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Items: 29


Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1.

García-Morales V, Rodríguez-Bey G, Gómez-Pérez L, Domínguez-Vías G, González-Forero D, Portillo F, Campos-Caro A, Gento-Caro Á, Issaoui N, Soler RM, Garcera A, Moreno-López B.

Nat Commun. 2019 Aug 22;10(1):3784. doi: 10.1038/s41467-019-11637-4.


Calpain Inhibition Increases SMN Protein in Spinal Cord Motoneurons and Ameliorates the Spinal Muscular Atrophy Phenotype in Mice.

de la Fuente S, Sansa A, Periyakaruppiah A, Garcera A, Soler RM.

Mol Neurobiol. 2019 Jun;56(6):4414-4427. doi: 10.1007/s12035-018-1379-z. Epub 2018 Oct 16.


Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy.

Piras A, Schiaffino L, Boido M, Valsecchi V, Guglielmotto M, De Amicis E, Puyal J, Garcera A, Tamagno E, Soler RM, Vercelli A.

Cell Death Dis. 2017 Dec 20;8(12):3223. doi: 10.1038/s41419-017-0086-4.


Smn-Deficiency Increases the Intrinsic Excitability of Motoneurons.

Arumugam S, Garcera A, Soler RM, Tabares L.

Front Cell Neurosci. 2017 Sep 5;11:269. doi: 10.3389/fncel.2017.00269. eCollection 2017.


Regulation of Survival Motor Neuron Protein by the Nuclear Factor-Kappa B Pathway in Mouse Spinal Cord Motoneurons.

Arumugam S, Mincheva-Tasheva S, Periyakaruppiah A, de la Fuente S, Soler RM, Garcera A.

Mol Neurobiol. 2018 Jun;55(6):5019-5030. doi: 10.1007/s12035-017-0710-4. Epub 2017 Aug 14.


Autophagy modulators regulate survival motor neuron protein stability in motoneurons.

Periyakaruppiah A, de la Fuente S, Arumugam S, Bahí N, Garcera A, Soler RM.

Exp Neurol. 2016 Sep;283(Pt A):287-97. doi: 10.1016/j.expneurol.2016.06.032. Epub 2016 Jun 30. No abstract available.


Calpain activation and CaMKIV reduction in spinal cords from hSOD1G93A mouse model.

Gou-Fabregas M, Ramírez-Núñez O, Cacabelos D, Bahi N, Portero M, Garcera A, Soler RM.

Mol Cell Neurosci. 2014 Jul;61:219-25. doi: 10.1016/j.mcn.2014.07.002. Epub 2014 Jul 22.


Survival motor neuron protein reduction deregulates autophagy in spinal cord motoneurons in vitro.

Garcera A, Bahi N, Periyakaruppiah A, Arumugam S, Soler RM.

Cell Death Dis. 2013 Jun 20;4:e686. doi: 10.1038/cddis.2013.209.


Notch signaling pathway is activated in motoneurons of spinal muscular atrophy.

Caraballo-Miralles V, Cardona-Rossinyol A, Garcera A, Torres-Benito L, Soler RM, Tabares L, Lladó J, Olmos G.

Int J Mol Sci. 2013 May 29;14(6):11424-37. doi: 10.3390/ijms140611424.


NF-κB signaling pathways: role in nervous system physiology and pathology.

Mincheva-Tasheva S, Soler RM.

Neuroscientist. 2013 Apr;19(2):175-94. doi: 10.1177/1073858412444007. Epub 2012 Jul 10. Review.


SMN deficiency attenuates migration of U87MG astroglioma cells through the activation of RhoA.

Caraballo-Miralles V, Cardona-Rossinyol A, Garcera A, Villalonga P, Soler RM, Olmos G, Lladó J.

Mol Cell Neurosci. 2012 Mar;49(3):282-9. doi: 10.1016/j.mcn.2011.12.003. Epub 2011 Dec 16.


The canonical nuclear factor-κB pathway regulates cell survival in a developmental model of spinal cord motoneurons.

Mincheva S, Garcera A, Gou-Fabregas M, Encinas M, Dolcet X, Soler RM.

J Neurosci. 2011 Apr 27;31(17):6493-503. doi: 10.1523/JNEUROSCI.0206-11.2011.


A new model to study spinal muscular atrophy: neurite degeneration and cell death is counteracted by BCL-X(L) Overexpression in motoneurons.

