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Items: 1 to 50 of 160

1.

Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-770.

Yeh HI, Qiu L, Sohma Y, Conrath K, Zou X, Hwang TC.

J Gen Physiol. 2019 Jul 1;151(7):912-928. doi: 10.1085/jgp.201912360. Epub 2019 Jun 4.

PMID:
31164398
2.

Photo-oxygenation inhibits tau amyloid formation.

Suzuki T, Hori Y, Sawazaki T, Shimizu Y, Nemoto Y, Taniguchi A, Ozawa S, Sohma Y, Kanai M, Tomita T.

Chem Commun (Camb). 2019 May 28;55(44):6165-6168. doi: 10.1039/c9cc01728c.

PMID:
31049495
3.

Design and properties of [Met35(O)]Aβ42-lactam(Asp23/Lys28) possessing a lactam tether as a salt-bridge surrogate.

Yamamoto M, Shinoda K, Sasaki D, Kanai M, Sohma Y.

Bioorg Med Chem. 2019 Mar 1;27(5):888-893. doi: 10.1016/j.bmc.2019.01.038. Epub 2019 Jan 30.

PMID:
30733085
4.

Convergent and Functional-Group-Tolerant Synthesis of B-Organo BODIPYs.

Sawazaki T, Shimizu Y, Oisaki K, Sohma Y, Kanai M.

Org Lett. 2018 Dec 21;20(24):7767-7770. doi: 10.1021/acs.orglett.8b03138. Epub 2018 Nov 30.

PMID:
30499675
5.

Hydroxy Group Directed Catalytic Hydrosilylation of Amides.

Ni J, Oguro T, Sawazaki T, Sohma Y, Kanai M.

Org Lett. 2018 Dec 7;20(23):7371-7374. doi: 10.1021/acs.orglett.8b03014. Epub 2018 Nov 12.

PMID:
30418782
6.

Palladium-Catalyzed C-H Heteroarylation of 2,5-Disubstituted Imidazoles.

Togo T, Sohma Y, Kuninobu Y, Kanai M.

Chem Pharm Bull (Tokyo). 2019 Mar 1;67(3):196-198. doi: 10.1248/cpb.c18-00586. Epub 2018 Oct 4.

7.

A chemically engineered, stable oligomer mimic of amyloid β42 containing an oxime switch for fibril formation.

Yamamoto M, Shinoda K, Ni J, Sasaki D, Kanai M, Sohma Y.

Org Biomol Chem. 2018 Sep 11;16(35):6537-6542. doi: 10.1039/c8ob01875h.

PMID:
30167602
8.

Characterization of Δ(G970-T1122)-CFTR, the most frequent CFTR mutant identified in Japanese cystic fibrosis patients.

Wakabayashi-Nakao K, Yu Y, Nakakuki M, Hwang TC, Ishiguro H, Sohma Y.

J Physiol Sci. 2019 Jan;69(1):103-112. doi: 10.1007/s12576-018-0626-4. Epub 2018 Jun 27.

PMID:
29951967
9.

Molecular dynamics simulation study on the structural instability of the most common cystic fibrosis-associated mutant ΔF508-CFTR.

Odera M, Furuta T, Sohma Y, Sakurai M.

Biophys Physicobiol. 2018 Feb 6;15:33-44. doi: 10.2142/biophysico.15.0_33. eCollection 2018.

10.

A common mechanism for CFTR potentiators.

Yeh HI, Sohma Y, Conrath K, Hwang TC.

J Gen Physiol. 2017 Dec 4;149(12):1105-1118. doi: 10.1085/jgp.201711886. Epub 2017 Oct 27.

11.

CFTR potentiators: from bench to bedside.

Jih KY, Lin WY, Sohma Y, Hwang TC.

Curr Opin Pharmacol. 2017 Jun;34:98-104. doi: 10.1016/j.coph.2017.09.015. Epub 2017 Nov 5. Review.

12.

Correction for Discovery of a Human Neuromedin U Receptor 1-Selective Hexapeptide Agonist with Enhanced Serum Stability.

Takayama K, Mori K, Tanaka A, Nomura E, Sohma Y, Mori M, Taguchi A, Taniguchi A, Sakane T, Yamamoto A, Minamino N, Miyazato M, Kangawa K, Hayashi Y.

J Med Chem. 2017 Sep 14;60(17):7613. doi: 10.1021/acs.jmedchem.7b01148. Epub 2017 Aug 18. No abstract available.

