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Items: 1 to 50 of 122

1.

Content-aware image restoration: pushing the limits of fluorescence microscopy.

Weigert M, Schmidt U, Boothe T, Müller A, Dibrov A, Jain A, Wilhelm B, Schmidt D, Broaddus C, Culley S, Rocha-Martins M, Segovia-Miranda F, Norden C, Henriques R, Zerial M, Solimena M, Rink J, Tomancak P, Royer L, Jug F, Myers EW.

Nat Methods. 2018 Dec;15(12):1090-1097. doi: 10.1038/s41592-018-0216-7. Epub 2018 Nov 26.

PMID:
30478326
2.

Detection of recombinant and endogenous mouse melatonin receptors by monoclonal antibodies targeting the C-terminal domain.

Cecon E, Ivanova A, Luka M, Gbahou F, Friederich A, Guillaume JL, Keller P, Knoch K, Ahmad R, Delagrange P, Solimena M, Jockers R.

J Pineal Res. 2019 Mar;66(2):e12540. doi: 10.1111/jpi.12540. Epub 2019 Jan 17.

PMID:
30475390
3.

The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans.

Gerst F, Jaghutriz BA, Staiger H, Schulte AM, Lorza-Gil E, Kaiser G, Panse M, Haug S, Heni M, Schütz M, Stadion M, Schürmann A, Marzetta F, Ibberson M, Sipos B, Fend F, Fleming T, Nawroth PP, Königsrainer A, Nadalin S, Wagner S, Peter A, Fritsche A, Richter D, Solimena M, Häring HU, Ullrich S, Wagner R.

J Clin Endocrinol Metab. 2018 Dec 1;103(12):4373-4383. doi: 10.1210/jc.2018-00791.

PMID:
30202879
4.

Virus-like infection induces human β cell dedifferentiation.

Oshima M, Knoch KP, Diedisheim M, Petzold A, Cattan P, Bugliani M, Marchetti P, Choudhary P, Huang GC, Bornstein SR, Solimena M, Albagli-Curiel O, Scharfmann R.

JCI Insight. 2018 Feb 8;3(3). pii: 97732. doi: 10.1172/jci.insight.97732. [Epub ahead of print]

5.

The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers.

Monzón-Casanova E, Screen M, Díaz-Muñoz MD, Coulson RMR, Bell SE, Lamers G, Solimena M, Smith CWJ, Turner M.

Nat Immunol. 2018 Mar;19(3):267-278. doi: 10.1038/s41590-017-0035-5. Epub 2018 Jan 22.

6.

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

Solimena M, Schulte AM, Marselli L, Ehehalt F, Richter D, Kleeberg M, Mziaut H, Knoch KP, Parnis J, Bugliani M, Siddiq A, Jörns A, Burdet F, Liechti R, Suleiman M, Margerie D, Syed F, Distler M, Grützmann R, Petretto E, Moreno-Moral A, Wegbrod C, Sönmez A, Pfriem K, Friedrich A, Meinel J, Wollheim CB, Baretton GB, Scharfmann R, Nogoceke E, Bonifacio E, Sturm D, Meyer-Puttlitz B, Boggi U, Saeger HD, Filipponi F, Lesche M, Meda P, Dahl A, Wigger L, Xenarios I, Falchi M, Thorens B, Weitz J, Bokvist K, Lenzen S, Rutter GA, Froguel P, von Bülow M, Ibberson M, Marchetti P.

Diabetologia. 2018 Mar;61(3):641-657. doi: 10.1007/s00125-017-4500-3. Epub 2017 Nov 28.

7.

Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes.

Ludwig B, Ludwig S, Steffen A, Knauf Y, Zimerman B, Heinke S, Lehmann S, Schubert U, Schmid J, Bleyer M, Schönmann U, Colton CK, Bonifacio E, Solimena M, Reichel A, Schally AV, Rotem A, Barkai U, Grinberg-Rashi H, Kaup FJ, Avni Y, Jones P, Bornstein SR.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11745-11750. doi: 10.1073/pnas.1708420114. Epub 2017 Oct 16.

8.

A 4D view on insulin secretory granule turnover in the β-cell.

