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The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid.

Bullen HE, Bisio H, Soldati-Favre D.

PLoS Pathog. 2019 May 23;15(5):e1007670. doi: 10.1371/journal.ppat.1007670. eCollection 2019 May.


Biogenesis and secretion of micronemes in Toxoplasma gondii.

Dubois DJ, Soldati-Favre D.

Cell Microbiol. 2019 May;21(5):e13018. doi: 10.1111/cmi.13018. Epub 2019 Mar 18. Review.


Three F-actin assembly centers regulate organelle inheritance, cell-cell communication and motility in Toxoplasma gondii.

Tosetti N, Dos Santos Pacheco N, Soldati-Favre D, Jacot D.

Elife. 2019 Feb 12;8. pii: e42669. doi: 10.7554/eLife.42669.


Phosphatidic acid governs natural egress in Toxoplasma gondii via a guanylate cyclase receptor platform.

Bisio H, Lunghi M, Brochet M, Soldati-Favre D.

Nat Microbiol. 2019 Mar;4(3):420-428. doi: 10.1038/s41564-018-0339-8. Epub 2019 Feb 11.


Structural Basis of Phosphatidic Acid Sensing by APH in Apicomplexan Parasites.

Darvill N, Dubois DJ, Rouse SL, Hammoudi PM, Blake T, Benjamin S, Liu B, Soldati-Favre D, Matthews S.

Structure. 2018 Aug 7;26(8):1059-1071.e6. doi: 10.1016/j.str.2018.05.001. Epub 2018 Jun 14.


Toxoplasma gondii TFP1 is an essential transporter family protein critical for microneme maturation and exocytosis.

Hammoudi PM, Maco B, Dogga SK, Frénal K, Soldati-Favre D.

Mol Microbiol. 2018 May 8. doi: 10.1111/mmi.13981. [Epub ahead of print]


Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases.

Mukherjee B, Tessaro F, Vahokoski J, Kursula I, Marq JB, Scapozza L, Soldati-Favre D.

EMBO J. 2018 Apr 3;37(7). pii: e98047. doi: 10.15252/embj.201798047. Epub 2018 Mar 8.


Functions of myosin motors tailored for parasitism.

Mueller C, Graindorge A, Soldati-Favre D.

Curr Opin Microbiol. 2017 Dec;40:113-122. doi: 10.1016/j.mib.2017.11.003. Epub 2017 Nov 21. Review.


A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress.

Pino P, Caldelari R, Mukherjee B, Vahokoski J, Klages N, Maco B, Collins CR, Blackman MJ, Kursula I, Heussler V, Brochet M, Soldati-Favre D.

Science. 2017 Oct 27;358(6362):522-528. doi: 10.1126/science.aaf8675.


Crosstalk between PKA and PKG controls pH-dependent host cell egress of Toxoplasma gondii.

Jia Y, Marq JB, Bisio H, Jacot D, Mueller C, Yu L, Choudhary J, Brochet M, Soldati-Favre D.

EMBO J. 2017 Nov 2;36(21):3250-3267. doi: 10.15252/embj.201796794. Epub 2017 Oct 13.


A druggable secretory protein maturase of Toxoplasma essential for invasion and egress.

Dogga SK, Mukherjee B, Jacot D, Kockmann T, Molino L, Hammoudi PM, Hartkoorn RC, Hehl AB, Soldati-Favre D.

Elife. 2017 Sep 12;6. pii: e27480. doi: 10.7554/eLife.27480.


Gliding motility powers invasion and egress in Apicomplexa.

Frénal K, Dubremetz JF, Lebrun M, Soldati-Favre D.

Nat Rev Microbiol. 2017 Nov;15(11):645-660. doi: 10.1038/nrmicro.2017.86. Epub 2017 Sep 4. Review.


Efficient invasion by Toxoplasma depends on the subversion of host protein networks.

Guérin A, Corrales RM, Parker ML, Lamarque MH, Jacot D, El Hajj H, Soldati-Favre D, Boulanger MJ, Lebrun M.

Nat Microbiol. 2017 Oct;2(10):1358-1366. doi: 10.1038/s41564-017-0018-1. Epub 2017 Aug 28.


Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii.

Frénal K, Jacot D, Hammoudi PM, Graindorge A, Maco B, Soldati-Favre D.

