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Items: 1 to 50 of 106

1.

Quantification of circulating cell-free DNA (cfDNA) in urine using a newborn piglet model of asphyxia.

Rajar P, Åsegg-Atneosen M, Saugstad OD, Solberg R, Baumbusch LO.

PLoS One. 2019 Dec 31;14(12):e0227066. doi: 10.1371/journal.pone.0227066. eCollection 2019.

2.

Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.

Lunde NN, Gregersen I, Ueland T, Shetelig C, Holm S, Kong XY, Michelsen AE, Otterdal K, Yndestad A, Broch K, Gullestad L, Nyman TA, Bendz B, Eritsland J, Hoffmann P, Skagen K, Gonçalves I, Nilsson J, Grenegård M, Poreba M, Drag M, Seljeflot I, Sporsheim B, Espevik T, Skjelland M, Johansen HT, Solberg R, Aukrust P, Björkbacka H, Andersen GØ, Halvorsen B.

Atherosclerosis. 2019 Dec 14. pii: S0021-9150(19)31626-0. doi: 10.1016/j.atherosclerosis.2019.12.008. [Epub ahead of print]

PMID:
31870625
3.

Mammalian legumain - A lysosomal cysteine protease with extracellular functions?

Lunde NN, Bosnjak T, Solberg R, Johansen HT.

Biochimie. 2019 Nov;166:77-83. doi: 10.1016/j.biochi.2019.06.002. Epub 2019 Jun 7. Review.

PMID:
31181234
4.

Lansoprazole inhibits the cysteine protease legumain by binding to the active site.

Bosnjak T, Solberg R, Hemati PD, Jafari A, Kassem M, Johansen HT.

Basic Clin Pharmacol Toxicol. 2019 Aug;125(2):89-99. doi: 10.1111/bcpt.13230. Epub 2019 Apr 11.

PMID:
30916878
5.

Temporal patterns of circulating cell-free DNA (cfDNA) in a newborn piglet model of perinatal asphyxia.

Manueldas S, Benterud T, Rueegg CS, Garberg HT, Huun MU, Pankratov L, Åsegg-Atneosen M, Solberg R, Escobar J, Saugstad OD, Baumbusch LO.

PLoS One. 2018 Nov 26;13(11):e0206601. doi: 10.1371/journal.pone.0206601. eCollection 2018.

6.

Dynamic TSPO-PET for assessing early effects of cerebral hypoxia and resuscitation in new born pigs.

de Lange C, Solberg R, Holtedahl JE, Tulipan A, Barlinn J, Trigg W, Wickstrøm T, Saugstad OD, Malinen E, Revheim ME.

Nucl Med Biol. 2018 Nov;66:49-57. doi: 10.1016/j.nucmedbio.2018.08.004. Epub 2018 Aug 24.

PMID:
30257223
7.

Regional differences of hypothermia on oxidative stress following hypoxia-ischemia: a study of DHA and hypothermia on brain lipid peroxidation in newborn piglets.

Huun MU, Garberg HT, Buonocore G, Longini M, Belvisi E, Bazzini F, Proietti F, Saugstad OD, Solberg R.

J Perinat Med. 2018 Dec 19;47(1):82-89. doi: 10.1515/jpm-2017-0355.

PMID:
30110254
8.

DHA and therapeutic hypothermia in a short-term follow-up piglet model of hypoxia-ischemia: Effects on H+MRS biomarkers.

Huun MU, Garberg H, Løberg EM, Escobar J, Martinez-Orgado J, Saugstad OD, Solberg R.

PLoS One. 2018 Aug 7;13(8):e0201895. doi: 10.1371/journal.pone.0201895. eCollection 2018.

9.

Cerebellum Susceptibility to Neonatal Asphyxia: Possible Protective Effects of N-Acetylcysteine Amide.

Benterud T, Manueldas S, Rivera S, Henckel E, Løberg EM, Norgren S, Baumbusch LO, Solberg R, Saugstad OD.

Dis Markers. 2018 Jan 30;2018:5046372. doi: 10.1155/2018/5046372. eCollection 2018.