Müller A, Mziaut H, Neukam M, Knoch KP, Solimena M.

Diabetes Obes Metab. 2017 Sep;19 Suppl 1:107-114. doi: 10.1111/dom.13015. Review.

PMID:
28880479
9.

Vessel Network Architecture of Adult Human Islets Promotes Distinct Cell-Cell Interactions In Situ and Is Altered After Transplantation.

Cohrs CM, Chen C, Jahn SR, Stertmann J, Chmelova H, Weitz J, Bähr A, Klymiuk N, Steffen A, Ludwig B, Kamvissi V, Wolf E, Bornstein SR, Solimena M, Speier S.

Endocrinology. 2017 May 1;158(5):1373-1385. doi: 10.1210/en.2016-1184.

PMID:
28324008
10.

A Global Approach for Quantitative Super Resolution and Electron Microscopy on Cryo and Epoxy Sections Using Self-labeling Protein Tags.

Müller A, Neukam M, Ivanova A, Sönmez A, Münster C, Kretschmar S, Kalaidzidis Y, Kurth T, Verbavatz JM, Solimena M.

Sci Rep. 2017 Feb 2;7(1):23. doi: 10.1038/s41598-017-00033-x.

11.

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.

Carrat GR, Hu M, Nguyen-Tu MS, Chabosseau P, Gaulton KJ, van de Bunt M, Siddiq A, Falchi M, Thurner M, Canouil M, Pattou F, Leclerc I, Pullen TJ, Cane MC, Prabhala P, Greenwald W, Schulte A, Marchetti P, Ibberson M, MacDonald PE, Manning Fox JE, Gloyn AL, Froguel P, Solimena M, McCarthy MI, Rutter GA.

Am J Hum Genet. 2017 Feb 2;100(2):238-256. doi: 10.1016/j.ajhg.2017.01.011. Epub 2017 Jan 26.

12.

The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512.

Mziaut H, Mulligan B, Hoboth P, Otto O, Ivanova A, Herbig M, Schumann D, Hildebrandt T, Dehghany J, Sönmez A, Münster C, Meyer-Hermann M, Guck J, Kalaidzidis Y, Solimena M.

Mol Metab. 2016 Jun 10;5(8):656-668. doi: 10.1016/j.molmet.2016.05.015. eCollection 2016 Aug.

13.

A human beta cell line with drug inducible excision of immortalizing transgenes.

Benazra M, Lecomte MJ, Colace C, Müller A, Machado C, Pechberty S, Bricout-Neveu E, Grenier-Godard M, Solimena M, Scharfmann R, Czernichow P, Ravassard P.

Mol Metab. 2015 Oct 20;4(12):916-25. doi: 10.1016/j.molmet.2015.09.008. eCollection 2015 Dec.

14.

Biochemical, biophysical, and functional properties of ICA512/IA-2 RESP18 homology domain.

Sosa L, Torkko JM, Primo ME, Llovera RE, Toledo PL, Rios AS, Flecha FL, Trabucchi A, Valdez SN, Poskus E, Solimena M, Ermácora MR.

Biochim Biophys Acta. 2016 May;1864(5):511-22. doi: 10.1016/j.bbapap.2016.01.013. Epub 2016 Feb 1.

PMID:
26836020
15.

Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice.

Anastasiou V, Ninou E, Alexopoulou D, Stertmann J, Müller A, Dahl A, Solimena M, Speier S, Serafimidis I, Gavalas A.

Diabetologia. 2016 Jan;59(1):139-50. doi: 10.1007/s00125-015-3784-4. Epub 2015 Oct 31.

16.

Mechanisms of Beta Cell Dysfunction Associated With Viral Infection.

Petzold A, Solimena M, Knoch KP.

Curr Diab Rep. 2015 Oct;15(10):73. doi: 10.1007/s11892-015-0654-x. Review.

17.

Blood Glucose Homeostasis in the Course of Partial Pancreatectomy--Evidence for Surgically Reversible Diabetes Induced by Cholestasis.

Ehehalt F, Sturm D, Rösler M, Distler M, Weitz J, Kersting S, Ludwig B, Schwanebeck U, Saeger HD, Solimena M, Grützmann R.

