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Items: 30

1.

The many isoforms of human adenylate kinases.

Panayiotou C, Solaroli N, Karlsson A.

Int J Biochem Cell Biol. 2014 Apr;49:75-83. doi: 10.1016/j.biocel.2014.01.014. Epub 2014 Feb 2. Review.

PMID:
24495878
2.

Late-onset respiratory failure due to TK2 mutations causing multiple mtDNA deletions.

Alston CL, Schaefer AM, Raman P, Solaroli N, Krishnan KJ, Blakely EL, He L, Craig K, Roberts M, Vyas A, Nixon J, Horvath R, Turnbull DM, Karlsson A, Gorman GS, Taylor RW.

Neurology. 2013 Dec 3;81(23):2051-3. doi: 10.1212/01.wnl.0000436931.94291.e6. Epub 2013 Nov 6.

3.

The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase.

Amiri M, Conserva F, Panayiotou C, Karlsson A, Solaroli N.

Int J Biochem Cell Biol. 2013 May;45(5):925-31. doi: 10.1016/j.biocel.2013.02.004. Epub 2013 Feb 14.

PMID:
23416111
4.

Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.

Quintiliani M, Persoons L, Solaroli N, Karlsson A, Andrei G, Snoeck R, Balzarini J, McGuigan C.

Bioorg Med Chem. 2011 Jul 15;19(14):4338-45. doi: 10.1016/j.bmc.2011.05.037. Epub 2011 May 27.

PMID:
21696963
5.

Synthesis, modeling and evaluation of 3'-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3'-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors.

Van Poecke S, Negri A, Janssens J, Solaroli N, Karlsson A, Gago F, Balzarini J, Van Calenbergh S.

Org Biomol Chem. 2011 Feb 7;9(3):892-901. doi: 10.1039/c0ob00591f. Epub 2010 Dec 2.

PMID:
21127790
6.

The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes.

Panayiotou C, Solaroli N, Xu Y, Johansson M, Karlsson A.

Biochem J. 2011 Feb 1;433(3):527-34. doi: 10.1042/BJ20101443.

PMID:
21080915
7.

Hematopoiesis in the thymidine kinase 2 deficient mouse model of mitochondrial DNA depletion syndrome.

Zhou X, Johansson M, Solaroli N, Rozell B, Grandien A, Karlsson A.

J Inherit Metab Dis. 2010 Jun;33(3):231-6. doi: 10.1007/s10545-010-9102-x. Epub 2010 May 4.

PMID:
20440651
8.

Retained sensitivity to cytotoxic pyrimidine nucleoside analogs in thymidine kinase 2 deficient human fibroblasts.

Bjerke M, Solaroli N, Lesko N, Balzarini J, Johansson M, Karlsson A.

Nucleosides Nucleotides Nucleic Acids. 2010 Jan;29(1):1-13. doi: 10.1080/15257770903454490.

PMID:
20391188
9.

3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase.

Van Poecke S, Negri A, Gago F, Van Daele I, Solaroli N, Karlsson A, Balzarini J, Van Calenbergh S.

J Med Chem. 2010 Apr 8;53(7):2902-12. doi: 10.1021/jm901532h.

PMID:
20218622
10.

Two novel mutations in thymidine kinase-2 cause early onset fatal encephalomyopathy and severe mtDNA depletion.

Lesko N, Naess K, Wibom R, Solaroli N, Nennesmo I, von Döbeln U, Karlsson A, Larsson NG.

Neuromuscul Disord. 2010 Mar;20(3):198-203. doi: 10.1016/j.nmd.2009.11.013. Epub 2010 Jan 18.

PMID:
20083405
11.

Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4.

Panayiotou C, Solaroli N, Johansson M, Karlsson A.

Int J Biochem Cell Biol. 2010 Jan;42(1):62-9. doi: 10.1016/j.biocel.2009.09.007. Epub 2009 Sep 18.

PMID:
19766732
12.

Identification of two active functional domains of human adenylate kinase 5.

Solaroli N, Panayiotou C, Johansson M, Karlsson A.

FEBS Lett. 2009 Sep 3;583(17):2872-6. doi: 10.1016/j.febslet.2009.07.047. Epub 2009 Aug 3.

13.

Human mitochondrial thymidine kinase is selectively inhibited by 3'-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity.

Balzarini J, Van Daele I, Negri A, Solaroli N, Karlsson A, Liekens S, Gago F, Van Calenbergh S.

Mol Pharmacol. 2009 May;75(5):1127-36. doi: 10.1124/mol.108.053785. Epub 2009 Feb 20.

PMID:
19233899
14.

Substrate specificity of feline and canine herpesvirus thymidine kinase.

Solaroli N, Johansson M, Persoons L, Balzarini J, Karlsson A.

Antiviral Res. 2008 Aug;79(2):128-32. doi: 10.1016/j.antiviral.2008.03.003. Epub 2008 Apr 14.

PMID:
18455811
15.

Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice.

