: 10.1371/journal.pone.0218854. eCollection 2019.


Plasticity and Constraints of tRNA Aminoacylation Define Directed Evolution of Aminoacyl-tRNA Synthetases.

Crnković A, Vargas-Rodriguez O, Söll D.

Int J Mol Sci. 2019 May 9;20(9). pii: E2294. doi: 10.3390/ijms20092294. Review.


Aminoacyl-tRNA Synthetases and tRNAs for an Expanded Genetic Code: What Makes them Orthogonal?

Melnikov SV, Söll D.

Int J Mol Sci. 2019 Apr 19;20(8). pii: E1929. doi: 10.3390/ijms20081929. Review.


Roles of the Transcription Factors Sfl2 and Efg1 in White-Opaque Switching in a/α Strains of Candida albicans.

Park YN, Conway K, Conway TP, Daniels KJ, Soll DR.

mSphere. 2019 Apr 17;4(2). pii: e00703-18. doi: 10.1128/mSphere.00703-18.


Engineered Aminoacyl-tRNA Synthetases with Improved Selectivity toward Noncanonical Amino Acids.

Kwok HS, Vargas-Rodriguez O, Melnikov SV, Söll D.

ACS Chem Biol. 2019 Apr 19;14(4):603-612. doi: 10.1021/acschembio.9b00088. Epub 2019 Apr 9.


Integrin α-3 ß-1's central role in breast cancer, melanoma and glioblastoma cell aggregation revealed by antibodies with blocking activity.

Lusche DF, Klemme MR, Soll BA, Reis RJ, Forrest CC, Nop TS, Wessels DJ, Berger B, Glover R, Soll DR.

MAbs. 2019 May/Jun;11(4):691-708. doi: 10.1080/19420862.2019.1583987. Epub 2019 Apr 16.


Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment.

Matthias J, Maul J, Noster R, Meinl H, Chao YY, Gerstenberg H, Jeschke F, Gasparoni G, Welle A, Walter J, Nordström K, Eberhardt K, Renisch D, Donakonda S, Knolle P, Soll D, Grabbe S, Garzorz-Stark N, Eyerich K, Biedermann T, Baumjohann D, Zielinski CE.

Sci Transl Med. 2019 Feb 20;11(480). pii: eaau0683. doi: 10.1126/scitranslmed.aau0683.


Muller's Ratchet and Ribosome Degeneration in the Obligate Intracellular Parasites Microsporidia.

Melnikov SV, Manakongtreecheep K, Rivera KD, Makarenko A, Pappin DJ, Söll D.

Int J Mol Sci. 2018 Dec 19;19(12). pii: E4125. doi: 10.3390/ijms19124125.


Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site.

Melnikov SV, Khabibullina NF, Mairhofer E, Vargas-Rodriguez O, Reynolds NM, Micura R, Söll D, Polikanov YS.

Nucleic Acids Res. 2019 Feb 28;47(4):2089-2100. doi: 10.1093/nar/gky1211.


Loss of protein synthesis quality control in host-restricted organisms.

Melnikov SV, van den Elzen A, Stevens DL, Thoreen CC, Söll D.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11505-E11512. doi: 10.1073/pnas.1815992115. Epub 2018 Nov 19.


Versatility of Synthetic tRNAs in Genetic Code Expansion.

Hoffman KS, Crnković A, Söll D.

Genes (Basel). 2018 Nov 7;9(11). pii: E537. doi: 10.3390/genes9110537. Review.


Designing seryl-tRNA synthetase for improved serylation of selenocysteine tRNAs.

Fu X, Crnković A, Sevostyanova A, Söll D.

FEBS Lett. 2018 Nov;592(22):3759-3768. doi: 10.1002/1873-3468.13271. Epub 2018 Oct 24.


Lysine Acetylation Regulates Alanyl-tRNA Synthetase Activity in Escherichia coli.

Umehara T, Kosono S, Söll D, Tamura K.

Genes (Basel). 2018 Sep 28;9(10). pii: E473. doi: 10.3390/genes9100473.


Transfer RNA function and evolution.

O'Donoghue P, Ling J, Söll D.

RNA Biol. 2018;15(4-5):423-426. doi: 10.1080/15476286.2018.1478942. No abstract available.


Upgrading aminoacyl-tRNA synthetases for genetic code expansion.

Vargas-Rodriguez O, Sevostyanova A, Söll D, Crnković A.

Curr Opin Chem Biol. 2018 Oct;46:115-122. doi: 10.1016/j.cbpa.2018.07.014. Epub 2018 Jul 27. Review.


[A facile method for producing selenocysteine-containing proteins].