Nat Commun. 2017 Jun 8;8:15710. doi: 10.1038/ncomms15710.


Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks.

Chiappino-Pepe A, Tymoshenko S, Ataman M, Soldati-Favre D, Hatzimanikatis V.

PLoS Comput Biol. 2017 Mar 23;13(3):e1005397. doi: 10.1371/journal.pcbi.1005397. eCollection 2017 Mar.


Erratum to "Toxoplasma gondii immune mapped protein 1 is anchored to the inner leaflet of the plasma membrane and adopts a novel protein fold" [Biochim. Biophys. Acta Protein Proteomics 1865/2 (2017) 208-219].

Jia Y, Benjamin S, Liu Q, Xu Y, Dogga SK, Liu J, Matthews S, Soldati-Favre D.

Biochim Biophys Acta Proteins Proteom. 2017 May;1865(5):631. doi: 10.1016/j.bbapap.2017.02.010. Epub 2017 Feb 17. No abstract available.


An Apicomplexan Actin-Binding Protein Serves as a Connector and Lipid Sensor to Coordinate Motility and Invasion.

Jacot D, Tosetti N, Pires I, Stock J, Graindorge A, Hung YF, Han H, Tewari R, Kursula I, Soldati-Favre D.

Cell Host Microbe. 2016 Dec 14;20(6):731-743. doi: 10.1016/j.chom.2016.10.020.


Toxoplasma gondii immune mapped protein 1 is anchored to the inner leaflet of the plasma membrane and adopts a novel protein fold.

Jia Y, Benjamin S, Liu Q, Xu Y, Dogga SK, Liu J, Matthews S, Soldati-Favre D.

Biochim Biophys Acta Proteins Proteom. 2017 Feb;1865(2):208-219. doi: 10.1016/j.bbapap.2016.11.010. Epub 2016 Nov 22. Erratum in: Biochim Biophys Acta. 2017 May;1865(5):631.


Parasite pathogenesis: Breaching the wall for brain access.

Krishnan A, Soldati-Favre D.

Nat Microbiol. 2016 Feb 24;1:16014. doi: 10.1038/nmicrobiol.2016.14. No abstract available.


Biology of rhomboid proteases in infectious diseases.

Dogga SK, Soldati-Favre D.

Semin Cell Dev Biol. 2016 Dec;60:38-45. doi: 10.1016/j.semcdb.2016.08.020. Epub 2016 Aug 24. Review.


A central role for phosphatidic acid as a lipid mediator of regulated exocytosis in apicomplexa.

Bullen HE, Soldati-Favre D.

FEBS Lett. 2016 Aug;590(15):2469-81. doi: 10.1002/1873-3468.12296. Epub 2016 Jul 26. Review.


Phosphatidic Acid-Mediated Signaling Regulates Microneme Secretion in Toxoplasma.

Bullen HE, Jia Y, Yamaryo-Botté Y, Bisio H, Zhang O, Jemelin NK, Marq JB, Carruthers V, Botté CY, Soldati-Favre D.

Cell Host Microbe. 2016 Mar 9;19(3):349-60. doi: 10.1016/j.chom.2016.02.006.


Structural and functional dissection of Toxoplasma gondii armadillo repeats only protein.

Mueller C, Samoo A, Hammoudi PM, Klages N, Kallio JP, Kursula I, Soldati-Favre D.

J Cell Sci. 2016 Mar 1;129(5):1031-45. doi: 10.1242/jcs.177386. Epub 2016 Jan 14.


The Conoid Associated Motor MyoH Is Indispensable for Toxoplasma gondii Entry and Exit from Host Cells.

Graindorge A, Frénal K, Jacot D, Salamun J, Marq JB, Soldati-Favre D.

PLoS Pathog. 2016 Jan 13;12(1):e1005388. doi: 10.1371/journal.ppat.1005388. eCollection 2016 Jan.


Phylogeny, Morphology, and Metabolic and Invasive Capabilities of Epicellular Fish Coccidium Goussia janae.

Dogga SK, Bartošová-Sojková P, Lukeš J, Soldati-Favre D.

Protist. 2015 Dec;166(6):659-76. doi: 10.1016/j.protis.2015.09.003. Epub 2015 Sep 30.


Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface.

