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Items: 1 to 50 of 84

1.

A Novel Triazole Derivative Drug Presenting In Vitro and In Vivo Anticancer Properties.

Filho RI, Gonzaga DTG, Demaria TM, Leandro JGB, Costa DCS, Ferreira VF, Sola-Penna M, de C da Silva F, Zancan P.

Curr Top Med Chem. 2018;18(17):1483-1493. doi: 10.2174/1568026618666180917100640.

PMID:
30221602
2.

A Novel Naphthotriazolyl-4-oxoquinoline Derivative that Selectively Controls Breast Cancer Cells Survival Through the Induction of Apoptosis.

Branco JR, Oliveira VG, Esteves AM, Chipoline IC, Lima MFO, Boechat FCS, da Silva FC, Ferreira VF, Sola-Penna M, de Souza MCBV, Zancan P.

Curr Top Med Chem. 2018;18(17):1465-1474. doi: 10.2174/1568026618666180821142458.

PMID:
30129412
3.

Design, Synthesis and Biological Evaluation of 1H-1,2,3-Triazole-Linked-1H-Dibenzo[b,h]xanthenes as Inductors of ROS-Mediated Apoptosis in the Breast Cancer Cell Line MCF-7.

Bortolot CS, da S M Forezi L, Marra RKF, Reis MIP, Sá BVFE, Filho RI, Ghasemishahrestani Z, Sola-Penna M, Zancan P, Ferreira VF, de C da Silva F.

Med Chem. 2019;15(2):119-129. doi: 10.2174/1573406414666180524071409.

PMID:
29792156
4.

Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis.

Machado DE, Perini JA, de Mendonça EM, Branco JR, Rodrigues-Baptista KC, Alessandra-Perini J, Espíndola-Netto JM, Dos Santos TA, Coelho WS, Nasciutti LE, Sola-Penna M, Zancan P.

Mol Cell Endocrinol. 2018 Nov 15;476:17-26. doi: 10.1016/j.mce.2018.04.005. Epub 2018 Apr 22.

5.

Insulin specifically regulates expression of liver and muscle phosphofructokinase isoforms.

Ausina P, Da Silva D, Majerowicz D, Zancan P, Sola-Penna M.

Biomed Pharmacother. 2018 Jul;103:228-233. doi: 10.1016/j.biopha.2018.04.033. Epub 2018 Apr 24.

PMID:
29655163
6.

Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway.

Torres RG, Casanova L, Carvalho J, Marcondes MC, Costa SS, Sola-Penna M, Zancan P.

J Bioenerg Biomembr. 2018 Apr;50(2):93-105. doi: 10.1007/s10863-018-9750-3. Epub 2018 Mar 28.

PMID:
29589262
7.

Discrete Fourier Transform-Based Multivariate Image Analysis: Application to Modeling of Aromatase Inhibitory Activity.

Barigye SJ, Freitas MP, Ausina P, Zancan P, Sola-Penna M, Castillo-Garit JA.

ACS Comb Sci. 2018 Feb 12;20(2):75-81. doi: 10.1021/acscombsci.7b00155. Epub 2018 Jan 22.

PMID:
29297675
8.

Effects of Food Additives on Immune Cells As Contributors to Body Weight Gain and Immune-Mediated Metabolic Dysregulation.

Paula Neto HA, Ausina P, Gomez LS, Leandro JGB, Zancan P, Sola-Penna M.

Front Immunol. 2017 Nov 6;8:1478. doi: 10.3389/fimmu.2017.01478. eCollection 2017. Review.

9.

Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer.

Espindola-Netto JM, Chini CCS, Tarragó M, Wang E, Dutta S, Pal K, Mukhopadhyay D, Sola-Penna M, Chini EN.

Oncotarget. 2017 Jun 29;8(49):85054-85067. doi: 10.18632/oncotarget.18841. eCollection 2017 Oct 17.

10.

Reference genes for quantitative PCR in the adipose tissue of mice with metabolic disease.

Almeida-Oliveira F, Leandro JGB, Ausina P, Sola-Penna M, Majerowicz D.

