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Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin.

Lim PJ, Duarte TL, Arezes J, Garcia-Santos D, Hamdi A, Pasricha SR, Armitage AE, Mehta H, Wideman S, Santos AG, Santos-Gonçalves A, Morovat A, Hughes JR, Soilleux E, Wang CY, Bayer AL, Klenerman P, Willberg CB, Hartley RC, Murphy MP, Babitt JL, Ponka P, Porto G, Drakesmith H.

Nat Metab. 2019 May;1(5):519-531. doi: 10.1038/s42255-019-0063-6. Epub 2019 May 13.


Correction: S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells.

Vrzalikova K, Ibrahim M, Vockerodt M, Perry T, Margielewska S, Lupino L, Nagy E, Soilleux E, Liebelt D, Hollows R, Last A, Reynolds G, Abdullah M, Curley H, Care M, Krappmann D, Tooze R, Allegood J, Spiegel S, Wei W, Woodman CBJ, Murray PG.

Leukemia. 2019 Aug;33(8):2126. doi: 10.1038/s41375-019-0511-z.


Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.

Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K, Cheng X, Cawthorne E, Coleman ML, Crockford TL, Davies B, Dow LE, Goldin R, Kranc K, Kudo H, Lawson H, McAuliffe J, Milward K, Scudamore CL, Soilleux E, Issa F, Ratcliffe PJ, Pugh CW.

J Clin Invest. 2019 Jun 4;130:3640-3656. doi: 10.1172/JCI124099.


Comparison of methodologies for the detection of BRAF mutations in bone marrow trephine specimens.

Cardus B, Colling R, Hamblin A, Soilleux E.

J Clin Pathol. 2019 Jun;72(6):406-411. doi: 10.1136/jclinpath-2019-205734. Epub 2019 Mar 14.


Contribution of immunoglobulin lambda light chain gene rearrangement analysis in the diagnosis of B-cell neoplasms.

Paterson AL, El-Daly H, Raso-Barnett L, Du MQ, Giger O, Soilleux E, Roberts T, Huang Y, Bibawi H, Matharu B, Bench A, Scott MA, Liu H.

Br J Haematol. 2019 Apr;185(2):261-265. doi: 10.1111/bjh.15762. Epub 2019 Jan 25.


Fully automated real-time PCR for EGFR testing in non-small cell lung carcinoma.

Colling R, Bancroft H, Langman G, Soilleux E.

Virchows Arch. 2019 Feb;474(2):187-192. doi: 10.1007/s00428-018-2486-y. Epub 2018 Nov 23.


A phase 1 study to assess the safety, tolerability, and pharmacokinetics of CXD101 in patients with advanced cancer.

Eyre TA, Collins GP, Gupta A, Coupe N, Sheikh S, Whittaker J, Wang LM, Campo L, Soilleux E, Tysoe F, Cousins R, La Thangue N, Folkes LK, Stratford MRL, Kerr D, Middleton MR.

Cancer. 2019 Jan 1;125(1):99-108. doi: 10.1002/cncr.31791. Epub 2018 Oct 17.


Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

Booth CAG, Barkas N, Neo WH, Boukarabila H, Soilleux EJ, Giotopoulos G, Farnoud N, Giustacchini A, Ashley N, Carrelha J, Jamieson L, Atkinson D, Bouriez-Jones T, Prinjha RK, Milne TA, Teachey DT, Papaemmanuil E, Huntly BJP, Jacobsen SEW, Mead AJ.

Cancer Cell. 2018 Feb 12;33(2):274-291.e8. doi: 10.1016/j.ccell.2018.01.006.


S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells.

Vrzalikova K, Ibrahim M, Vockerodt M, Perry T, Margielewska S, Lupino L, Nagy E, Soilleux E, Liebelt D, Hollows R, Last A, Reynolds G, Abdullah M, Curley H, Care M, Krappmann D, Tooze R, Allegood J, Spiegel S, Wei W, Woodman CBJ, Murray PG.