PLoS One. 2015 Aug 6;10(8):e0134140. doi: 10.1371/journal.pone.0134140. eCollection 2015.

18.

Adaptive lipid packing and bioactivity in membrane domains.

Sezgin E, Gutmann T, Buhl T, Dirkx R, Grzybek M, Coskun Ü, Solimena M, Simons K, Levental I, Schwille P.

PLoS One. 2015 Apr 23;10(4):e0123930. doi: 10.1371/journal.pone.0123930. eCollection 2015.

19.

A Spatial Model of Insulin-Granule Dynamics in Pancreatic β-Cells.

Dehghany J, Hoboth P, Ivanova A, Mziaut H, Müller A, Kalaidzidis Y, Solimena M, Meyer-Hermann M.

Traffic. 2015 Aug;16(8):797-813. doi: 10.1111/tra.12286. Epub 2015 May 1.

20.

Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies.

Hoboth P, Müller A, Ivanova A, Mziaut H, Dehghany J, Sönmez A, Lachnit M, Meyer-Hermann M, Kalaidzidis Y, Solimena M.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E667-76. doi: 10.1073/pnas.1409542112. Epub 2015 Feb 2. Erratum in: Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2114.

21.

Stability of proICA512/IA-2 and its targeting to insulin secretory granules require β4-sheet-mediated dimerization of its ectodomain in the endoplasmic reticulum.

Torkko JM, Primo ME, Dirkx R, Friedrich A, Viehrig A, Vergari E, Borgonovo B, Sönmez A, Wegbrod C, Lachnit M, Münster C, Sica MP, Ermácora MR, Solimena M.

Mol Cell Biol. 2015 Mar;35(6):914-27. doi: 10.1128/MCB.00994-14. Epub 2015 Jan 5.

22.

Creating a "Transcampus" in diabetes research between King's College London and the Technische Universität Dresden: update on islet biology and transplantation.

Bornstein SR, Amiel SA, Rubino F, Mingrone G, Kamvissi V, Solimena M, Bonifacio E, Jones P, Schwarz P, Birkenfeld AL, Behrens A, Barthel A, Lechler R, Peakman M.

Horm Metab Res. 2015 Jan;47(1):1-3. doi: 10.1055/s-0034-1394453. Epub 2014 Dec 5. No abstract available.

PMID:
25478704
23.

X-ray structure of the mature ectodomain of phogrin.

Noguera ME, Primo ME, Jakoncic J, Poskus E, Solimena M, Ermácora MR.

J Struct Funct Genomics. 2015 Mar;16(1):1-9. doi: 10.1007/s10969-014-9191-0. Epub 2014 Nov 26.

PMID:
25421040
24.

Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology.

Marciniak A, Cohrs CM, Tsata V, Chouinard JA, Selck C, Stertmann J, Reichelt S, Rose T, Ehehalt F, Weitz J, Solimena M, Slak Rupnik M, Speier S.

Nat Protoc. 2014 Dec;9(12):2809-22. doi: 10.1038/nprot.2014.195. Epub 2014 Nov 13.

PMID:
25393778
25.

PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells.

Knoch KP, Nath-Sain S, Petzold A, Schneider H, Beck M, Wegbrod C, Sönmez A, Münster C, Friedrich A, Roivainen M, Solimena M.

Mol Metab. 2014 May 14;3(5):518-30. doi: 10.1016/j.molmet.2014.05.002. eCollection 2014 Aug.

26.

Regulation of β-cell function by RNA-binding proteins.

Magro MG, Solimena M.

Mol Metab. 2013 Sep 25;2(4):348-55. doi: 10.1016/j.molmet.2013.09.003. Review.

27.

Transplantation of human islets without immunosuppression.

Ludwig B, Reichel A, Steffen A, Zimerman B, Schally AV, Block NL, Colton CK, Ludwig S, Kersting S, Bonifacio E, Solimena M, Gendler Z, Rotem A, Barkai U, Bornstein SR.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19054-8. doi: 10.1073/pnas.1317561110. Epub 2013 Oct 28.

28.

The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance.