10.

Adjusting D-dimer cutoffs: Brief literature summary and issues in clinical use.

Solberg R, Glass G.

Am J Emerg Med. 2018 Nov;36(11):2105-2107. doi: 10.1016/j.ajem.2018.03.027. Epub 2018 Mar 14. Review. No abstract available.

PMID:
29571827
11.

Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome.

Thomas AM, Schjalm C, Nilsson PH, Lindenskov PHH, Rørtveit R, Solberg R, Saugstad OD, Berglund MM, Strömberg P, Lau C, Espevik T, Jansen JH, Castellheim A, Mollnes TE, Barratt-Due A.

Neonatology. 2018;113(4):322-330. doi: 10.1159/000486542. Epub 2018 Feb 27.

12.
13.

DHA reduces oxidative stress following hypoxia-ischemia in newborn piglets: a study of lipid peroxidation products in urine and plasma.

Huun MU, Garberg HT, Escobar J, Chafer C, Vento M, Holme IM, Saugstad OD, Solberg R.

J Perinat Med. 2018 Feb 23;46(2):209-217. doi: 10.1515/jpm-2016-0334.

PMID:
28632497
14.

High-Dose Cannabidiol Induced Hypotension after Global Hypoxia-Ischemia in Piglets.

Garberg HT, Solberg R, Barlinn J, Martinez-Orgado J, Løberg EM, Saugstad OD.

Neonatology. 2017;112(2):143-149. doi: 10.1159/000471786. Epub 2017 Jun 1.

PMID:
28564654
15.

Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functions.

Lunde NN, Haugen MH, Bodin Larsen KB, Damgaard I, Pettersen SJ, Kasem R, Rut W, Drag M, Poreba M, Johansen HT, Solberg R.

Biochimie. 2017 Aug;139:27-37. doi: 10.1016/j.biochi.2017.05.009. Epub 2017 May 17.

PMID:
28528272
16.

Plasma metabolite score correlates with Hypoxia time in a newly born piglet model for asphyxia.

Kuligowski J, Solberg R, Sánchez-Illana Á, Pankratov L, Parra-Llorca A, Quintás G, Saugstad OD, Vento M.

Redox Biol. 2017 Aug;12:1-7. doi: 10.1016/j.redox.2017.02.002. Epub 2017 Feb 7.

17.

Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis.

Jafari A, Qanie D, Andersen TL, Zhang Y, Chen L, Postert B, Parsons S, Ditzel N, Khosla S, Johansen HT, Kjærsgaard-Andersen P, Delaisse JM, Abdallah BM, Hesselson D, Solberg R, Kassem M.

Stem Cell Reports. 2017 Feb 14;8(2):373-386. doi: 10.1016/j.stemcr.2017.01.003. Epub 2017 Feb 2.

18.

DHA Reduces Oxidative Stress after Perinatal Asphyxia: A Study in Newborn Piglets.

Solberg R, Longini M, Proietti F, Perrone S, Felici C, Porta A, Saugstad OD, Buonocore G.

Neonatology. 2017;112(1):1-8. doi: 10.1159/000454982. Epub 2017 Feb 1.

PMID:
28142140
19.

Assessment of phospholipid synthesis related biomarkers for perinatal asphyxia: a piglet study.

Sánchez-Illana Á, Solberg R, Lliso I, Pankratov L, Quintás G, Saugstad OD, Vento M, Kuligowski J.

Sci Rep. 2017 Jan 10;7:40315. doi: 10.1038/srep40315.

20.

Increased levels of legumain in plasma and plaques from patients with carotid atherosclerosis.

Lunde NN, Holm S, Dahl TB, Elyouncha I, Sporsheim B, Gregersen I, Abbas A, Skjelland M, Espevik T, Solberg R, Johansen HT, Halvorsen B.

Atherosclerosis. 2017 Feb;257:216-223. doi: 10.1016/j.atherosclerosis.2016.11.026. Epub 2016 Nov 28.

PMID:
27940038
21.