Leukemia. 2018 Jan;32(1):214-223. doi: 10.1038/leu.2017.275. Epub 2017 Sep 7. Erratum in: Leukemia. 2019 Aug;33(8):2126.


Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.

Pasricha SR, Lim PJ, Duarte TL, Casu C, Oosterhuis D, Mleczko-Sanecka K, Suciu M, Da Silva AR, Al-Hourani K, Arezes J, McHugh K, Gooding S, Frost JN, Wray K, Santos A, Porto G, Repapi E, Gray N, Draper SJ, Ashley N, Soilleux E, Olinga P, Muckenthaler MU, Hughes JR, Rivella S, Milne TA, Armitage AE, Drakesmith H.

Nat Commun. 2017 Sep 1;8(1):403. doi: 10.1038/s41467-017-00500-z.


Haematological cancers: improving outcomes. A summary of updated NICE service guidance in relation to Specialist Integrated Haematological Malignancy Diagnostic Services (SIHMDS).

Snowden JA, O'Connell S, Hawkins J, Dalley C, Jack A, Mannari D, McNamara C, Scott M, Shenton G, Soilleux E, Macbeth F; Guideline Committee.

J Clin Pathol. 2017 Jun;70(6):461-468. doi: 10.1136/jclinpath-2016-204029. Epub 2017 Apr 7. Review.


Validating a fully automated real-time PCR-based system for use in the molecular diagnostic analysis of colorectal carcinoma: a comparison with NGS and IHC.

Colling R, Wang LM, Soilleux E.

J Clin Pathol. 2017 Jul;70(7):610-614. doi: 10.1136/jclinpath-2017-204356. Epub 2017 Mar 14.


Vitamin D Receptor Expression in Plasmablastic Lymphoma and Myeloma Cells Confers Susceptibility to Vitamin D.

Gascoyne DM, Lyne L, Spearman H, Buffa FM, Soilleux EJ, Banham AH.

Endocrinology. 2017 Mar 1;158(3):503-515. doi: 10.1210/en.2016-1802.


Transformation of CLL to ALCL: the role of clonality studies in diagnostic molecular haematopathology.

Colling R, Royston D, Soilleux E.

J Hematop. 2016 Aug 8;9(3):143-147. eCollection 2016 Sep.


Multi-Center Evaluation of the Fully Automated PCR-Based Idylla™ KRAS Mutation Assay for Rapid KRAS Mutation Status Determination on Formalin-Fixed Paraffin-Embedded Tissue of Human Colorectal Cancer.

Solassol J, Vendrell J, Märkl B, Haas C, Bellosillo B, Montagut C, Smith M, O'Sullivan B, D'Haene N, Le Mercier M, Grauslund M, Melchior LC, Burt E, Cotter F, Stieber D, Schmitt FL, Motta V, Lauricella C, Colling R, Soilleux E, Fassan M, Mescoli C, Collin C, Pagès JC, Sillekens P.

PLoS One. 2016 Sep 29;11(9):e0163444. doi: 10.1371/journal.pone.0163444. eCollection 2016.


Dendritic and mast cell involvement in the inflammatory response to primary malignant bone tumours.

Inagaki Y, Hookway E, Williams KA, Hassan AB, Oppermann U, Tanaka Y, Soilleux E, Athanasou NA.

Clin Sarcoma Res. 2016 Aug 1;6:13. doi: 10.1186/s13569-016-0053-3. eCollection 2016.


Induced Disruption of the Iron-Regulatory Hormone Hepcidin Inhibits Acute Inflammatory Hypoferraemia.

Armitage AE, Lim PJ, Frost JN, Pasricha SR, Soilleux EJ, Evans E, Morovat A, Santos A, Diaz R, Biggs D, Davies B, Gileadi U, Robbins PA, Lakhal-Littleton S, Drakesmith H.

J Innate Immun. 2016;8(5):517-28. doi: 10.1159/000447713. Epub 2016 Jul 16.