Hammoudi PM, Jacot D, Mueller C, Di Cristina M, Dogga SK, Marq JB, Romano J, Tosetti N, Dubrot J, Emre Y, Lunghi M, Coppens I, Yamamoto M, Sojka D, Pino P, Soldati-Favre D.

PLoS Pathog. 2015 Oct 16;11(10):e1005211. doi: 10.1371/journal.ppat.1005211. eCollection 2015 Oct.


Apicomplexan Energy Metabolism: Carbon Source Promiscuity and the Quiescence Hyperbole.

Jacot D, Waller RF, Soldati-Favre D, MacPherson DA, MacRae JI.

Trends Parasitol. 2016 Jan;32(1):56-70. doi: 10.1016/ Epub 2015 Oct 17. Review.


Epicellular Apicomplexans: Parasites "On the Way In".

Bartošová-Sojková P, Oppenheim RD, Soldati-Favre D, Lukeš J.

PLoS Pathog. 2015 Sep 24;11(9):e1005080. doi: 10.1371/journal.ppat.1005080. eCollection 2015 Sep. Review. No abstract available.


Plasticity and Redundancy in Proteins Important for Toxoplasma Invasion.

Frénal K, Soldati-Favre D.

PLoS Pathog. 2015 Aug 13;11(8):e1005069. doi: 10.1371/journal.ppat.1005069. eCollection 2015 Aug. Review. No abstract available.


Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis.

Tymoshenko S, Oppenheim RD, Agren R, Nielsen J, Soldati-Favre D, Hatzimanikatis V.

PLoS Comput Biol. 2015 May 22;11(5):e1004261. doi: 10.1371/journal.pcbi.1004261. eCollection 2015 May.


Distinct contribution of Toxoplasma gondii rhomboid proteases 4 and 5 to micronemal protein protease 1 activity during invasion.

Rugarabamu G, Marq JB, Guérin A, Lebrun M, Soldati-Favre D.

Mol Microbiol. 2015 Jul;97(2):244-62. doi: 10.1111/mmi.13021. Epub 2015 May 9.


Plasticity between MyoC- and MyoA-glideosomes: an example of functional compensation in Toxoplasma gondii invasion.

Frénal K, Marq JB, Jacot D, Polonais V, Soldati-Favre D.

PLoS Pathog. 2014 Nov 13;10(10):e1004504. doi: 10.1371/journal.ppat.1004504. eCollection 2014 Oct.


Structure of Toxoplasma gondii coronin, an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress.

Salamun J, Kallio JP, Daher W, Soldati-Favre D, Kursula I.

FASEB J. 2014 Nov;28(11):4729-47. doi: 10.1096/fj.14-252569. Epub 2014 Aug 11.


BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei.

Oppenheim RD, Creek DJ, Macrae JI, Modrzynska KK, Pino P, Limenitakis J, Polonais V, Seeber F, Barrett MP, Billker O, McConville MJ, Soldati-Favre D.

PLoS Pathog. 2014 Jul 17;10(7):e1004263. doi: 10.1371/journal.ppat.1004263. eCollection 2014 Jul.


Plasticity and redundancy among AMA-RON pairs ensure host cell entry of Toxoplasma parasites.

Lamarque MH, Roques M, Kong-Hap M, Tonkin ML, Rugarabamu G, Marq JB, Penarete-Vargas DM, Boulanger MJ, Soldati-Favre D, Lebrun M.

Nat Commun. 2014 Jun 17;5:4098. doi: 10.1038/ncomms5098.


Assessment of phosphorylation in Toxoplasma glideosome assembly and function.

Jacot D, Frénal K, Marq JB, Sharma P, Soldati-Favre D.

Cell Microbiol. 2014 Oct;16(10):1518-32. doi: 10.1111/cmi.12307. Epub 2014 May 23.


Emerging roles for protein S-palmitoylation in Toxoplasma biology.

Frénal K, Kemp LE, Soldati-Favre D.

Int J Parasitol. 2014 Feb;44(2):121-31. doi: 10.1016/j.ijpara.2013.09.004. Epub 2013 Nov 1. Review.


Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii.

Kemp LE, Rusch M, Adibekian A, Bullen HE, Graindorge A, Freymond C, Rottmann M, Braun-Breton C, Baumeister S, Porfetye AT, Vetter IR, Hedberg C, Soldati-Favre D.