Garcera A, Mincheva S, Gou-Fabregas M, Caraballo-Miralles V, Lladó J, Comella JX, Soler RM.

Neurobiol Dis. 2011 Jun;42(3):415-26. doi: 10.1016/j.nbd.2011.02.003. Epub 2011 Feb 16.


The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins.

Moubarak RS, Solé C, Pascual M, Gutierrez H, Llovera M, Pérez-García MJ, Gozzelino R, Segura MF, Iglesias-Guimarais V, Reix S, Soler RM, Davies AM, Soriano E, Yuste VJ, Comella JX.

J Neurosci. 2010 Apr 28;30(17):6094-105. doi: 10.1523/JNEUROSCI.0537-10.2010.


Specific vulnerability of mouse spinal cord motoneurons to membrane depolarization.

Gou-Fabregas M, Garcera A, Mincheva S, Perez-Garcia MJ, Comella JX, Soler RM.

J Neurochem. 2009 Sep;110(6):1842-54. doi: 10.1111/j.1471-4159.2009.06278.x. Epub 2009 Jul 13.


Tumor necrosis factor alpha and interferon gamma cooperatively induce oxidative stress and motoneuron death in rat spinal cord embryonic explants.

Mir M, Asensio VJ, Tolosa L, Gou-Fabregas M, Soler RM, Lladó J, Olmos G.

Neuroscience. 2009 Sep 15;162(4):959-71. doi: 10.1016/j.neuroscience.2009.05.049. Epub 2009 May 27.


Tyr-701 is a new regulatory site for neurotrophin receptor TrkA trafficking and function.

de Pablo Y, Pérez-García MJ, Georgieva MV, Sanchis D, Lindqvist N, Soler RM, Comella JX, Llovera M.

J Neurochem. 2008 Jan;104(1):124-39. doi: 10.1111/j.1471-4159.2007.05027.x.


Neuroprotection by neurotrophic factors and membrane depolarization is regulated by calmodulin kinase IV.

Pérez-García MJ, Gou-Fabregas M, de Pablo Y, Llovera M, Comella JX, Soler RM.

J Biol Chem. 2008 Feb 15;283(7):4133-44. Epub 2007 Dec 13.


Pyruvate protects cerebellar granular cells from 6-hydroxydopamine-induced cytotoxicity by activating the Akt signaling pathway and increasing glutathione peroxidase expression.

Fernandez-Gomez FJ, Pastor MD, Garcia-Martinez EM, Melero-Fernandez de Mera R, Gou-Fabregas M, Gomez-Lazaro M, Calvo S, Soler RM, Galindo MF, Jordán J.

Neurobiol Dis. 2006 Nov;24(2):296-307. Epub 2006 Sep 15.


Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway.

Pérez-García MJ, Ceña V, de Pablo Y, Llovera M, Comella JX, Soler RM.

J Biol Chem. 2004 Feb 13;279(7):6132-42. Epub 2003 Nov 20.


Cytokines promote motoneuron survival through the Janus kinase-dependent activation of the phosphatidylinositol 3-kinase pathway.

Dolcet X, Soler RM, Gould TW, Egea J, Oppenheim RW, Comella JX.

Mol Cell Neurosci. 2001 Dec;18(6):619-31.


Neuronal survival induced by neurotrophins requires calmodulin.

Egea J, Espinet C, Soler RM, Dolcet X, Yuste VJ, Encinas M, Iglesias M, Rocamora N, Comella JX.

J Cell Biol. 2001 Aug 6;154(3):585-97.


Nerve growth factor activation of the extracellular signal-regulated kinase pathway is modulated by Ca(2+) and calmodulin.

Egea J, Espinet C, Soler RM, Peiró S, Rocamora N, Comella JX.

Mol Cell Biol. 2000 Mar;20(6):1931-46.


Calmodulin is involved in membrane depolarization-mediated survival of motoneurons by phosphatidylinositol-3 kinase- and MAPK-independent pathways.

Soler RM, Egea J, Mintenig GM, Sanz-Rodriguez C, Iglesias M, Comella JX.

J Neurosci. 1998 Feb 15;18(4):1230-9.


S-laminin and N-acetylgalactosamine located at the synaptic basal lamina of skeletal muscle are involved in synaptic recognition by growing neurites.

Iglesias M, Soler RM, Hunter DD, Ribera J, Esquerda JE, Comella JX.

J Neurocytol. 1995 Dec;24(12):903-15.


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