Short-term effects of cannabidiol after global hypoxia-ischemia in newborn piglets.

Garberg HT, Huun MU, Escobar J, Martinez-Orgado J, Løberg EM, Solberg R, Didrik Saugstad O.

Pediatr Res. 2016 Nov;80(5):710-718. doi: 10.1038/pr.2016.149. Epub 2016 Jul 21.

PMID:
27441365
22.

Temporal Profile of Circulating microRNAs after Global Hypoxia-Ischemia in Newborn Piglets.

Garberg HT, Huun MU, Baumbusch LO, Åsegg-Atneosen M, Solberg R, Saugstad OD.

Neonatology. 2017;111(2):133-139. doi: 10.1159/000449032. Epub 2016 Oct 18.

PMID:
27750254
23.

N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia.

Benterud T, Ystgaard MB, Manueldas S, Pankratov L, Alfaro-Cervello C, Florholmen G, Ahmed MS, Sandvik L, Norgren S, Bjørås M, Baumbusch LO, Solberg R, Saugstad OD.

Neonatology. 2017;111(1):12-21. Epub 2016 Aug 6.

PMID:
27497671
24.

Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes.

Poreba M, Solberg R, Rut W, Lunde NN, Kasperkiewicz P, Snipas SJ, Mihelic M, Turk D, Turk B, Salvesen GS, Drag M.

Cell Chem Biol. 2016 Aug 18;23(8):1023-35. doi: 10.1016/j.chembiol.2016.05.020. Epub 2016 Jul 28.

25.

Development of a reliable analytical method to determine lipid peroxidation biomarkers in newborn plasma samples.

Cháfer-Pericás C, Torres-Cuevas I, Sanchez-Illana A, Escobar J, Kuligowski J, Solberg R, Garberg HT, Huun MU, Saugstad OD, Vento M.

Talanta. 2016 Jun 1;153:152-7. doi: 10.1016/j.talanta.2016.03.010. Epub 2016 Mar 4.

PMID:
27130102
26.

Changes of the plasma metabolome of newly born piglets subjected to postnatal hypoxia and resuscitation with air.

Solberg R, Kuligowski J, Pankratov L, Escobar J, Quintás G, Lliso I, Sánchez-Illana Á, Saugstad OD, Vento M.

Pediatr Res. 2016 Aug;80(2):284-92. doi: 10.1038/pr.2016.66. Epub 2016 Apr 7.

PMID:
27055187
27.

Protein-bound tyrosine oxidation, nitration and chlorination by-products assessed by ultraperformance liquid chromatography coupled to tandem mass spectrometry.

Torres-Cuevas I, Kuligowski J, Cárcel M, Cháfer-Pericás C, Asensi M, Solberg R, Cubells E, Nuñez A, Saugstad OD, Vento M, Escobar J.

Anal Chim Acta. 2016 Mar 24;913:104-10. doi: 10.1016/j.aca.2016.01.054. Epub 2016 Feb 3.

PMID:
26944994
28.

Development of a reliable method based on ultra-performance liquid chromatography coupled to tandem mass spectrometry to measure thiol-associated oxidative stress in whole blood samples.

Escobar J, Sánchez-Illana Á, Kuligowski J, Torres-Cuevas I, Solberg R, Garberg HT, Huun MU, Saugstad OD, Vento M, Cháfer-Pericás C.

J Pharm Biomed Anal. 2016 May 10;123:104-12. doi: 10.1016/j.jpba.2016.02.007. Epub 2016 Feb 9.

PMID:
26895495
29.

The prehospital and hospital costs of emergency care for frequent ED patients.

Solberg RG, Edwards BL, Chidester JP, Perina DG, Brady WJ, Williams MD.

Am J Emerg Med. 2016 Mar;34(3):459-63. doi: 10.1016/j.ajem.2015.11.066. Epub 2015 Dec 4.

PMID:
26763824
30.

Perinatal Asphyxia May Influence the Level of Beta-Amyloid (1-42) in Cerebrospinal Fluid: An Experimental Study on Newborn Pigs.