NCRI phase II study of CHOP in combination with ofatumumab in induction and maintenance in newly diagnosed Richter syndrome.

Eyre TA, Clifford R, Bloor A, Boyle L, Roberts C, Cabes M, Collins GP, Devereux S, Follows G, Fox CP, Gribben J, Hillmen P, Hatton CS, Littlewood TJ, McCarthy H, Murray J, Pettitt AR, Soilleux E, Stamatopoulos B, Love SB, Wotherspoon A, Schuh A.

Br J Haematol. 2016 Oct;175(1):43-54. doi: 10.1111/bjh.14177. Epub 2016 Jul 5.


Diagnostic dilemmas of high-grade transformation (Richter's syndrome) of chronic lymphocytic leukaemia: results of the phase II National Cancer Research Institute CHOP-OR clinical trial specialist haemato-pathology central review.

Soilleux EJ, Wotherspoon A, Eyre TA, Clifford R, Cabes M, Schuh AH.

Histopathology. 2016 Dec;69(6):1066-1076. doi: 10.1111/his.13024. Epub 2016 Sep 9.


MRI Based Localisation and Quantification of Abscesses following Experimental S. aureus Intravenous Challenge: Application to Vaccine Evaluation.

Allen ER, van Diemen P, Yamaguchi Y, Lindemann C, Soilleux E, Rollier C, Hill F, Schneider J, Wyllie DH.

PLoS One. 2016 May 26;11(5):e0154705. doi: 10.1371/journal.pone.0154705. eCollection 2016.


FOXP2-positive diffuse large B-cell lymphomas exhibit a poor response to R-CHOP therapy and distinct biological signatures.

Wong KK, Gascoyne DM, Soilleux EJ, Lyne L, Spearman H, Roncador G, Pedersen LM, Møller MB, Green TM, Banham AH.

Oncotarget. 2016 Aug 16;7(33):52940-52956. doi: 10.18632/oncotarget.9507.


Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1.

Reschen ME, Lin D, Chalisey A, Soilleux EJ, O'Callaghan CA.

Atherosclerosis. 2016 Jul;250:95-105. doi: 10.1016/j.atherosclerosis.2016.04.025. Epub 2016 May 2.


Acute EBV masquerading as peripheral T-cell lymphoma.

Zhang XY, Collins GP, Soilleux E, Eyre TA.

BMJ Case Rep. 2016 Feb 2;2016. pii: bcr2015213573. doi: 10.1136/bcr-2015-213573.


Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia.

Watson AS, Riffelmacher T, Stranks A, Williams O, De Boer J, Cain K, MacFarlane M, McGouran J, Kessler B, Khandwala S, Chowdhury O, Puleston D, Phadwal K, Mortensen M, Ferguson D, Soilleux E, Woll P, Jacobsen SE, Simon AK.

Cell Death Discov. 2015 Aug 17;1. pii: 15008.


Automated PCR detection of BRAF mutations in colorectal adenocarcinoma: a diagnostic test accuracy study.

Colling R, Wang LM, Soilleux E.

J Clin Pathol. 2016 May;69(5):398-402. doi: 10.1136/jclinpath-2015-203345. Epub 2015 Nov 4.


FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas.

Brown PJ, Wong KK, Felce SL, Lyne L, Spearman H, Soilleux EJ, Pedersen LM, Møller MB, Green TM, Gascoyne DM, Banham AH.

Leukemia. 2016 Mar;30(3):605-16. doi: 10.1038/leu.2015.299. Epub 2015 Oct 26.


Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines.

Scudamore CL, Soilleux EJ, Karp NA, Smith K, Poulsom R, Herrington CS, Day MJ, Brayton CF, Bolon B, Whitelaw B, White ES, Everitt JI, Arends MJ.

J Pathol. 2016 Jan;238(2):359-67. doi: 10.1002/path.4642. Epub 2015 Nov 28. Review.


Techniques for the Detection of Autophagy in Primary Mammalian Cells.