Mukai T, Sevostyanova A, Suzuki T, Fu X, Söll D.

Angew Chem Weinheim Bergstr Ger. 2018 Jun 11;130(24):7333-7337. Epub 2018 Apr 6. German. No abstract available.


Error-prone protein synthesis in parasites with the smallest eukaryotic genome.

Melnikov SV, Rivera KD, Ostapenko D, Makarenko A, Sanscrainte ND, Becnel JJ, Solomon MJ, Texier C, Pappin DJ, Söll D.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6245-E6253. doi: 10.1073/pnas.1803208115. Epub 2018 Jun 18.


Recoding of the selenocysteine UGA codon by cysteine in the presence of a non-canonical tRNACys and elongation factor SelB.

Vargas-Rodriguez O, Englert M, Merkuryev A, Mukai T, Söll D.

RNA Biol. 2018;15(4-5):471-479. doi: 10.1080/15476286.2018.1474074. Epub 2018 Jun 18.


Overexpressing TPTE2 (TPIP), a homolog of the human tumor suppressor gene PTEN, rescues the abnormal phenotype of the PTEN-/- mutant.

Lusche DF, Buchele EC, Russell KB, Soll BA, Vitolo MI, Klemme MR, Wessels DJ, Soll DR.

Oncotarget. 2018 Apr 20;9(30):21100-21121. doi: 10.18632/oncotarget.24941. eCollection 2018 Apr 20.


A Facile Method for Producing Selenocysteine-Containing Proteins.

Mukai T, Sevostyanova A, Suzuki T, Fu X, Söll D.

Angew Chem Int Ed Engl. 2018 Jun 11;57(24):7215-7219. doi: 10.1002/anie.201713215. Epub 2018 May 9.


Candida albicans White-Opaque Switching Influences Virulence but Not Mating during Oropharyngeal Candidiasis.

Solis NV, Park YN, Swidergall M, Daniels KJ, Filler SG, Soll DR.

Infect Immun. 2018 May 22;86(6). pii: e00774-17. doi: 10.1128/IAI.00774-17. Print 2018 Jun.


Revising the Structural Diversity of Ribosomal Proteins Across the Three Domains of Life.

Melnikov S, Manakongtreecheep K, Söll D.

Mol Biol Evol. 2018 Jul 1;35(7):1588-1598. doi: 10.1093/molbev/msy021.


Generating a Battery of Monoclonal Antibodies Against Firefly Luciferase for Dot Blot Analysis, Western Blot Analysis, and Immunostaining of Cells in Culture and Paraffin Sections.

Conway TP, Daniels KJ, Park YN, Soll DR.

Monoclon Antib Immunodiagn Immunother. 2018 Feb;37(1):45-51. doi: 10.1089/mab.2017.0057.


Challenges of site-specific selenocysteine incorporation into proteins by Escherichia coli.

Fu X, Söll D, Sevostyanova A.

RNA Biol. 2018;15(4-5):461-470. doi: 10.1080/15476286.2018.1440876. Epub 2018 Mar 12. Review.


Effects of Heterologous tRNA Modifications on the Production of Proteins Containing Noncanonical Amino Acids.

Crnković A, Vargas-Rodriguez O, Merkuryev A, Söll D.

Bioengineering (Basel). 2018 Feb 2;5(1). pii: E11. doi: 10.3390/bioengineering5010011.


Drugging tRNA aminoacylation.

Ho JM, Bakkalbasi E, Söll D, Miller CA.

RNA Biol. 2018;15(4-5):667-677. doi: 10.1080/15476286.2018.1429879. Epub 2018 Feb 2. Review.


Errata: Continuous directed evolution of aminoacyl-tRNA synthetases.

Bryson DI, Fan C, Guo LT, Miller C, Söll D, Liu DR.

Nat Chem Biol. 2018 Jan 16;14(2):186. doi: 10.1038/nchembio0218-186.


Engineering posttranslational proofreading to discriminate nonstandard amino acids.

Kunjapur AM, Stork DA, Kuru E, Vargas-Rodriguez O, Landon M, Söll D, Church GM.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):619-624. doi: 10.1073/pnas.1715137115. Epub 2018 Jan 4.


Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase.

Suzuki T, Miller C, Guo LT, Ho JML, Bryson DI, Wang YS, Liu DR, Söll D.

Nat Chem Biol. 2017 Dec;13(12):1261-1266. doi: 10.1038/nchembio.2497. Epub 2017 Oct 16.


Continuous directed evolution of aminoacyl-tRNA synthetases.

Bryson DI, Fan C, Guo LT, Miller C, Söll D, Liu DR.