J Biol Chem. 2013 Sep 20;288(38):27002-18. doi: 10.1074/jbc.M113.460709. Epub 2013 Aug 2.


Functional genomics of Plasmodium falciparum using metabolic modelling and analysis.

Tymoshenko S, Oppenheim RD, Soldati-Favre D, Hatzimanikatis V.

Brief Funct Genomics. 2013 Jul;12(4):316-27. doi: 10.1093/bfgp/elt017. Epub 2013 Jun 22.


[The glideosome, a unique machinery that assists the Apicomplexa in gliding into host cells].

Frénal K, Soldati-Favre D.

Med Sci (Paris). 2013 May;29(5):515-22. doi: 10.1051/medsci/2013295015. Epub 2013 May 28. French.


Toxoplasma gondii myosin F, an essential motor for centrosomes positioning and apicoplast inheritance.

Jacot D, Daher W, Soldati-Favre D.

EMBO J. 2013 Jun 12;32(12):1702-16. doi: 10.1038/emboj.2013.113. Epub 2013 May 21.


Global analysis of apicomplexan protein S-acyl transferases reveals an enzyme essential for invasion.

Frénal K, Tay CL, Mueller C, Bushell ES, Jia Y, Graindorge A, Billker O, Rayner JC, Soldati-Favre D.

Traffic. 2013 Aug;14(8):895-911. doi: 10.1111/tra.12081. Epub 2013 May 29.


The Toxoplasma protein ARO mediates the apical positioning of rhoptry organelles, a prerequisite for host cell invasion.

Mueller C, Klages N, Jacot D, Santos JM, Cabrera A, Gilberger TW, Dubremetz JF, Soldati-Favre D.

Cell Host Microbe. 2013 Mar 13;13(3):289-301. doi: 10.1016/j.chom.2013.02.001.


The Plasmodium berghei Ca(2+)/H(+) exchanger, PbCAX, is essential for tolerance to environmental Ca(2+) during sexual development.

Guttery DS, Pittman JK, Frénal K, Poulin B, McFarlane LR, Slavic K, Wheatley SP, Soldati-Favre D, Krishna S, Tewari R, Staines HM.

PLoS Pathog. 2013 Feb;9(2):e1003191. doi: 10.1371/journal.ppat.1003191. Epub 2013 Feb 28.


The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii.

Limenitakis J, Oppenheim RD, Creek DJ, Foth BJ, Barrett MP, Soldati-Favre D.

Mol Microbiol. 2013 Feb;87(4):894-908. doi: 10.1111/mmi.12139. Epub 2013 Jan 11.


A tetracycline-repressible transactivator system to study essential genes in malaria parasites.

Pino P, Sebastian S, Kim EA, Bush E, Brochet M, Volkmann K, Kozlowski E, Llinás M, Billker O, Soldati-Favre D.

Cell Host Microbe. 2012 Dec 13;12(6):824-34. doi: 10.1016/j.chom.2012.10.016.


Prison break: pathogens' strategies to egress from host cells.

Friedrich N, Hagedorn M, Soldati-Favre D, Soldati T.

Microbiol Mol Biol Rev. 2012 Dec;76(4):707-20. doi: 10.1128/MMBR.00024-12. Review.


Subversion of host cellular functions by the apicomplexan parasites.

Kemp LE, Yamamoto M, Soldati-Favre D.

FEMS Microbiol Rev. 2013 Jul;37(4):607-31. doi: 10.1111/1574-6976.12013. Epub 2012 Dec 27. Review.


Does protein phosphorylation govern host cell entry and egress by the Apicomplexa?

Jacot D, Soldati-Favre D.

Int J Med Microbiol. 2012 Oct;302(4-5):195-202. doi: 10.1016/j.ijmm.2012.07.012. Epub 2012 Aug 27. Review.


Shedding of TRAP by a rhomboid protease from the malaria sporozoite surface is essential for gliding motility and sporozoite infectivity.

Ejigiri I, Ragheb DR, Pino P, Coppi A, Bennett BL, Soldati-Favre D, Sinnis P.

PLoS Pathog. 2012;8(7):e1002725. doi: 10.1371/journal.ppat.1002725. Epub 2012 Jul 26.

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