PMID:
28820261
13.

Discovery of a Human Neuromedin U Receptor 1-Selective Hexapeptide Agonist with Enhanced Serum Stability.

Takayama K, Mori K, Tanaka A, Nomura E, Sohma Y, Mori M, Taguchi A, Taniguchi A, Sakane T, Yamamoto A, Minamino N, Miyazato M, Kangawa K, Hayashi Y.

J Med Chem. 2017 Jun 22;60(12):5228-5234. doi: 10.1021/acs.jmedchem.7b00694. Epub 2017 Jun 2. Erratum in: J Med Chem. 2017 Sep 14;60(17):7613.

PMID:
28548497
14.

Chemical Biology for Pharmaceutical Sciences (Novel Ideas for "Drug" Discovery).

Sohma Y, Itoh Y.

Yakugaku Zasshi. 2017;137(3):281-282. doi: 10.1248/yakushi.16-00231-F. Japanese. No abstract available.

15.

Scandium(iii) triflate-promoted serine/threonine-selective peptide bond cleavage.

Ni J, Sohma Y, Kanai M.

Chem Commun (Camb). 2017 Mar 16;53(23):3311-3314. doi: 10.1039/c6cc10300f.

PMID:
28144647
16.

Bicarbonate-rich fluid secretion predicted by a computational model of guinea-pig pancreatic duct epithelium.

Yamaguchi M, Steward MC, Smallbone K, Sohma Y, Yamamoto A, Ko SB, Kondo T, Ishiguro H.

J Physiol. 2017 Mar 15;595(6):1947-1972. doi: 10.1113/JP273306. Epub 2017 Feb 8.

17.

Switchable photooxygenation catalysts that sense higher-order amyloid structures.

Taniguchi A, Shimizu Y, Oisaki K, Sohma Y, Kanai M.

Nat Chem. 2016 Oct;8(10):974-82. doi: 10.1038/nchem.2550. Epub 2016 Jun 27.

PMID:
27657874
18.

Transition Metal-Free Tryptophan-Selective Bioconjugation of Proteins.

Seki Y, Ishiyama T, Sasaki D, Abe J, Sohma Y, Oisaki K, Kanai M.

J Am Chem Soc. 2016 Aug 31;138(34):10798-801. doi: 10.1021/jacs.6b06692. Epub 2016 Aug 17.

PMID:
27534812
20.

Marker-less tracking of brain surface deformations by non-rigid registration integrating surface and vessel/sulci features.

Jiang J, Nakajima Y, Sohma Y, Saito T, Kin T, Oyama H, Saito N.

Int J Comput Assist Radiol Surg. 2016 Sep;11(9):1687-701. doi: 10.1007/s11548-016-1358-7. Epub 2016 Mar 5.

PMID:
26945999
21.

On the mechanism of gating defects caused by the R117H mutation in cystic fibrosis transmembrane conductance regulator.

Yu YC, Sohma Y, Hwang TC.

J Physiol. 2016 Jun 15;594(12):3227-44. doi: 10.1113/JP271723. Epub 2016 Mar 23.

22.

Medicinal Chemistry Focusing on Aggregation of Amyloid-β.

Sohma Y.

Chem Pharm Bull (Tokyo). 2016;64(1):1-7. doi: 10.1248/cpb.c15-00742. Review.

23.

Synthesis of chemically-tethered amyloid-β segment trimer possessing amyloidogenic properties.

Shinoda K, Sohma Y, Kanai M.

Bioorg Med Chem Lett. 2015 Aug 1;25(15):2976-9. doi: 10.1016/j.bmcl.2015.05.029. Epub 2015 May 19.

PMID:
26048787
24.

Covalent modifier-type aggregation inhibitor of amyloid-β based on a cyclo-KLVFF motif.

Kino R, Araya T, Arai T, Sohma Y, Kanai M.

Bioorg Med Chem Lett. 2015 Aug 1;25(15):2972-5. doi: 10.1016/j.bmcl.2015.05.027. Epub 2015 May 19.

PMID:
26045033
25.

Discovery of potent hexapeptide agonists to human neuromedin u receptor 1 and identification of their serum metabolites.

Takayama K, Mori K, Sohma Y, Taketa K, Taguchi A, Yakushiji F, Minamino N, Miyazato M, Kangawa K, Hayashi Y.