Phieler J, Chung KJ, Chatzigeorgiou A, Klotzsche-von Ameln A, Garcia-Martin R, Sprott D, Moisidou M, Tzanavari T, Ludwig B, Baraban E, Ehrhart-Bornstein M, Bornstein SR, Mziaut H, Solimena M, Karalis KP, Economopoulou M, Lambris JD, Chavakis T.

J Immunol. 2013 Oct 15;191(8):4367-74. doi: 10.4049/jimmunol.1300038. Epub 2013 Sep 16.

29.

Age-dependent labeling and imaging of insulin secretory granules.

Ivanova A, Kalaidzidis Y, Dirkx R, Sarov M, Gerlach M, Schroth-Diez B, Müller A, Liu Y, Andree C, Mulligan B, Münster C, Kurth T, Bickle M, Speier S, Anastassiadis K, Solimena M.

Diabetes. 2013 Nov;62(11):3687-96. doi: 10.2337/db12-1819. Epub 2013 Aug 8.

30.

Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets.

Krautz C, Wolk S, Steffen A, Knoch KP, Ceglarek U, Thiery J, Bornstein S, Saeger HD, Solimena M, Kersting S.

Diabetologia. 2013 Jul;56(7):1596-604. doi: 10.1007/s00125-013-2895-z. Epub 2013 Mar 27.

PMID:
23532258
31.

Improved protocol for laser microdissection of human pancreatic islets from surgical specimens.

Sturm D, Marselli L, Ehehalt F, Richter D, Distler M, Kersting S, Grützmann R, Bokvist K, Froguel P, Liechti R, Jörns A, Meda P, Baretton GB, Saeger HD, Schulte AM, Marchetti P, Solimena M.

J Vis Exp. 2013 Jan 6;(71). pii: 50231. doi: 10.3791/50231.

32.

Polymorphism rs11085226 in the gene encoding polypyrimidine tract-binding protein 1 negatively affects glucose-stimulated insulin secretion.

Heni M, Ketterer C, Wagner R, Linder K, Böhm A, Herzberg-Schäfer SA, Machicao F, Knoch KP, Fritsche A, Staiger H, Häring HU, Solimena M.

PLoS One. 2012;7(10):e46154. doi: 10.1371/journal.pone.0046154. Epub 2012 Oct 15.

33.

CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells.

Brambillasca S, Altkrueger A, Colombo SF, Friederich A, Eickelmann P, Mark M, Borgese N, Solimena M.

J Biol Chem. 2012 Dec 7;287(50):41808-19. doi: 10.1074/jbc.M112.376558. Epub 2012 Oct 9.

34.

Cholesterol-enriched membrane rafts and insulin secretion.

Dirkx R Jr, Solimena M.

J Diabetes Investig. 2012 Aug 20;3(4):339-46. doi: 10.1111/j.2040-1124.2012.00200.x. Review.

35.

Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression.

Bonner SM, Pietropaolo SL, Fan Y, Chang Y, Sethupathy P, Morran MP, Beems M, Giannoukakis N, Trucco G, Palumbo MO, Solimena M, Pugliese A, Polychronakos C, Trucco M, Pietropaolo M.

J Biol Chem. 2012 May 18;287(21):17882-93. doi: 10.1074/jbc.M111.319020. Epub 2012 Mar 24.

36.

Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling.

Fava E, Dehghany J, Ouwendijk J, Müller A, Niederlein A, Verkade P, Meyer-Hermann M, Solimena M.

Diabetologia. 2012 Apr;55(4):1013-23. doi: 10.1007/s00125-011-2438-4. Epub 2012 Jan 18.

37.

Protein-protein interactions in crystals of the human receptor-type protein tyrosine phosphatase ICA512 ectodomain.

Primo ME, Jakoncic J, Noguera ME, Risso VA, Sosa L, Sica MP, Solimena M, Poskus E, Ermácora MR.

PLoS One. 2011;6(9):e24191. doi: 10.1371/journal.pone.0024191. Epub 2011 Sep 15.

38.

Isolation of human islets from partially pancreatectomized patients.

Bötticher G, Sturm D, Ehehalt F, Knoch KP, Kersting S, Grützmann R, Baretton GB, Solimena M, Saeger HD.