Zhou X, Solaroli N, Bjerke M, Stewart JB, Rozell B, Johansson M, Karlsson A.

Hum Mol Genet. 2008 Aug 1;17(15):2329-35. doi: 10.1093/hmg/ddn133. Epub 2008 Apr 22.

PMID:
18434326
16.

Design, synthesis and anti flaviviridae activity of N(6)-, 5',3'-O- and 5',2'-O-substituted adenine nucleoside analogs.

Angusti A, Manfredini S, Durini E, Ciliberti N, Vertuani S, Solaroli N, Pricl S, Ferrone M, Fermeglia M, Loddo R, Secci B, Visioli A, Sanna T, Collu G, Pezzullo M, La Colla P.

Chem Pharm Bull (Tokyo). 2008 Apr;56(4):423-32.

17.

Mitochondrial expression of the Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.

Solaroli N, Zheng X, Johansson M, Balzarini J, Karlsson A.

Mol Pharmacol. 2007 Dec;72(6):1593-8. Epub 2007 Sep 12.

PMID:
17855655
18.

Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity.

Ciliberti N, Manfredini S, Angusti A, Durini E, Solaroli N, Vertuani S, Buzzoni L, Bonache MC, Ben-Shalom E, Karlsson A, Saada A, Balzarini J.

Bioorg Med Chem. 2007 Apr 15;15(8):3065-81. Epub 2007 Feb 2.

PMID:
17324575
19.

Substrate specificity of three viral thymidine kinases (TK): vaccinia virus TK, feline herpesvirus TK, and canine herpesvirus TK.

Solaroli N, Johansson M, Balzarini J, Karlsson A.

Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1189-92.

PMID:
17065088
20.

Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design.

El Omari K, Solaroli N, Karlsson A, Balzarini J, Stammers DK.

BMC Struct Biol. 2006 Oct 24;6:22.

21.

A non-invasive method for the in vivo determination of skin antioxidant capacity (IAC-S).

Ziosi P, Besco E, Vertuani S, Solaroli N, Manfredini S.

Skin Res Technol. 2006 Nov;12(4):303-8.

PMID:
17026664
22.

Enhanced toxicity of purine nucleoside analogs in cells expressing Drosophila melanogaster nucleoside kinase mutants.

Solaroli N, Johansson M, Balzarini J, Karlsson A.

Gene Ther. 2007 Jan;14(1):86-92. Epub 2006 Aug 3.

PMID:
16885999
23.

Adenosine phosphonoacetic acid is slowly metabolized by NDP kinase.

Chen Y, Morera S, Pasti C, Angusti A, Solaroli N, Véron M, Janin J, Manfredini S, Deville-Bonne D.

Med Chem. 2005 Nov;1(6):529-36.

PMID:
16787337
24.

Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation.

Balzarini J, Liekens S, Solaroli N, El Omari K, Stammers DK, Karlsson A.

J Biol Chem. 2006 Jul 14;281(28):19273-9. Epub 2006 May 15.

25.

Investigation of the substrate recognition of Drosophila melanogaster nucleoside kinase by site directed mutagenesis.

Solaroli N, Bjerke M, Johansson M, Karlsson A.

Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1527-9.

PMID:
15571291
26.

Design and synthesis of phosphonoacetic acid (PPA) ester and amide bioisosters of ribofuranosylnucleoside diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory, cytostatic and antiviral activity.

Manfredini S, Solaroli N, Angusti A, Nalin F, Durini E, Vertuani S, Pricl S, Ferrone M, Spadari S, Focher F, Verri A, De Clercq E, Balzarini J.

Antivir Chem Chemother. 2003 Jul;14(4):183-94.

PMID:
14582847
27.

Determination of antioxidant efficacy of cosmetic formulations by non-invasive measurements.

Vertuani S, Ziosi P, Solaroli N, Buzzoni V, Carli M, Lucchi E, Valgimigli L, Baratto G, Manfredini S.

Skin Res Technol. 2003 Aug;9(3):245-53.

PMID:
12877686
28.

Active site mutants of Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.

Solaroli N, Bjerke M, Amiri MH, Johansson M, Karlsson A.

Eur J Biochem. 2003 Jul;270(13):2879-84.

29.

Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.

Manfredini S, Baraldi PG, Durini E, Porcu L, Angusti A, Vertuani S, Solaroli N, De Clercq E, Karlsson A, Balzarini J.

Bioorg Med Chem Lett. 2001 May 21;11(10):1329-32.

PMID:
11392548
30.

Design, synthesis and binding at cloned muscarinic receptors of N-[5-(1'-substituted-acetoxymethyl)-3-oxadiazolyl] and N-[4-(1'-substituted-acetoxymethyl)-2-dioxolanyl] dialkyl amines.

Manfredini S, Lampronti I, Vertuani S, Solaroli N, Recanatini M, Bryan D, McKinney M.

Bioorg Med Chem. 2000 Jul;8(7):1559-66.

PMID:
10976504

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