Puleston D, Phadwal K, Watson AS, Soilleux EJ, Chittaranjan S, Bortnik S, Gorski SM, Ktistakis N, Simon AK.

Cold Spring Harb Protoc. 2015 Sep 1;2015(9):pdb.top070391. doi: 10.1101/pdb.top070391.


Detection of p62 on Paraffin Sections by Immunohistochemistry.

Watson AS, Soilleux EJ.

Cold Spring Harb Protoc. 2015 Aug 3;2015(8):756-60. doi: 10.1101/pdb.prot086280.


A perianal presentation of myeloid sarcoma.

Nagra NS, Lozano E, Soilleux E, Mullerat P.

BMJ Case Rep. 2015 May 12;2015. pii: bcr2015209832. doi: 10.1136/bcr-2015-209832.


Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding.

Reschen ME, Gaulton KJ, Lin D, Soilleux EJ, Morris AJ, Smyth SS, O'Callaghan CA.

PLoS Genet. 2015 Apr 2;11(4):e1005061. doi: 10.1371/journal.pgen.1005061. eCollection 2015 Apr.


A phase II trial of AZD1152 in relapsed/refractory diffuse large B-cell lymphoma.

Collins GP, Eyre TA, Linton KM, Radford J, Vallance GD, Soilleux E, Hatton C.

Br J Haematol. 2015 Sep;170(6):886-90. doi: 10.1111/bjh.13333. Epub 2015 Feb 26. No abstract available.


Identification of a novel mutation in MAGT1 and progressive multifocal leucoencephalopathy in a 58-year-old man with XMEN disease.

Dhalla F, Murray S, Sadler R, Chaigne-Delalande B, Sadaoka T, Soilleux E, Uzel G, Miller J, Collins GP, Hatton CS, Bhole M, Ferry B, Chapel HM, Cohen JI, Patel SY.

J Clin Immunol. 2015 Feb;35(2):112-8. doi: 10.1007/s10875-014-0116-2. Epub 2014 Dec 13. Review.


Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients.

Wong KK, Gascoyne DM, Brown PJ, Soilleux EJ, Snell C, Chen H, Lyne L, Lawrie CH, Gascoyne RD, Pedersen LM, Møller MB, Pulford K, Murphy D, Green TM, Banham AH.

Leukemia. 2014 Feb;28(2):362-72. doi: 10.1038/leu.2013.224. Epub 2013 Jul 25. Erratum in: Leukemia. 2014 Feb;28(2):470.


Isolated paediatric neurosarcoidosis presenting as epilepsia partialis continua: a case report and review of literature.

Anand G, Sin FE, Soilleux E, Chandra J, Piddington K, Quaghebeur G, Wilkinson N, Zaiwalla Z, Kennett R, McShane T.

Eur J Paediatr Neurol. 2013 Sep;17(5):429-36. doi: 10.1016/j.ejpn.2013.03.005. Epub 2013 May 16. Review.


Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.

Bertram S, Heurich A, Lavender H, Gierer S, Danisch S, Perin P, Lucas JM, Nelson PS, Pöhlmann S, Soilleux EJ.

PLoS One. 2012;7(4):e35876. doi: 10.1371/journal.pone.0035876. Epub 2012 Apr 30.


IgG4 orbitopathy: unravelling a multisystem diagnostic challenge.

Peter NM, Khooshabeh R, Soilleux EJ.

Eye (Lond). 2012 Aug;26(8):1150-1. doi: 10.1038/eye.2012.81. Epub 2012 Apr 27. No abstract available.


Ocular lymphoma with extrascleral extension as primary manifestation of Richter syndrome.

Mota PM, Dedes W, Yeoh SL, Soilleux E, Hague S.

Eye (Lond). 2012 Jun;26(6):891-3. doi: 10.1038/eye.2012.41. Epub 2012 Mar 16. No abstract available.


Inter- and intra-observational variability in immunohistochemistry: a multicentre analysis of diffuse large B-cell lymphoma staining.