Benterud T, Pankratov L, Solberg R, Bolstad N, Skinningsrud A, Baumbusch L, Sandvik L, Saugstad OD.

PLoS One. 2015 Oct 26;10(10):e0140966. doi: 10.1371/journal.pone.0140966. eCollection 2015.

31.

Legumain expression, activity and secretion are increased during monocyte-to-macrophage differentiation and inhibited by atorvastatin.

Solberg R, Smith R, Almlöf M, Tewolde E, Nilsen H, Johansen HT.

Biol Chem. 2015 Jan;396(1):71-80. doi: 10.1515/hsz-2014-0172.

PMID:
25205715
32.

Detection of batch effects in liquid chromatography-mass spectrometry metabolomic data using guided principal component analysis.

Kuligowski J, Pérez-Guaita D, Lliso I, Escobar J, León Z, Gombau L, Solberg R, Saugstad OD, Vento M, Quintás G.

Talanta. 2014 Dec;130:442-8. doi: 10.1016/j.talanta.2014.07.031. Epub 2014 Jul 18.

PMID:
25159433
33.

Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity.

Smith RL, Åstrand OA, Nguyen LM, Elvestrand T, Hagelin G, Solberg R, Johansen HT, Rongved P.

Bioorg Med Chem. 2014 Jul 1;22(13):3309-15. doi: 10.1016/j.bmc.2014.04.056. Epub 2014 May 6.

PMID:
24842619
34.

Metabolic adaptation and neuroprotection differ in the retina and choroid in a piglet model of acute postnatal hypoxia.

Arduini A, Escobar J, Vento M, Escrig R, Quintás G, Sastre J, Saugstad OD, Solberg R.

Pediatr Res. 2014 Aug;76(2):127-34. doi: 10.1038/pr.2014.70. Epub 2014 May 12.

PMID:
24819373
35.

Simvastatin inhibits glucose metabolism and legumain activity in human myotubes.

Smith R, Solberg R, Jacobsen LL, Voreland AL, Rustan AC, Thoresen GH, Johansen HT.

PLoS One. 2014 Jan 8;9(1):e85721. doi: 10.1371/journal.pone.0085721. eCollection 2014. Erratum in: PLoS One. 2014;9(3):e93202.

36.

Metabolomic Analysis of the Effect of Postnatal Hypoxia on the Retina in a Newly Born Piglet Model.

Solberg R, Escobar J, Arduini A, Torres-Cuevas I, Lahoz A, Sastre J, Saugstad OD, Vento M, Kuligowski J, Quintás G.

PLoS One. 2013 Jun 18;8(6):e66540. doi: 10.1371/journal.pone.0066540. Print 2013.

37.

Nuclear legumain activity in colorectal cancer.

Haugen MH, Johansen HT, Pettersen SJ, Solberg R, Brix K, Flatmark K, Maelandsmo GM.

PLoS One. 2013;8(1):e52980. doi: 10.1371/journal.pone.0052980. Epub 2013 Jan 10. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/05c95441-890f-4707-a1bc-c4d386561191.

38.

Autoactivation of prolegumain is accelerated by glycosaminoglycans.

Berven L, Johansen HT, Solberg R, Kolset SO, Samuelsen AB.

Biochimie. 2013 Apr;95(4):772-81. doi: 10.1016/j.biochi.2012.11.002. Epub 2012 Nov 14.

PMID:
23160071
39.

Oxygenation of the newborn: a molecular approach.

Saugstad OD, Sejersted Y, Solberg R, Wollen EJ, Bjørås M.

Neonatology. 2012;101(4):315-25. doi: 10.1159/000337345. Epub 2012 Jun 1.

PMID:
22940621
40.

Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M.

Smith R, Johansen HT, Nilsen H, Haugen MH, Pettersen SJ, Mælandsmo GM, Abrahamson M, Solberg R.

Biochimie. 2012 Dec;94(12):2590-9. doi: 10.1016/j.biochi.2012.07.026. Epub 2012 Aug 10.

PMID:
22902879
41.