ACS Med Chem Lett. 2015 Jan 28;6(3):302-7. doi: 10.1021/ml500494j. eCollection 2015 Mar 12.

26.

A cyclic KLVFF-derived peptide aggregation inhibitor induces the formation of less-toxic off-pathway amyloid-β oligomers.

Arai T, Sasaki D, Araya T, Sato T, Sohma Y, Kanai M.

Chembiochem. 2014 Nov 24;15(17):2577-83. doi: 10.1002/cbic.201402430. Epub 2014 Sep 26.

PMID:
25262917
27.

Expression and localization of aquaporin-4 in sensory ganglia.

Kato J, Takai Y, Hayashi MK, Kato Y, Tanaka M, Sohma Y, Abe Y, Yasui M.

Biochem Biophys Res Commun. 2014 Sep 5;451(4):562-7. doi: 10.1016/j.bbrc.2014.08.026. Epub 2014 Aug 12.

PMID:
25124666
28.

Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR.

Guo JH, Chen H, Ruan YC, Zhang XL, Zhang XH, Fok KL, Tsang LL, Yu MK, Huang WQ, Sun X, Chung YW, Jiang X, Sohma Y, Chan HC.

Nat Commun. 2014 Jul 15;5:4420. doi: 10.1038/ncomms5420.

29.

Non-pretreated O-acyl isopeptide of amyloid β peptide 1-42 is monomeric with a random coil structure but starts to aggregate in a concentration-dependent manner.

Yoshiya T, Maruno T, Uemura T, Kubo S, Kiso Y, Sohma Y, Yoshizawa-Kumagaye K, Kobayashi Y, Nishiuchi Y.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3861-4. doi: 10.1016/j.bmcl.2014.06.052. Epub 2014 Jun 25.

30.

Rational design and identification of a non-peptidic aggregation inhibitor of amyloid-β based on a pharmacophore motif obtained from cyclo[-Lys-Leu-Val-Phe-Phe-].

Arai T, Araya T, Sasaki D, Taniguchi A, Sato T, Sohma Y, Kanai M.

Angew Chem Int Ed Engl. 2014 Jul 28;53(31):8236-9. doi: 10.1002/anie.201405109. Epub 2014 Jun 16.

PMID:
24931598
31.

O-acyl isopeptide method: development of an O-acyl isodipeptide unit for Boc SPPS and its application to the synthesis of Aβ1-42 isopeptide.

Yoshiya T, Uemura T, Maruno T, Kubo S, Kiso Y, Sohma Y, Kobayashi Y, Yoshizawa-Kumagaye K, Nishiuchi Y.

J Pept Sci. 2014 Sep;20(9):669-74. doi: 10.1002/psc.2662. Epub 2014 May 28.

PMID:
24889810
32.

Serine-selective aerobic cleavage of peptides and a protein using a water-soluble copper-organoradical conjugate.

Seki Y, Tanabe K, Sasaki D, Sohma Y, Oisaki K, Kanai M.

Angew Chem Int Ed Engl. 2014 Jun 16;53(25):6501-5. doi: 10.1002/anie.201402618. Epub 2014 May 14.

PMID:
24826926
33.

Synthesis of an O-acyl isopeptide by using native chemical ligation in an aqueous solvent system.

Kawashima H, Kuruma T, Yamashita M, Sohma Y, Akaji K.

J Pept Sci. 2014 May;20(5):361-5. doi: 10.1002/psc.2622. Epub 2014 Mar 4.

PMID:
24596115
34.

Attenuation of the aggregation and neurotoxicity of amyloid-β peptides by catalytic photooxygenation.

Taniguchi A, Sasaki D, Shiohara A, Iwatsubo T, Tomita T, Sohma Y, Kanai M.

Angew Chem Int Ed Engl. 2014 Jan 27;53(5):1382-5. doi: 10.1002/anie.201308001. Epub 2013 Dec 11.

PMID:
24339209
35.

A new class of aggregation inhibitor of amyloid-β peptide based on an O-acyl isopeptide.

Kawashima H, Sohma Y, Nakanishi T, Kitamura H, Mukai H, Yamashita M, Akaji K, Kiso Y.

Bioorg Med Chem. 2013 Nov 1;21(21):6323-7. doi: 10.1016/j.bmc.2013.08.062. Epub 2013 Sep 7.

PMID:
24076366
36.