Biomed Pharmacother. 2017 Apr;88:948-955. doi: 10.1016/j.biopha.2017.01.091. Epub 2017 Feb 6.

PMID:
28178626
11.

Subversion of Schwann cell glucose metabolism by Mycobacterium leprae.

Medeiros RC, Girardi KD, Cardoso FK, Mietto BS, Pinto TG, Gomez LS, Rodrigues LS, Gandini M, Amaral JJ, Antunes SL, Corte-Real S, Rosa PS, Pessolani MC, Nery JA, Sarno EN, Batista-Silva LR, Sola-Penna M, de Oliveira MF, Moraes MO, Lara FA.

J Biol Chem. 2016 Nov 18;291(47):24803. No abstract available.

12.

Phosphofructokinase-P Modulates P44/42 MAPK Levels in HeLa Cells.

Cardim Pires TR, Albanese JM, Schwab M, Marette A, Carvalho RS, Sola-Penna M, Zancan P.

J Cell Biochem. 2017 May;118(5):1216-1226. doi: 10.1002/jcb.25774. Epub 2017 Jan 10.

PMID:
27791266
13.

Subversion of Schwann Cell Glucose Metabolism by Mycobacterium leprae.

Medeiros RC, Girardi KD, Cardoso FK, Mietto BS, Pinto TG, Gomez LS, Rodrigues LS, Gandini M, Amaral JJ, Antunes SL, Corte-Real S, Rosa PS, Pessolani MC, Nery JA, Sarno EN, Batista-Silva LR, Sola-Penna M, Oliveira MF, Moraes MO, Lara FA.

J Biol Chem. 2016 Oct 7;291(41):21375-21387. Epub 2016 Aug 23. Erratum in: J Biol Chem. 2016 Nov 18;291(47):24803.

14.

The Use of NMR Metabolite Profiling and in vivo Hypoglycemic Assay for Comparison of Unfractionated Aqueous Leaf Extracts of Two Ocimum Species.

Casanova LM, Espíndola-Netto JM, Tinoco LW, Sola-Penna M, Costa SS.

Chem Biodivers. 2016 Jun;13(6):686-94. doi: 10.1002/cbdv.201500180. Epub 2016 May 24.

PMID:
27218231
15.

Epithelial Mesenchymal Transition Induces Aberrant Glycosylation through Hexosamine Biosynthetic Pathway Activation.

Lucena MC, Carvalho-Cruz P, Donadio JL, Oliveira IA, de Queiroz RM, Marinho-Carvalho MM, Sola-Penna M, de Paula IF, Gondim KC, McComb ME, Costello CE, Whelan SA, Todeschini AR, Dias WB.

J Biol Chem. 2016 Jun 17;291(25):12917-29. doi: 10.1074/jbc.M116.729236. Epub 2016 Apr 18.

16.

Unique PFK regulatory property from some mosquito vectors of disease, and from Drosophila melanogaster.

Nunes RD, Romeiro NC, De Carvalho HT, Moreira JR, Sola-Penna M, Silva-Neto MA, Braz GR.

Parasit Vectors. 2016 Feb 25;9:107. doi: 10.1186/s13071-016-1391-y.

17.

Exogenous citrate impairs glucose tolerance and promotes visceral adipose tissue inflammation in mice.

Leandro JG, Espindola-Netto JM, Vianna MC, Gomez LS, DeMaria TM, Marinho-Carvalho MM, Zancan P, Paula Neto HA, Sola-Penna M.

Br J Nutr. 2016 Mar 28;115(6):967-73. doi: 10.1017/S0007114516000027. Epub 2016 Feb 11.

PMID:
26863933
18.

SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway.

Chini CC, Espindola-Netto JM, Mondal G, Guerrico AM, Nin V, Escande C, Sola-Penna M, Zhang JS, Billadeau DD, Chini EN.

Clin Cancer Res. 2016 May 15;22(10):2496-507. doi: 10.1158/1078-0432.CCR-15-1760. Epub 2015 Dec 11.

19.

Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma.

Coelho RG, Calaça IC, Celestrini DM, Correia-Carneiro AH, Costa MM, Zancan P, Sola-Penna M.