Resuscitation with supplementary oxygen induces oxidative injury in the cerebral cortex.

Solberg R, Longini M, Proietti F, Vezzosi P, Saugstad OD, Buonocore G.

Free Radic Biol Med. 2012 Sep 1;53(5):1061-7. doi: 10.1016/j.freeradbiomed.2012.07.022. Epub 2012 Jul 24.

PMID:
22842050
42.

Alternaria alternata allergen Alt a 1: a unique β-barrel protein dimer found exclusively in fungi.

Chruszcz M, Chapman MD, Osinski T, Solberg R, Demas M, Porebski PJ, Majorek KA, Pomés A, Minor W.

J Allergy Clin Immunol. 2012 Jul;130(1):241-7.e9. doi: 10.1016/j.jaci.2012.03.047. Epub 2012 Jun 2.

43.

Risks and benefits of oxygen in the delivery room.

Solberg R, Perrone S, Saugstad OD, Buonocore G.

J Matern Fetal Neonatal Med. 2012 Apr;25 Suppl 1:41-4. doi: 10.3109/14767058.2012.665236. Epub 2012 Mar 13. Review.

PMID:
22356586
44.

Structural and immunologic characterization of Ara h 1, a major peanut allergen.

Chruszcz M, Maleki SJ, Majorek KA, Demas M, Bublin M, Solberg R, Hurlburt BK, Ruan S, Mattison CP, Breiteneder H, Minor W.

J Biol Chem. 2011 Nov 11;286(45):39318-27. doi: 10.1074/jbc.M111.270132. Epub 2011 Sep 14. Erratum in: J Biol Chem. 2011 Dec 23;286(51):44294. Mattisohn, Christopher P [corrected to Mattison, Christopher P].

45.

Resuscitation of newborn piglets. short-term influence of FiO2 on matrix metalloproteinases, caspase-3 and BDNF.

Solberg R, Løberg EM, Andresen JH, Wright MS, Charrat E, Khrestchatisky M, Rivera S, Saugstad OD.

PLoS One. 2010 Dec 9;5(12):e14261. doi: 10.1371/journal.pone.0014261.

46.

Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs.

Solberg R, Enot D, Deigner HP, Koal T, Scholl-Bürgi S, Saugstad OD, Keller M.

PLoS One. 2010 Mar 9;5(3):e9606. doi: 10.1371/journal.pone.0009606.

47.

Cystatin E/M suppresses legumain activity and invasion of human melanoma.

Briggs JJ, Haugen MH, Johansen HT, Riker AI, Abrahamson M, Fodstad Ø, Maelandsmo GM, Solberg R.

BMC Cancer. 2010 Jan 15;10:17. doi: 10.1186/1471-2407-10-17.

48.

Resuscitation of hypoxic newborn piglets with supplementary oxygen induces dose-dependent increase in matrix metalloproteinase-activity and down-regulates vital genes.

Solberg R, Andresen JH, Pettersen S, Wright MS, Munkeby BH, Charrat E, Khrestchatisky M, Rivera S, Saugstad OD.

Pediatr Res. 2010 Mar;67(3):250-6. doi: 10.1203/PDR.0b013e3181cde843.

PMID:
20010314
49.

Newborn piglets exposed to hypoxia after nicotine or saline pretreatment: long-term effects on brain and heart.

Andresen JH, Carlsen B, Solberg R, Mørkrid L, Goverud IL, Løberg EM, Saugstad OD.

J Matern Fetal Neonatal Med. 2009 Feb;22(2):161-8. doi: 10.1080/14767050802663186.

PMID:
19253165
50.

Improved cognitive development among preterm infants attributable to early supplementation of human milk with docosahexaenoic acid and arachidonic acid.

Henriksen C, Haugholt K, Lindgren M, Aurvåg AK, Rønnestad A, Grønn M, Solberg R, Moen A, Nakstad B, Berge RK, Smith L, Iversen PO, Drevon CA.

Pediatrics. 2008 Jun;121(6):1137-45. doi: 10.1542/peds.2007-1511.

PMID:
18519483

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