Nat Chem Biol. 2017 Dec;13(12):1253-1260. doi: 10.1038/nchembio.2474. Epub 2017 Oct 16. Erratum in: Nat Chem Biol. 2018 Jan 16;14 (2):186.


Protocol for Identifying Natural Agents That Selectively Affect Adhesion, Thickness, Architecture, Cellular Phenotypes, Extracellular Matrix, and Human White Blood Cell Impenetrability of Candida albicans Biofilms.

Park YN, Srikantha T, Daniels KJ, Jacob MR, Agarwal AK, Li XC, Soll DR.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01319-17. doi: 10.1128/AAC.01319-17. Print 2017 Nov.


Rewriting the Genetic Code.

Mukai T, Lajoie MJ, Englert M, Söll D.

Annu Rev Microbiol. 2017 Sep 8;71:557-577. doi: 10.1146/annurev-micro-090816-093247. Epub 2017 Jul 11. Review.


RNA-Dependent Cysteine Biosynthesis in Bacteria and Archaea.

Mukai T, Crnković A, Umehara T, Ivanova NN, Kyrpides NC, Söll D.

mBio. 2017 May 9;8(3). pii: e00561-17. doi: 10.1128/mBio.00561-17.


The central role of tRNA in genetic code expansion.

Reynolds NM, Vargas-Rodriguez O, Söll D, Crnković A.

Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt B):3001-3008. doi: 10.1016/j.bbagen.2017.03.012. Epub 2017 Mar 18. Review.


A genomically modified Escherichia coli strain carrying an orthogonal E. coli histidyl-tRNA synthetase•tRNAHis pair.

Englert M, Vargas-Rodriguez O, Reynolds NM, Wang YS, Söll D, Umehara T.

Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt B):3009-3015. doi: 10.1016/j.bbagen.2017.03.003. Epub 2017 Mar 10.


Melanoma cells undergo aggressive coalescence in a 3D Matrigel model that is repressed by anti-CD44.

Wessels D, Lusche DF, Voss E, Kuhl S, Buchele EC, Klemme MR, Russell KB, Ambrose J, Soll BA, Bossler A, Milhem M, Goldman C, Soll DR.

PLoS One. 2017 Mar 6;12(3):e0173400. doi: 10.1371/journal.pone.0173400. eCollection 2017.


Pyrrolysyl-tRNA synthetase, an aminoacyl-tRNA synthetase for genetic code expansion.

Crnković A, Suzuki T, Söll D, Reynolds NM.

Croat Chem Acta. 2016 Jun;89(2):163-174. doi: 10.5562/cca2825. Epub 2016 Jun 14.


Bioinformatic Analysis Reveals Archaeal tRNATyr and tRNATrp Identities in Bacteria.

Mukai T, Reynolds NM, Crnković A, Söll D.

Life (Basel). 2017 Feb 21;7(1). pii: E8. doi: 10.3390/life7010008.


Transfer RNAs with novel cloverleaf structures.

Mukai T, Vargas-Rodriguez O, Englert M, Tripp HJ, Ivanova NN, Rubin EM, Kyrpides NC, Söll D.

Nucleic Acids Res. 2017 Mar 17;45(5):2776-2785. doi: 10.1093/nar/gkw898.


Allergies - A T cells perspective in the era beyond the TH1/TH2 paradigm.

Berker M, Frank LJ, Geßner AL, Grassl N, Holtermann AV, Höppner S, Kraef C, Leclaire MD, Maier P, Messerer DA, Möhrmann L, Nieke JP, Schoch D, Soll D, Woopen CM.

Clin Immunol. 2017 Jan;174:73-83. doi: 10.1016/j.clim.2016.11.001. Epub 2016 Nov 12. Review.


A chemical biology route to site-specific authentic protein modifications.

Yang A, Ha S, Ahn J, Kim R, Kim S, Lee Y, Kim J, Söll D, Lee HY, Park HS.

Science. 2016 Nov 4;354(6312):623-626. Epub 2016 Sep 29.


A [3Fe-4S] cluster is required for tRNA thiolation in archaea and eukaryotes.

Liu Y, Vinyard DJ, Reesbeck ME, Suzuki T, Manakongtreecheep K, Holland PL, Brudvig GW, Söll D.

Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12703-12708. doi: 10.1073/pnas.1615732113. Epub 2016 Oct 24.


Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation.

Dobosz-Bartoszek M, Pinkerton MH, Otwinowski Z, Chakravarthy S, Söll D, Copeland PR, Simonović M.

Nat Commun. 2016 Oct 6;7:12941. doi: 10.1038/ncomms12941.

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