Oncotarget. 2015 Oct 6;6(30):29375-87. doi: 10.18632/oncotarget.4910.

20.

Nanomicellar Formulation of Clotrimazole Improves Its Antitumor Action toward Human Breast Cancer Cells.

Marcondes MC, Fernandes AC, Itabaiana I Jr, de Souza RO, Sola-Penna M, Zancan P.

PLoS One. 2015 Jun 22;10(6):e0130555. doi: 10.1371/journal.pone.0130555. eCollection 2015.

21.

Phosphatidylinositol-3-kinase as a putative target for anticancer action of clotrimazole.

Furtado CM, Marcondes MC, Carvalho RS, Sola-Penna M, Zancan P.

Int J Biochem Cell Biol. 2015 May;62:132-41. doi: 10.1016/j.biocel.2015.03.004. Epub 2015 Mar 17.

PMID:
25794423
22.

Therapeutic nanosystems for oral administration of insulin.

do Carmo FA, Sathler PC, Zancan P, Rodrigues CR, Castro HC, de Sousa VP, Sola-Penna M, Cabral LM.

Curr Pharm Biotechnol. 2014;15(7):620-8. Review.

PMID:
25219867
23.

Antidiabetic activity of Sedum dendroideum: metabolic enzymes as putative targets for the bioactive flavonoid kaempferitrin.

Da Silva D, Casanova LM, Marcondes MC, Espindola-Netto JM, Paixão LP, De Melo GO, Zancan P, Sola-Penna M, Costa SS.

IUBMB Life. 2014 May;66(5):361-70. doi: 10.1002/iub.1270. Epub 2014 May 10.

24.

Identification of chicoric acid as a hypoglycemic agent from Ocimum gratissimum leaf extract in a biomonitoring in vivo study.

Casanova LM, da Silva D, Sola-Penna M, Camargo LM, Celestrini Dde M, Tinoco LW, Costa SS.

Fitoterapia. 2014 Mar;93:132-41. doi: 10.1016/j.fitote.2013.12.024. Epub 2014 Jan 10.

25.

Amylin induces hypoglycemia in mice.

Guerreiro LH, Da Silva D, Sola-Penna M, Mizurini DM, Lima LM.

An Acad Bras Cienc. 2013 Mar;85(1):349-54. Epub 2013 Mar 1.

26.

Resveratrol decreases breast cancer cell viability and glucose metabolism by inhibiting 6-phosphofructo-1-kinase.

Gomez LS, Zancan P, Marcondes MC, Ramos-Santos L, Meyer-Fernandes JR, Sola-Penna M, Da Silva D.

Biochimie. 2013 Jun;95(6):1336-43. doi: 10.1016/j.biochi.2013.02.013. Epub 2013 Feb 27.

27.

Rhodnius prolixus lipophorin: lipid composition and effect of high temperature on physiological role.

Majerowicz D, Cezimbra MP, Alves-Bezerra M, Entringer PF, Atella GC, Sola-Penna M, Meyer-Fernandes JR, Gondim KC.

Arch Insect Biochem Physiol. 2013 Mar;82(3):129-40. doi: 10.1002/arch.21080. Epub 2013 Jan 29.

PMID:
23361613
28.

Serotonin regulates 6-phosphofructo-1-kinase activity in a PLC-PKC-CaMK II- and Janus kinase-dependent signaling pathway.

Coelho WS, Sola-Penna M.

Mol Cell Biochem. 2013 Jan;372(1-2):211-20. doi: 10.1007/s11010-012-1462-0. Epub 2012 Sep 26.

PMID:
23010892
29.

Metformin reverses hexokinase and phosphofructokinase downregulation and intracellular distribution in the heart of diabetic mice.

Da Silva D, Ausina P, Alencar EM, Coelho WS, Zancan P, Sola-Penna M.

IUBMB Life. 2012 Sep;64(9):766-74. doi: 10.1002/iub.1063. Epub 2012 Jun 23.

30.

Herpes simplex type 1 activates glycolysis through engagement of the enzyme 6-phosphofructo-1-kinase (PFK-1).

Abrantes JL, Alves CM, Costa J, Almeida FC, Sola-Penna M, Fontes CF, Souza TM.