J Vis Exp. 2011 Jul 30;(53). pii: 2962. doi: 10.3791/2962.

39.

Functional assessment of automatically sorted pancreatic islets using large particle flow cytometry.

Steffen A, Ludwig B, Krautz C, Bornstein S, Solimena M.

Islets. 2011 Sep-Oct;3(5):267-70. Epub 2011 Sep 1.

40.

PTBP1 is required for embryonic development before gastrulation.

Suckale J, Wendling O, Masjkur J, Jäger M, Münster C, Anastassiadis K, Stewart AF, Solimena M.

PLoS One. 2011 Feb 17;6(2):e16992. doi: 10.1371/journal.pone.0016992.

41.

Human stiff-person syndrome IgG induces anxious behavior in rats.

Geis C, Weishaupt A, Grünewald B, Wultsch T, Reif A, Gerlach M, Dirkx R, Solimena M, Perani D, Heckmann M, Toyka KV, Folli F, Sommer C.

PLoS One. 2011 Feb 8;6(2):e16775. doi: 10.1371/journal.pone.0016775.

42.

Impaired insulin turnover in islets from type 2 diabetic patients.

Ehehalt F, Knoch K, Erdmann K, Krautz C, Jäger M, Steffen A, Wegbrod C, Meisterfeld R, Kersting S, Bergert H, Kuhlisch E, Bornstein S, Bonifacio E, Saeger HD, Solimena M.

Islets. 2010 Jan-Feb;2(1):30-6. doi: 10.4161/isl.2.1.10098.

PMID:
21099291
43.

Tamoxifen-independent recombination in the RIP-CreER mouse.

Liu Y, Suckale J, Masjkur J, Magro MG, Steffen A, Anastassiadis K, Solimena M.

PLoS One. 2010 Oct 22;5(10):e13533. doi: 10.1371/journal.pone.0013533.

44.

β2-Syntrophin is a Cdk5 substrate that restrains the motility of insulin secretory granules.

Schubert S, Knoch KP, Ouwendijk J, Mohammed S, Bodrov Y, Jäger M, Altkrüger A, Wegbrod C, Adams ME, Kim Y, Froehner SC, Jensen ON, Kalaidzidis Y, Solimena M.

PLoS One. 2010 Sep 23;5(9):e12929. doi: 10.1371/journal.pone.0012929.

45.

Insulin release: shedding light on a complex matter.

Solimena M, Speier S.

Cell Metab. 2010 Jul 7;12(1):5-6. doi: 10.1016/j.cmet.2010.06.002.

46.

The insulin secretory granule as a signaling hub.

Suckale J, Solimena M.

Trends Endocrinol Metab. 2010 Oct;21(10):599-609. doi: 10.1016/j.tem.2010.06.003. Epub 2010 Jul 6. Review.

PMID:
20609596
47.

Automated suppression of sample-related artifacts in Fluorescence Correlation Spectroscopy.

Ries J, Bayer M, Csúcs G, Dirkx R, Solimena M, Ewers H, Schwille P.

Opt Express. 2010 May 24;18(11):11073-82. doi: 10.1364/OE.18.011073.

PMID:
20588964
48.

beta-Cells at the crossroads: choosing between insulin granule production and proliferation.

Liu Y, Mziaut H, Ivanova A, Solimena M.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:54-64. doi: 10.1111/j.1463-1326.2009.01107.x. Review.

PMID:
19817789
49.

An update on preventive and regenerative therapies in diabetes mellitus.

Reimann M, Bonifacio E, Solimena M, Schwarz PE, Ludwig B, Hanefeld M, Bornstein SR.

Pharmacol Ther. 2009 Mar;121(3):317-31. doi: 10.1016/j.pharmthera.2008.11.009. Epub 2008 Dec 25. Review.

PMID:
19168093
50.

Pancreatic disorders and diabetes mellitus.

Meisterfeld R, Ehehalt F, Saeger HD, Solimena M.

Exp Clin Endocrinol Diabetes. 2008 Sep;116 Suppl 1:S7-S12. doi: 10.1055/s-2008-1080918. Epub 2008 Sep 5. Review.

PMID:
18777459

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