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Items: 24


Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells.

Bernatchez JA, Coste M, Beck S, Wells GA, Luna LA, Clark AE, Zhu Z, Hecht D, Rich JN, Sohl CD, Purse BW, Siqueira-Neto JL.

Viruses. 2019 Apr 20;11(4). pii: E365. doi: 10.3390/v11040365.


A Tie2 kinase mutation causing venous malformations increases phosphorylation rates and enhances cooperativity.

Kennedy MA, Xu Z, Wu Y, Sohl CD.

Biochem Biophys Res Commun. 2019 Feb 19;509(4):898-902. doi: 10.1016/j.bbrc.2019.01.020. Epub 2019 Jan 11.


The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT.

Ryan MR, Sohl CD, Luo B, Anderson KS.

Mol Cancer Res. 2019 Feb;17(2):532-543. doi: 10.1158/1541-7786.MCR-18-0429. Epub 2018 Sep 26.


Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants.

Avellaneda Matteo D, Wells GA, Luna LA, Grunseth AJ, Zagnitko O, Scott DA, Hoang A, Luthra A, Swairjo MA, Schiffer JM, Sohl CD.

Biochem J. 2018 Oct 22;475(20):3221-3238. doi: 10.1042/BCJ20180424.


Development and Validation of a Phenotypic High-Content Imaging Assay for Assessing the Antiviral Activity of Small-Molecule Inhibitors Targeting Zika Virus.

Bernatchez JA, Yang Z, Coste M, Li J, Beck S, Liu Y, Clark AE, Zhu Z, Luna LA, Sohl CD, Purse BW, Li R, Siqueira-Neto JL.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00725-18. doi: 10.1128/AAC.00725-18. Print 2018 Oct.


Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency.

Avellaneda Matteo D, Grunseth AJ, Gonzalez ER, Anselmo SL, Kennedy MA, Moman P, Scott DA, Hoang A, Sohl CD.

J Biol Chem. 2017 May 12;292(19):7971-7983. doi: 10.1074/jbc.M117.776179. Epub 2017 Mar 22.


Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ.

Sohl CD, Szymanski MR, Mislak AC, Shumate CK, Amiralaei S, Schinazi RF, Anderson KS, Yin YW.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8596-601. doi: 10.1073/pnas.1421733112. Epub 2015 Jun 29. Erratum in: Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E662.


Pools and Pols: Mechanism of a mutator phenotype.

Sohl CD, Ray S, Sweasy JB.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):5864-5. doi: 10.1073/pnas.1505169112. Epub 2015 Apr 30. No abstract available.


Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy.

Sohl CD, Ryan MR, Luo B, Frey KM, Anderson KS.

ACS Chem Biol. 2015 May 15;10(5):1319-29. doi: 10.1021/acschembio.5b00014. Epub 2015 Feb 24.


Fluorescence resonance energy transfer studies of DNA polymerase β: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection.

Towle-Weicksel JB, Dalal S, Sohl CD, Doublié S, Anderson KS, Sweasy JB.

J Biol Chem. 2014 Jun 6;289(23):16541-50. doi: 10.1074/jbc.M114.561878. Epub 2014 Apr 24.


Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) using pre-steady-state kinetics.

Muftuoglu Y, Sohl CD, Mislak AC, Mitsuya H, Sarafianos SG, Anderson KS.

Antiviral Res. 2014 Jun;106:1-4. doi: 10.1016/j.antiviral.2014.03.001. Epub 2014 Mar 12.


Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients.

Sohl CD, Kasiviswanathan R, Copeland WC, Anderson KS.

Hum Mol Genet. 2013 Mar 15;22(6):1074-85. doi: 10.1093/hmg/dds509. Epub 2012 Dec 3.


Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4.

Cheng Q, Sohl CD, Yoshimoto FK, Guengerich FP.

J Biol Chem. 2012 Aug 24;287(35):29554-67. doi: 10.1074/jbc.M112.390047. Epub 2012 Jul 7.


Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.

Sohl CD, Kasiviswanathan R, Kim J, Pradere U, Schinazi RF, Copeland WC, Mitsuya H, Baba M, Anderson KS.

Mol Pharmacol. 2012 Jul;82(1):125-33. doi: 10.1124/mol.112.078758. Epub 2012 Apr 18.


Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity.

Sohl CD, Singh K, Kasiviswanathan R, Copeland WC, Mitsuya H, Sarafianos SG, Anderson KS.

Antimicrob Agents Chemother. 2012 Mar;56(3):1630-4. doi: 10.1128/AAC.05729-11. Epub 2011 Dec 12.


Multi-step oxidations catalyzed by cytochrome P450 enzymes: Processive vs. distributive kinetics and the issue of carbonyl oxidation in chemical mechanisms.

Guengerich FP, Sohl CD, Chowdhury G.

Arch Biochem Biophys. 2011 Mar 1;507(1):126-34. doi: 10.1016/ Epub 2010 Sep 4. Review.


Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1.

Sohl CD, Guengerich FP.

J Biol Chem. 2010 Jun 4;285(23):17734-43. doi: 10.1074/jbc.M110.123711. Epub 2010 Apr 12.


High-throughput fluorescence assay of cytochrome P450 3A4.

Cheng Q, Sohl CD, Guengerich FP.

Nat Protoc. 2009;4(9):1258-61. doi: 10.1038/nprot.2009.123. Epub 2009 Aug 6.


Chromatographic assays of drug oxidation by human cytochrome P450 3A4.

Sohl CD, Cheng Q, Guengerich FP.

Nat Protoc. 2009;4(9):1252-7. doi: 10.1038/nprot.2009.122. Epub 2009 Aug 6.


Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase.

Guengerich FP, Martin MV, Sohl CD, Cheng Q.

Nat Protoc. 2009;4(9):1245-51. doi: 10.1038/nprot.2009.121. Epub 2009 Aug 6.


Cooperativity of cytochrome P450 1A2: interactions of 1,4-phenylene diisocyanide and 1-isopropoxy-4-nitrobenzene.

Isin EM, Sohl CD, Eoff RL, Guengerich FP.

Arch Biochem Biophys. 2008 May 1;473(1):69-75. doi: 10.1016/ Epub 2008 Feb 29.


Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding.

Sohl CD, Isin EM, Eoff RL, Marsch GA, Stec DF, Guengerich FP.

J Biol Chem. 2008 Mar 14;283(11):7293-308. doi: 10.1074/jbc.M709783200. Epub 2008 Jan 10.


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