[Molecular imaging of a targeted molecule in the process of drug design--from still imaging to moving imaging].

Sohma Y, Sato C.

Nihon Yakurigaku Zasshi. 2013 May;141(5):229. Japanese. No abstract available.

PMID:
24073469
37.

Direct visualization and quantitative analysis of water diffusion in complex biological tissues using CARS microscopy.

Yu YC, Sohma Y, Takimoto S, Miyauchi T, Yasui M.

Sci Rep. 2013 Sep 25;3:2745. doi: 10.1038/srep02745.

38.

Amiodarone inhibits apamin-sensitive potassium currents.

Turker I, Yu CC, Chang PC, Chen Z, Sohma Y, Lin SF, Chen PS, Ai T.

PLoS One. 2013 Jul 29;8(7):e70450. doi: 10.1371/journal.pone.0070450. Print 2013.

39.

[ATP hydrolysis-driven gating of an ABC transporter CFTR channel: from stills to movies].

Sohma Y, Yamashita H.

Nihon Yakurigaku Zasshi. 2013 May;141(5):230-4. Review. Japanese. No abstract available.

PMID:
23665551
40.

Biosorption of heavy metals by lactic acid bacteria and identification of mercury binding protein.

Kinoshita H, Sohma Y, Ohtake F, Ishida M, Kawai Y, Kitazawa H, Saito T, Kimura K.

Res Microbiol. 2013 Sep;164(7):701-9. doi: 10.1016/j.resmic.2013.04.004. Epub 2013 Apr 17.

PMID:
23603782
41.

[ABC transporter superfamily].

Sohma Y.

Nihon Yakurigaku Zasshi. 2013 Apr;141(4):222-3. Review. Japanese. No abstract available.

PMID:
23575429
42.

Synthesis of O-acyl isopeptides.

Sohma Y, Kiso Y.

Chem Rec. 2013 Apr;13(2):218-23. doi: 10.1002/tcr.201200023. Epub 2013 Mar 20.

PMID:
23512813
43.

Comparative properties of Aβ1-42, Aβ11-42, and [Pyr¹¹]Aβ11-42 generated from O-acyl isopeptides.

Sohma Y, Yamasaki M, Kawashima H, Taniguchi A, Yamashita M, Akaji K, Mukai H, Kiso Y.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1326-9. doi: 10.1016/j.bmcl.2012.12.082. Epub 2013 Jan 5.

PMID:
23352512
44.
45.

Mechanisms underlying regional differences in the Ca2+ sensitivity of BK(Ca) current in arteriolar smooth muscle.

Yang Y, Sohma Y, Nourian Z, Ella SR, Li M, Stupica A, Korthuis RJ, Davis MJ, Braun AP, Hill MA.

J Physiol. 2013 Mar 1;591(5):1277-93. doi: 10.1113/jphysiol.2012.241562. Epub 2013 Jan 7.

46.

The power stroke driven by ATP binding in CFTR as studied by molecular dynamics simulations.

Furukawa-Hagiya T, Furuta T, Chiba S, Sohma Y, Sakurai M.

J Phys Chem B. 2013 Jan 10;117(1):83-93. doi: 10.1021/jp308315w. Epub 2012 Dec 19.

PMID:
23214920
47.

Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation.

Jih KY, Sohma Y, Hwang TC.

J Gen Physiol. 2012 Oct;140(4):347-59. Epub 2012 Sep 10.

48.

Through the looking glass--a new world of proteins enabled by chemical synthesis.

Kent S, Sohma Y, Liu S, Bang D, Pentelute B, Mandal K.

J Pept Sci. 2012 Jul;18(7):428-36. doi: 10.1002/psc.2421. Epub 2012 Jun 4. Review.

PMID:
22674813
49.

Heterogenous GABA(B) receptor-mediated pathways are involved in the local GABAergic system of the rat trigeminal ganglion: possible involvement of KCTD proteins.

Hayasaki H, Sohma Y, Kanbara K, Otsuki Y.

Neuroscience. 2012 Aug 30;218:344-58. doi: 10.1016/j.neuroscience.2012.05.038. Epub 2012 May 22.

PMID:
22626642
50.

Identification of a novel post-hydrolytic state in CFTR gating.

Jih KY, Sohma Y, Li M, Hwang TC.

J Gen Physiol. 2012 May;139(5):359-70. doi: 10.1085/jgp.201210789. Epub 2012 Apr 16.

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