Lawrie CH, Ballabio E, Soilleux E, Sington J, Hatton CS, Dirnhofer S, Tzankov A.

Histopathology. 2012 Jul;61(1):18-25. doi: 10.1111/j.1365-2559.2012.04179.x. Epub 2012 Feb 28.


NF-κB regulates MICA gene transcription in endothelial cell through a genetically inhibitable control site.

Lin D, Lavender H, Soilleux EJ, O'Callaghan CA.

J Biol Chem. 2012 Feb 3;287(6):4299-310. doi: 10.1074/jbc.M111.282152. Epub 2011 Dec 14.


Sudden death in epilepsy: standards of reporting and the value of toxicological analysis.

Barrow M, Roberts IS, Soilleux EJ.

J Clin Pathol. 2011 Nov;64(11):1025-8. doi: 10.1136/jclinpath-2011-200109.


Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease.

Bertram S, Glowacka I, Müller MA, Lavender H, Gnirss K, Nehlmeier I, Niemeyer D, He Y, Simmons G, Drosten C, Soilleux EJ, Jahn O, Steffen I, Pöhlmann S.

J Virol. 2011 Dec;85(24):13363-72. doi: 10.1128/JVI.05300-11. Epub 2011 Oct 12.


Suppressor of cytokine signalling protein SOCS3 expression is increased at sites of acute and chronic inflammation.

White GE, Cotterill A, Addley MR, Soilleux EJ, Greaves DR.

J Mol Histol. 2011 Apr;42(2):137-51. doi: 10.1007/s10735-011-9317-7. Epub 2011 Mar 1.


The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.

Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Lutteropp M, Sadighi-Akha E, Stranks AJ, Glanville J, Knight S, Jacobsen SE, Kranc KR, Simon AK.

J Exp Med. 2011 Mar 14;208(3):455-67. doi: 10.1084/jem.20101145. Epub 2011 Feb 21.


Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response.

Glowacka I, Bertram S, Müller MA, Allen P, Soilleux E, Pfefferle S, Steffen I, Tsegaye TS, He Y, Gnirss K, Niemeyer D, Schneider H, Drosten C, Pöhlmann S.

J Virol. 2011 May;85(9):4122-34. doi: 10.1128/JVI.02232-10. Epub 2011 Feb 16.


Derivation of new reference tables for human heart weights in light of increasing body mass index.

Gaitskell K, Perera R, Soilleux EJ.

J Clin Pathol. 2011 Apr;64(4):358-62. doi: 10.1136/jcp.2010.084574. Epub 2010 Nov 7.


A panel of cancer-testis genes exhibiting broad-spectrum expression in haematological malignancies.

Liggins AP, Lim SH, Soilleux EJ, Pulford K, Banham AH.

Cancer Immun. 2010 Aug 23;10:8.


High glucose disrupts oligosaccharide recognition function via competitive inhibition: a potential mechanism for immune dysregulation in diabetes mellitus.

Ilyas R, Wallis R, Soilleux EJ, Townsend P, Zehnder D, Tan BK, Sim RB, Lehnert H, Randeva HS, Mitchell DA.

Immunobiology. 2011 Jan-Feb;216(1-2):126-31. doi: 10.1016/j.imbio.2010.06.002. Epub 2010 Jul 1.


TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells.

Bertram S, Glowacka I, Blazejewska P, Soilleux E, Allen P, Danisch S, Steffen I, Choi SY, Park Y, Schneider H, Schughart K, Pöhlmann S.

J Virol. 2010 Oct;84(19):10016-25. doi: 10.1128/JVI.00239-10. Epub 2010 Jul 14.


Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer.

Jubb AM, Soilleux EJ, Turley H, Steers G, Parker A, Low I, Blades J, Li JL, Allen P, Leek R, Noguera-Troise I, Gatter KC, Thurston G, Harris AL.

Am J Pathol. 2010 Apr;176(4):2019-28. doi: 10.2353/ajpath.2010.090908. Epub 2010 Feb 18.

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