Biochim Biophys Acta. 2012 Aug;1822(8):1198-206. doi: 10.1016/j.bbadis.2012.04.011. Epub 2012 Apr 21.

31.

Clotrimazole preferentially inhibits human breast cancer cell proliferation, viability and glycolysis.

Furtado CM, Marcondes MC, Sola-Penna M, de Souza ML, Zancan P.

PLoS One. 2012;7(2):e30462. doi: 10.1371/journal.pone.0030462. Epub 2012 Feb 8.

32.

Polymeric particles for the controlled release of human amylin.

Guerreiro LH, Da Silva D, Ricci-Junior E, Girard-Dias W, Mascarenhas CM, Sola-Penna M, Miranda K, Lima LM.

Colloids Surf B Biointerfaces. 2012 Jun 1;94:101-6. doi: 10.1016/j.colsurfb.2012.01.021. Epub 2012 Jan 28.

PMID:
22326343
33.

Proteomic analysis of the secretions of Pseudallescheria boydii, a human fungal pathogen with unknown genome.

da Silva BA, Sodré CL, Souza-Gonçalves AL, Aor AC, Kneipp LF, Fonseca BB, Rozental S, Romanos MT, Sola-Penna M, Perales J, Kalume DE, dos Santos AL.

J Proteome Res. 2012 Jan 1;11(1):172-88. doi: 10.1021/pr200875x. Epub 2011 Dec 5.

PMID:
22142336
34.

Serotonin modulates hepatic 6-phosphofructo-1-kinase in an insulin synergistic manner.

Coelho WS, Da Silva D, Marinho-Carvalho MM, Sola-Penna M.

Int J Biochem Cell Biol. 2012 Jan;44(1):150-7. doi: 10.1016/j.biocel.2011.10.010. Epub 2011 Oct 22.

35.

Muscle-type 6-phosphofructo-1-kinase and aldolase associate conferring catalytic advantages for both enzymes.

Marcondes MC, Sola-Penna M, Torres Rda S, Zancan P.

IUBMB Life. 2011 Jun;63(6):435-45. doi: 10.1002/iub.464.

36.

Clotrimazole disrupts glycolysis in human breast cancer without affecting non-tumoral tissues.

Coelho RG, Calaça Ide C, Celestrini Dde M, Correia AH, Costa MA, Sola-Penna M.

Mol Genet Metab. 2011 Aug;103(4):394-8. doi: 10.1016/j.ymgme.2011.04.003. Epub 2011 Apr 16.

PMID:
21531601
37.

Glucuronoxylomannan from Cryptococcus neoformans down-regulates the enzyme 6-phosphofructo-1-kinase of macrophages.

Grechi J, Marinho-Carvalho M, Zancan P, Cinelli LP, Gomes AM, Rodrigues ML, Nimrichter L, Sola-Penna M.

J Biol Chem. 2011 Apr 29;286(17):14820-9. doi: 10.1074/jbc.M110.177030. Epub 2011 Mar 9.

38.

Regulation of mammalian muscle type 6-phosphofructo-1-kinase and its implication for the control of the metabolism.

Sola-Penna M, Da Silva D, Coelho WS, Marinho-Carvalho MM, Zancan P.

IUBMB Life. 2010 Nov;62(11):791-6. doi: 10.1002/iub.393. Review.

39.

Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice.

Leite TC, Coelho RG, Da Silva D, Coelho WS, Marinho-Carvalho MM, Sola-Penna M.

FEBS Lett. 2011 Jan 3;585(1):92-8. doi: 10.1016/j.febslet.2010.11.009. Epub 2010 Nov 11.

40.

Microcapsules of alginate/chitosan containing magnetic nanoparticles for controlled release of insulin.

Finotelli PV, Da Silva D, Sola-Penna M, Rossi AM, Farina M, Andrade LR, Takeuchi AY, Rocha-Leão MH.

Colloids Surf B Biointerfaces. 2010 Nov 1;81(1):206-11. doi: 10.1016/j.colsurfb.2010.07.008. Epub 2010 Jul 14.

PMID:
20688491
41.

Differential expression of phosphofructokinase-1 isoforms correlates with the glycolytic efficiency of breast cancer cells.

Zancan P, Sola-Penna M, Furtado CM, Da Silva D.

Mol Genet Metab. 2010 Aug;100(4):372-8. doi: 10.1016/j.ymgme.2010.04.006. Epub 2010 Apr 18.

PMID:
20483646
42.

A new class of mechanism-based inhibitors for Trypanosoma cruzi trans-sialidase and their influence on parasite virulence.

Carvalho ST, Sola-Penna M, Oliveira IA, Pita S, Gonçalves AS, Neves BC, Sousa FR, Freire-de-Lima L, Kurogochi M, Hinou H, Nishimura S, Mendonça-Previato L, Previato JO, Todeschini AR.

Glycobiology. 2010 Aug;20(8):1034-45. doi: 10.1093/glycob/cwq065. Epub 2010 Apr 22.

PMID:
20466651
43.

Clotrimazole potentiates the inhibitory effects of ATP on the key glycolytic enzyme 6-phosphofructo-1-kinase.

Marcondes MC, Sola-Penna M, Zancan P.

Arch Biochem Biophys. 2010 May;497(1-2):62-7. doi: 10.1016/j.abb.2010.03.013. Epub 2010 Mar 25.

PMID:
20346906
44.

Filamentous actin and its associated binding proteins are the stimulatory site for 6-phosphofructo-1-kinase association within the membrane of human erythrocytes.

Real-Hohn A, Zancan P, Da Silva D, Martins ER, Salgado LT, Mermelstein CS, Gomes AM, Sola-Penna M.

Biochimie. 2010 May;92(5):538-44. doi: 10.1016/j.biochi.2010.01.023. Epub 2010 Feb 6.

PMID:
20144679
45.

Metformin reverses hexokinase and 6-phosphofructo-1-kinase inhibition in skeletal muscle, liver and adipose tissues from streptozotocin-induced diabetic mouse.

Da Silva D, Zancan P, Coelho WS, Gomez LS, Sola-Penna M.

Arch Biochem Biophys. 2010 Apr 1;496(1):53-60. doi: 10.1016/j.abb.2010.01.013. Epub 2010 Feb 1.

PMID:
20117072
46.

Serotonin regulates an acyl-CoA-binding protein (ACBP) gene expression in the midgut of Rhodnius prolixus.

Alves-Bezerra M, Majerowicz D, Grillo LA, Tremonte H, Almeida CB, Braz GR, Sola-Penna M, Paiva-Silva GO, Gondim KC.

Insect Biochem Mol Biol. 2010 Feb;40(2):119-25. doi: 10.1016/j.ibmb.2010.01.002. Epub 2010 Jan 15.

PMID:
20079838
47.

Calmodulin upregulates skeletal muscle 6-phosphofructo-1-kinase reversing the inhibitory effects of allosteric modulators.

Marinho-Carvalho MM, Costa-Mattos PV, Spitz GA, Zancan P, Sola-Penna M.

Biochim Biophys Acta. 2009 Aug;1794(8):1175-80. doi: 10.1016/j.bbapap.2009.02.006. Epub 2009 Feb 27.

PMID:
19250982
48.

Acetylsalicylic acid and salicylic acid decrease tumor cell viability and glucose metabolism modulating 6-phosphofructo-1-kinase structure and activity.

Spitz GA, Furtado CM, Sola-Penna M, Zancan P.

Biochem Pharmacol. 2009 Jan 1;77(1):46-53. doi: 10.1016/j.bcp.2008.09.020. Epub 2008 Sep 21.

PMID:
18851958
49.

Crude ethanol extract from babassu (Orbignya speciosa): cytotoxicity on tumoral and non-tumoral cell lines.

Rennó MN, Barbosa GM, Zancan P, Veiga VF, Alviano CS, Sola-Penna M, Menezes FS, Holandino C.

An Acad Bras Cienc. 2008 Sep;80(3):467-76.

50.

Metabolic regulation by lactate.

Sola-Penna M.

IUBMB Life. 2008 Sep;60(9):605-8. doi: 10.1002/iub.97. Review.

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